Publications by authors named "Robin M Warren"

100Publications

Use of the MILLIPLEX bovine cytokine/chemokine multiplex assay to identify Mycobacterium bovis-infection biomarkers in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2020 Nov 11;231:110152. Epub 2020 Nov 11.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2020.110152DOI Listing
November 2020

Genetic Diversity in Clinical Isolates and Resulting Outcomes of Tuberculosis Infection and Disease.

Annu Rev Genet 2020 Sep 14. Epub 2020 Sep 14.

Department of Science and Innovation-National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-genet-022820-085940DOI Listing
September 2020

The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana).

Sci Rep 2020 09 2;10(1):14482. Epub 2020 Sep 2.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-71568-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468236PMC
September 2020

The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer).

BMC Vet Res 2020 Jun 29;16(1):220. Epub 2020 Jun 29.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town, 8000, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12917-020-02438-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325085PMC
June 2020

Spatial distribution of Mycobacterium Tuberculosis in metropolitan Harare, Zimbabwe.

PLoS One 2020 21;15(4):e0231637. Epub 2020 Apr 21.

Division of Molecular Biology and Human Genetics, NRF/DST Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173793PMC
July 2020

Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics.

BMC Mol Cell Biol 2020 Mar 23;21(1):19. Epub 2020 Mar 23.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, Cape Town, 7505, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12860-020-00261-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092591PMC
March 2020

Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study.

Lancet Respir Med 2020 04 14;8(4):368-382. Epub 2020 Feb 14.

NRF-DST Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(19)30370-4DOI Listing
April 2020

Extract from used Xpert MTB/RIF Ultra cartridges is useful for accurate second-line drug-resistant tuberculosis diagnosis with minimal rpoB-amplicon cross-contamination risk.

Sci Rep 2020 02 14;10(1):2633. Epub 2020 Feb 14.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-59164-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021780PMC
February 2020

Rifampicin Resistant Tuberculosis in Lesotho: Diagnosis, Treatment Initiation and Outcomes.

Sci Rep 2020 02 5;10(1):1917. Epub 2020 Feb 5.

DST-NRF Centre for Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-58690-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002499PMC
February 2020

Discordances between molecular assays for rifampicin resistance in Mycobacterium tuberculosis: frequency, mechanisms and clinical impact.

J Antimicrob Chemother 2020 May;75(5):1123-1129

South African Medical Research Council Centre for Tuberculosis Research/DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkz564DOI Listing
May 2020

Test Characteristics of Assays to Detect Infection in High-Prevalence African Buffalo () Herds.

J Wildl Dis 2020 04 21;56(2):462-465. Epub 2019 Nov 21.

Department of Science and Technology-National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.

View Article

Download full-text PDF

Source
April 2020

Cytokine gene expression assay as a diagnostic tool for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).

Sci Rep 2019 11 11;9(1):16525. Epub 2019 Nov 11.

Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-53045-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848127PMC
November 2019

The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.

Lancet Respir Med 2019 09;7(9):820-826

South African Medical Research Council Centre for Tuberculosis Research/Department of Science and Technology/ National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(19)30263-2DOI Listing
September 2019

Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2019 Nov 8;217:109923. Epub 2019 Aug 8.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town 8000, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2019.109923DOI Listing
November 2019

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes.

Tuberculosis (Edinb) 2019 09 12;118:101859. Epub 2019 Aug 12.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2019.101859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839616PMC
September 2019

Utility of Targeted, Amplicon-Based Deep Sequencing To Detect Resistance to First-Line Tuberculosis Drugs in Botswana.

Antimicrob Agents Chemother 2019 11 22;63(11). Epub 2019 Oct 22.

Sue & Bill Gross School of Nursing, University of California Irvine, Irvine, California, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00982-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811446PMC
November 2019

Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Prev Vet Med 2019 Aug 23;169:104700. Epub 2019 May 23.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prevetmed.2019.104700DOI Listing
August 2019

Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting.

