Roderic G Eckenhoff

Roderic G Eckenhoff

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Roderic G Eckenhoff

Roderic G Eckenhoff

Publications by authors named "Roderic G Eckenhoff"

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Anesth Analg 2019 Sep;129(3):e112-e113

Anesthesiology Department, Duke University Medical Center, Durham, North Carolina, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University, Palo Alto, California Department of Anesthesiology, Perioperative & Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts Departments of Anesthesiology and Clinical and Health Psychology, University of Florida, Gainesville, Florida Department of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital, Melbourne, Australia Department of Anesthesiology, Columbia University Medical Center, New York, New York Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1213/ANE.0000000000004300DOI Listing
September 2019

Recommendations for a new perioperative cognitive impairment nomenclature.

Alzheimers Dement 2019 Aug;15(8):1115-1116

Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2019.05.005DOI Listing
August 2019

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats.

Behav Brain Res 2019 Jul 18;367:59-67. Epub 2019 Mar 18.

Neuroanesthesia Laboratory, Atlanta VA Medical Center/Emory University, Atlanta, GA, USA; Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA; Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2019.03.029DOI Listing
July 2019

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

Trends Pharmacol Sci 2019 Jul 27;40(7):464-481. Epub 2019 May 27.

Departments of Anesthesiology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Departments of Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.05.001DOI Listing
July 2019

Prevalence and Multivariable Factors Associated With Preoperative Cognitive Impairment in Outpatient Surgery in the United States.

Anesth Analg 2019 Jul;129(1):e5-e7

From the Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1213/ANE.0000000000004035DOI Listing
July 2019

Volatile anesthetics affect macrophage phagocytosis.

PLoS One 2019 9;14(5):e0216163. Epub 2019 May 9.

Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508649PMC
May 2019

High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles.

Methods Enzymol 2018 3;602:177-187. Epub 2018 Mar 3.

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.01.007DOI Listing
April 2019

Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry.

Methods Enzymol 2018 2;602:231-246. Epub 2018 Mar 2.

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.01.009DOI Listing
April 2019

Preface.

Methods Enzymol 2018 ;602:xv-xvi

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http://dx.doi.org/10.1016/S0076-6879(18)30118-6DOI Listing
April 2019

Preface.

Methods Enzymol 2018 ;603:xv-xvi

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http://dx.doi.org/10.1016/S0076-6879(18)30164-2DOI Listing
March 2019

Gone Fishing….

Anesthesiology 2018 09;129(3):392-393

From the Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1097/ALN.0000000000002328DOI Listing
September 2018

Propofol inhibits prokaryotic voltage-gated Na channels by promoting activation-coupled inactivation.

J Gen Physiol 2018 09 17;150(9):1299-1316. Epub 2018 Jul 17.

Vickie and Jack Farber Institute for Neuroscience and Department of Neuroscience, Sidney Kimmel Medical College and Jefferson College of Biomedical Sciences, Thomas Jefferson University, Philadelphia, PA

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http://www.jgp.org/lookup/doi/10.1085/jgp.201711924
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http://dx.doi.org/10.1085/jgp.201711924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122921PMC
September 2018

Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.

FASEB J 2018 08 5;32(8):4172-4189. Epub 2018 Mar 5.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.201701347RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044061PMC
August 2018

Between a ROCK and an IR Place.

Anesth Analg 2018 03;126(3):750-751

Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1213/ANE.0000000000002821DOI Listing
March 2018

Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels.

Mol Neurobiol 2018 02 15;55(2):1692-1702. Epub 2017 Feb 15.

Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, 900 Walnut Street, Room JHN 416, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1007/s12035-017-0437-2DOI Listing
February 2018

Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation.

ACS Chem Biol 2017 05 3;12(5):1353-1362. Epub 2017 Apr 3.

Department of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/acschembio.7b00222DOI Listing
May 2017

Common general anesthetic propofol impairs kinesin processivity.

Proc Natl Acad Sci U S A 2017 05 8;114(21):E4281-E4287. Epub 2017 May 8.

Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180;

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http://dx.doi.org/10.1073/pnas.1701482114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448234PMC
May 2017

Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B production.

