Dr. Robin A Felder, PhD - The University of Virginia - Professor of Pathology

Dr. Robin A Felder

PhD

The University of Virginia

Professor of Pathology

Charlottesville, VA | Afghanistan

Main Specialties: Chemical Pathology

Additional Specialties: Laboratory Medicine, Medical Robotics

Dr. Robin A Felder, PhD - The University of Virginia - Professor of Pathology

Dr. Robin A Felder

PhD

Introduction

Dr. Robin Felder is a Professor of Pathology and Associate Director of Laboratory Medicine at the University of Virginia in Charlottesville, Virginia. Dr. Felder received his BS in Chemistry from the College of William and Mary (Williamsburg, VA) and his PhD in Biochemistry from Georgetown University (Washington, DC). He spent a year in post-doctoral training at the National Institutes of Health (Bethesda, MD) and in 1998, a year of sabbatical training under Professor Bernard Rossier, in Lausanne, Switzerland. Dr. Felder has distinguished himself in three principal areas basic biomedical research, medical automation, and creating and managing a commercial craft distillery.

Areas of contribution

Wellness – Dr. Felder has been involved in personalized wellness research and education for over 20 years. In 2000 he initiated a wellness monitoring research group that developed a number of passive monitoring sensors and associated web based caregiver tool that has been clinically tested, and was subsequently commercialized with over 6,000 monitored individuals. He also co-organized and chaired the Medical Automation International Conference which has focused on wellness and a shift in the way health care will be delivered to that of a system that is based in the home and is personal, predictive, and passive. .

Medical Automation - He is considered one of the early pioneers in clinical laboratory robotics and automation and has been awarded 27 patents. In automation he has published over 150 papers, reviews, and chapters, and served as co-editor of three textbooks on various aspects of medical automation. He served as the founding Director of the Medical Automation Research Center (MARC) from 2002-2008. He was also the founder of the Association for Laboratory Automation (now called SLAS) and founding editor of its journal, the Journal of the Association for Laboratory Automation (JALA) (now called SLAS Technology and SLAS Discovery). 6,000 registrants participated in the 2017 meeting. His automation research has been funded by the NIH, NSF, and various biomedical companies. He has been awarded the Manitoba Society of Clinical Chemistry Lectureship Award, the Engelberger Award for Leadership in Robotics (2009), and the Award for Excellence in an area of Research from both the American Association for Clinical Chemistry and National Academy for Clinical Biochemistry (2010). Dr. Felder was also awarded the University of Virginia’s first Innovator of the Year award in 2012.

Basic Biomedical Research - Dr. Felder also has been continuously funded by the National Institutes of Health since 1984 for his work on the etiology, diagnosis, and treatment of hypertension and salt sensitivity. In hypertension he has published over 200 peer reviewed papers, reviews, and chapters. He has been recognized for his contributions to this field by receiving awards from the American Physiological Society, The American Federation for Clinical Research, The Association for Clinical Scientists, The American Association for Clinical Chemistry and National Academy for Clinical Biochemistry.

Non-institutional pursuits – Robin has been a pewter smith for over 30 years crafting a variety of items in his workshop which are sold locally in Charlottesville gift shops. In addition, Robin is an avid organic pear, peach, and apricot farmer and master distiller. He is working to expand commercial pear farming in Virginia by expanding the number of blight resistant pear trees and rare Indian blood peaches and capturing their essences in the form of a brandy (eau-de-vie) in his commercial craft distillery (Monte Piccolo Farm and Distillery). In addition, he is pioneering the crafting of varietal gins from each species of juniper.

Commercial pursuits - In addition to his academic career, Dr. Felder has co-founded 9 private ventures spun out from the University of Virginia, including Medical Automation Systems (point of care management tools): http://www.medicalautomation.com, Global Cell Solutions (regenerative medicine biotech): http://globalcellsolutions.com, Hypogen (pharmaceutical company) http://hypogen.com, LabAutomation (now SLAS) http://SLAS.org, Medical Automation (non-profit educational organization) , http://medicalautomation.org, Well Aware Systems (personalized medicine) acquired by HealthSence, and recently by GreatCall.com, BioPhile (automated -80C biorepository, now part of Hamilton Automation Storage Solutions), BlinkBit (minimally invasive diabetes monitoring), Medical Robotics (medical automation consulting), Medical Automation Research Institute (MARI). Several of Dr. Felder’s inventions and commercially available instruments were named a top 10 pick by the Scientist Magazine in 2010 and 2012. Dr. Felder has also received several local entrepreneurial awards such as the Charlottesville Navigator, Rocket, Founder, and Business Plan, awards.