Infect Genet Evol 2019 11 2;75:103948. Epub 2019 Jul 2.

NRF/DST Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.103948DOI Listing
November 2019

Evolution of rifampicin treatment for tuberculosis.

Infect Genet Evol 2019 10 24;74:103937. Epub 2019 Jun 24.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.103937DOI Listing
October 2019

The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda.

Lancet Respir Med 2019 10 22;7(10):892-906. Epub 2019 Mar 22.

Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; African Microbiome Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(18)30501-0DOI Listing
October 2019

Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Am J Respir Crit Care Med 2019 08;200(3):370-380

1Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1164/rccm.201807-1361OC
Publisher Site
http://dx.doi.org/10.1164/rccm.201807-1361OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680310PMC
August 2019

Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection.

Antimicrob Agents Chemother 2019 03 26;63(3). Epub 2019 Feb 26.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://aac.asm.org/lookup/doi/10.1128/AAC.02164-18
Publisher Site
http://dx.doi.org/10.1128/AAC.02164-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395899PMC
March 2019

Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2018 Oct 18;204:40-43. Epub 2018 Sep 18.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2018.09.004DOI Listing
October 2018

Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Lancet Infect Dis 2019 03 13;19(3):e77-e88. Epub 2018 Dec 13.

Department of Infection and Immunity, University College London, London, UK; Africa Health Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(18)30537-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474238PMC
March 2019

Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol.

BMC Infect Dis 2018 Sep 29;18(1):488. Epub 2018 Sep 29.

Section of Infectious Diseases, Boston University School of Medicine, 801 Massachusetts Avenue, 2nd floor, Crosstown Center, Boston, MA, 02118, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-018-3396-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162918PMC
September 2018

Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa.

PLoS One 2018 1;13(8):e0200632. Epub 2018 Aug 1.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research /SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070189PMC
January 2019

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis.

J Antimicrob Chemother 2018 10;73(10):2667-2674

Global Health Institute, Epidemiology and Social Medicine Faculty of Medicine, University of Antwerp, Antwerp, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dky248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148329PMC
October 2018

Rv1460, a SufR homologue, is a repressor of the suf operon in Mycobacterium tuberculosis.

PLoS One 2018 6;13(7):e0200145. Epub 2018 Jul 6.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200145PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034842PMC
January 2019

Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.

J Clin Microbiol 2018 09 27;56(9). Epub 2018 Aug 27.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.00531-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113470PMC
September 2018

IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).

Vet Immunol Immunopathol 2018 Jul 21;201:43-48. Epub 2018 May 21.

Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652427183009
Publisher Site
http://dx.doi.org/10.1016/j.vetimm.2018.05.007DOI Listing
July 2018

Mycobacterial nucleoid associated proteins: An added dimension in gene regulation.

Tuberculosis (Edinb) 2018 01 13;108:169-177. Epub 2017 Dec 13.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14729792173034
Publisher Site
http://dx.doi.org/10.1016/j.tube.2017.12.004DOI Listing
January 2018

Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping.

Sci Rep 2017 11 1;7(1):14854. Epub 2017 Nov 1.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-14385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666021PMC
November 2017

Isoniazid Resistance and Dosage as Treatment for Patients with Tuberculosis.

Curr Drug Metab 2017 ;18(11):1030-1039

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town. South Africa.

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/156686/article
Publisher Site
http://dx.doi.org/10.2174/1389200218666171031121905DOI Listing
September 2018

Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates.

J Proteome Res 2017 10 11;16(10):3841-3851. Epub 2017 Sep 11.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town 7505, South Africa.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00483
Publisher Site
http://dx.doi.org/10.1021/acs.jproteome.7b00483DOI Listing
October 2017

Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study.

Clin Infect Dis 2017 Jun;64(11):1502-1508

Department of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research/South Africa Medical Research Council for Molecular Biology and Human Genetics, Stellenbosch University, Tyberberg.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/cix128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434334PMC
June 2017

Implementation of new tools for multidrug-resistant tuberculosis detection and control.

