Publications by authors named "Robert Wynn"

124Publications

Lifelong Immune Modulation Versus Hematopoietic Cell Therapy for Inborn Errors of Immunity.

Authors:
Megan A Cooper Ofer Zimmerman Ramya Nataraj Robert F Wynn

J Allergy Clin Immunol Pract 2021 Feb;9(2):628-639

Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, United Kingdom. Electronic address:

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February 2021

Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders.

Authors:
Ashish O Gupta Jaap Jan Boelens Christen L Ebens Joanne Kurtzberg Troy C Lund Angela R Smith John E Wagner Robert Wynn Bruce R Blazar Paul J Orchard

Bone Marrow Transplant 2021 Jan 13. Epub 2021 Jan 13.

Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.

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January 2021

Outcome After Cord Blood Transplantation Using Busulfan Pharmacokinetics-Targeted Myeloablative Conditioning for Hurler Syndrome.

Authors:
Su Han Lum Paul J Orchard Troy C Lund Weston P Miller Jaap Jan Boelens Robert Wynn

Biol Blood Marrow Transplant 2020 Sep 20. Epub 2020 Sep 20.

Department of Paediatric Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK. Electronic address:

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September 2020

Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency.

Authors:
Anu Goenka John A Doherty Tariq Al-Farsi Christopher Jagger Siddharth Banka Edmund Cheesman Andrew Fagbemi Stephen M Hughes Robert F Wynn Tracy Hussell Peter D Arkwright

J Leukoc Biol 2020 Sep 15. Epub 2020 Sep 15.

Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

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September 2020

Cord blood CD8+ T-cell expansion following granulocyte transfusions eradicates refractory leukemia.

Authors:
Prashant Hiwarkar Stuart Adams Kimberly Gilmour Ramya Nataraj Denise Bonney Kay Poulton Robert Wynn

Blood Adv 2020 Sep;4(17):4165-4174

Department of Bone Marrow Transplantation, Royal Manchester Children's Hospital, Manchester, United Kingdom.

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September 2020

A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients.

Authors:
Kay Poulton Paul Wright Pamela Hughes Sinisa Savic Matthew Welberry Smith Malcolm Guiver Muir Morton David van Dellen Eleni Tholouli Robert Wynn Brendan Clark

Int J Immunogenet 2020 Aug 5;47(4):324-328. Epub 2020 Jul 5.

Transplant Immunology, St James's University Hospital, Leeds, UK.

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August 2020

Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults.

Authors:
Robert Chiesa Junfeng Wang Henric-Jan Blok Sheree Hazelaar Benedicte Neven Despina Moshous Ansgar Schulz Manfred Hoenig Fabian Hauck Amal Al Seraihy Jolanta Gozdzik Per Ljungman Caroline A Lindemans Juliana F Fernandes Krzysztof Kalwak Brigitte Strahm Urs Schanz Petr Sedlacek Karl-Walter Sykora Serap Aksoylar Franco Locatelli Polina Stepensky Robert Wynn Su Han Lum Marco Zecca Fulvio Porta Mervi Taskinen Brenda Gibson Susanne Matthes Musa Karakukcu Mathias Hauri-Hohl Paul Veys Andrew R Gennery Giovanna Lucchini Matthias Felber Michael H Albert Dmitry Balashov Arjan Lankester Tayfun Güngör Mary A Slatter

Blood 2020 Sep;136(10):1201-1211

Department of Paediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

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September 2020

Targeted busulfan-based reduced-intensity conditioning and HLA-matched HSCT cure hemophagocytic lymphohistiocytosis.

Authors:
Matthias Felber Colin G Steward Karim Kentouche Anders Fasth Robert F Wynn Ulrike Zeilhofer Veronika Haunerdinger Benjamin Volkmer Seraina Prader Bernd Gruhn Stephan Ehl Kai Lehmberg Daniel Müller Andrew R Gennery Michael H Albert Fabian Hauck Kanchan Rao Paul Veys Moustapha Hassan Arjan C Lankester Jana Pachlopnik Schmid Mathias M Hauri-Hohl Tayfun Güngör

Blood Adv 2020 05;4(9):1998-2010

Department of Immunology. Hematology, Oncology and SCT, University Children's Hospital, Zurich, Switzerland.

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May 2020

HSCT provides effective treatment for lymphoproliferative disorders in children with primary immunodeficiency.