Primary Affiliation: The University of Virginia - Charlottesville, VA , Afghanistan

Specialties:

Additional Specialties:

Research Interests:

Education

Jun 1984
National Institutes of Health
Post Doctoral Training
Apr 1984
Georgetown University
PhD Biochemistry
May 1977
College of Willian
BS Chemistry

Experience

Apr 2018
Journal of the Association for Laboratory Automation (JALA)
Founder, Editor
This journal is now hosted as two journals by SLAS
Apr 2014
Charlottesville VA Top 5 Founders Award
Awarded at the annual Thomas Jefferson Festival
Sep 2011
Association for Clinical Biochemists (United Kingdom) and American Association for Clinical Chemistry Transatlantic Lectureship Award
European Laboratory Medicine Awardee
Jul 2010
American Association for Clinical Chemistry and National Academy for Clinical Biochemistry Awards for Outstanding Contributions in a Selected Area of Research
Laboratory Medicine Awardee
May 2009
Engelberger Annual Robotics Award for Leadership; sponsored by the Robotics Industry Association and the International Federation for Robotics
Robotics Awardee
Jan 1990
Founder Association for Laboratory Automation
Founder, President
This organization is now SLAS

Publications

103Publications

1233Reads

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1517PubMed Central Citations

Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA.

Am J Physiol Endocrinol Metab 2017 01 25;312(1):E1-E10. Epub 2016 Oct 25.

Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Centre, Peking Union Medical, Beijing, China;

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http://dx.doi.org/10.1152/ajpendo.00116.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283882PMC
January 2017
19 Reads
3.790 Impact Factor

The Renal Sodium Bicarbonate Cotransporter NBCe2: Is It a Major Contributor to Sodium and pH Homeostasis?

Curr Hypertens Rep 2016 09;18(9):71

Department of Pathology, The University of Virginia, Charlottesville, VA, 22903, USA.

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http://dx.doi.org/10.1007/s11906-016-0679-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175536PMC
September 2016
28 Reads
3.440 Impact Factor

The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.

PLoS One 2016 11;11(1):e0146641. Epub 2016 Jan 11.

Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical Collage (PUMC), Beijing, P. R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146641PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709046PMC
July 2016
11 Reads
6 Citations
3.234 Impact Factor

Gastrorenal Axis.

Hypertension 2016 06 4;67(6):1056-63. Epub 2016 Apr 4.

From the Departments of Medicine and Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC (P.A.J.); Department of Pathology, The University of Virginia, Charlottesville (R.A.F.); Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Centre, Peking Union Medical College, Beijing, P.R. China (Z.Y.); Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing Institute of Cardiology, Chongqing, P.R. China (C.Z.); and Department of Medicine, Georgetown University Medical Center, Washington, DC (G.M.E.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968949PMC
June 2016
20 Reads
1 Citation
6.480 Impact Factor

The importance of the gastrorenal axis in the control of body sodium homeostasis.

Exp Physiol 2016 Apr 2;101(4):465-70. Epub 2016 Mar 2.

Department of Pathology, The University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1113/EP085286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818653PMC
April 2016
7 Reads
6 Citations
2.670 Impact Factor

Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.

Hypertension 2016 Feb 14;67(2):325-34. Epub 2015 Dec 14.

From the Division of Pediatric Nephrology, Department of Pediatrics, Georgetown University of School of Medicine, Washington, DC (Z.W.); Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, P.R. China (C.Z.); Chongqing Institute of Cardiology, Chongqing, P.R. China; Division of Nephrology, Department of Medicine (V.A.M.V., X.W., L.D.A., J.E.J., Y.Y., M.R.W., I.A., P.A.J.) and Department of Physiology (P.A.J.), University of Maryland School of Medicine, Baltimore, MD; Department of Physiology and Pharmacology, University of Georgia, Athens, GA (S.-Y.C.); Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Fukushima, Japan (H.S.); Department of Pathology, The University of Virginia Health Sciences Center, Charlottesville (R.A.F.); Department of Medicine, Georgetown University Medical Center, Washington, DC (G.M.E.); Division of Renal Diseases and Hypertension, Department of Medicine (P.A.J.) and Department of Physiology (P.A.J.), The George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713262PMC
February 2016
30 Reads
5 Citations
6.480 Impact Factor

The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.

