Robert W Mahley

Robert W Mahley

UNVERIFIED PROFILE

Are you Robert W Mahley?   Register this Author

Register author
Robert W Mahley

Robert W Mahley

Publications by authors named "Robert W Mahley"

Are you Robert W Mahley?   Register this Author

53Publications

1136Reads

34Profile Views

Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases.

Authors:
Robert W Mahley

Clin Chem 2017 01;63(1):14-20

Gladstone Institute of Neurological Disease;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2016.255695DOI Listing
January 2017

Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.

Authors:
Robert W Mahley

Arterioscler Thromb Vasc Biol 2016 07 12;36(7):1305-15. Epub 2016 May 12.

From the Gladstone Institute of Neurological Disease, San Francisco, CA; and Departments of Pathology and Medicine, University of California, San Francisco.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.116.307023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942259PMC
July 2016

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.

Authors:
Robert W Mahley

J Mol Med (Berl) 2016 07 9;94(7):739-46. Epub 2016 Jun 9.

Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA, 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00109-016-1427-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921111PMC
July 2016

Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

Neurobiol Dis 2014 Dec 27;72 Pt A:3-12. Epub 2014 Aug 27.

Gladstone Institute of Neurological Disease, University of California, San Francisco 94158, USA; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94158, USA; Department of Pathology, University of California, San Francisco 94158, USA; Department of Medicine, University of California, San Francisco 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2014.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253862PMC
December 2014

Ancient human genomes suggest three ancestral populations for present-day Europeans.

Authors:
Iosif Lazaridis Nick Patterson Alissa Mittnik Gabriel Renaud Swapan Mallick Karola Kirsanow Peter H Sudmant Joshua G Schraiber Sergi Castellano Mark Lipson Bonnie Berger Christos Economou Ruth Bollongino Qiaomei Fu Kirsten I Bos Susanne Nordenfelt Heng Li Cesare de Filippo Kay Prüfer Susanna Sawyer Cosimo Posth Wolfgang Haak Fredrik Hallgren Elin Fornander Nadin Rohland Dominique Delsate Michael Francken Jean-Michel Guinet Joachim Wahl George Ayodo Hamza A Babiker Graciela Bailliet Elena Balanovska Oleg Balanovsky Ramiro Barrantes Gabriel Bedoya Haim Ben-Ami Judit Bene Fouad Berrada Claudio M Bravi Francesca Brisighelli George B J Busby Francesco Cali Mikhail Churnosov David E C Cole Daniel Corach Larissa Damba George van Driem Stanislav Dryomov Jean-Michel Dugoujon Sardana A Fedorova Irene Gallego Romero Marina Gubina Michael Hammer Brenna M Henn Tor Hervig Ugur Hodoglugil Aashish R Jha Sena Karachanak-Yankova Rita Khusainova Elza Khusnutdinova Rick Kittles Toomas Kivisild William Klitz Vaidutis Kučinskas Alena Kushniarevich Leila Laredj Sergey Litvinov Theologos Loukidis Robert W Mahley Béla Melegh Ene Metspalu Julio Molina Joanna Mountain Klemetti Näkkäläjärvi Desislava Nesheva Thomas Nyambo Ludmila Osipova Jüri Parik Fedor Platonov Olga Posukh Valentino Romano Francisco Rothhammer Igor Rudan Ruslan Ruizbakiev Hovhannes Sahakyan Antti Sajantila Antonio Salas Elena B Starikovskaya Ayele Tarekegn Draga Toncheva Shahlo Turdikulova Ingrida Uktveryte Olga Utevska René Vasquez Mercedes Villena Mikhail Voevoda Cheryl A Winkler Levon Yepiskoposyan Pierre Zalloua Tatijana Zemunik Alan Cooper Cristian Capelli Mark G Thomas Andres Ruiz-Linares Sarah A Tishkoff Lalji Singh Kumarasamy Thangaraj Richard Villems David Comas Rem Sukernik Mait Metspalu Matthias Meyer Evan E Eichler Joachim Burger Montgomery Slatkin Svante Pääbo Janet Kelso David Reich Johannes Krause

Nature 2014 Sep;513(7518):409-13

1] Institute for Archaeological Sciences, University of Tübingen, Tübingen 72074, Germany. [2] Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tübingen, 72070 Tübingen, Germany. [3] Max Planck Institut für Geschichte und Naturwissenschaften, Jena 07745, Germany.

View Article

Download full-text PDF

Source
https://genetics.med.harvard.edu/reich/Reich_Lab/Welcome_fil
Web Search
http://biorxiv.org/content/biorxiv/early/2013/12/23/001552.f
Web Search
http://www.geo.uni-tuebingen.de/fileadmin/website/arbeitsber
Web Search
http://www.nature.com/doifinder/10.1038/nature13673
Publisher Site
http://dx.doi.org/10.1038/nature13673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170574PMC
September 2014

Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Neuron 2012 Dec;76(5):871-85

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2012.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891195PMC
December 2012

Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.

J Med Chem 2012 Nov 5;55(21):8997-9008. Epub 2012 Oct 5.

Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm3008618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904786PMC
November 2012

Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations.