Authors:
Robin M Warren

Int J Mycobacteriol 2016 Dec 21;5 Suppl 1:S67. Epub 2016 Sep 21.

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, P.O. Box 241, Cape Town 8000, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmyco.2016.08.014DOI Listing
December 2016

Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2016 07 30;99:128-30. Epub 2016 May 30.

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963978PMC
July 2016

The stability of plasma IP-10 enhances its utility for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2016 May 25;173:17-20. Epub 2016 Mar 25.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2016.03.013DOI Listing
May 2016

MDR tuberculosis control: time to change the dogma?

Lancet Respir Med 2015 Dec 18;3(12):907-9. Epub 2015 Nov 18.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S221326001500477
Publisher Site
http://dx.doi.org/10.1016/S2213-2600(15)00477-4DOI Listing
December 2015

Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy.

J Antimicrob Chemother 2016 Jan 15;71(1):17-26. Epub 2015 Oct 15.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/
Publisher Site
http://dx.doi.org/10.1093/jac/dkv316DOI Listing
January 2016

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis.

PLoS One 2015 28;10(7):e0133869. Epub 2015 Jul 28.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; International Health Unit, Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133869PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517823PMC
May 2016

Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.

Infect Genet Evol 2015 Aug 6;34:221-9. Epub 2015 Jul 6.

MRC Centre for Tuberculosis Research and the DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2015.07.004DOI Listing
August 2015

Fighting an old disease with next-generation sequencing.

Elife 2015 Mar 3;4. Epub 2015 Mar 3.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for TB Research and the Division of Molecular Biology and Human Genetics, Stellenbosch University, Stellenbosch, South Africa

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.06782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345822PMC
March 2015

Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: expanding the mycobacterial phosphoproteome catalog.

Front Microbiol 2015 10;6. Epub 2015 Feb 10.

Division of Molecular Biology and Human Genetics, Faculty Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Stellenbosch University Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2015.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322841PMC
February 2015

Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania.

Tuberculosis (Edinb) 2015 Mar 29;95(2):170-8. Epub 2014 Nov 29.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/ Medical Research Council (MRC) Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, P. O. Box 19063, Tygerberg, 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2014.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364622PMC
March 2015

The evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2014 Dec 26;162(3-4):198-202. Epub 2014 Oct 26.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Tuberculosis Research/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2014.10.008DOI Listing
December 2014

Rapid diagnosis of pediatric mycobacterial lymphadenitis using fine needle aspiration biopsy.

Pediatr Infect Dis J 2014 Sep;33(9):893-6

From the *Division of Anatomical Pathology University Stellenbosch and National Health Laboratory Service (NHLS), Tygerberg Hospital, Port Elizabeth; †Division of Medical Microbiology, University of Cape Town and NHLS Groote Schuur Hospital; ‡Centre for Tropical Opportunistic and Hospital Infections, National Institute for Communicable Diseases and NHLS Groote Schuur Hospital; and §Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/INF.0000000000000312DOI Listing
September 2014

Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility.

J Clin Microbiol 2014 Nov 27;52(11):4056-7. Epub 2014 Aug 27.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.02438-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313251PMC
November 2014

Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2014 Jul 4;160(1-2):133-8. Epub 2014 Apr 4.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2014.03.015DOI Listing
July 2014

The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study.

Clin Infect Dis 2014 Jun 18;58(12):1676-83. Epub 2014 Mar 18.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciu186DOI Listing
June 2014

Energy metabolism and drug efflux in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2014 May 10;58(5):2491-503. Epub 2014 Mar 10.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02293-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993223PMC
May 2014

Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations.

Antimicrob Agents Chemother 2014 May 10;58(5):2912-5. Epub 2014 Feb 10.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, US/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02583-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993264PMC
May 2014

Alcohol, hospital discharge, and socioeconomic risk factors for default from multidrug resistant tuberculosis treatment in rural South Africa: a retrospective cohort study.