Am J Physiol Regul Integr Comp Physiol 2015 Dec 7;309(11):R1447-59. Epub 2015 Oct 7.

University of Virginia Department of Pathology, Charlottesville, Virginia;

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http://dx.doi.org/10.1152/ajpregu.00150.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698408PMC
December 2015
17 Reads
6 Citations
3.110 Impact Factor

Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells.

Endocrinology 2015 Jun 31;156(6):2211-21. Epub 2015 Mar 31.

Department of Physiology and Biophysics (F.L., P.A.J.), Georgetown University Medical Center, Washington, DC 20057; Liver Disease Branch (F.L.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; Department of Nutrition (J.Y.), Daping Hospital, The Third Military Medical University, Chongqing 400042, People's Republic of China; Division of Nephrology (J.Y.J.E.J., V.A.M.V., P.Y., I.A., P.A.J.), Department of Medicine, and Department of Physiology (P.A.J.), University of Maryland School of Medicine, Baltimore, Maryland 21201; and University of Virginia Health Sciences Center (R.A.F.), Charlottesville, Virginia 22908.

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http://dx.doi.org/10.1210/en.2014-1638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430625PMC
June 2015
7 Reads
1 Citation
4.503 Impact Factor

Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells.

Redox Biol 2014 22;2:570-9. Epub 2014 Feb 22.

Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA ; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.redox.2014.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969603PMC
June 2015
23 Reads
8 Citations

MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells.

Hypertension 2015 May 23;65(5):1118-25. Epub 2015 Mar 23.

From the Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (F.H., J.C.); Division of Nephrology, Department of Medicine (P.K., P.A.J., I.A.) and Department of Physiology (P.A.J.), University of Maryland School of Medicine, Baltimore; and Department of Pathology, University of Virginia School of Medicine, Charlottesville (J.G., R.A.F.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.05096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393363PMC
May 2015
10 Reads
10 Citations
6.480 Impact Factor

Association between control to target blood pressures and healthy lifestyle factors among Japanese hypertensive patients: longitudinal data analysis from Fukushima Research of Hypertension (FRESH).

Obes Res Clin Pract 2014 Jul-Aug;8(4):e364-73. Epub 2013 Sep 14.

Department of Public Health, Fukushima Medical University School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.1016/j.orcp.2013.08.004DOI Listing
April 2015
27 Reads
1 Citation
0.700 Impact Factor

Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.

Cell Signal 2014 Nov 15;26(11):2521-9. Epub 2014 Jul 15.

Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, United States.

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http://dx.doi.org/10.1016/j.cellsig.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166567PMC
November 2014
2 Reads
7 Citations
4.320 Impact Factor

Association between lifestyle-related disorders and visceral fat mass in Japanese males: a hospital based cross-sectional study.

Environ Health Prev Med 2014 Nov 24;19(6):429-35. Epub 2014 Sep 24.

Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Aizubange Town, Fukushima, Japan.

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http://dx.doi.org/10.1007/s12199-014-0411-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235847PMC
November 2014
19 Reads

Process evaluation of an open architecture real-time molecular laboratory platform.

J Lab Autom 2014 Oct 8;19(5):468-73. Epub 2014 May 8.

BD Diagnostics, Sparks, MD, USA.

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http://dx.doi.org/10.1177/2211068214533195DOI Listing
October 2014
13 Reads
2 Citations
1.500 Impact Factor

Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells.

Clin Biochem 2014 Oct 27;47(15):89-94. Epub 2014 Jun 27.

The University of Virginia Health System, Department of Pathology, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.clinbiochem.2014.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384615PMC
October 2014
38 Reads
12 Citations
2.230 Impact Factor

The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport.

Kidney Int 2014 Jul 19;86(1):118-26. Epub 2014 Feb 19.

The University of Virginia Health System, Department of Pathology, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1038/ki.2014.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077925PMC
July 2014
6 Reads
8 Citations
8.563 Impact Factor

Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats.