Authors:
Giulia Prunotto Ugonna T Offor Sujith Samarasinghe Robert Wynn Ajay Vora Ben Carpenter Claire Gowdy Kieran McHugh Kevin P Windebank Attilio Maria Rovelli Mary A Slatter Andrew R Gennery Paul Veys Chris M Bacon Simon Bomken Giovanna Lucchini

J Allergy Clin Immunol 2020 Aug 1;146(2):447-450. Epub 2020 May 1.

BMT Department, Great Ormond Street Hospital NHS Trust, London, United Kingdom. Electronic address:

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August 2020

Burden of adenoviraemia predicts survival in paediatric recipients of allogeneic haematopoietic stem cell transplant.

Authors:
David Deambrosis Emma Davies Andrew Turner Malcolm Guiver Denise Bonney Helen Campbell Robert F Wynn Prashant Hiwarkar

J Clin Virol 2020 06 19;127:104373. Epub 2020 Apr 19.

Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, United Kingdom.

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June 2020

Correction: Long-term outcome after allogeneic hematopoietic stem cell transplantation for Shwachman-Diamond syndrome: a retrospective analysis and a review of the literature by the Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP-EBMT).

Authors:
Simone Cesaro Marta Pillon Martin Sauer Frans Smiers Maura Faraci Cristina Diaz de Heredia Robert Wynn Johann Greil Franco Locatelli Paul Veys Anne Uyttebroeck Per Ljungman Patrice Chevalier Marc Ansari Isabel Badell Tayfun Güngör Rahuman Salim Johanna Tischer Cristina Tecchio Nigel Russell Alicja Chybicka Jan Styczynski Gergely Krivan Owen Smith Jerry Stein Boris Afanasyev Cécile Pochon Maria Cristina Menconi Paul Bosman Margherita Mauro Gloria Tridello Regis Peffault de Latour Carlo Dufour

Bone Marrow Transplant 2020 Sep;55(9):1884

G. Gaslini Research Institute (IRRCS), Genova, Italy.

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September 2020

Long-term outcome after allogeneic hematopoietic stem cell transplantation for Shwachman-Diamond syndrome: a retrospective analysis and a review of the literature by the Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP-EBMT).

Authors:
Simone Cesaro Marta Pillon Martin Sauer Frans Smiers Maura Faraci Cristina Diaz de Heredia Robert Wynn Johann Greil Franco Locatelli Paul Veys Anne Uyttebroeck Per Ljungman Patrice Chevalier Marc Ansari Isabel Badell Tayfun Güngör Rahuman Salim Johanna Tischer Cristina Tecchio Nigel Russell Alicja Chybicka Jan Styczynski Gergely Krivan Owen Smith Jerry Stein Boris Afanasyev Cécile Pochon Maria Cristina Menconi Paul Bosman Margherita Mauro Gloria Tridello Regis Peffault de Latour Carlo Dufour

Bone Marrow Transplant 2020 09 19;55(9):1796-1809. Epub 2020 Mar 19.

G. Gaslini Research Institute (IRRCS), Genova, Italy.

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September 2020

Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.

Authors:
Emmanuel Martin Norbert Minet Anne-Claire Boschat Sylvia Sanquer Steicy Sobrino Christelle Lenoir Jean Pierre de Villartay Maria Leite-de-Moraes Capucine Picard Claire Soudais Tim Bourne Sophie Hambleton Stephen M Hughes Robert F Wynn Tracy A Briggs Smita Patel Monica G Lawrence Alain Fischer Peter D Arkwright Sylvain Latour

JCI Insight 2020 03 12;5(5). Epub 2020 Mar 12.

Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Inserm UMR 1163, Imagine Institute, Paris, France.

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March 2020

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in .

Authors:
Christopher J A Duncan Benjamin J Thompson Rui Chen Gillian I Rice Florian Gothe Dan F Young Simon C Lovell Victoria G Shuttleworth Vicky Brocklebank Bronte Corner Andrew J Skelton Vincent Bondet Jonathan Coxhead Darragh Duffy Cecile Fourrage John H Livingston Julija Pavaine Edmund Cheesman Stephania Bitetti Angela Grainger Meghan Acres Barbara A Innes Aneta Mikulasova Ruyue Sun Rafiqul Hussain Ronnie Wright Robert Wynn Mohammed Zarhrate Leo A H Zeef Katrina Wood Stephen M Hughes Claire L Harris Karin R Engelhardt Yanick J Crow Richard E Randall David Kavanagh Sophie Hambleton Tracy A Briggs

Sci Immunol 2019 12;4(42)

Division of Evolution and Genomic Sciences, School of Biological Sciences, University of Manchester, Manchester, UK.