FASEB J 2017 04 9;31(4):1584-1594. Epub 2017 Jan 9.

Division of Cardiac Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston Massachusetts, USA;

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http://dx.doi.org/10.1096/fj.201601095RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349797PMC
April 2017

Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.

Anesth Analg 2016 11;123(5):1253-1262

From the Departments of *Anesthesiology and Critical Care and †Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; ‡Department of Chemistry, University of Pennsylvania School of Arts and Sciences, Philadelphia, Pennsylvania; and §Department of Physics, Rutgers University, Camden, New Jersey.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072990PMC
http://dx.doi.org/10.1213/ANE.0000000000001365DOI Listing
November 2016

Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac.

Proc Natl Acad Sci U S A 2016 11 15;113(48):13762-13767. Epub 2016 Nov 15.

Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261;

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http://dx.doi.org/10.1073/pnas.1609939113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137747PMC
November 2016

Molecular mechanism of anesthetic-induced depression of myocardial contraction.

FASEB J 2016 08 11;30(8):2915-25. Epub 2016 May 11.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1096/fj.201600290RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072354PMC
August 2016

Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review.

Anesth Analg 2016 08;123(2):326-35

From the *Department of Anesthesiology, Perioperative and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, Massachusetts; †Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts; and ‡Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851113PMC
http://dx.doi.org/10.1213/ANE.0000000000001403DOI Listing
August 2016

Fallacy…. Really?

Anesthesiology 2016 08;125(2):426-8

University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (R.G.E.).

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http://dx.doi.org/10.1097/ALN.0000000000001180DOI Listing
August 2016

Neurocognitive Adverse Effects of Anesthesia in Adults and Children: Gaps in Knowledge.

Drug Saf 2016 07;39(7):613-26

Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s40264-016-0415-zDOI Listing
July 2016

Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.

Anesthesiology 2016 Mar;124(3):664-73

From the Departments of Anesthesiology (M.N.K., Q.C., Y.X., P.T.), Pharmacology and Chemical Biology (Y.X., P.T.), Structural Biology (Y.X.), and Computational and Systems Biology (P.T.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (W.B., R.G.E.).

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http://dx.doi.org/10.1097/ALN.0000000000001005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755840PMC
March 2016

Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics.

Biophys J 2015 Nov;109(10):2003-11

Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.bpj.2015.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656854PMC
November 2015

Taxane modulation of anesthetic sensitivity in surgery for nonmetastatic breast cancer.

J Clin Anesth 2015 Sep 30;27(6):481-5. Epub 2015 May 30.

University of Pennsylvania, Department of Anesthesiology; Evidera, Outcomes Research. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2015.05.001DOI Listing
September 2015

Potential Adverse Effects of Anesthesia in Children.

JAMA 2015 Jul;314(4):408-9

Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jama.2015.7378DOI Listing
July 2015

Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1.

PLoS One 2014 6;9(5):e96649. Epub 2014 May 6.

Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096649PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011845PMC
June 2015

Role for the propofol hydroxyl in anesthetic protein target molecular recognition.

ACS Chem Neurosci 2015 Jun 30;6(6):927-35. Epub 2015 Mar 30.

§Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, 900 Walnut Street, JHN 417, Philadelphia, Pennsylvania 19107, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936777PMC
June 2015

Functional outcomes after critical illness in the elderly.

Crit Care Med 2015 Jun;43(6):1340-1

Department of Anesthesiology and Critical Care; and Department of Internal Medicine, Division of Geriatric Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, PA Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/CCM.0000000000001026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869168PMC
June 2015

General anesthetic and the risk of dementia in elderly patients: current insights.

Clin Interv Aging 2014 24;9:1619-28. Epub 2014 Sep 24.

Division of Geriatric Psychiatry, Department of Psychiatry, Queen's University, Durham, NC, USA.

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http://dx.doi.org/10.2147/CIA.S49680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181446PMC
April 2015

Macroscopic and macromolecular specificity of alkylphenol anesthetics for neuronal substrates.

Sci Rep 2015 Apr 8;5:9695. Epub 2015 Apr 8.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1038/srep09695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894431PMC
April 2015

Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site.

J Biol Chem 2015 Mar 9;290(13):8559-68. Epub 2015 Feb 9.