Kidney Int 2014 Mar 16;85(3):561-9. Epub 2013 Oct 16.

Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ki.2013.397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943540PMC
March 2014
41 Reads
9 Citations
8.563 Impact Factor

Automated specimen inspection, quality analysis, and its impact on patient safety: beyond the bar code.

Authors:
Robin A Felder

Clin Chem 2014 Mar 9;60(3):433-4. Epub 2014 Jan 9.

Department of Pathology, University of Virginia, Charlottesville, VA.

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http://dx.doi.org/10.1373/clinchem.2013.219352DOI Listing
March 2014
2 Reads
7.911 Impact Factor

Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure.

Clin Biochem 2013 Aug 29;46(12):1131-1134. Epub 2013 May 29.

Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2013.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786136PMC
August 2013
2 Reads
17 Citations
2.230 Impact Factor

A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells.

Hypertension 2013 May 18;61(5):1021-7. Epub 2013 Mar 18.

Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640476PMC
May 2013
24 Reads
2 Citations
6.480 Impact Factor

Isolation, growth, and characterization of human renal epithelial cells using traditional and 3D methods.

Methods Mol Biol 2013 ;945:329-45

Department of Pathology, The University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1007/978-1-62703-125-7_20DOI Listing
March 2013
10 Reads
12 Citations

High body mass index is an important risk factor for the development of type 2 diabetes.

Intern Med 2012 15;51(14):1821-6. Epub 2012 Jul 15.

Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540801PMC
http://dx.doi.org/10.2169/internalmedicine.51.7410DOI Listing
January 2013
23 Reads
10 Citations
0.970 Impact Factor

Diagnostic tools for hypertension and salt sensitivity testing.

Curr Opin Nephrol Hypertens 2013 Jan;22(1):65-76

Department of Pathology, The University of Virginia, Health Sciences Center, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1097/MNH.0b013e32835b3693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724405PMC
January 2013
18 Reads
20 Citations
3.862 Impact Factor

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.

J Biol Chem 2013 Jan 14;288(1):152-63. Epub 2012 Nov 14.

Center for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington DC 20010, USA.

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http://dx.doi.org/10.1074/jbc.M112.428458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537009PMC
January 2013
7 Reads
8 Citations
4.573 Impact Factor

Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase.

Free Radic Biol Med 2012 Aug 23;53(3):437-46. Epub 2012 May 23.

Center for Molecular Physiology Research, Children's National Medical Center, George Washington University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408834PMC
August 2012
34 Reads
18 Citations
5.740 Impact Factor

Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults.

Int J Hypertens 2012 21;2012:806810. Epub 2012 Feb 21.

Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University, School of Medicine, 1 Hikarigaoka Fukushima, Fukushima 960-1295, Japan.

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http://dx.doi.org/10.1155/2012/806810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296214PMC
August 2012
11 Reads
7 Citations

Preanalytical errors introduced by sample-transportation systems: a means to assess them.

Authors:
Robin A Felder

Clin Chem 2011 Oct 11;57(10):1349-50. Epub 2011 Aug 11.

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http://dx.doi.org/10.1373/clinchem.2011.172452DOI Listing
October 2011
2 Reads
1 Citation
7.911 Impact Factor

Achievement status toward goal blood pressure levels and healthy lifestyles among Japanese hypertensive patients; cross-sectional survey results from Fukushima Research of Hypertension (FRESH).

Intern Med 2011 1;50(11):1149-56. Epub 2011 Jun 1.

Department of General Medicine, Juntendo University School of Medicine, Japan.

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http://dx.doi.org/10.2169/internalmedicine.50.4969DOI Listing
October 2011
3 Reads
4 Citations
0.970 Impact Factor

Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk.

Free Radic Biol Med 2011 Apr 28;50(7):832-40. Epub 2010 Dec 28.

Center for Molecular Physiology Research, Children's National Medical Center, Department of Pediatrics, George Washington University School of Medicine, Washington, DC 20010, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066436PMC
April 2011
6 Reads
9 Citations
5.740 Impact Factor

Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor.

Endocrinology 2011 Apr 8;152(4):1582-8. Epub 2011 Feb 8.

Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan 960-1295.

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http://dx.doi.org/10.1210/en.2010-1070DOI Listing
April 2011
6 Reads
16 Citations
4.503 Impact Factor

Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy.

