Publications by authors named "Roderick Bronson"

100Publications

A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis.

Nat Biomed Eng 2020 Nov 30. Epub 2020 Nov 30.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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November 2020

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.

Mol Cell 2020 10;80(2):279-295.e8

Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia. Electronic address:

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October 2020

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas.

Cell Rep 2020 Sep;32(13):108196

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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September 2020

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells.

Cell Stem Cell 2020 Oct 4;27(4):663-678.e8. Epub 2020 Sep 4.

Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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October 2020

Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.

Crit Care Med 2020 May;48(5):e409-e417

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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May 2020

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer.

Proc Natl Acad Sci U S A 2020 01 23;117(1):513-521. Epub 2019 Dec 23.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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January 2020

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.

Mol Ther Methods Clin Dev 2019 Dec 16;15:18-26. Epub 2019 Aug 16.

Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, and Neurodiscovery Center, Harvard Medical School, Charlestown, MA, USA.

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December 2019

BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis.

PLoS One 2019 17;14(9):e0222400. Epub 2019 Sep 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.

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March 2020

Increased PHGDH expression promotes aberrant melanin accumulation.

BMC Cancer 2019 Jul 22;19(1):723. Epub 2019 Jul 22.

Koch Institute for Integrative Cancer Research, Cambridge, 02139, MA, USA.

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July 2019

Neutralization of BCL-2/X Enhances the Cytotoxicity of T-DM1 .

Mol Cancer Ther 2019 06 8;18(6):1115-1126. Epub 2019 Apr 8.

Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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June 2019

The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice.

Mol Nutr Food Res 2019 04 4;63(8):e1801097. Epub 2019 Feb 4.

Vitamins & Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111.

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April 2019

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.

Cell Rep 2018 12;25(12):3504-3518.e6

Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UK; Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UK. Electronic address:

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December 2018

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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December 2018

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.

J Clin Invest 2019 01 26;129(1):215-222. Epub 2018 Nov 26.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, Massachusetts, USA.

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January 2019

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Nat Commun 2018 11 23;9(1):4945. Epub 2018 Nov 23.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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November 2018

Neural blastocyst complementation enables mouse forebrain organogenesis.

Nature 2018 11 10;563(7729):126-130. Epub 2018 Oct 10.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

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November 2018

A novel mouse model of hemangiopericytoma due to loss of Tsc2.

Hum Mol Genet 2018 12;27(24):4169-4175

Division of Pulmonary Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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December 2018

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.

Cell 2018 06 14;174(1):156-171.e16. Epub 2018 Jun 14.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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June 2018

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Cancer Metab 2018 31;6. Epub 2018 May 31.

1David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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May 2018

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

Cancer Cell 2018 06 24;33(6):985-1003.e7. Epub 2018 May 24.

Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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June 2018

Ablation of insulin receptor substrates 1 and 2 suppresses -driven lung tumorigenesis.

Proc Natl Acad Sci U S A 2018 04 2;115(16):4228-4233. Epub 2018 Apr 2.

Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115;

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April 2018

Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys.

Cell 2018 05 29;173(5):1111-1122.e10. Epub 2018 Mar 29.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address:

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May 2018

E-Cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma.

Am J Respir Cell Mol Biol 2018 08;59(2):237-245

1 Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston Massachusetts.

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August 2018

γδ T Cells Contribute to Injury in the Developing Brain.

Am J Pathol 2018 03 15;188(3):757-767. Epub 2017 Dec 15.

Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

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March 2018

FOXO protects against age-progressive axonal degeneration.

Aging Cell 2018 02 26;17(1). Epub 2017 Nov 26.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

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February 2018

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.

Stem Cell Reports 2017 11 26;9(5):1706-1720. Epub 2017 Oct 26.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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November 2017

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.

JCI Insight 2017 10 5;2(19). Epub 2017 Oct 5.

Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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October 2017

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

NPJ Breast Cancer 2017 22;3:38. Epub 2017 Sep 22.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 USA.

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September 2017

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

NPJ Breast Cancer 2017 1;3:18. Epub 2017 May 1.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115 MA USA.

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May 2017

Ontak-like human IL-2 fusion toxin.

J Immunol Methods 2017 09 24;448:51-58. Epub 2017 May 24.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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September 2017

Semiconductor diode laser device adjuvanting intradermal vaccine.

Vaccine 2017 04 30;35(18):2404-2412. Epub 2017 Mar 30.

Vaccine and Immunotherapy Center, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, United States. Electronic address:

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April 2017

Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.

Nat Commun 2017 02 13;8:14431. Epub 2017 Feb 13.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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February 2017

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.

Cell Metab 2017 03 2;25(3):661-672. Epub 2017 Feb 2.

Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115, USA; Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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March 2017

Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.

