Roberta De Tullio

Roberta De Tullio

UNVERIFIED PROFILE

Are you Roberta De Tullio?   Register this Author

Register author
Roberta De Tullio

Roberta De Tullio

Publications by authors named "Roberta De Tullio"

Are you Roberta De Tullio?   Register this Author

28Publications

116Reads

47Profile Views

A new human calpastatin skipped of the inhibitory region protects calpain-1 from inactivation and degradation.

Biochim Biophys Acta Mol Cell Res 2019 08 5;1866(8):1260-1271. Epub 2019 Apr 5.

Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, Viale Benedetto XV, 1-16132 Genova, Italy; Centre of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV, 7-16132 Genova, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2019.04.005DOI Listing
August 2019

Production and Purification of Recombinant Calpastatin.

Methods Mol Biol 2019 ;1915:163-185

Department of Experimental Medicine (DIMES)-Biochemistry Section, University of Genova, Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8988-1_13DOI Listing
June 2019

Isolation of Endogenous Calpastatin.

Methods Mol Biol 2019 ;1915:187-194

Department of Experimental Medicine (DIMES)-Biochemistry Section, University of Genova, Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8988-1_14DOI Listing
June 2019

Immunoblotting for Calpastatin Expression.

Methods Mol Biol 2019 ;1915:195-206

Department of Experimental Medicine (DIMES)-Biochemistry Section, University of Genova, Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8988-1_15DOI Listing
June 2019

Cell protection from Ca-overloading by bioactive molecules extracted from olive pomace.

Nat Prod Res 2019 May 4;33(10):1449-1455. Epub 2018 Jan 4.

a Department of Experimental Medicine (DIMES) - Biochemistry Section , University of Genoa , Genova , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2017.1422181DOI Listing
May 2019

Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain.

Biosci Rep 2018 04 20;38(2). Epub 2018 Apr 20.

Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, Viale Benedetto XV-1, 16132 Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20180147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968184PMC
April 2018

Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients.

Arch Biochem Biophys 2016 08 25;604:103-12. Epub 2016 Jun 25.

Department of Experimental Medicine (DIMES) - Biochemistry Section, Viale Benedetto XV, 1, 16132, Genova, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2016.06.015DOI Listing
August 2016

Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex.

PLoS One 2015 2;10(10):e0139750. Epub 2015 Oct 2.

Department of Experimental Medicine (DIMES)-Biochemistry Section, University of Genova, Viale Benedetto XV, 1-16132, Genova, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV, 1-16132, Genova, Italy.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139750PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592069PMC
June 2016

Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease.

PLoS One 2015 9;10(1):e0116738. Epub 2015 Jan 9.

Department of Experimental Medicine (DIMES)-Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116738PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289065PMC
December 2015

Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin.

Biochim Biophys Acta 2014 Nov 12;1843(11):2583-91. Epub 2014 Jul 12.

Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, Viale Benedetto XV, 1-16132 Genova, Italy; Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 7-16132 Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2014.07.002DOI Listing
November 2014

Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.

PLoS One 2013 13;8(6):e66089. Epub 2013 Jun 13.

Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066089PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681946PMC
January 2014

Evidence for alteration of calpain/calpastatin system in PBMC of cystic fibrosis patients.

Biochim Biophys Acta 2011 Dec 29;1812(12):1649-57. Epub 2011 Sep 29.

Department of Experimental Medicine, University of Genoa, Viale Benedetto XV, Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2011.09.013DOI Listing
December 2011

Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR.

Biochim Biophys Acta 2011 Jan 24;1813(1):50-9. Epub 2010 Nov 24.

Department of Experimental Medicine, University of Genoa, Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2010.11.008DOI Listing
January 2011

Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover.

Biochem J 2010 Sep;430(2):255-63

Biochemistry Section, Department of Experimental Medicine, University of Genoa, Viale Benedetto XV, Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20100344DOI Listing
September 2010

Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis.