J Biomed Opt 2010 Sep-Oct;15(5):056003

Children's Research Institute, Children's National Medical Center, Center for Molecular Physiology Research, Washington, DC 20010, USA.

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http://dx.doi.org/10.1117/1.3484751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966490PMC
March 2011
6 Reads
6 Citations
2.860 Impact Factor

Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney.

Endocrinology 2011 Feb 29;152(2):680-8. Epub 2010 Dec 29.

Department of Cardiorenal and Cerebrovascular Medicine, Life Sciences Research Center, Kagawa University, Kagawa 761-0793, Japan.

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http://dx.doi.org/10.1210/en.2010-0829DOI Listing
February 2011
3 Reads
11 Citations
4.503 Impact Factor

Characteristics of antihypertensive medication and change of prescription over 1 year of follow up in Japan: Fukushima Research of Hypertension (FRESH).

Am J Hypertens 2010 Dec 19;23(12):1299-305. Epub 2010 Aug 19.

Department of Public Health, Fukushima Medical University School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.1038/ajh.2010.175DOI Listing
December 2010
6 Reads
2 Citations
2.852 Impact Factor

Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation.

Biochim Biophys Acta 2010 Dec 12;1802(12):1259-67. Epub 2010 Feb 12.

Children's National Medical Center, George Washington University for the Health Sciences, Washington, DC, USA.

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http://dx.doi.org/10.1016/j.bbadis.2010.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892632PMC
December 2010
2 Reads
34 Citations

HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling.

Hypertension 2010 Sep 26;56(3):505-11. Epub 2010 Jul 26.

University of Virginia, PO Box 801400, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.152256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537327PMC
September 2010
7 Reads
13 Citations
6.480 Impact Factor

Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension.

Am J Clin Nutr 2010 Jul 5;92(1):77-82. Epub 2010 May 5.

Department of Nephrology, Fukushima Medical University School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.3945/ajcn.2009.29028DOI Listing
July 2010
3 Reads
28 Citations
6.770 Impact Factor

Sleep assessment using a passive ballistocardiography-based system: preliminary validation.

Conf Proc IEEE Eng Med Biol Soc 2009 ;2009:4319-22

University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1109/IEMBS.2009.5333805DOI Listing
April 2010
6 Reads
1 Citation

Caveolin-1 and dopamine-mediated internalization of NaKATPase in human renal proximal tubule cells.

Hypertension 2009 Nov 14;54(5):1070-6. Epub 2009 Sep 14.

Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.134338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897144PMC
November 2009
16 Reads
17 Citations
6.480 Impact Factor

Inhibitory effect of ETB receptor on Na(+)-K(+) ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells.

Hypertens Res 2009 Oct 7;32(10):846-52. Epub 2009 Aug 7.

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, PR China.

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http://dx.doi.org/10.1038/hr.2009.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879332PMC
October 2009
4 Reads
9 Citations
2.660 Impact Factor

G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.

J Biol Chem 2009 Aug 11;284(32):21425-34. Epub 2009 Jun 11.

National Institute of Molecular Biology and Biotechnology, University of the Philippines, Diliman, Quezon City 1101, Philippines.

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http://dx.doi.org/10.1074/jbc.M109.003665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755867PMC
August 2009
4 Reads
30 Citations
4.573 Impact Factor

D1-like receptors regulate NADPH oxidase activity and subunit expression in lipid raft microdomains of renal proximal tubule cells.

Hypertension 2009 Jun 20;53(6):1054-61. Epub 2009 Apr 20.

Center for Molecular Physiology Research, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.120642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879618PMC
June 2009
3 Reads
14 Citations
6.480 Impact Factor

Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II.

Am J Physiol Renal Physiol 2009 May 4;296(5):F1052-60. Epub 2009 Mar 4.

Department of Internal Medicine 3, Fukushima Medical University, School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.1152/ajprenal.00580.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067119PMC
May 2009
2 Reads
13 Citations

3D cell culture opens new dimensions in cell-based assays.

Drug Discov Today 2009 Jan 26;14(1-2):102-7. Epub 2008 Dec 26.

Global Cell Solutions, Inc., 770 Harris Street, Suite 104, Charlottesville, VA 22903, USA.

