Publications by authors named "Roberto Testi"

50Publications

Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders.

Antimicrob Agents Chemother 2020 Oct 26. Epub 2020 Oct 26.

Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01902-20DOI Listing
October 2020

Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia.

Mov Disord 2019 03 9;34(3):323-334. Epub 2019 Jan 9.

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.27604DOI Listing
March 2019

Biophysical characterisation of the recombinant human frataxin precursor.

FEBS Open Bio 2018 03 25;8(3):390-405. Epub 2018 Jan 25.

Institute of Biological Chemistry and Physicochemistry Dr Alejandro Paladini (UBA-CONICET) University of Buenos Aires Argentina.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/2211-5463.12376
Publisher Site
http://dx.doi.org/10.1002/2211-5463.12376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832983PMC
March 2018

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.

Cell Rep 2017 02;18(8):2007-2017

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, 00133 Rome, Italy; Fratagene Therapeutics Srl, Viale dei Campioni 8, 00144 Rome, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.01.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329121PMC
February 2017

Analyzing the Effects of a G137V Mutation in the FXN Gene.

Front Mol Neurosci 2015 25;8:66. Epub 2015 Nov 25.

Department of Basic and Clinical Neuroscience, Maurice Wohl Institute, King's College London London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2015.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658817PMC
December 2015

GIFT-1, a phase IIa clinical trial to test the safety and efficacy of IFNγ administration in FRDA patients.

Neurol Sci 2016 Mar 30;37(3):361-4. Epub 2015 Nov 30.

Department of Medical Surgical Sciences and Biotechnologies, Polo Pontino-University of Rome "Sapienza", V. dell'Università 30, 00185, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-015-2427-3DOI Listing
March 2016

A Biological and Procedural Review of Forensically Significant Dermestes Species (Coleoptera: Dermestidae).

J Med Entomol 2015 Sep 25;52(5):755-69. Epub 2015 Jul 25.

Program in Forensic Anthropology, Department of Anatomy & Neurobiology, Boston University School of Medicine - 72 East Concord St (L 1004) Boston, Massachusetts 02118.

View Article

Download full-text PDF

Source
https://academic.oup.com/jme/article-lookup/doi/10.1093/jme/
Publisher Site
http://dx.doi.org/10.1093/jme/tjv106DOI Listing
September 2015

Src inhibitors modulate frataxin protein levels.

Hum Mol Genet 2015 Aug 6;24(15):4296-305. Epub 2015 May 6.

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddv162DOI Listing
August 2015

Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.

Neurobiol Dis 2015 Mar 27;75:91-9. Epub 2014 Dec 27.

Laboratory of Signal Transduction, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Via Montpellier 1, Rome 00133, Italy; Fratagene Therapeutics Ltd., 22 Northumberland Rd., Dublin, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2014.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358773PMC
March 2015

Diffuse leukoencephalopathy due to lymphomatosis cerebri: a clinicopathological report.

Neurol Sci 2015 Jun 29;36(6):1071-3. Epub 2014 Oct 29.

Centro Regionale Diagnosi ed Osservazione Malattie Prioniche DOMP, ASL To2, Via Cibrario72, 10144, Turin, Italy,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-014-1974-3DOI Listing
June 2015

Clinical and neuropathological findings in Hashimoto's encephalopathy: a case report.

Neurol Sci 2014 Feb 24;35(2):327-9. Epub 2013 Sep 24.

Centro Regionale Diagnosi ed Osservazione Malattie Prioniche DOMP, ASL To2, Via Cibrario 72, 10144, Turin, Italy,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-013-1554-yDOI Listing
February 2014

Preventing the ubiquitin-proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia.

Hum Mol Genet 2011 Apr 7;20(7):1253-61. Epub 2011 Jan 7.

Laboratory of Signal Transduction, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddq566DOI Listing
April 2011

A role for p53 in mitochondrial stress response control of longevity in C. elegans.

Exp Gerontol 2010 Aug 19;45(7-8):550-7. Epub 2010 Feb 19.

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565100007
Publisher Site
http://dx.doi.org/10.1016/j.exger.2010.02.007DOI Listing
August 2010

Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.

Hum Mol Genet 2010 Apr 6;19(7):1221-9. Epub 2010 Jan 6.

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddp592DOI Listing
April 2010

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.

Aging Cell 2009 Aug 22;8(4):380-93. Epub 2009 Apr 22.

Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1474-9726.2009.00482.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730656PMC
August 2009

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.

Blood 2008 Jan 11;111(2):829-37. Epub 2007 Oct 11.

Dulbecco Telethon Institute, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-04-085399DOI Listing
January 2008

In vivo maturation of human frataxin.

Hum Mol Genet 2007 Jul 27;16(13):1534-40. Epub 2007 Apr 27.