Nat Commun 2017 01 17;8:14013. Epub 2017 Jan 17.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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January 2017

Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development.

PLoS One 2016 8;11(12):e0168009. Epub 2016 Dec 8.

Mother Infant Research Institute (MIRI) at Tufts Medical Center and Floating Hospital for Children, Boston, MA, United States.

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July 2017

Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice.

Sci Rep 2016 11 7;6:36696. Epub 2016 Nov 7.

Department of Surgery, University of Michigan Hospital, Ann Arbor, MI, 48019, USA.

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November 2016

Sox2 Suppresses Gastric Tumorigenesis in Mice.

Cell Rep 2016 08 4;16(7):1929-41. Epub 2016 Aug 4.

Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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August 2016

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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September 2016

The impact of the MYB-NFIB fusion proto-oncogene in vivo.

Oncotarget 2016 May;7(22):31681-8

Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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May 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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May 2016

Unrecognized "AIDS" in Monkeys, 1969-1980: Explanations and Implications.

Am J Public Health 2016 Jun 14;106(6):1015-22. Epub 2016 Apr 14.

Theodore M. Hammett is with Abt Associates, Cambridge, MA. Roderick T. Bronson is with Harvard Medical School, Boston, MA.

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June 2016

Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression.

Cancer Res 2016 04 15;76(7):1869-81. Epub 2016 Feb 15.

Division of Genetics, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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April 2016

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Oncotarget 2015 Dec;6(40):42445-67

Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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December 2015

Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.

Elife 2015 Oct 24;4. Epub 2015 Oct 24.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States.

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October 2015

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Genes Dev 2015 Sep;29(17):1850-62

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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September 2015

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

Immunity 2015 Sep 1;43(3):579-90. Epub 2015 Sep 1.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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September 2015

Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.

Biochem Biophys Res Commun 2015 Sep 28;465(2):167-73. Epub 2015 Jul 28.

Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine. Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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September 2015

Histopathology of the human inner ear in Alström's syndrome.

Audiol Neurootol 2015 24;20(4):267-72. Epub 2015 Jun 24.

Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.

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June 2016

Cloning and variation of ground state intestinal stem cells.

Nature 2015 Jun 3;522(7555):173-8. Epub 2015 Jun 3.

1] The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA [2] Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02118, USA [4] Department of Medicine, National University of Singapore, 119228 Singapore [5] Multiclonal Therapeutics, Inc., Farmington, Connecticut 06032, USA.

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June 2015

Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo.

Pigment Cell Melanoma Res 2015 Sep 20;28(5):603-6. Epub 2015 Jun 20.

Graduate Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA.

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September 2015

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.

Neurobiol Dis 2015 Oct 24;82:22-31. Epub 2015 May 24.

Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA. Electronic address:

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October 2015

CD11c+ Dendritic Cells Accelerate the Rejection of Older Cardiac Transplants via Interleukin-17A.

Circulation 2015 Jul 8;132(2):122-31. Epub 2015 May 8.

From Transplantation Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.O., T.H., H.R.C.B., K.H., K.E., H.U., M.Q., F.V., F.K., B.S., A.E., S.G.T.); Department of Visceral, Transplant, and Thoracic Surgery, Center for Operative Medicine, Innsbruck Medical University, Austria (R.O.); Institute of Medical Immunology (T.H.) and Department for General, Visceral, Transplant, Vascular, and Thorax Surgery (J.P.), Charité-Universitätsmedizin Berlin, Germany; Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland (H.R.C.B., M.J.W.); Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA (O.B., R.A.); Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (O.B.); Division of Transplantation, Department of Surgery, Medical University of Vienna, Austria (K.H.); Rodent Histopathology Core, Harvard Medical School, Boston, MA (R.T.B.); Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan (R.T.B.); Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, University Hospital of Leipzig, Germany (M.Q., F.K.); and Division of Transplant Surgery, Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands (B.S.).

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July 2015

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

Cancer Discov 2015 Jul 16;5(7):740-51. Epub 2015 Apr 16.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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July 2015

Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models.

PLoS One 2015 17;10(3):e0120628. Epub 2015 Mar 17.

Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States of America.

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December 2015

Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.

Front Oncol 2015 24;5:50. Epub 2015 Feb 24.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.

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March 2015

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.

Cancer Discov 2015 Apr 22;5(4):396-409. Epub 2015 Jan 22.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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April 2015

Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.

Cancer Res 2015 Mar 16;75(6):1068-79. Epub 2015 Jan 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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March 2015

A vascular model of Tsc1 deficiency accelerates renal tumor formation with accompanying hemangiosarcomas.

Mol Cancer Res 2015 Mar 29;13(3):548-55. Epub 2014 Dec 29.

Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts.

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March 2015

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Nature 2014 Dec 22;516(7531):428-31. Epub 2014 Oct 22.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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December 2014