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http://dx.doi.org/10.1016/j.drudis.2008.11.006DOI Listing
January 2009
5 Reads
43 Citations
6.691 Impact Factor

Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice.

Pediatr Nephrol 2008 Dec 10;23(12):2131-46. Epub 2008 Jul 10.

Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1007/s00467-008-0901-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724362PMC
December 2008
3 Reads
20 Citations
2.860 Impact Factor

Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor as demonstrated by fluorescence resonance energy transfer microscopy.

J Biomed Opt 2008 May-Jun;13(3):031206

Georgetown University Medical Center, Department of Pediatrics, Washington, DC 20057, USA.

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http://dx.doi.org/10.1117/1.2943286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731076PMC
September 2008
23 Reads
15 Citations
2.860 Impact Factor

Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats.

Hypertens Res 2008 Jul;31(7):1455-64

Department of Internal Medicine III, Fukushima Medical University School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.1291/hypres.31.1455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731072PMC
July 2008
5 Reads
8 Citations
2.660 Impact Factor

G protein-coupled receptor kinase 4: role in blood pressure regulation.

Hypertension 2008 Jun 17;51(6):1449-55. Epub 2008 Mar 17.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing City, People's Republic of China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.096487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722601PMC
June 2008
25 Reads
13 Citations
6.480 Impact Factor

Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.

Am J Physiol Heart Circ Physiol 2008 Feb 14;294(2):H551-69. Epub 2007 Dec 14.

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City 400042, People's Republic of China.

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http://dx.doi.org/10.1152/ajpheart.01036.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029502PMC
February 2008
6 Reads
33 Citations
3.840 Impact Factor

Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor.

Hypertension 2008 Feb 2;51(2):360-6. Epub 2008 Jan 2.

Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.100099DOI Listing
February 2008
4 Reads
24 Citations
6.480 Impact Factor

Impact of passive health status monitoring to care providers and payers in assisted living.

Telemed J E Health 2007 Jun;13(3):279-85

Medical Automation Research Center, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1089/tmj.2006.0056DOI Listing
June 2007
9 Reads
3 Citations
1.544 Impact Factor

The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production.

Am J Physiol Heart Circ Physiol 2007 May 26;292(5):H2083-92. Epub 2007 Jan 26.

Georgetown University School of Medicine, 4000 Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1152/ajpheart.00944.2006DOI Listing
May 2007
5 Reads
19 Citations
3.840 Impact Factor

Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism.

Hypertension 2007 Jan 20;49(1):155-61. Epub 2006 Nov 20.

Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/01.HYP.0000251881.89610.eeDOI Listing
January 2007
6 Reads
30 Citations
6.480 Impact Factor

Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity.

Nat Clin Pract Nephrol 2006 Nov;2(11):637-50

Department of Pathology, Post Office Box 800403, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1038/ncpneph0301DOI Listing
November 2006
3 Reads
40 Citations

A new approach for treatment of hypertension: modifying D1 dopamine receptor function.

Cardiovasc Hematol Agents Med Chem 2006 Oct;4(4):369-77

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City, PR China.

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http://dx.doi.org/10.2174/187152506778520727DOI Listing
October 2006
10 Reads
7 Citations

Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.

Circ Res 2006 Sep 10;99(5):494-500. Epub 2006 Aug 10.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, People's Republic of China.

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http://dx.doi.org/10.1161/01.RES.0000240500.96746.ecDOI Listing
September 2006
7 Reads
45 Citations
11.020 Impact Factor

Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression.

Hypertension 2006 Jun 24;47(6):1131-9. Epub 2006 Apr 24.

Department of Internal Medicine III, Fukushima Medical University School of Medicine, Fukushima, Japan.

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http://dx.doi.org/10.1161/01.HYP.0000222004.74872.17DOI Listing
June 2006
5 Reads
27 Citations
6.480 Impact Factor

[G protein kinase 4gammaA142V overexpression induced hypertension by downregulating D1 receptors in transgenic mice].

Zhonghua Xin Xue Guan Bing Za Zhi 2006 May;34(5):411-4

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

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May 2006
14 Reads
1 Citation

D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells.

Hypertension 2006 Mar 9;47(3):573-9. Epub 2006 Jan 9.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.

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http://dx.doi.org/10.1161/01.HYP.0000199983.24674.83DOI Listing
March 2006
7 Reads
10 Citations
6.480 Impact Factor

Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.

