Robin M Warren

Robin M Warren

UNVERIFIED PROFILE

Are you Robin M Warren?   Register this Author

Register author
Robin M Warren

Robin M Warren

Publications by authors named "Robin M Warren"

Are you Robin M Warren?   Register this Author

100Publications

1725Reads

8Profile Views

Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Am J Respir Crit Care Med 2019 Aug;200(3):370-380

1Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1164/rccm.201807-1361OC
Publisher Site
http://dx.doi.org/10.1164/rccm.201807-1361OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680310PMC
August 2019

Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Prev Vet Med 2019 Aug 23;169:104700. Epub 2019 May 23.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prevetmed.2019.104700DOI Listing
August 2019

Utility of targeted, amplicon-based deep sequencing to detect resistance to first-line tuberculosis drugs in Botswana.

Antimicrob Agents Chemother 2019 Aug 12. Epub 2019 Aug 12.

Sue and Bill Gross School of Nursing, University of California Irvine, Irvine, CA 92697, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00982-19DOI Listing
August 2019

Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting.

Infect Genet Evol 2019 Jul 2;75:103948. Epub 2019 Jul 2.

NRF/DST Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.103948DOI Listing
July 2019

Evolution of rifampicin treatment for tuberculosis.

Infect Genet Evol 2019 Jun 24;74:103937. Epub 2019 Jun 24.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.103937DOI Listing
June 2019

Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Lancet Infect Dis 2019 Mar 13;19(3):e77-e88. Epub 2018 Dec 13.

Department of Infection and Immunity, University College London, London, UK; Africa Health Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(18)30537-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474238PMC
March 2019

Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection.

Antimicrob Agents Chemother 2019 Mar 26;63(3). Epub 2019 Feb 26.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://aac.asm.org/lookup/doi/10.1128/AAC.02164-18
Publisher Site
http://dx.doi.org/10.1128/AAC.02164-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395899PMC
March 2019

The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda.

Lancet Respir Med 2019 Mar 22. Epub 2019 Mar 22.

Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; South African Medical Research Council Centre for Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; African Microbiome Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(18)30501-0DOI Listing
March 2019

Rv1460, a SufR homologue, is a repressor of the suf operon in Mycobacterium tuberculosis.

PLoS One 2018 6;13(7):e0200145. Epub 2018 Jul 6.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200145PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034842PMC
January 2019

Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa.

PLoS One 2018 1;13(8):e0200632. Epub 2018 Aug 1.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research /SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070189PMC
January 2019

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis.

J Antimicrob Chemother 2018 Oct;73(10):2667-2674

Global Health Institute, Epidemiology and Social Medicine Faculty of Medicine, University of Antwerp, Antwerp, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dky248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148329PMC
October 2018

Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2018 Oct 18;204:40-43. Epub 2018 Sep 18.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2018.09.004DOI Listing
October 2018

Isoniazid Resistance and Dosage as Treatment for Patients with Tuberculosis.

Curr Drug Metab 2017 ;18(11):1030-1039

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town. South Africa.

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/156686/article
Publisher Site
http://dx.doi.org/10.2174/1389200218666171031121905DOI Listing
September 2018

Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.

J Clin Microbiol 2018 09 27;56(9). Epub 2018 Aug 27.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.00531-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113470PMC
September 2018

Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol.

BMC Infect Dis 2018 Sep 29;18(1):488. Epub 2018 Sep 29.

Section of Infectious Diseases, Boston University School of Medicine, 801 Massachusetts Avenue, 2nd floor, Crosstown Center, Boston, MA, 02118, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-018-3396-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162918PMC
September 2018

IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).

Vet Immunol Immunopathol 2018 Jul 21;201:43-48. Epub 2018 May 21.

Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652427183009
Publisher Site
http://dx.doi.org/10.1016/j.vetimm.2018.05.007DOI Listing
July 2018

Mycobacterial nucleoid associated proteins: An added dimension in gene regulation.

Tuberculosis (Edinb) 2018 01 13;108:169-177. Epub 2017 Dec 13.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14729792173034
Publisher Site
http://dx.doi.org/10.1016/j.tube.2017.12.004DOI Listing
January 2018

Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping.

