Robin S B Williams

Robin S B Williams

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Robin S B Williams

Robin S B Williams

Publications by authors named "Robin S B Williams"

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Advice on avoiding the Valley of Death: insights from a 3Rs model of aversive and emetic compound identification.

ALTEX 2019 2;36(3):466-469. Epub 2019 Apr 2.

Division of Biomedical Sciences, St George's University of London, Tooting, London, United Kingdom.

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http://dx.doi.org/10.14573/altex.1810182DOI Listing
April 2019

Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures.

Epilepsia 2018 11 15;59(11):e172-e178. Epub 2018 Oct 15.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

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http://doi.wiley.com/10.1111/epi.14578
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http://dx.doi.org/10.1111/epi.14578DOI Listing
November 2018

Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in .

Dis Model Mech 2018 08 21;11(9). Epub 2018 Aug 21.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK

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http://dx.doi.org/10.1242/dmm.035600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176992PMC
August 2018

All You Need Is Fats-for Seizure Control: Using Amoeba to Advance Epilepsy Research.

Front Cell Neurosci 2018 11;12:199. Epub 2018 Jul 11.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway, University of London, Egham, United Kingdom.

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http://dx.doi.org/10.3389/fncel.2018.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050470PMC
July 2018

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells.

Neuropharmacology 2018 Jan 22;128:54-62. Epub 2017 Sep 22.

Department of Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.09.031DOI Listing
January 2018

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders.

Lancet Neurol 2018 01 16;17(1):84-93. Epub 2017 Dec 16.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14744422173040
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http://dx.doi.org/10.1016/S1474-4422(17)30408-8DOI Listing
January 2018

Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in .

Dis Model Mech 2018 01 29;11(1). Epub 2018 Jan 29.

Centre of Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX UK

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http://dx.doi.org/10.1242/dmm.032375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818083PMC
January 2018

Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research.

Methods Mol Biol 2016 ;1407:123-30

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, TW20 OEX, UK.

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http://dx.doi.org/10.1007/978-1-4939-3480-5_9DOI Listing
December 2017

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid.

Neurobiol Dis 2017 Oct 21;106:63-75. Epub 2017 Jun 21.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.06.011DOI Listing
October 2017

Tipping the scales: Lessons from simple model systems on inositol imbalance in neurological disorders.

Eur J Cell Biol 2017 Mar 25;96(2):154-163. Epub 2017 Jan 25.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW20 OEX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ejcb.2017.01.007DOI Listing
March 2017

Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays.

ALTEX 2016 22;33(3):225-36. Epub 2015 Dec 22.

Centre of Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

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http://www.altex.ch/resources/Cocorocchio_of_151222.pdf
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http://www.altex.ch/Online-first.95.html
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http://dx.doi.org/10.14573/altex.1509011DOI Listing
January 2017

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.

Mol Cell Biol 2016 05 2;36(10):1464-79. Epub 2016 May 2.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, United Kingdom

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http://dx.doi.org/10.1128/MCB.00039-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859692PMC
May 2016

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling.

Neuropharmacology 2016 Feb 24;101:566-75. Epub 2015 Jun 24.

Department of Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2015.06.013DOI Listing
February 2016

Seizure control by decanoic acid through direct AMPA receptor inhibition.

Brain 2016 Feb 25;139(Pt 2):431-43. Epub 2015 Nov 25.

1 Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK

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http://dx.doi.org/10.1093/brain/awv325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805082PMC
February 2016

Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model.

Br J Pharmacol 2015 Nov 22;172(22):5306-17. Epub 2015 Oct 22.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK.

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http://doi.wiley.com/10.1111/bph.13320
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http://dx.doi.org/10.1111/bph.13320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123713PMC
November 2015

New experimental therapies for status epilepticus in preclinical development.

Epilepsy Behav 2015 Aug 17;49:290-3. Epub 2015 Jul 17.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2015.06.009DOI Listing
August 2015

Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency.

J Pharmacol Exp Ther 2015 Jan 17;352(1):43-52. Epub 2014 Oct 17.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom (P.C., A.M.E.Z., J.P.M., R.S.B.W.); Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, United Kingdom (A.J.C., J.S.); and Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom (S.W., M.C.-J., M.C.W.)

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http://dx.doi.org/10.1124/jpet.114.218768DOI Listing
January 2015

Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms.

Seizure 2015 Jan 13;24:44-51. Epub 2014 Oct 13.

School of Biological Sciences, Royal Holloway College, University of London, Egham Hill, Egham, Surrey TW20 0EX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2014.09.018DOI Listing
January 2015

Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.

Neurobiol Dis 2014 Feb 19;62:296-306. Epub 2013 Oct 19.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898270PMC
February 2014

The search for better epilepsy treatments: from slime mould to coconuts.

Biochem Soc Trans 2013 Dec;41(6):1625-8

*Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, U.K.

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http://dx.doi.org/10.1042/BST20130183DOI Listing
December 2013

Zizimin and Dock guanine nucleotide exchange factors in cell function and disease.

Small GTPases 2013 Jan-Mar;4(1):22-7. Epub 2012 Dec 17.

Centre for Biomedical Sciences, Royal Holloway University of London, Surrey, UK.

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http://dx.doi.org/10.4161/sgtp.22087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620097PMC
September 2013

Seizure control by ketogenic diet-associated medium chain fatty acids.

Neuropharmacology 2013 Jun 20;69:105-14. Epub 2012 Nov 20.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK.