From the Departments of Anesthesiology and Critical Care and

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http://dx.doi.org/10.1074/jbc.M114.620732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375505PMC
March 2015

Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop.

Anesth Analg 2015 Mar;120(3):649-52

From the *Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; †Department of Anesthesiology, Surgical Services and Intensive Care Medicine Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; and ‡Department of Anesthesiology & Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://pdfs.journals.lww.com/anesthesia-analgesia/2015/03000
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1213/ANE.0000000000000624DOI Listing
March 2015

Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors.

Sci Signal 2015 Mar 31;8(370):ra33. Epub 2015 Mar 31.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.2005912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520235PMC
March 2015

Forward to the past.

Anesth Analg 2015 Feb;120(2):259-60

From the *Department of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; and †Department of Anesthesia, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1213/ANE.0000000000000534DOI Listing
February 2015

Discovery of a novel general anesthetic chemotype using high-throughput screening.

Anesthesiology 2015 Feb;122(2):325-33

From the Department of Anesthesiology and Critical Care (A.R.M.-W., W.B., R.G.E.) and Department of Pharmacology (B.P.W.), University of Pennsylvania, Philadelphia, Pennsylvania; National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland (G.R., W.A.L., A.S., A.J., D.J.M.); and College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania (D.F.L.).

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http://dx.doi.org/10.1097/ALN.0000000000000505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300529PMC
February 2015

Sites and functional consequence of VDAC-alkylphenol anesthetic interactions.

FEBS Lett 2014 Nov 18;588(23):4398-403. Epub 2014 Oct 18.

Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254586PMC
November 2014

Computational investigation of cholesterol binding sites on mitochondrial VDAC.

J Phys Chem B 2014 Aug 11;118(33):9852-60. Epub 2014 Aug 11.

Department of Anesthesiology and Critical Care and ‡Department of Pharmacology, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/jp504516aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141696PMC
August 2014

Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms.

Proc Natl Acad Sci U S A 2014 May 21;111(18):6726-31. Epub 2014 Apr 21.

Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107.

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http://dx.doi.org/10.1073/pnas.1405768111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020080PMC
May 2014

Mechanisms revealed through general anesthetic photolabeling.

Curr Anesthesiol Rep 2014 Mar;4(1):57-66

Department of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104.

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http://link.springer.com/content/pdf/10.1007%2Fs40140-013-00
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http://link.springer.com/10.1007/s40140-013-0040-7
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http://dx.doi.org/10.1007/s40140-013-0040-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927792PMC
March 2014

Photoaffinity labeling the propofol binding site in GLIC.

Biochemistry 2014 Jan 30;53(1):135-42. Epub 2013 Dec 30.

Department of Neurobiology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/bi401492kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935609PMC
January 2014

Anesthesia, surgery, illness and Alzheimer's disease.

Prog Neuropsychopharmacol Biol Psychiatry 2013 Dec 21;47:162-6. Epub 2012 Jun 21.

Department of Anesthesiology & Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2012.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509241PMC
December 2013

Differential general anesthetic effects on microglial cytokine expression.

PLoS One 2013 31;8(1):e52887. Epub 2013 Jan 31.

Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052887PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561404PMC
September 2013

Using the problem-based learning discussion (PBLD) to facilitate research.

J Clin Anesth 2013 Sep 17;25(6):433. Epub 2013 Aug 17.

Department of Anesthesiology & Critical Care, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2013.05.002DOI Listing
September 2013

Anesthetic drug development: Novel drugs and new approaches.

Surg Neurol Int 2013 19;4(Suppl 1):S2-S10. Epub 2013 Mar 19.

Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.4103/2152-7806.109179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642742PMC
May 2013

Direct modulation of microtubule stability contributes to anthracene general anesthesia.

J Am Chem Soc 2013 Apr 29;135(14):5389-98. Epub 2013 Mar 29.

Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/ja311171uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671381PMC
April 2013

Modulation of murine Alzheimer pathogenesis and behavior by surgery.

Ann Surg 2013 Mar;257(3):439-48

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1097/SLA.0b013e318269d623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525732PMC
March 2013

Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

J Biol Chem 2013 Mar 8;288(9):6178-89. Epub 2013 Jan 8.