Laboratory of Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddm102DOI Listing
July 2007

Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases.

Exp Gerontol 2006 Oct 1;41(10):974-91. Epub 2006 Sep 1.

Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80302, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2006.06.060DOI Listing
October 2006

5-aminosalicylic acid enhances anchorage-independent colorectal cancer cell death.

Eur J Cancer 2006 Oct 17;42(15):2609-16. Epub 2006 Aug 17.

Dipartimento di Medicina Interna, Cattedra di Gastroenterologia, e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Università Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2006.03.030DOI Listing
October 2006

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.

EMBO J 2006 May 13;25(9):1895-905. Epub 2006 Apr 13.

Department of Experimental Medicine and Biochemical Sciences, Dulbecco Telethon Institute, University of Rome Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456929PMC
May 2006

A pool of extramitochondrial frataxin that promotes cell survival.

J Biol Chem 2006 Jun 11;281(24):16750-6. Epub 2006 Apr 11.

Laboratory of Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M511960200DOI Listing
June 2006

9-O-acetyl GD3 protects tumor cells from apoptosis.

Int J Cancer 2006 Jul;119(1):67-73

Institute of Immunology, Technical University of Dresden, Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21788DOI Listing
July 2006

Ceramide catabolism critically controls survival of human dendritic cells.

J Leukoc Biol 2006 Jan 21;79(1):166-72. Epub 2005 Oct 21.

Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.1004601DOI Listing
January 2006

The ganglioside GD3 as the Greek goddess Hecate: several faces turned towards as many directions.

IUBMB Life 2005 Jul;57(7):477-82

Laboratory of Immunology and Signal Transduction, Department of Experimental Medecine and Biochemical sciences, University "Tor Vergata", Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15216540500167179DOI Listing
July 2005

Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans.

Aging Cell 2005 Apr;4(2):109-12

Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447 Boulder, CO 80309-0447 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1474-9726.2005.00149.xDOI Listing
April 2005

Differential regulation of apoptotic cell death in senescent human cells.

Exp Gerontol 2004 Nov-Dec;39(11-12):1713-21

Department of Molecular and Cellular Biology, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2004.05.010DOI Listing
April 2005

Calnexin suppresses GD3 synthase-induced apoptosis.

FASEB J 2004 Oct 19;18(13):1553-5. Epub 2004 Aug 19.

Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.04-1675fjeDOI Listing
October 2004

Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies.

Cell Biochem Funct 2003 Sep;21(3):263-7

Dipartimento di Biopatologia e Diagnostica per Immagini, Università di Roma Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.1021DOI Listing
September 2003

Mitochondrial lipids as apoptosis regulators.

Curr Med Chem 2003 Aug;10(16):1573-80

Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Via Montpellier, 1. 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929867033457188DOI Listing
August 2003

A caspaselike activity is triggered by LPS and is required for survival of human dendritic cells.

Blood 2003 Oct 26;102(8):2910-5. Epub 2003 Jun 26.

Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-03-0967DOI Listing
October 2003

Caspase-dependent cleavage of c-Abl contributes to apoptosis.

Mol Cell Biol 2003 Apr;23(8):2790-9

Dulbecco Telethon Institute and Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152541PMC
http://dx.doi.org/10.1128/mcb.23.8.2790-2799.2003DOI Listing
April 2003

GD3 ganglioside and apoptosis.

Biochim Biophys Acta 2002 Dec;1585(2-3):179-87

Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1388-1981(02)00339-6DOI Listing
December 2002

Is it cytotoxicity or apoptosis which causes cell death in autoimmunity?

Springer Semin Immunopathol 2002 Dec;24(3):331-41

Laboratory of Immunology and Signal Transduction, University of Tor Vergata. Via Montpellier 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00281-002-0108-9DOI Listing
December 2002

Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

J Exp Med 2002 Dec;196(12):1535-41

Laboratory of Immunology and Signal Transduction, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196066PMC
http://dx.doi.org/10.1084/jem.20020960DOI Listing
December 2002

GD3 in cellular ageing and apoptosis.

Exp Gerontol 2002 Oct-Nov;37(10-11):1273-82

Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0531-5565(02)00138-9DOI Listing
April 2003

Lipid signaling in CD95-mediated apoptosis.

Subcell Biochem 2002 ;36:285-308

Department of Experimental Medicine and Biochemical Science, University of Rome Tor Vergata, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/0-306-47931-1_15DOI Listing
July 2002

Mitochondria as sensors of sphingolipids.

Biochimie 2002 Feb-Mar;84(2-3):123-9

Laboratory of Immunology and Signal Transduction, Department of Experimental Medecine and Biochemical Science, University of Rome, Tor Vergata, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0300-9084(02)01377-9DOI Listing
September 2002