Sci Rep 2017 11 1;7(1):14854. Epub 2017 Nov 1.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-14385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666021PMC
November 2017

Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates.

J Proteome Res 2017 10 11;16(10):3841-3851. Epub 2017 Sep 11.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town 7505, South Africa.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00483
Publisher Site
http://dx.doi.org/10.1021/acs.jproteome.7b00483DOI Listing
October 2017

Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study.

Clin Infect Dis 2017 Jun;64(11):1502-1508

Department of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research/South Africa Medical Research Council for Molecular Biology and Human Genetics, Stellenbosch University, Tyberberg.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/cix128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434334PMC
June 2017

Implementation of new tools for multidrug-resistant tuberculosis detection and control.

Authors:
Robin M Warren

Int J Mycobacteriol 2016 Dec 21;5 Suppl 1:S67. Epub 2016 Sep 21.

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, P.O. Box 241, Cape Town 8000, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmyco.2016.08.014DOI Listing
December 2016

Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2016 07 30;99:128-30. Epub 2016 May 30.

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963978PMC
July 2016

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis.

PLoS One 2015 28;10(7):e0133869. Epub 2015 Jul 28.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; International Health Unit, Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133869PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517823PMC
May 2016

The stability of plasma IP-10 enhances its utility for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2016 May 25;173:17-20. Epub 2016 Mar 25.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2016.03.013DOI Listing
May 2016

Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy.

J Antimicrob Chemother 2016 Jan 15;71(1):17-26. Epub 2015 Oct 15.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/
Publisher Site
http://dx.doi.org/10.1093/jac/dkv316DOI Listing
January 2016

MDR tuberculosis control: time to change the dogma?

Lancet Respir Med 2015 Dec 18;3(12):907-9. Epub 2015 Nov 18.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S221326001500477
Publisher Site
http://dx.doi.org/10.1016/S2213-2600(15)00477-4DOI Listing
December 2015

Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.

Infect Genet Evol 2015 Aug 6;34:221-9. Epub 2015 Jul 6.

MRC Centre for Tuberculosis Research and the DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2015.07.004DOI Listing
August 2015

Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania.

Tuberculosis (Edinb) 2015 Mar 29;95(2):170-8. Epub 2014 Nov 29.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/ Medical Research Council (MRC) Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, P. O. Box 19063, Tygerberg, 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2014.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364622PMC
March 2015

Fighting an old disease with next-generation sequencing.

Elife 2015 Mar 3;4. Epub 2015 Mar 3.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for TB Research and the Division of Molecular Biology and Human Genetics, Stellenbosch University, Stellenbosch, South Africa

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.06782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345822PMC
March 2015

Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: expanding the mycobacterial phosphoproteome catalog.

Front Microbiol 2015 10;6. Epub 2015 Feb 10.

Division of Molecular Biology and Human Genetics, Faculty Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Stellenbosch University Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2015.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322841PMC
February 2015

The evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2014 Dec 26;162(3-4):198-202. Epub 2014 Oct 26.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Tuberculosis Research/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2014.10.008DOI Listing
December 2014

Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility.

J Clin Microbiol 2014 Nov 27;52(11):4056-7. Epub 2014 Aug 27.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.02438-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313251PMC
November 2014

Alcohol, hospital discharge, and socioeconomic risk factors for default from multidrug resistant tuberculosis treatment in rural South Africa: a retrospective cohort study.

PLoS One 2013 13;8(12):e83480. Epub 2013 Dec 13.

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa ; Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862731PMC
September 2014

Rapid diagnosis of pediatric mycobacterial lymphadenitis using fine needle aspiration biopsy.

Pediatr Infect Dis J 2014 Sep;33(9):893-6

From the *Division of Anatomical Pathology University Stellenbosch and National Health Laboratory Service (NHLS), Tygerberg Hospital, Port Elizabeth; †Division of Medical Microbiology, University of Cape Town and NHLS Groote Schuur Hospital; ‡Centre for Tropical Opportunistic and Hospital Infections, National Institute for Communicable Diseases and NHLS Groote Schuur Hospital; and §Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/INF.0000000000000312DOI Listing
September 2014

Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2014 Jul 4;160(1-2):133-8. Epub 2014 Apr 4.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2014.03.015DOI Listing
July 2014

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.