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http://dx.doi.org/10.1016/j.neuropharm.2012.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625124PMC
June 2013

The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium.

J Cell Sci 2012 May 24;125(Pt 10):2457-65. Epub 2012 Feb 24.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.100966
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http://dx.doi.org/10.1242/jcs.100966DOI Listing
May 2012

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

Dis Model Mech 2012 Mar 14;5(2):231-40. Epub 2011 Oct 14.

Centre for Biomedical Sciences, School of Biological Science, Royal Holloway University of London, Egham, Surrey, UK.

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http://dx.doi.org/10.1242/dmm.008391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291644PMC
March 2012

RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense.

PLoS One 2011 2;6(11):e27311. Epub 2011 Nov 2.

Institute of Biochemistry I, Medical Faculty, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Köln, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027311PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206951PMC
March 2012

Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment.

J R Soc Interface 2011 Aug 2;8(61):1185-91. Epub 2011 Feb 2.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK.

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http://dx.doi.org/10.1098/rsif.2010.0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119884PMC
August 2011

Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium.

J Cell Sci 2011 Jul 7;124(Pt 13):2267-76. Epub 2011 Jun 7.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW200EX, UK.

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http://dx.doi.org/10.1242/jcs.084285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113673PMC
July 2011

Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.

Semin Cell Dev Biol 2011 Feb 18;22(1):105-13. Epub 2010 Nov 18.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

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http://dx.doi.org/10.1016/j.semcdb.2010.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032892PMC
February 2011

Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP.

Epilepsia 2010 Aug 1;51(8):1533-42. Epub 2009 Dec 1.

UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1111/j.1528-1167.2009.02412.xDOI Listing
August 2010

Quantifying in vivo phosphoinositide turnover in chemotactically competent Dictyostelium cells.

Methods Mol Biol 2009 ;571:283-90

Bourne Laboratory, Biomedical Sciences Division, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK.

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http://dx.doi.org/10.1007/978-1-60761-198-1_19DOI Listing
January 2010

PtdIns(3,4,5)P(3) and inositol depletion as a cellular target of mood stabilizers.

Biochem Soc Trans 2009 Oct;37(Pt 5):1110-4

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK.

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http://dx.doi.org/10.1042/BST0371110DOI Listing
October 2009

PtdIns(3,4,5)P(3) and inositol depletion as a cellular target of mood stabilizers.

Biochem Soc Trans 2009 Oct;37(Pt 5):1110-4

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK.

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http://dx.doi.org/10.1042/BST0371110DOI Listing
October 2009

Structure-function studies for the panacea, valproic acid.

Biochem Soc Trans 2009 Oct;37(Pt 5):1126-32

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

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http://dx.doi.org/10.1042/BST0371126DOI Listing
October 2009

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells.

Dis Model Mech 2009 May-Jun;2(5-6):306-12. Epub 2009 Apr 21.

Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK.

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http://dx.doi.org/10.1242/dmm.001271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675811PMC
July 2009

Pharmacogenetics: defining the genetic basis of drug action and inositol trisphosphate analysis.

Methods Mol Biol 2006 ;346:517-34

Department of Biology, University College London, UK.

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http://dx.doi.org/10.1385/1-59745-144-4:517DOI Listing
October 2006

The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum.

Eur J Cell Biol 2006 Sep 8;85(9-10):1047-57. Epub 2006 Jun 8.

Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.ejcb.2006.04.013DOI Listing
September 2006

Towards a molecular understanding of human diseases using Dictyostelium discoideum.

Trends Mol Med 2006 Sep 4;12(9):415-24. Epub 2006 Aug 4.

Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.molmed.2006.07.003DOI Listing
September 2006

Pharmacogenetics in model systems: defining a common mechanism of action for mood stabilisers.

Prog Neuropsychopharmacol Biol Psychiatry 2005 Jul;29(6):1029-37

Department of Biology and Wolfson Institute for Biomedical Research, University College London, Gower St., London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1016/j.pnpbp.2005.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1249490PMC
July 2005

Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients.

Bipolar Disord 2004 Apr;6(2):156-61

Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK.

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April 2004

An inverse PCR technique to rapidly isolate the flanking DNA of dictyostelium insertion mutants.

Mol Biotechnol 2004 Mar;26(3):221-4

MCR Laboratory Molecular Cell Biology and Dept. of Biology, University College London, Gower St., London WC1E 6BT, UK.

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http://dx.doi.org/10.1385/MB:26:3:221DOI Listing
March 2004

Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium.

Mech Dev 2002 Aug;116(1-2):117-27

MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK.

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http://dx.doi.org/10.1016/s0925-4773(02)00152-1DOI Listing
August 2002

A common mechanism of action for three mood-stabilizing drugs.

Nature 2002 May;417(6886):292-5

Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK.

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http://www.nature.com/articles/417292a
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http://dx.doi.org/10.1038/417292aDOI Listing
May 2002

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

J Biol Chem 2002 Jan 13;277(3):2176-85. Epub 2001 Nov 13.

Cancer Research Campaign Centre for Cell and Molecular Biology and Section of Structural Biology, Institute of Cancer Research, 237 Fulham Rd., London SW3 6JB, United Kingdom.

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http://www.jbc.org/content/277/3/2176.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M109462200
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http://dx.doi.org/10.1074/jbc.M109462200DOI Listing
January 2002