Robert V Farese

Robert V Farese

UNVERIFIED PROFILE

Are you Robert V Farese?   Register this Author

Register author
Robert V Farese

Robert V Farese

Publications by authors named "Robert V Farese"

Are you Robert V Farese?   Register this Author

100Publications

2599Reads

35Profile Views

Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics.

Dev Cell 2019 Sep;50(5):530-532

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2019.08.009DOI Listing
September 2019

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.

J Lipid Res 2019 Jun 1;60(6):1112-1120. Epub 2019 Apr 1.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M093112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547635PMC
June 2019

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.

Mol Cell 2019 04 4;74(1):32-44.e8. Epub 2019 Mar 4.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2019.01.036DOI Listing
April 2019

Atypical PKC: therapeutic target for Alzheimer's?

Aging (Albany NY) 2018 12;11(1):13-14

Division of Endocrinology and Metabolism, Department of Internal Medicine, University of South Florida, College of Medicine, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.101730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339803PMC
December 2018

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Atherosclerosis 2018 10 30;277:145-154. Epub 2018 Aug 30.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA; Bluefield Project to Cure FTD, San Francisco, CA, 94107, USA; Broad Institute, Cambridge, MA, 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432779PMC
October 2018

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Mol Biol Cell 2018 08 27;29(17):2045-2054. Epub 2018 Jun 27.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E18-05-0282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232964PMC
August 2018

Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.

Mol Cell Proteomics 2018 05 5;17(5):836-849. Epub 2018 Feb 5.

From the ‡Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, 02115.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.RA117.000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930403PMC
May 2018

Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.

Cell Signal 2018 03 18;43:62-70. Epub 2017 Dec 18.

Medical and Research Services, James A. Haley Veterans Administration Hospital, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33704, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2017.12.005DOI Listing
March 2018

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

Biochemistry 2018 Feb 26;57(5):827-838. Epub 2017 Dec 26.

Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute , La Jolla, California 92037, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.7b01028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854151PMC
February 2018

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.

Neurobiol Aging 2018 01 15;61:225-237. Epub 2017 Sep 15.

Internal Medicine and Research Services, James A. Haley Veterans Medical Center, Tampa, Florida, USA; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705272PMC
January 2018

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.

Dev Cell 2018 Jan 8;44(1):73-86.e4. Epub 2018 Jan 8.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02124, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2017.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764114PMC
January 2018

Lipid Droplet Biogenesis.

Annu Rev Cell Dev Biol 2017 10 9;33:491-510. Epub 2017 Aug 9.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; email: ,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-cellbio-100616-060608DOI Listing
October 2017

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Cell Metab 2017 Aug;26(2):407-418.e3

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2017.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195226PMC
August 2017

Lipid droplets and liver disease: from basic biology to clinical implications.

Nat Rev Gastroenterol Hepatol 2017 Jun 21;14(6):343-355. Epub 2017 Apr 21.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2017.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319657PMC
June 2017

Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.

Proteomics 2016 11;16(21):2759-2763

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201600269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688516PMC
November 2016

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.

Diabetes 2016 07 19;65(7):1892-903. Epub 2016 Feb 19.

Medical, Neurology, Psychiatry, and Research Services, James A. Haley Veterans Hospital, Tampa, FL Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-1428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915579PMC
July 2016

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.

Trends Cell Biol 2016 07 16;26(7):535-546. Epub 2016 Mar 16.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute (HHMI), Boston, MA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcb.2016.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976449PMC
July 2016

Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats.

PLoS One 2015 21;10(7):e0132575. Epub 2015 Jul 21.

Department of Internal Medicine, The University of South Florida, Tampa, FL 33620, United States of America; James A Hayley Veterans Medical Center, Tampa, FL, 33612, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132575PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510579PMC
May 2016

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.

J Lipid Res 2016 Apr 15;57(4):616-30. Epub 2016 Feb 15.

Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.

View Article

Download full-text PDF

Source
http://www.jlr.org/content/early/2016/02/15/jlr.M065896.full
Web Search
http://www.jlr.org/lookup/doi/10.1194/jlr.M065896
Publisher Site
http://dx.doi.org/10.1194/jlr.M065896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808770PMC
April 2016

Lipid droplets go nuclear.

J Cell Biol 2016 Jan;212(1):7-8

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA 02115 Howard Hughes Medical Institute, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Broad Institute of MIT and Harvard, Cambridge, MA 02142

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201512056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700486PMC
January 2016

BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.

Metabolism 2015 Nov 24;64(11):1454-65. Epub 2015 Aug 24.