PLoS One 2013 23;8(8):e70919. Epub 2013 Aug 23.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa ; Swiss Tropical and Public Health Institute, Basel, Switzerland ; University of Basel, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070919PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751934PMC
June 2014

The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study.

Clin Infect Dis 2014 Jun 18;58(12):1676-83. Epub 2014 Mar 18.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciu186DOI Listing
June 2014

Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations.

Antimicrob Agents Chemother 2014 May 10;58(5):2912-5. Epub 2014 Feb 10.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, US/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02583-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993264PMC
May 2014

Energy metabolism and drug efflux in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2014 May 10;58(5):2491-503. Epub 2014 Mar 10.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02293-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993223PMC
May 2014

Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.

J Infect Dis 2014 Jan 14;209(2):216-23. Epub 2013 Aug 14.

MRC Centre for Molecular and Cellular Biology and the DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jit443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873786PMC
January 2014

Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.

Vaccine 2013 Dec 19;31(50):5934-9. Epub 2013 Oct 19.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2013.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886241PMC
December 2013

The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.

PLoS One 2013 19;8(3):e59414. Epub 2013 Mar 19.

DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059414PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602005PMC
September 2013

Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12911-6. Epub 2013 Jul 22.

Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1222041110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740907PMC
August 2013

embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis.

Chemotherapy 2012 17;58(5):358-63. Epub 2012 Nov 17.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000343474DOI Listing
July 2013

Epidemic spread of multidrug-resistant tuberculosis in Johannesburg, South Africa.

J Clin Microbiol 2013 Jun 3;51(6):1818-25. Epub 2013 Apr 3.

Sydney Emerging Infectious Diseases and Biosecurity Institute, the University of Sydney, Sydney, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.00200-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716102PMC
June 2013

Infection of African buffalo (Syncerus caffer) by oryx bacillus, a rare member of the antelope clade of the Mycobacterium tuberculosis complex.

J Wildl Dis 2012 Oct;48(4):849-57

Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, South Africa.

View Article

Download full-text PDF

Source
http://www.jwildlifedis.org/doi/10.7589/2010-07-178
Publisher Site
http://dx.doi.org/10.7589/2010-07-178DOI Listing
October 2012

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.

PLoS One 2012 4;7(4):e30593. Epub 2012 Apr 4.

Department of Science and Technology, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030593PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319526PMC
August 2012

Development of a diagnostic gene expression assay for tuberculosis and its use under field conditions in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2012 Aug 19;148(3-4):337-42. Epub 2012 May 19.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Stellenbosch University, P.O. Box 19063, Tygerberg, 7505, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2012.04.025DOI Listing
August 2012

SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes.

PLoS One 2011 5;6(12):e28365. Epub 2011 Dec 5.

Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, (CIb/LIS, pb 22), Bilthoven, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028365PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230589PMC
July 2012

Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa.

Infect Genet Evol 2012 Jun 4;12(4):686-94. Epub 2011 Aug 4.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2011.07.019DOI Listing
June 2012

gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis.

J Antimicrob Chemother 2012 May 22;67(5):1088-93. Epub 2012 Feb 22.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dks033DOI Listing
May 2012

Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis.

Microb Drug Resist 2012 Apr 6;18(2):193-7. Epub 2011 Jul 6.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/mdr.2011.0063DOI Listing
April 2012

Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa.

J Clin Microbiol 2012 Mar 14;50(3):995-1002. Epub 2011 Dec 14.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics,Faculty of Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.05832-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295122PMC
March 2012

Xpert MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needle-aspiration biopsy specimens.

J Clin Microbiol 2011 Nov 31;49(11):3967-70. Epub 2011 Aug 31.