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M112.435909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585054PMC
March 2013

In reply.

Anesthesiology 2013 Feb;118(2):466

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http://dx.doi.org/10.1097/ALN.0b013e31827e3bf1DOI Listing
February 2013

In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets.

J Biol Chem 2013 Jan 26;288(2):1279-85. Epub 2012 Nov 26.

Department of Anesthesia and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M112.413989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543011PMC
January 2013

Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.

FASEB J 2012 Nov 19;26(11):4408-17. Epub 2012 Jul 19.

Department of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital Boston, 300 Longwood Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1096/fj.12-212746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475260PMC
November 2012

Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.

PLoS One 2012 16;7(2):e32070. Epub 2012 Feb 16.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281113PMC
August 2012

Neurodevelopmental consequences of sub-clinical carbon monoxide exposure in newborn mice.

PLoS One 2012 10;7(2):e32029. Epub 2012 Feb 10.

Division of Anesthesiology and Pain Medicine, Children's National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032029PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277503PMC
July 2012

Ferritin couples iron and fatty acid metabolism.

FASEB J 2012 Jun 23;26(6):2394-400. Epub 2012 Feb 23.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1096/fj.11-198853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360150PMC
June 2012

A novel fluorescent general anesthetic enables imaging of sites of action in vivo.

Anesthesiology 2012 Jun;116(6):1363

Department of Anesthesiology & Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/ALN.0b013e31824cb4b1DOI Listing
June 2012

Is hydrogen sulfide-induced suspended animation general anesthesia?

J Pharmacol Exp Ther 2012 Jun 13;341(3):735-42. Epub 2012 Mar 13.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1124/jpet.111.187237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362879PMC
June 2012

General anesthetics predicted to block the GLIC pore with micromolar affinity.

PLoS Comput Biol 2012 May 31;8(5):e1002532. Epub 2012 May 31.

Department of Chemistry and Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America.

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http://dx.plos.org/10.1371/journal.pcbi.1002532
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364936PMC
May 2012

Postoperative cognitive decline: where art tau?

Anesthesiology 2012 Apr;116(4):751-2

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http://dx.doi.org/10.1097/ALN.0b013e31824be8e1DOI Listing
April 2012

Anesthetic mechanisms: worms light the way.

Curr Biol 2011 Dec;21(24):R985-6

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cub.2011.11.012DOI Listing
December 2011

Human Alzheimer and inflammation biomarkers after anesthesia and surgery.

Anesthesiology 2011 Oct;115(4):727-32

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/ALN.0b013e31822e9306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429370PMC
October 2011

Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.

Alzheimers Dement 2011 Sep 13;7(5):521-531.e1. Epub 2011 Jul 13.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167023PMC
September 2011

Anesthetic modulation of neuroinflammation in Alzheimer's disease.

Curr Opin Anaesthesiol 2011 Aug;24(4):389-94

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/ACO.0b013e32834871c5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289136PMC
August 2011

m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol.

J Med Chem 2010 Aug;53(15):5667-75

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia,Pennsylvania, USA.

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https://pubs.acs.org/doi/10.1021/jm1004072
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http://dx.doi.org/10.1021/jm1004072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917171PMC
August 2010

Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14122-7. Epub 2010 Jul 26.

Institute for Computational and Molecular Science, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1073/pnas.1008534107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922517PMC
August 2010

A smoking gun but still no victim.

J Alzheimers Dis 2010 ;19(4):1259-60; discussion 1261

Department of Anesthesiology & Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-2010-1324DOI Listing
July 2010

Inhalational anesthetic photolabeling.

Methods Mol Biol 2010 ;617:437-43

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993002PMC
http://dx.doi.org/10.1007/978-1-60327-323-7_31DOI Listing
June 2010

Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors.

J Pharmacol Exp Ther 2010 Apr 19;333(1):14-22. Epub 2010 Jan 19.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1124/jpet.109.161562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846020PMC
April 2010

Anesthesia and the old brain.

