Publications by authors named "Robin C Allshire"

75Publications

: A fast and efficient CRISPR/Cas9 method for fission yeast.

Wellcome Open Res 2020 24;5:274. Epub 2020 Nov 24.

Wellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.

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November 2020

Large domains of heterochromatin direct the formation of short mitotic chromosome loops.

Elife 2020 09 11;9. Epub 2020 Sep 11.

Wellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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September 2020

Epigenetic gene silencing by heterochromatin primes fungal resistance.

Nature 2020 09 9;585(7825):453-458. Epub 2020 Sep 9.

Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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September 2020

TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.

Nat Commun 2020 07 27;11(1):3739. Epub 2020 Jul 27.

Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.

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July 2020

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.

Nature 2020 08 16;584(7822):635-639. Epub 2020 Jul 16.

Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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August 2020

Hap2-Ino80-facilitated transcription promotes de novo establishment of CENP-A chromatin.

Genes Dev 2020 02 9;34(3-4):226-238. Epub 2020 Jan 9.

Wellcome Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.

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February 2020

Interspecies conservation of organisation and function between nonhomologous regional centromeres.

Nat Commun 2019 05 28;10(1):2343. Epub 2019 May 28.

Wellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.

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May 2019

Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle.

Curr Biol 2018 12 29;28(24):3924-3936.e4. Epub 2018 Nov 29.

Wellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, UK. Electronic address:

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December 2018

Ten principles of heterochromatin formation and function.

Nat Rev Mol Cell Biol 2018 04 13;19(4):229-244. Epub 2017 Dec 13.

Chan-Zuckerberg BioHub, San Francisco, California 94158, USA.

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April 2018

Emerging Properties and Functional Consequences of Noncoding Transcription.

Genetics 2017 10;207(2):357-367

Copenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark

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October 2017

Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference.

Nucleic Acids Res 2016 12 8;44(22):10619-10630. Epub 2016 Sep 8.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK

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December 2016

Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.

Cold Spring Harb Perspect Biol 2015 Jul 1;7(7):a018770. Epub 2015 Jul 1.

Department of Biosciences and Nutrition, Karolinska Institutet, Center for Biosciences, NOVUM, S-141 83, Huddinge, Sweden.

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July 2015

Epigenetics. Restricted epigenetic inheritance of H3K9 methylation.

Science 2015 Apr;348(6230):132-5

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Max Born Crescent, Edinburgh EH9 3BF, Scotland, UK.

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April 2015

Sequence features and transcriptional stalling within centromere DNA promote establishment of CENP-A chromatin.

PLoS Genet 2015 Mar 4;11(3):e1004986. Epub 2015 Mar 4.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom.

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March 2015

Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.

Mol Cell Biol 2015 Feb 8;35(4):662-74. Epub 2014 Dec 8.

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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February 2015

Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast.

Nat Commun 2014 Nov 27;5:5576. Epub 2014 Nov 27.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Max Born Crescent, Edinburgh EH9 3BF, Scotland, UK.

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November 2014

A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Genome Biol 2014 ;15(10):481

Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, UK.

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October 2015

The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast.

PLoS One 2014 4;9(8):e104161. Epub 2014 Aug 4.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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November 2015

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.

Open Biol 2014 Apr 30;4:140043. Epub 2014 Apr 30.

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, UK.

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April 2014

Anarchic centromeres: deciphering order from apparent chaos.

Curr Opin Cell Biol 2014 Feb 19;26:41-50. Epub 2013 Oct 19.

Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, 6.34 Swann Building, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK. Electronic address:

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February 2014

Reply to "CENP-A octamers do not confer a reduction in nucleosome height by AFM".

Nat Struct Mol Biol 2014 Jan;21(1):5-8

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh Scotland, UK.

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January 2014

Telomeric repeats facilitate CENP-A(Cnp1) incorporation via telomere binding proteins.

PLoS One 2013 31;8(7):e69673. Epub 2013 Jul 31.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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April 2014

CENP-A confers a reduction in height on octameric nucleosomes.

Nat Struct Mol Biol 2013 Jun 5;20(6):763-5. Epub 2013 May 5.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK.

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June 2013

Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance.

EMBO J 2013 May 9;32(9):1250-64. Epub 2013 Apr 9.

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.

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May 2013

Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.

PLoS Genet 2012 Sep 20;8(9):e1002985. Epub 2012 Sep 20.

Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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September 2012

Identification of noncoding transcripts from within CENP-A chromatin at fission yeast centromeres.

J Biol Chem 2011 Jul 28;286(26):23600-7. Epub 2011 Apr 28.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, United Kingdom.

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July 2011

Common ground: small RNA programming and chromatin modifications.

Curr Opin Cell Biol 2011 Jun 7;23(3):258-65. Epub 2011 Apr 7.

