Publications by authors named "Roberto Dal Zuffo"

12 Publications

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.

ACS Med Chem Lett 2020 May 13;11(5):754-759. Epub 2020 Feb 13.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.

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May 2020

Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.

Authors:

Roberto Ravasio Elena Ceccacci Luciano Nicosia Amir Hosseini Pier Luigi Rossi Iros Barozzi Lorenzo Fornasari Roberto Dal Zuffo Sergio Valente Rossella Fioravanti Ciro Mercurio Mario Varasi Andrea Mattevi Antonello Mai Giulio Pavesi Tiziana Bonaldi Saverio Minucci

Sci Adv 2020 04 8;6(15):eaax2746. Epub 2020 Apr 8.

Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.

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April 2020

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Authors:

Paolo Trifirò Anna Cappa Silvia Brambillasca Oronza A Botrugno Maria Rosaria Cera Roberto Dal Zuffo Paola Dessanti Giuseppe Meroni Florian Thaler Manuela Villa Saverio Minucci Ciro Mercurio Mario Varasi Paola Vianello

Future Med Chem 2017 07 19;9(11):1161-1174. Epub 2017 Jul 19.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.

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July 2017

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Authors:

Paola Vianello Oronza A Botrugno Anna Cappa Roberto Dal Zuffo Paola Dessanti Antonello Mai Biagina Marrocco Andrea Mattevi Giuseppe Meroni Saverio Minucci Giulia Stazi Florian Thaler Paolo Trifiró Sergio Valente Manuela Villa Mario Varasi Ciro Mercurio

J Med Chem 2016 Feb 7;59(4):1501-17. Epub 2016 Jan 7.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology , Via Adamello 16, 20139 Milan, Italy.

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February 2016

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

Authors:

Mohamed Elgendy Marco Ciro Amal Kamal Abdel-Aziz Giuseppe Belmonte Roberto Dal Zuffo Ciro Mercurio Clelia Miracco Luisa Lanfrancone Marco Foiani Saverio Minucci

Nat Commun 2014 Dec 4;5:5637. Epub 2014 Dec 4.

1] Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy [2] Department of Biosciences, University of Milan, 20100 Milan, Italy [3] Drug Development Program, European Institute of Oncology, IEO, 20139 Milan, Italy.

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December 2014

Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.

Authors:

Raffaella Amici Chiara Bigogno Roberto Boggio Andrea Colombo Stephen M Courtney Roberto Dal Zuffo Giulio Dondio Fulvia Fusar Stefania Gagliardi Saverio Minucci Marco Molteni Christian A G N Montalbetti Annalisa Mortoni Mario Varasi Stefania Vultaggio Ciro Mercurio

ChemMedChem 2014 Jul 17;9(7):1574-85. Epub 2014 Apr 17.

Genextra Group, Congenia s.r.l., Via Adamello 16, 20139 Milan (Italy); Current address: Drug Discovery Program, Department of Experimental Oncology, IEO-European Institute of Oncology, Via Adamello 16, 20139 Milan (Italy).

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July 2014

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.

Authors:

Florian Thaler Mario Varasi Agnese Abate Giacomo Carenzi Andrea Colombo Chiara Bigogno Roberto Boggio Roberto Dal Zuffo Daniela Rapetti Anna Resconi Nickolas Regalia Stefania Vultaggio Giulio Dondio Stefania Gagliardi Saverio Minucci Ciro Mercurio

Eur J Med Chem 2013 Jun 10;64:273-84. Epub 2013 Apr 10.

Genextra Group, Congenia s.r.l., Via Adamello 16, 20139 Milan, Italy.

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June 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Authors:

Fabio Santoro Oronza A Botrugno Roberto Dal Zuffo Isabella Pallavicini Geoffrey M Matthews Leonie Cluse Iros Barozzi Silvia Senese Lorenzo Fornasari Simona Moretti Lucia Altucci Pier Giuseppe Pelicci Susanna Chiocca Ricky W Johnstone Saverio Minucci

Blood 2013 Apr 25;121(17):3459-68. Epub 2013 Feb 25.

Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, via Adamello 16, Milan, Italy.

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April 2013

Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity.

Authors:

Florian Thaler Mario Varasi Giacomo Carenzi Andrea Colombo Agnese Abate Chiara Bigogno Roberto Boggio Simone Carrara Tiziana Cataudella Roberto Dal Zuffo Veronica Reali Stefania Vultaggio Giulio Dondio Stefania Gagliardi Saverio Minucci Ciro Mercurio

ChemMedChem 2012 Apr 22;7(4):709-21. Epub 2012 Feb 22.

Genextra Group, Congenia s.r.l., Via Adamello 16, 20139 Milan,

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April 2012

Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.

Authors:

Mario Varasi Florian Thaler Agnese Abate Chiara Bigogno Roberto Boggio Giacomo Carenzi Tiziana Cataudella Roberto Dal Zuffo Maria Carmela Fulco Marco Giulio Rozio Antonello Mai Giulio Dondio Saverio Minucci Ciro Mercurio

J Med Chem 2011 Apr 1;54(8):3051-64. Epub 2011 Apr 1.

Genextra Group, DAC SRL, Milan, Italy.

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April 2011

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

Authors:

Raffaella Di Micco Gabriele Sulli Miryana Dobreva Michalis Liontos Oronza A Botrugno Gaetano Gargiulo Roberto dal Zuffo Valentina Matti Giovanni d'Ario Erica Montani Ciro Mercurio William C Hahn Vassilis Gorgoulis Saverio Minucci Fabrizio d'Adda di Fagagna

Nat Cell Biol 2011 Mar 20;13(3):292-302. Epub 2011 Feb 20.

IFOM Foundation - FIRC Institute of Molecular Oncology Foundation, Milan, Italy.

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March 2011

Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples.

Authors:

Mirco Fanelli Stefano Amatori Iros Barozzi Matias Soncini Roberto Dal Zuffo Gabriele Bucci Maria Capra Micaela Quarto Gaetano Ivan Dellino Ciro Mercurio Myriam Alcalay Giuseppe Viale Pier Giuseppe Pelicci Saverio Minucci

Proc Natl Acad Sci U S A 2010 Dec 24;107(50):21535-40. Epub 2010 Nov 24.

Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61032 Fano, Italy.

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December 2010