Research and Internal Medicine Services of the James A. Haley VA Medical Center, Tampa, FL; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2015.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576742PMC
November 2015

The GARP complex is required for cellular sphingolipid homeostasis.

Elife 2015 Sep 10;4. Epub 2015 Sep 10.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.08712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600884PMC
September 2015

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.

Dev Cell 2015 Aug 23;34(3):351-63. Epub 2015 Jul 23.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536137PMC
August 2015

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.

J Lipid Res 2015 Jan 13;56(1):70-80. Epub 2014 Nov 13.

Medical and Research Services, James A. Haley Veterans Medical Center, Tampa, FL Division of Endocrinology and Metabolism, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M052977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274073PMC
January 2015

MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.

Am J Physiol Endocrinol Metab 2014 Dec 14;307(11):E1065-72. Epub 2014 Oct 14.

Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00376.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254982PMC
December 2014

The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.

J Biol Chem 2014 Dec 7;289(52):35770-80. Epub 2014 Nov 7.

From the Gladstone Institute of Virology and Immunology, San Francisco, California 94158, UCSF Liver Center, University of California, San Francisco, California 94158, Department of Medicine, University of California, San Francisco, California 94158,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.587816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276846PMC
December 2014

Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

J Biol Chem 2014 Oct 25;289(43):29881-91. Epub 2014 Aug 25.

From the Divisions of Preventive Medicine and Nutrition and Cardiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, Division of Endocrinology, Diabetes, and Metabolism, New York University Langone School of Medicine, New York, New York 10016

View Article

Download full-text PDF

Source
http://www.jbc.org/content/289/43/29881.full.pdf
Web Search
http://www.jbc.org/lookup/doi/10.1074/jbc.M114.601864
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.601864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207999PMC
October 2014

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.

Nat Med 2014 Oct 28;20(10):1157-64. Epub 2014 Sep 28.

1] Gladstone Institute of Neurological Disease, San Francisco, California, USA. [2] Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196723PMC
October 2014

Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.

J Biol Chem 2014 Sep 17;289(36):25021-30. Epub 2014 Jul 17.

From the Medical and Research Services, James A. Haley Veterans Medical Center, Tampa, Florida 33612 and the Division of Endocrinology and Metabolism, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.565671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155669PMC
September 2014

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

J Exp Med 2014 Sep 25;211(10):1937-45. Epub 2014 Aug 25.

Gladstone Institute of Neurological Diseases, Department of Neurology, Department of Medicine, Gladstone Institute of Cardiovascular Disease, University of California, San Franciso, San Francisco, CA 94158 Gladstone Institute of Neurological Diseases, Department of Neurology, Department of Medicine, Gladstone Institute of Cardiovascular Disease, University of California, San Franciso, San Francisco, CA 94158

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20140214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172214PMC
September 2014

Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.

Diabetes 2014 Aug 4;63(8):2690-701. Epub 2014 Apr 4.

Medical and Research Services, James A. Haley Veterans Medical Center; Tampa, FLDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db13-1863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113067PMC
August 2014

Lipid droplet biogenesis.

Curr Opin Cell Biol 2014 Aug 14;29:39-45. Epub 2014 Apr 14.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA; Department of Medicine, University of California-San Francisco, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceb.2014.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526149PMC
August 2014

High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.

J Lipid Res 2014 07 27;55(7):1465-77. Epub 2014 May 27.

Department of Biochemistry and Biophysics University of California, San Francisco, CA 94158 Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158 Department of Medicine, University of California, San Francisco, CA 94158.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M050229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076087PMC
July 2014

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

Mol Endocrinol 2014 Jul 30;28(7):1097-107. Epub 2014 May 30.

James A. Haley Veterans Medical Center (M.P.S., R.A.I., M.L., S.M., R.V.F.), Tampa, Florida 33612; Department of Internal Medicine (M.P.S., R.V.F.), University of South Florida College of Medicine, Tampa, Florida; 33612 Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute (M.J.J., V.T.S., G.I.S.), Yale University School of Medicine, New Haven, Connecticut 06510; and Division of Nephrology, Department of Medicine (U.B., M.L.), Hannover Medical School, Hannover, Germany; and Biotechnology Centre of Oslo (U.B., M.L.), Oslo, Norway 0349.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2014-1025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075159PMC
July 2014

In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy.

J Am Chem Soc 2014 Jun 9;136(24):8820-8. Epub 2014 Jun 9.

Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja504199sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073829PMC
June 2014

Progranulin: at the interface of neurodegenerative and metabolic diseases.