Anesth Analg 2010 Feb 9;110(2):421-6. Epub 2009 Oct 9.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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https://insights.ovid.com/crossref?an=00000539-201002000-000
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http://dx.doi.org/10.1213/ANE.0b013e3181b80939DOI Listing
February 2010

Inhaled anesthetic potency in aged Alzheimer mice.

Anesth Analg 2010 Feb 9;110(2):427-30. Epub 2009 Oct 9.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1213/ANE.0b013e3181b5a292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899815PMC
February 2010

A unitary anesthetic binding site at high resolution.

J Biol Chem 2009 Sep 15;284(36):24176-84. Epub 2009 Jul 15.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M109.017814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782011PMC
September 2009

A high-throughput approach for identification of novel general anesthetics.

PLoS One 2009 Sep 24;4(9):e7150. Epub 2009 Sep 24.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746312PMC
September 2009

Structure-based shape pharmacophore modeling for the discovery of novel anesthetic compounds.

Bioorg Med Chem 2009 Jul 29;17(14):5133-8. Epub 2009 May 29.

Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Technology Enterprise (BRITE), North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, United States.

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http://dx.doi.org/10.1016/j.bmc.2009.05.060DOI Listing
July 2009

Identification of a fluorescent general anesthetic, 1-aminoanthracene.

Proc Natl Acad Sci U S A 2009 Apr 3;106(16):6501-6. Epub 2009 Apr 3.

Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0810590106
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http://dx.doi.org/10.1073/pnas.0810590106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672486PMC
April 2009

Why can all of biology be anesthetized?

Anesth Analg 2008 Sep;107(3):859-61

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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September 2008

Does it add up?

Anesth Analg 2008 Aug;107(2):365-6

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http://dx.doi.org/10.1213/ane.0b013e31817e0e5bDOI Listing
August 2008

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics.

Neurobiol Aging 2008 Jul 7;29(7):1002-10. Epub 2007 Mar 7.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 305 John Morgan, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899817PMC
July 2008

Inhaled anesthetics elicit region-specific changes in protein expression in mammalian brain.

Proteomics 2008 Jul;8(14):2983-92

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/pmic.200800057DOI Listing
July 2008

The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors.

Anesthesiology 2008 Feb;108(2):251-60

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/01.anes.0000299435.59242.0eDOI Listing
February 2008

A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity.

Anesth Analg 2008 Feb;106(2):492-500, table of contents

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1213/ane.0b013e3181605b71DOI Listing
February 2008

Thermodynamics of xenon binding to cryptophane in water and human plasma.

J Am Chem Soc 2007 Aug 7;129(30):9262-3. Epub 2007 Jul 7.

Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA.

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http://dx.doi.org/10.1021/ja072965pDOI Listing
August 2007

Limitations of microarray studies.

Anesth Analg 2007 May;104(5):1300-1; author reply 1301-2

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http://dx.doi.org/10.1213/01.ane.0000260459.35198.c9DOI Listing
May 2007

Risk factors for venous gas emboli after decompression from prolonged hyperbaric exposures.

Aviat Space Environ Med 2007 May;78(5):493-9

Department of Anesthesia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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May 2007

Halothane binding proteome in human brain cortex.

J Proteome Res 2007 Feb;6(2):582-92

Department of Anesthesiology and Critical Care, University of Pennsylvania Health System, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1021/pr060311uDOI Listing
February 2007

High throughput modular chambers for rapid evaluation of anesthetic sensitivity.

BMC Anesthesiol 2006 Nov 10;6:13. Epub 2006 Nov 10.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, USA.

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http://dx.doi.org/10.1186/1471-2253-6-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1657002PMC
November 2006

Image not living up to goal.

Anesthesiology 2006 Sep;105(3):626-7; author reply 628, 629-30

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http://dx.doi.org/10.1097/00000542-200609000-00033DOI Listing
September 2006

Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions.

ACS Chem Biol 2006 Jul;1(6):377-84

Department of Anesthesiology & Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/cb600207dDOI Listing
July 2006

Interactions of volatile anesthetics with neurodegenerative-disease-associated proteins.

Anesthesiol Clin 2006 Jun;24(2):381-405

Department of Anesthesiology and Critical Care, University of Pennsylvania Health Systems, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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June 2006