Robert T Abraham

Robert T Abraham

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Robert T Abraham

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Lysosomal adaptation: How cells respond to lysosomotropic compounds.

PLoS One 2017 16;12(3):e0173771. Epub 2017 Mar 16.

Drug Safety Research and Development, Pfizer Inc., San Diego, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354416PMC
September 2017

The PI3K Pathway in Human Disease.

Cell 2017 Aug;170(4):605-635

Oncology R&D Group, Pfizer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173086
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http://dx.doi.org/10.1016/j.cell.2017.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726441PMC
August 2017

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase.

Cell Rep 2017 06;19(13):2665-2680

Oncology R&D Group, Pfizer Worldwide Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.043DOI Listing
June 2017

The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration.

Mol Cell 2017 Mar;65(6):959-960

Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.030DOI Listing
March 2017

4E-BP2 hardwires lymphocytes for rapamycin sensitivity.

Authors:
Robert T Abraham

Sci Signal 2016 05 31;9(430):fs10. Epub 2016 May 31.

Oncology-Rinat Research and Development Group, Pfizer Worldwide Research and Development, 10646 Science Center Drive/CB4, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1126/scisignal.aaf8190DOI Listing
May 2016

Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.

Authors:
Robert T Abraham

Cell Metab 2016 Mar;23(3):397-8

Oncology-Rinat R&D Group, Pfizer Worldwide Research & Development, 10646 Science Center Drive/CB4, San Diego, CA 92121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.02.012DOI Listing
March 2016

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment.

Clin Cancer Res 2015 Jul 4;21(13):2905-10. Epub 2015 May 4.

Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, California.

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http://clincancerres.aacrjournals.org/content/early/2015/05/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-14-0816DOI Listing
July 2015

Cell biology. Making sense of amino acid sensing.

Authors:
Robert T Abraham

Science 2015 Jan;347(6218):128-9

Oncology Research Unit, Pfizer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1126/science.aaa4570DOI Listing
January 2015

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.

Nat Commun 2014 Sep 25;5:4900. Epub 2014 Sep 25.

Oncology Research Unit, Pfizer Worldwide Research and Development, 10777 Science Center Drive, La Jolla, California 92121, USA.

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http://dx.doi.org/10.1038/ncomms5900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200525PMC
September 2014

Too little mTORC1 activity injures the liver.

Authors:
Robert T Abraham

Cell Metab 2014 Jul;20(1):4-6

Oncology Research Unit, Pfizer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.06.005DOI Listing
July 2014

MTOR mutations in the crosshairs of targeted therapy.

Cancer Discov 2014 May;4(5):513-5

Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, California.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0332DOI Listing
May 2014

Self-eating limits EGFR-dependent tumor growth.

Cell 2013 Sep;154(6):1184-6

Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA.

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http://dx.doi.org/10.1016/j.cell.2013.08.040DOI Listing
September 2013

The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease.

Annu Rev Pharmacol Toxicol 2013 ;53:89-106

Oncology Research Unit, Pfizer Worldwide Research and Development, Pearl River, New York 10965, USA.

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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134717DOI Listing
July 2013

The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics.

Nat Prod Rep 2013 May;30(5):625-39

Pfizer Worldwide Research and Development, Oncology Research Unit, 401 Middletown Road, Pearl River, NY, USA.

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http://dx.doi.org/10.1039/c3np20113aDOI Listing
May 2013

Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer.

Authors:
Robert T Abraham

Cancer Cell 2012 Dec;22(6):703-5

Oncology Research, Pfizer Worldwide Research and Development, 10777 Science Center Drive, CB3/1376, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.11.012DOI Listing
December 2012

Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies.

Pigment Cell Melanoma Res 2012 Nov 14;25(6):819-31. Epub 2012 Sep 14.

Oncology Research Unit, Pfizer Worldwide Research and Development, 10777 Science Center Drive, San Diego, CA, USA.