Clin Chem 2006 Mar 26;52(3):352-60. Epub 2006 Jan 26.

Third Department of Internal Medicine, Fukushima Medical University, School of Medicine, Fukushima City, Japan.

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http://dx.doi.org/10.1373/clinchem.2005.059139DOI Listing
March 2006
20 Reads
42 Citations
7.911 Impact Factor

D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure.

Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R96-R104

Department of Pediatrics and Physiology, Georgetown University Medical Center, 3800 Reservoir Rd., NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1152/ajpregu.00434.2005DOI Listing
January 2006
12 Reads
46 Citations
3.110 Impact Factor

[Hypertension in D3 dopamine receptor deficient mice].

Zhonghua Xin Xue Guan Bing Za Zhi 2005 Dec;33(12):1132-6

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

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December 2005
9 Reads
1 Citation

Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats.

Hypertension 2005 Oct 6;46(4):926-31. Epub 2005 Sep 6.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, PR China.

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http://dx.doi.org/10.1161/01.HYP.0000174595.41637.13DOI Listing
October 2005
20 Reads
8 Citations
6.480 Impact Factor

Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalized renal proximal tubule cells.

Hypertension 2005 Oct 19;46(4):799-805. Epub 2005 Sep 19.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, PR China.

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http://dx.doi.org/10.1161/01.HYP.0000184251.01159.72DOI Listing
October 2005
4 Reads
13 Citations
6.480 Impact Factor

Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats.

Kidney Int 2005 Aug;68(2):623-31

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.

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http://dx.doi.org/10.1111/j.1523-1755.2005.00440.xDOI Listing
August 2005
12 Reads
7 Citations
8.563 Impact Factor

Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells.

Hypertension 2005 Apr 7;45(4):804-10. Epub 2005 Feb 7.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

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http://dx.doi.org/10.1161/01.HYP.0000155212.33212.99DOI Listing
April 2005
4 Reads
32 Citations
6.480 Impact Factor

Dopamine receptor and hypertension.

Curr Med Chem Cardiovasc Hematol Agents 2005 Jan;3(1):69-77

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City, P. R. China.

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http://dx.doi.org/10.2174/1568016052773289DOI Listing
January 2005
3 Reads
10 Citations

D5 dopamine receptor regulation of phospholipase D.

Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H55-61

Department of Physiology and Biophysics, Georgetown University Medical Center, 3800 Reservoir Rd. NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1152/ajpheart.00627.2004DOI Listing
January 2005
7 Reads
14 Citations
3.840 Impact Factor

D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells.

Kidney Int 2004 Dec;66(6):2167-80

Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C., USA.

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http://dx.doi.org/10.1111/j.1523-1755.2004.66007.xDOI Listing
December 2004
4 Reads
37 Citations
8.563 Impact Factor

Multilocus analysis of hypertension: a hierarchical approach.

Hum Hered 2004 ;57(1):28-38

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1159/000077387DOI Listing
November 2004
9 Reads
43 Citations
1.474 Impact Factor

Functional genomics of the dopaminergic system in hypertension.

Physiol Genomics 2004 Nov;19(3):233-46

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.

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http://dx.doi.org/10.1152/physiolgenomics.00127.2004DOI Listing
November 2004
6 Reads
38 Citations
2.374 Impact Factor

Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.

Hypertension 2004 May 8;43(5):1133-9. Epub 2004 Mar 8.

Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908-1414, USA.

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http://dx.doi.org/10.1161/01.HYP.0000123574.60586.7dDOI Listing
May 2004
70 Reads
10 Citations
6.480 Impact Factor

Protein phosphatase 2A B56alpha during development in the spontaneously hypertensive rat.

Clin Exp Hypertens 2004 Apr;26(3):243-54

Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia 20057, USA.

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http://dx.doi.org/10.1081/ceh-120030233DOI Listing
April 2004
4 Reads
2 Citations
1.460 Impact Factor

Dopamine D1 receptor augmentation of D3 receptor action in rat aortic or mesenteric vascular smooth muscles.

Hypertension 2004 Mar 9;43(3):673-9. Epub 2004 Feb 9.

Department of Pediatrics, PHC-2 Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1161/01.HYP.0000118958.27649.6fDOI Listing
March 2004
7 Reads
14 Citations
6.480 Impact Factor

Aberrant D1 and D3 dopamine receptor transregulation in hypertension.