Ann Hum Genet 2012 Mar;76(2):128-41

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1469-1809.2011.00701.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904778PMC
March 2012

Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.

J Lipid Res 2010 Feb 4;51(2):422-30. Epub 2009 Sep 4.

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.P001578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803245PMC
February 2010

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

J Lipid Res 2009 Apr 22;50 Suppl:S183-8. Epub 2008 Dec 22.

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.R800069-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674716PMC
April 2009

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.

Obesity (Silver Spring) 2008 Nov 21;16(11):2468-71. Epub 2008 Aug 21.

Department of Medicine and Diabetes Center, University of California, San Francisco/Mt. Zion Medical Center, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2008.397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486356PMC
November 2008

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.

Proc Natl Acad Sci U S A 2008 Jun 18;105(25):8718-23. Epub 2008 Jun 18.

Division of Experimental Medicine, Department of Medicine, and Division of Neonatology, Department of Pediatrics, University of California, San Francisco, CA 94110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0803526105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438419PMC
June 2008

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

Proc Natl Acad Sci U S A 2008 Jan 22;105(4):1343-6. Epub 2008 Jan 22.

Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, The J. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0709906104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234140PMC
January 2008

Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.

Curr Alzheimer Res 2007 Dec;4(5):537-40

Gladstone Institute of Neurological Disease 1650 Owens Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156720507783018334DOI Listing
December 2007

Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.

J Clin Invest 2007 Jan;117(1):94-8

Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI30889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716223PMC
January 2007

Human prions and plasma lipoproteins.

Proc Natl Acad Sci U S A 2006 Jul 18;103(30):11312-7. Epub 2006 Jul 18.

Institute for Neurodegenerative Diseases, Department of Neurology, University of California, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0604021103
Publisher Site
http://dx.doi.org/10.1073/pnas.0604021103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544083PMC
July 2006

Putting cholesterol in its place: apoE and reverse cholesterol transport.

J Clin Invest 2006 May;116(5):1226-9

Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI28632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1451226PMC
May 2006

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Proc Natl Acad Sci U S A 2006 Apr 27;103(15):5644-51. Epub 2006 Mar 27.

Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0600549103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414631PMC
April 2006

Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.

Alzheimers Dement 2006 Apr;2(2):71-3

Gladstone Institute of Neurological Disease, Department of Pathology, University of California, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2005.12.006DOI Listing
April 2006

Smoking and obesity make a bad problem worse: genetics and lifestyle affect high density lipoprotein levels in Turks.

Anadolu Kardiyol Derg 2006 Mar;6(1):60-7

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
March 2006

High density lipoprotein cholesterol in coronary artery patients: is it as low as expected?

Anadolu Kardiyol Derg 2006 Mar;6(1):94-6; author reply 96

View Article

Download full-text PDF

Source
March 2006

Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.

J Biol Chem 2006 Feb 17;281(5):2683-92. Epub 2005 Nov 17.

Gladstone Institute of Neurological Disease, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158,USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M506646200DOI Listing
February 2006

Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.

J Lipid Res 2006 Jan 28;47(1):144-53. Epub 2005 Oct 28.

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M500343-JLR200DOI Listing
January 2006

Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.

Atherosclerosis 2005 Dec 2;183(2):199-212. Epub 2005 Jun 2.

Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2005.03.004DOI Listing
December 2005

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

Proc Natl Acad Sci U S A 2005 Dec 12;102(51):18694-9. Epub 2005 Dec 12.

Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0508254102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1311737PMC
December 2005

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.

J Biol Chem 2004 Oct 20;279(43):44795-801. Epub 2004 Aug 20.

Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141-9100, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M408127200DOI Listing
October 2004

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

J Mol Neurosci 2004 ;23(3):189-204

Gladstone Institute of Neurological Disease, Gladstone Institute of Cardiovascular Disease, and the Department of Pathology, University of California, San Francisco, CA 94141-9100, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/JMN:23:3:189DOI Listing
August 2004

Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

J Biol Chem 2004 Jun 30;279(24):25511-6. Epub 2004 Mar 30.

Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94141, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M311256200
Publisher Site
http://dx.doi.org/10.1074/jbc.M311256200DOI Listing
June 2004

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.

J Biol Chem 2004 Jan 29;279(5):3862-8. Epub 2003 Oct 29.

Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141-9100, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M309475200DOI Listing
January 2004

Risk determination of dyslipidemia in populations characterized by low levels of high-density lipoprotein cholesterol.

Am Heart J 2003 Dec;146(6):1052-9

Gladstone Institute, American Hospital, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0002-8703(03)00516-7DOI Listing
December 2003

Managing dyslipidemia in Turkey: suggested guidelines for a population characterized by low levels of high density lipoprotein cholesterol.

Anadolu Kardiyol Derg 2002 Dec;2(4):315-22

Gladstone Institute, Koç American Hospital, Istanbul, Turkey, and Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA.

View Article

Download full-text PDF

Source
December 2002

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.

J Biol Chem 2002 Jun 23;277(24):21821-8. Epub 2002 Mar 23.

Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141-9100, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112109200DOI Listing
June 2002

Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC).

Hum Mutat 2002 May;19(5):536-42

Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.10079DOI Listing
May 2002