Publications by authors named "Robin Thambudorai"

5 Publications

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Radical radiotherapy or chemoradiotherapy for inoperable, locally advanced, non-small cell lung cancer: Analysis of patient profile, treatment approaches, and outcomes for 213 patients at a tertiary cancer center.

Indian J Cancer 2018 Apr-Jun;55(2):125-133

Department of Radiation Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Introduction: Radical radiotherapy (RT) with curative intent, with or without chemotherapy, is the standard treatment for inoperable, locally advanced nonsmall cell lung cancer (NSCLC).

Materials And Methods: We retrospectively reviewed the data for all 288 patients who presented with inoperable, locally advanced NSCLC at our institution, between May 2011 and December 2016.

Results: RT alone or sequential chemoradiotherapy (SCRT) or concurrent chemoradiotherapy (CCRT) was used for 213 patients. Median age was 64 years (range: 27-88 years). Stage-III was the biggest stage group with 189 (88.7%) patients. Most patients with performance status (PS) 0 or 1 received CCRT, whereas most patients with PS 2 received RT alone (P < 0.001). CCRT, SCRT, and RT alone were used for 120 (56.3%), 24 (11.3%), and 69 (32.4%) patients, respectively. A third of all patients (32.4%) required either volumetric-modulated arc radiotherapy (VMAT) or tomotherapy. Median follow-up was 16 months. The median progression-free survival and median overall survival (OS) were 11 and 20 months, respectively. One-year OS and 2-year OS were 67.9% and 40.7%, respectively. Patients treated using CCRT lived significantly longer with a median survival of 28 months, compared with 13 months using SCRT and RT alone (P < 0.001). On multivariate analysis, OS was significantly affected by age, stage group, treatment approach, and response to treatment.

Conclusion: RT including CCRT is feasible, safe, and well tolerated in our patient population and results in survival benefits comparable with published literature. CCRT should be considered for all patients with inoperable, locally advanced NSCLC, who are fit and have good PS.
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http://dx.doi.org/10.4103/ijc.IJC_469_17DOI Listing
April 2019

Lymphoscintigraphy combined with single-photon emission computed tomography-computed tomography (SPECT-CT): A very effective imaging approach for identification of the site of leak in postoperative chylothorax.

Indian J Nucl Med 2015 Apr-Jun;30(2):177-9

Department of Nuclear Medicine, Tata Medical Center, Kolkata, West Bengal, India.

Post operative chylothorax is a known complication of various thoracic surgeries. It needs identification of precise site of leak in the thoracic duct. Lymphosicintigraphy can identify chyle leak but cannot delineate exact site of leak. SPECT-CT is precise in anatomic localisation and hence SPECT-CT should be combined with every lymphoscintigraphy in evaluation of clinically suspected case of post operative chylothorax. We report such a case.
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http://dx.doi.org/10.4103/0972-3919.152988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379685PMC
April 2015

Tuberculosis nearly preventing a curative resection for colorectal liver metastasis: A case report.

Indian J Surg 2010 Jul 20;72(Suppl 1):312-4. Epub 2010 Oct 20.

Department of Surgery, Christian Medical College and Hospital, Ludhiana, Punjab India.

Perihepatic lymph node involvement portends a poor prognosis, and is reported to be the most important prognostic factor following R0 resection of colorectal liver metastases. Tuberculous lymphadenitis is one of the common presentations of tuberculosis and is often diagnosed only after histopathological confirmation. In this patient, a frozen section revealing tuberculosis in the perihepatic nodes allowed us to proceed with the curative liver resection.
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http://dx.doi.org/10.1007/s12262-010-0086-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451862PMC
July 2010

An ideal suture for midline abdominal closure?

Indian J Surg 2009 Jun 10;71(3):128-32. Epub 2009 Jun 10.

Department of Surgery, Christian Medical College and Hospital, Ludhiana, 141 008 Punjab India.

Background: Within the last decade the customary trend of using non absorbable sutures has changed, with numerous studies and meta-analyses advocating the use of slowly absorbable sutures, claiming comparable wound strength with significantly lower incidence of wound complications. It was the objective of this randomized clinical trial to compare two universally accepted suture materials, the non-absorbable Nylon and the slowly absorbable Polydioxanone for midline abdominal closure in the Indian context.

Method: 64 patients undergoing midline laparotomy were allocated, using block randomization, to mass closure of the abdominal wall with continuous polyamide (34 patients) or continuous polydioxanone (30 patients).

Results: There was an alarmingly higher incidence of wound dehiscence in the PDS group requiring secondary suturing (Nylon 0; PDS 5). Mid-way through the trial, an interim analysis was performed which revealed an unacceptably high incidence of wound dehiscence in the PDS group. This necessitated a premature curtailment of the study. There was, however, a statistically significantly higher incidence of scar pain in the Nylon group (Nylon 9; PDS 1).

Conclusion: There is a need for a study with larger series, and PDS as a choice of suture for midline wound closure cannot be recommended.
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http://dx.doi.org/10.1007/s12262-009-0036-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452482PMC
June 2009