Hypertension 2004 Mar 19;43(3):654-60. Epub 2004 Jan 19.

Department of Pediatrics, PHC-2, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1161/01.HYP.0000114601.30306.bfDOI Listing
March 2004
3 Reads
7 Citations
6.480 Impact Factor

Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells.

Hypertension 2004 Feb 12;43(2):286-91. Epub 2004 Jan 12.

Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA.

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http://dx.doi.org/10.1161/01.HYP.0000112421.18551.1eDOI Listing
February 2004
6 Reads
16 Citations
6.480 Impact Factor

Regulation of blood pressure by dopamine receptors.

Nephron Physiol 2003 ;95(2):p19-27

Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1159/000073676DOI Listing
February 2004
2 Reads
21 Citations
1.545 Impact Factor

Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats.

Hypertension 2003 Oct 4;42(4):787-92. Epub 2003 Aug 4.

Department of Pediatrics, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1161/01.HYP.0000085334.34963.4EDOI Listing
October 2003
3 Reads
33 Citations
6.480 Impact Factor

Push for patient safety is nudge for automation.

Authors:
Robin A Felder

CAP Today 2003 May;17(5):33-6, 38, 40 passim

Medical Automation Research Center, University of Virginia, Charlottesville, USA.

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May 2003

Dopamine and the kidney: a role in hypertension?

Curr Opin Nephrol Hypertens 2003 Mar;12(2):189-94

Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1097/00041552-200303000-00010DOI Listing
March 2003
5 Reads
14 Citations
3.862 Impact Factor

Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR.

Hypertension 2003 Mar 23;41(3 Pt 2):724-9. Epub 2002 Dec 23.

Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1161/01.HYP.0000047880.78462.0EDOI Listing
March 2003
6 Reads
21 Citations
6.480 Impact Factor

Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron.

Hypertension 2003 Mar 24;41(3):604-10. Epub 2003 Feb 24.

Department of Pediatrics, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1161/01.HYP.0000057422.75590.D7DOI Listing
March 2003
8 Reads
29 Citations
6.480 Impact Factor

Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers.

Clin Chem 2002 Dec;48(12):2131-40

Department of Pathology, The University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA.

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December 2002
10 Reads
27 Citations
7.911 Impact Factor

Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4.

Kidney Int 2002 Sep;62(3):790-8

Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1046/j.1523-1755.2002.00525.xDOI Listing
September 2002
42 Reads
25 Citations
8.563 Impact Factor

LabAutomation 2002: Internet access to health data: elder-care, home-care, and self-care programs--Part 4.

Am Clin Lab 2002 Jun;21(5):8-12

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June 2002
5 Reads
1 Citation

Dopamine receptor-coupling defect in hypertension.

Curr Hypertens Rep 2002 Jun;4(3):237-44

Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1007/s11906-002-0013-6DOI Listing
June 2002
6 Reads
1 Citation
3.440 Impact Factor

Elevated renal cortical calmodulin-dependent protein kinase activity and blood pressure.

Clin Exp Hypertens 2002 May;24(4):289-300

School of Pharmacy, University of Missouri-Kansas City, USA.

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http://dx.doi.org/10.1081/ceh-120004232DOI Listing
May 2002
4 Reads
2 Citations
1.460 Impact Factor

Evaluation of an automated preanalytical robotic workstation at two academic health centers.

Clin Chem 2002 Mar;48(3):540-8

University of Virginia Medical Automation Research Center (MARC), Department of Pathology, PO Box 800214, Charlottesville, VA 22908, USA.

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March 2002
4 Reads
1 Citation
7.910 Impact Factor

Role of dopamine receptors in the kidney in the regulation of blood pressure.

Curr Opin Nephrol Hypertens 2002 Jan;11(1):87-92

Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1097/00041552-200201000-00013DOI Listing
January 2002
4 Reads
21 Citations
3.860 Impact Factor

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Pedro A Jose

University of Maryland School of Medicine

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Gilbert M Eisner

The George Washington University School of Medicine and Health Sciences

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Chunyu Zeng

Daping Hospital

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University of Maryland School of Medicine

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University of Virginia

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University of Maryland School of Medicine

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University of Maryland School of Medicine

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