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

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June 2011

Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

PLoS One 2010 Oct 18;5(10):e13488. Epub 2010 Oct 18.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, United Kingdom.

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October 2010

Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.

Cell 2010 Mar;140(5):666-77

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

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March 2010

Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.

EMBO Rep 2010 Feb 8;11(2):112-8. Epub 2010 Jan 8.

Wellcome Trust Centre for Cell Biology, School of Biological Sciences, 6.34 Swann Building, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

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February 2010

Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres.

Science 2009 Jun;324(5935):1716-9

Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, 6.34 Swann Building, Edinburgh EH9 3JR, Scotland, UK.

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June 2009

Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.

Mol Cell 2009 Feb;33(3):299-311

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, 6.34 Swann Building, Edinburgh EH93JR, Scotland, UK.

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February 2009

Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

Nat Rev Genet 2008 Dec;9(12):923-37

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, 6.34 Swann Building, Mayfield Road, Edinburgh EH9 3JR, UK.

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December 2008

Splicing factors facilitate RNAi-directed silencing in fission yeast.

Science 2008 Oct;322(5901):602-6

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, 6.34 Swann Building, Edinburgh EH9 3JR, UK.

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October 2008

RNAi-mediated chromatin silencing in fission yeast.

Curr Top Microbiol Immunol 2008 ;320:157-83

Welcome Trust Centre for Cell Biology, Institute of Cell Biology, The University of Edinburgh, Edinburgh, EH9 3JR Scotland, UK.

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March 2008

Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres.

Science 2008 Jan;319(5859):94-7

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, 6.34 Swann Building, Edinburgh EH9 3JR, Scotland, UK.

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January 2008

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.

Mol Cell 2007 Dec;28(6):1029-44

Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, 6.34 Swann Building, Edinburgh EH9 3JR, Scotland, UK.

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December 2007

The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.

EMBO J 2007 Nov 18;26(22):4670-82. Epub 2007 Oct 18.

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.

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November 2007

Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4.

PLoS Genet 2007 Jul 7;3(7):e121. Epub 2007 Jun 7.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.

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July 2007

The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.

Curr Biol 2007 Jul 5;17(14):1219-24. Epub 2007 Jul 5.

European Molecular Biology Laboratory, Gene Expression Unit, Structural and Computational Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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July 2007

DegrAAAded into silence.

Cell 2007 May;129(4):651-3

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Building, Mayfield Road, Edinburgh, EH9 3JR, UK.

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May 2007

Molecular biology: silencing unlimited.

Curr Biol 2006 Aug;16(16):R635-8

Wellcome Trust Centre for Cell Biology, 6.34 Swann Building, King's Buildings, University of Edinburgh, Edinburgh EH9 3JR, UK.

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August 2006

RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.

Genes Dev 2005 Oct;19(19):2301-6

Karolinska Institutet, Department of Biosciences, School of Life Sciences, University College Sodertorn, S-141 89 Huddinge, Sweden.

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October 2005

RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription.

Nature 2005 Jun 19;435(7046):1275-9. Epub 2005 Jun 19.

Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, King's Buildings, University of Edinburgh, Edinburgh EH9 3JR, UK.

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June 2005

RNA-directed transcriptional gene silencing in mammals.

Trends Genet 2005 Jul;21(7):370-3

The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK.

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July 2005

The role of heterochromatin in centromere function.

Philos Trans R Soc Lond B Biol Sci 2005 Mar;360(1455):569-79

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK.

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March 2005

RNA silencing and genome regulation.

Trends Cell Biol 2005 May;15(5):251-8

Wellcome Trust Centre for Cell Biology, 6.34 Swann Building, King's Buildings, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

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May 2005

Methylation: lost in hydroxylation?

EMBO Rep 2005 Apr;6(4):315-20

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh EH9 3JR, UK.

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April 2005

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.

Cell 2004 Nov;119(5):603-14

The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, United Kingdom.

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November 2004

Kinetochore and heterochromatin domains of the fission yeast centromere.

Chromosome Res 2004 ;12(6):521-34

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.

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February 2005

Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres.

Nat Cell Biol 2003 Dec 16;5(12):1111-6. Epub 2003 Nov 16.

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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December 2003

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.

Curr Biol 2003 Oct;13(20):1748-57

Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, 6.34 Swann Building, The University of Edinburgh, Mayfield Road, EH9 3JR, Edinburgh, United Kingdom.

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October 2003

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.

J Cell Biol 2003 Apr;161(2):295-307

Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, 6.34 Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.

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April 2003

Stretching it: putting the CEN(P-A) in centromere.

Curr Opin Genet Dev 2003 Apr;13(2):191-8

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Institute of Cell and Molecular Biology, Edinburgh, EH9 3JR, UK.

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April 2003

The mal2p protein is an essential component of the fission yeast centromere.

Mol Cell Biol 2002 Oct;22(20):7168-83

Institut für Mikrobiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.

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October 2002