J Biol Chem 2010 Jan 30;285(1):631-43. Epub 2009 Oct 30.

Department of Experimental Medicine, Biochemistry Section, and Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M109.031674
Publisher Site
http://dx.doi.org/10.1074/jbc.M109.031674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804211PMC
January 2010

Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells.

J Neurochem 2009 Jul 5;110(1):412-21. Epub 2009 May 5.

Department of Experimental Medicine (DIMES), Biochemistry Section, and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2009.06149.xDOI Listing
July 2009

Involvement of exon 6-mediated calpastatin intracellular movements in the modulation of calpain activation.

Biochim Biophys Acta 2009 Mar 21;1790(3):182-7. Epub 2008 Nov 21.

Department of Experimental Medicine (DIMES), Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 1-16132 Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2008.11.002DOI Listing
March 2009

Role of the calpain-calpastatin system in the density-dependent growth arrest.

Arch Biochem Biophys 2008 Nov 13;479(2):145-52. Epub 2008 Sep 13.

Department of Experimental Medicine (DIMES), Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2008.09.002DOI Listing
November 2008

Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells.

J Biol Chem 2008 Oct 5;283(43):29069-76. Epub 2008 Aug 5.

Department of Experimental Medicine (DIMES), Biochemistry Section, and Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M803638200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662009PMC
October 2008

In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS-HSP90 heterocomplex.

FEBS J 2008 May 8;275(10):2501-11. Epub 2008 Apr 8.

Department of Experimental Medicine (DIMES)-Biochemistry Section, and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2008.06394.xDOI Listing
May 2008

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

FEBS J 2007 Dec 29;274(23):6116-27. Epub 2007 Oct 29.

Department of Experimental Medicine (DIMES)-Biochemistry Section and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2007.06133.xDOI Listing
December 2007

Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons.

Arch Biochem Biophys 2007 Sep 30;465(1):148-56. Epub 2007 May 30.

Department of Experimental Medicine (DIMES)-Biochemistry Section, and Centre of Excellence for Biomedical Research (CEBR), University of Genoa Viale Benedetto XV, 1-16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2007.05.007DOI Listing
September 2007

Regulation of calpain activity in rat brain with altered Ca2+ homeostasis.

J Biol Chem 2007 Jan 29;282(4):2656-65. Epub 2006 Nov 29.

Department of Experimental Medicine (DIMES), Biochemistry Section, and Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M606919200DOI Listing
January 2007

Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease?

J Biol Chem 2006 Aug 27;281(34):24945-54. Epub 2006 Jun 27.

Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132 Genova, Italy.

View Article

Download full-text PDF

Source
http://www.jbc.org/content/early/2006/06/27/jbc.M601449200.f
Web Search
http://www.jbc.org/lookup/doi/10.1074/jbc.M601449200
Publisher Site
http://dx.doi.org/10.1074/jbc.M601449200DOI Listing
August 2006

Interaction between catalytically inactive calpain and calpastatin. Evidence for its occurrence in stimulated cells.

FEBS J 2006 Apr;273(8):1660-8

Department of Experimental Medicine (DIMES), Section of Biochemistry and Centre of Excellence for Biomedical Research (CEBR), University of Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2006.05180.xDOI Listing
April 2006

Characterization of a new p94-like calpain form in human lymphocytes.

Biochem J 2003 Nov;375(Pt 3):689-96

Department of Experimental Medicine, Biochemistry Section, and Excellence Center for Biomedical Research, University of Genova Viale Benedetto XV, 1, 16132 Genova, Italy.

View Article

Download full-text PDF

Source
http://www.biochemj.org/content/ppbiochemj/375/3/689.full.pd
Web Search
http://biochemj.org/lookup/doi/10.1042/bj20030706
Publisher Site
http://dx.doi.org/10.1042/BJ20030706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223710PMC
November 2003