Publications


Computed Tomography and MR Imaging in Rheumatoid Arthritis.
Radiol Clin North Am 2017 Sep 12;55(5):997-1007. Epub 2017 Jun 12.
Diagnostic and Interventional Radiology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, L'Aquila, Coppito 67100, Italy.

Macrophage activation syndrome in Still's disease: analysis of clinical characteristics and survival in paediatric and adult patients.
Clin Rheumatol 2017 Sep 15. Epub 2017 Sep 15.
Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Cryoglobulinemia in Sjögren Syndrome: A Disease Subset that Links Higher Systemic Disease Activity, Autoimmunity, and Local B Cell Proliferation in Mucosa-associated Lymphoid Tissue.
J Rheumatol 2017 Aug 15;44(8):1179-1183. Epub 2017 May 15.
From the Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine; Rheumatology Unit, Department of Internal Medicine, University of Pisa, Pisa; Rheumatology Unit, Sapienza University of Rome, Rome; Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia; Rheumatology Unit, University of L'Aquila, L'Aquila, Italy.

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis: Results from a cross-sectional study.
Medicine (Baltimore) 2017 Aug;96(34):e7896
aDivision of Rheumatology, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila bDepartment of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro cDivision of Rheumatology, Department of Internal Medicine, University of Palermo, Palermo, Italy.

Poor clinical response in rheumatoid arthritis is the main risk factor for diabetes development in the short-term: A 1-year, single-centre, longitudinal study.
PLoS One 2017 12;12(7):e0181203. Epub 2017 Jul 12.
Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.


Interstitial lung disease in systemic sclerosis: current and future treatment.
Rheumatol Int 2017 Jun 6;37(6):853-863. Epub 2017 Jan 6.
Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100, L'Aquila, Italy.




Correlation between ESSDAI and ClinESSDAI in a real-life cohort of patients with Sjögren's syndrome.
Clin Exp Rheumatol 2017 May-Jun;35(3):546-547. Epub 2017 Feb 10.
Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria 'S. Maria della Misericordia', Udine, Italy.



Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers.
BMC Med 2016 Dec 1;14(1):194. Epub 2016 Dec 1.
Rheumatology Section, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100, L'Aquila, Italy.



IL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone?
Expert Rev Clin Immunol 2016 Aug 12;12(8):849-55. Epub 2016 Apr 12.
a Division of Rheumatology, Department of Biotechnological and Applied Clinical Science , School of Medicine, University of L'Aquila , L'Aquila , Italy.



Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.
J Rheumatol 2016 Jul 1;43(7):1340-9. Epub 2016 Jun 1.
From the Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, and the Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila, L'Aquila; Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo, Palermo, Italy.P. Cipriani, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; P. Di Benedetto, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; P. Ruscitti, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; V. Liakouli, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; O. Berardicurti, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; F. Carubbi, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; F. Ciccia, MD, PhD, Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo; G. Guggino, MD, Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo; F. Zazzeroni, PhD, Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila; E. Alesse, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila; G. Triolo, MD, PhD, Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo; R. Giacomelli, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School


Anti-SSA/SSB-negative Sjögren's syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution.
Autoimmun Rev 2015 Nov 8;14(11):1019-22. Epub 2015 Jul 8.
Rheumatology Clinic, Department of Medical and Biological Sciences, Azienda Ospedaliero-Universitaria "S. Maria della Misericordia", Udine, Italy. Electronic address:

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist.
J Rheumatol 2015 Oct 15;42(10):1808-16. Epub 2015 Aug 15.
From the Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, and the Department of Applied Clinical Sciences and Biotechnology, General Phatology Unit, University of L'Aquila, L'Aquila; Medical and Scientific Direction, Actelion Pharmaceuticals Italy, Imola, Italy; Drug Discovery Department, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland.P. Cipriani, MD, PhD; P. Di Benedetto, PhD; P. Ruscitti, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; D. Capece, PhD; F. Zazzeroni, PhD, Department of Applied Clinical Sciences and Biotechnology, General Phatology Unit, University of L'Aquila; V. Liakouli, MD, PhD; I. Pantano, MD; O. Berardicurti, MD; F. Carubbi, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; G. Pecetti, MD; S. Turricchia, MD, Medical and Scientific Direction, Actelion Pharmaceuticals Italy; E. Alesse, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila; M. Iglarz, PhD, Drug Discovery Department, Actelion Pharmaceuticals Ltd.; R. Giacomelli, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila.

Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts.
Arthritis Res Ther 2015 Sep 10;17:247. Epub 2015 Sep 10.
Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100, L'Aquila, Italy.


Efficacy of inhibition of IL-1 in patients with rheumatoid arthritis and type 2 diabetes mellitus: two case reports and review of the literature.
J Med Case Rep 2015 Jun 2;9:123. Epub 2015 Jun 2.
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Rheumatology Unit, delta 6 building, PO Box 67100, L'Aquila, Italy.

Quality of life and unmet needs in patients with inflammatory arthropathies: results from the multicentre, observational RAPSODIA study.
Rheumatology (Oxford) 2015 May 6;54(5):792-7. Epub 2014 Oct 6.
Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Rheumatology Unit, University of Brescia, Brescia, Rheumatology Unit, University of Ferrara, Ferrara, Rheumatology Unit of the Second University of Naples, Naples, Rheumatology Unit, Polytechnic University of the Marche, Jesi, Ancona, Rheumatology Unit, Department of Internal Medicine, University of Pisa, Pisa, Rheumatology Unit, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Division of Rheumatology, Department of Biomedicine, University of Florence, Florence, Rheumatology Unit, Department of Clinical and Experimental Medicine, University Federico II, Naples, Division of Rheumatology, Misericordia e Dolce Hospital, Prato, Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Rheumatology Unit, University of Bari, Bari, Rheumatology Unit, G Pini Hospital, Milan, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, School of Medicine, Catholic University of the Sacred Heart, Rome, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera and Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.



Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis.
Fibrogenesis Tissue Repair 2014 15;7:13. Epub 2014 Sep 15.
Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100 L'Aquila, Italy.

Rituximab modulates IL-17 expression in the salivary glands of patients with primary Sjögren's syndrome.
Rheumatology (Oxford) 2014 Jul 6;53(7):1313-20. Epub 2014 Mar 6.
Dipartimento Biomedico di Medicina Interna e Specialistiche, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Sezione di Anatomia Patologica, Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo and Dipartimento di Medicina Interna e Salute pubblica, Sezione di Reumatologia, Università di L'Aquila, L'Aquila, Italy.



CD4(-)CD8(-) T-cells in primary Sjögren's syndrome: association with the extent of glandular involvement.
J Autoimmun 2014 Jun 24;51:38-43. Epub 2014 Jan 24.
Rheumatology Unit, Department of Medicine, University of Perugia, Via Enrico Dal Pozzo, s.n.c., Perugia I-06126, Italy. Electronic address:

Scleroderma Mesenchymal Stem Cells display a different phenotype from healthy controls; implications for regenerative medicine.
Angiogenesis 2013 Jul 15;16(3):595-607. Epub 2013 Feb 15.
Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100 L'Aquila, Italy.









Resistance to apoptosis in circulating alpha/beta and gamma/delta T lymphocytes from patients with systemic sclerosis.
J Rheumatol 2006 Oct;33(10):2003-14
Department of Internal Medicine, University of L'Aquila, School of Medicine, Rheumatology Unit, University of Rome Tor Vergata School of Medicine, Rome, Italy.






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