Division of Anatomical Pathology, National Health Laboratory Service, Tygerberg Hospital, Tygerberg, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://jcm.asm.org/lookup/doi/10.1128/JCM.01310-11
Publisher Site
http://dx.doi.org/10.1128/JCM.01310-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209093PMC
November 2011

Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa.

Clin Infect Dis 2011 Aug;53(4):369-72

Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/cir406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202325PMC
August 2011

Detecting drug-resistant tuberculosis: the importance of rapid testing.

Mol Diagn Ther 2011 Aug;15(4):189-94

Division of Medical Microbiology, Department of Pathology, University of Stellenbosch, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2165/11593780-000000000-00000DOI Listing
August 2011

Modification of the QuantiFERON-TB Gold (In-Tube) assay for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Vet Immunol Immunopathol 2011 Jul 20;142(1-2):113-8. Epub 2011 Apr 20.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular/Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2011.04.006DOI Listing
July 2011

Mutations in the regulatory network underlie the recent clonal expansion of a dominant subclone of the Mycobacterium tuberculosis Beijing genotype.

Infect Genet Evol 2011 Apr 28;11(3):587-97. Epub 2011 Jan 28.

Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment, Centre for Infectious Disease Control, (CIb/LIS, pb 22), Bilthoven, The Netherlands.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S156713481100012
Publisher Site
http://dx.doi.org/10.1016/j.meegid.2011.01.009DOI Listing
April 2011

Tuberculosis assays: past, present and future.

Expert Rev Anti Infect Ther 2011 Apr;9(4):457-69

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, University of Stellenbosch, PO Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/eri.11.23DOI Listing
April 2011

Molecular detection of mixed infections of Mycobacterium tuberculosis strains in sputum samples from patients in Karonga District, Malawi.

J Clin Microbiol 2010 Dec 20;48(12):4512-8. Epub 2010 Oct 20.

Department of Pathogen Molecular Biology, Faculty of Infectious & Tropical Diseases, LSHTM, Keppel St., London WC1E 7HT, United Kingdom.

View Article

Download full-text PDF

Source
http://jcm.asm.org/lookup/doi/10.1128/JCM.01683-10
Publisher Site
http://dx.doi.org/10.1128/JCM.01683-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008455PMC
December 2010

Insertion element IS6110-based restriction fragment length polymorphism genotyping of Mycobacterium tuberculosis.

Methods Mol Biol 2009 ;465:353-70

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, DST/NRF Centre of Excellence in Biomedical Tuberculosis Research, Stellenbosch University, PO Box 19063, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-207-6_24DOI Listing
September 2010

Extensively drug-resistant tuberculosis: epidemiology and management challenges.

Infect Dis Clin North Am 2010 Sep;24(3):705-25

Lung Infection and Immunity Unit, Division of Pulmonology and Clinical Immunology & UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idc.2010.05.001DOI Listing
September 2010

Detection of Mycobacterium kansasii infection in a rhesus macaque (Macaca mulatta) using a modified QuantiFERON-TB Gold assay.

Vet Immunol Immunopathol 2010 Aug 30;136(3-4):330-4. Epub 2010 Mar 30.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2010.03.020DOI Listing
August 2010

Novel Mycobacterium tuberculosis complex pathogen, M. mungi.

Emerg Infect Dis 2010 Aug;16(8):1296-9

Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid1608.100314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298296PMC
August 2010

Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON-TB gold (in-tube) assay.

J Med Primatol 2009 Dec 14;38(6):411-7. Epub 2009 Jul 14.

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1600-0684.2009.00367.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-0684.2009.00367.xDOI Listing
December 2009

Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes.

Tuberculosis (Edinb) 2009 Nov 6;89(6):439-42. Epub 2009 Sep 6.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2009.08.001DOI Listing
November 2009

Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.

BMC Evol Biol 2009 Sep 21;9:237. Epub 2009 Sep 21.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2148-9-237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758852PMC
September 2009

Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa.

J Wildl Dis 2008 Jan;44(1):151-4

DST/NRF Centre of Excellence for Biomedical TB Research/Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences-Stellenbosch University, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7589/0090-3558-44.1.151DOI Listing
January 2008