Trends Endocrinol Metab 2013 Dec 10;24(12):597-606. Epub 2013 Sep 10.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tem.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842380PMC
December 2013

The biophysics and cell biology of lipid droplets.

Nat Rev Mol Cell Biol 2013 Dec 13;14(12):775-86. Epub 2013 Nov 13.

1] Yale School of Medicine, Department of Cell Biology, 333 Cedar Street, New Haven, Connecticut 06510, USA. [2] Laboratoire de Physique Statistique, Ecole Normale Supérieure de Paris, Université Pierre et Marie Curie, Université Paris Diderot, Centre National de la Recherche Scientifique, 24 rue Lhomond, 75005 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm3699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526153PMC
December 2013

Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.

Diabetologia 2013 Nov 10;56(11):2507-16. Epub 2013 Aug 10.

Research Service-151, James A. Haley Veterans Medical Center, 13000 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-013-3010-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973184PMC
November 2013

Cellular fatty acid metabolism and cancer.

Cell Metab 2013 Aug 20;18(2):153-61. Epub 2013 Jun 20.

Department of Biochemistry & Biophysics, University of California, San Francisco, 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2013.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742569PMC
August 2013

Balancing the fat: lipid droplets and human disease.

EMBO Mol Med 2013 Jul 6;5(7):973-83. Epub 2013 Jun 6.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/emmm.201100671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721468PMC
July 2013

Protein correlation profiles identify lipid droplet proteins with high confidence.

Mol Cell Proteomics 2013 May 14;12(5):1115-26. Epub 2013 Jan 14.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M112.020230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650325PMC
May 2013

Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.

J Biol Chem 2013 Apr 18;288(14):9915-23. Epub 2013 Feb 18.

Gladstone Institute of Virology and Immunology, Leibniz Institute for Experimental Virology, Hamburg 20251, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.434910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617291PMC
April 2013

Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).

J Biol Chem 2013 Mar 30;288(12):8627-35. Epub 2013 Jan 30.

Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.441949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605681PMC
March 2013

The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface.

J Cell Biol 2012 Sep 27;198(5):895-911. Epub 2012 Aug 27.

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201201139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432760PMC
September 2012

Lipid droplets and cellular lipid metabolism.

Annu Rev Biochem 2012 13;81:687-714. Epub 2012 Apr 13.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-biochem-061009-102430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767414PMC
August 2012

Atypical protein kinase C in cardiometabolic abnormalities.

Curr Opin Lipidol 2012 Jun;23(3):175-81

Research Service, James. A. Haley Veterans Medical Center, 13000 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOL.0b013e328352c4c7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519242PMC
June 2012

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.

Cell Metab 2012 May;15(5):570-3

Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767424PMC
May 2012

Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.

J Biol Chem 2011 Dec 7;286(49):42615-25. Epub 2011 Oct 7.

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.285148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234948PMC
December 2011

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes.

J Lipid Res 2011 Apr 11;52(4):657-67. Epub 2011 Feb 11.

Gladstone Institute for Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M013003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284159PMC
April 2011

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.

Proc Natl Acad Sci U S A 2011 Mar 28;108(11):4441-6. Epub 2011 Feb 28.

Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1100650108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060230PMC
March 2011

A new way to look at fat.

Nat Methods 2011 Feb;8(2):132-3

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth0211-132DOI Listing
February 2011

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.

Nat Med 2010 Nov 10;16(11):1295-8. Epub 2010 Oct 10.

Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.2238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431199PMC
November 2010

Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats.

J Appl Physiol (1985) 2010 Jun 25;108(6):1631-40. Epub 2010 Mar 25.

University of Michigan, School of Kinesiology, Rm. 4745F, 401 Washtenaw Ave., Ann Arbor, MI 48109-2214, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.01412.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886681PMC
June 2010

MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.

PLoS One 2010 May 10;5(5):e10551. Epub 2010 May 10.

Gladstone Institute of Neurological Disease, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866661PMC
May 2010

Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.

Am J Physiol Endocrinol Metab 2010 Mar 8;298(3):E385-94. Epub 2009 Dec 8.

James A. Haley Veteran's Administration Medical Center, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpendo.00608.2009
Publisher Site
http://dx.doi.org/10.1152/ajpendo.00608.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774273PMC
March 2010

Lipid droplets finally get a little R-E-S-P-E-C-T.

Cell 2009 Nov;139(5):855-60

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2009.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097139PMC
November 2009

SnapShot: Lipid Droplets.

Cell 2009 Nov;139(5):1024-1024.e1

Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2009.11.023DOI Listing
November 2009