PLoS One 2013 13;8(12):e83480. Epub 2013 Dec 13.

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa ; Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862731PMC
September 2014

Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.

Vaccine 2013 Dec 19;31(50):5934-9. Epub 2013 Oct 19.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2013.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886241PMC
December 2013

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.

PLoS One 2013 23;8(8):e70919. Epub 2013 Aug 23.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa ; Swiss Tropical and Public Health Institute, Basel, Switzerland ; University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070919PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751934PMC
June 2014

Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.

J Infect Dis 2014 Jan 14;209(2):216-23. Epub 2013 Aug 14.

MRC Centre for Molecular and Cellular Biology and the DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jit443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873786PMC
January 2014

Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12911-6. Epub 2013 Jul 22.

Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1222041110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740907PMC
August 2013

Epidemic spread of multidrug-resistant tuberculosis in Johannesburg, South Africa.

J Clin Microbiol 2013 Jun 3;51(6):1818-25. Epub 2013 Apr 3.

Sydney Emerging Infectious Diseases and Biosecurity Institute, the University of Sydney, Sydney, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.00200-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716102PMC
June 2013

The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.

PLoS One 2013 19;8(3):e59414. Epub 2013 Mar 19.

DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059414PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602005PMC
September 2013

embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis.

Chemotherapy 2012 17;58(5):358-63. Epub 2012 Nov 17.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000343474DOI Listing
July 2013

Infection of African buffalo (Syncerus caffer) by oryx bacillus, a rare member of the antelope clade of the Mycobacterium tuberculosis complex.

J Wildl Dis 2012 Oct;48(4):849-57

Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, South Africa.

View Article

Download full-text PDF

Source
http://www.jwildlifedis.org/doi/10.7589/2010-07-178
Publisher Site
http://dx.doi.org/10.7589/2010-07-178DOI Listing
October 2012

Development of a diagnostic gene expression assay for tuberculosis and its use under field conditions in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2012 Aug 19;148(3-4):337-42. Epub 2012 May 19.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Stellenbosch University, P.O. Box 19063, Tygerberg, 7505, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2012.04.025DOI Listing
August 2012

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.

PLoS One 2012 4;7(4):e30593. Epub 2012 Apr 4.

Department of Science and Technology, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030593PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319526PMC
August 2012

gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis.

J Antimicrob Chemother 2012 May 22;67(5):1088-93. Epub 2012 Feb 22.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dks033DOI Listing
May 2012

Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa.

J Clin Microbiol 2012 Mar 14;50(3):995-1002. Epub 2011 Dec 14.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics,Faculty of Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.05832-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295122PMC
March 2012

SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes.

PLoS One 2011 5;6(12):e28365. Epub 2011 Dec 5.

Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, (CIb/LIS, pb 22), Bilthoven, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028365PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230589PMC
July 2012

Detecting drug-resistant tuberculosis: the importance of rapid testing.

Mol Diagn Ther 2011 Aug;15(4):189-94

Division of Medical Microbiology, Department of Pathology, University of Stellenbosch, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/BF03256410DOI Listing
August 2011

Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens.

J Clin Microbiol 2011 Nov 31;49(11):3967-70. Epub 2011 Aug 31.

Division of Anatomical Pathology, National Health Laboratory Service, Tygerberg Hospital, Tygerberg, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://jcm.asm.org/lookup/doi/10.1128/JCM.01310-11
Publisher Site
http://dx.doi.org/10.1128/JCM.01310-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209093PMC
November 2011

Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa.

Infect Genet Evol 2012 Jun 4;12(4):686-94. Epub 2011 Aug 4.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2011.07.019DOI Listing
June 2012

Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa.

Clin Infect Dis 2011 Aug;53(4):369-72

Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/cir406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202325PMC
August 2011