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December 2019

Hematopoietic Stem Cell Transplantation in Inborn Errors of Metabolism.

Authors:
Emily Y Tan Jaap Jan Boelens Simon A Jones Robert F Wynn

Front Pediatr 2019 25;7:433. Epub 2019 Oct 25.

Metabolic and Blood and Marrow Transplant Units, Royal Manchester Children's Hospital, Manchester, United Kingdom.

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October 2019

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR.

Authors:
Sara Ghorashian Anne Marijn Kramer Shimobi Onuoha Gary Wright Jack Bartram Rachel Richardson Sarah J Albon Joan Casanovas-Company Fernanda Castro Bilyana Popova Krystle Villanueva Jenny Yeung Winston Vetharoy Aleks Guvenel Patrycja A Wawrzyniecka Leila Mekkaoui Gordon Weng-Kit Cheung Danielle Pinner Jan Chu Giovanna Lucchini Juliana Silva Oana Ciocarlie Arina Lazareva Sarah Inglott Kimberly C Gilmour Gulrukh Ahsan Mathieu Ferrari Somayya Manzoor Kim Champion Tony Brooks Andre Lopes Allan Hackshaw Farzin Farzaneh Robert Chiesa Kanchan Rao Denise Bonney Sujith Samarasinghe Nicholas Goulden Ajay Vora Paul Veys Rachael Hough Robert Wynn Martin A Pule Persis J Amrolia

Nat Med 2019 09 2;25(9):1408-1414. Epub 2019 Sep 2.

Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.

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September 2019

Recommendations for the management of MPS IVA: systematic evidence- and consensus-based guidance.

Authors:
Mehmet Umut Akyol Tord D Alden Hernan Amartino Jane Ashworth Kumar Belani Kenneth I Berger Andrea Borgo Elizabeth Braunlin Yoshikatsu Eto Jeffrey I Gold Andrea Jester Simon A Jones Cengiz Karsli William Mackenzie Diane Ruschel Marinho Andrew McFadyen Jim McGill John J Mitchell Joseph Muenzer Torayuki Okuyama Paul J Orchard Bob Stevens Sophie Thomas Robert Walker Robert Wynn Roberto Giugliani Paul Harmatz Christian Hendriksz Maurizio Scarpa

Orphanet J Rare Dis 2019 06 13;14(1):137. Epub 2019 Jun 13.

Center for Rare Diseases at Host Schmidt Kliniken, Wiesbaden, Germany and Department of Paediatrics University of Padova, Padova, Italy.

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June 2019

Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance.

Authors:
Mehmet Umut Akyol Tord D Alden Hernan Amartino Jane Ashworth Kumar Belani Kenneth I Berger Andrea Borgo Elizabeth Braunlin Yoshikatsu Eto Jeffrey I Gold Andrea Jester Simon A Jones Cengiz Karsli William Mackenzie Diane Ruschel Marinho Andrew McFadyen Jim McGill John J Mitchell Joseph Muenzer Torayuki Okuyama Paul J Orchard Bob Stevens Sophie Thomas Robert Walker Robert Wynn Roberto Giugliani Paul Harmatz Christian Hendriksz Maurizio Scarpa

Orphanet J Rare Dis 2019 05 29;14(1):118. Epub 2019 May 29.

Center for Rare Diseases at Host Schmidt Kliniken, Wiesbaden, Germany and Department of Paediatrics, University of Padova, Padova, Italy.

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May 2019

The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia.

Authors:
Amy K Keating Jurgen Langenhorst John E Wagner Kristin M Page Paul Veys Robert F Wynn Heather Stefanski Reem Elfeky Roger Giller Richard Mitchell Filippo Milano Tracey A O'Brien Ann Dahlberg Colleen Delaney Joanne Kurtzberg Michael R Verneris Jaap Jan Boelens

Blood Adv 2019 04;3(7):1118-1128

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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April 2019