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http://dx.doi.org/10.1111/pcmr.12007DOI Listing
November 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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April 2012

A novel role for hSMG-1 in stress granule formation.

Mol Cell Biol 2011 Nov 12;31(22):4417-29. Epub 2011 Sep 12.

Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia.

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November 2011

Serine biosynthesis: fuel for the melanoma cell growth engine.

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October 2011

Glutamine: pleiotropic roles in tumor growth and stress resistance.

J Mol Med (Berl) 2011 Mar 8;89(3):229-36. Epub 2011 Feb 8.

Oncology Research Unit, Pfizer Worldwide Research and Development, Pearl River, NY 10965, USA.

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March 2011

Glutaminolysis yields a metabolic by-product that stimulates autophagy.

Autophagy 2010 Oct 20;6(7):968-70. Epub 2010 Oct 20.

Center for Integrative Biology and Biotherapeutics, Pfizer, Pearl River, NY, USA.

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October 2010

Lysosomal Rag-ulation of mTOR complex 1 activity.

Authors:
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Cell Metab 2010 May;11(5):341-2

Center for Integrative Biology and Biotherapeutics, Pfizer Biopharmaceuticals, 401 N. Middletown Road, Pearl River, NY 10965, USA.

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May 2010

A metabolic (re-)balancing act.

Mol Cell 2010 May;38(4):481-2

Center for Integrative Biology and Biotherapeutics, Pfizer Biopharmaceuticals, Pearl River, NY 10965, USA.

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May 2010

Ammonia derived from glutaminolysis is a diffusible regulator of autophagy.

Sci Signal 2010 Apr 27;3(119):ra31. Epub 2010 Apr 27.

Center for Integrative Biology and Biotherapeutics, Pfizer, Pearl River, NY 10965, USA.

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April 2010

Targeting mTOR globally in cancer: thinking beyond rapamycin.

Cell Cycle 2009 Dec 14;8(23):3831-7. Epub 2009 Dec 14.

Discovery Oncology, Wyeth Research, Pearl River, NY, USA.

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December 2009

Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth.

Semin Oncol 2009 Dec;36 Suppl 3:S3-S17

Department of Oncology Discovery, Pfizer Inc., 401 N Middletown Rd., Pearl River, NY 10960, USA.

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December 2009

Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.

Mol Biol Cell 2009 Sep 8;20(17):3953-64. Epub 2009 Jul 8.

The Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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September 2009

GOLPH3 links the Golgi network to mTOR signaling and human cancer.

Authors:
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Pigment Cell Melanoma Res 2009 Aug;22(4):378-9

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August 2009

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

Mol Cell 2009 Aug;35(4):442-53

Department of Pharmacology, Case Comprehensive Caner Center, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Wood Building W343A, Cleveland, OH 44106, USA.

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August 2009

Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again.

Authors:
Robert T Abraham

F1000 Biol Rep 2009 Jan 21;1. Epub 2009 Jan 21.

Department of Oncology Discovery Research Wyeth, 401 N Middletown Road, Pearl River, NY 10965 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920679PMC
January 2009

A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis.

J Biol Chem 2008 May 6;283(19):13174-84. Epub 2008 Mar 6.

Department of Experimental Therapeutics, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, Florida 33612, USA.

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May 2008

Moving out: mobilizing activated T cells from lymphoid tissues.

Nat Immunol 2008 May;9(5):455-7

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May 2008

Mammalian target of rapamycin as a therapeutic target in oncology.

Expert Opin Ther Targets 2008 Feb;12(2):209-22

Oncology Discovery Research, Wyeth, 401 N. Middletown Road, Pearl River, NY 10965, USA.

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February 2008

A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer.

Cancer Res 2008 Feb;68(4):1144-53

Oral and Pharyngeal Cancer Branch, National Institute of Craniofacial and Dental Research, NIH, Bethesda, Maryland 20892-4330, USA.

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February 2008

SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.

Mol Immunol 2008 Jan 20;45(2):510-22. Epub 2007 Jul 20.

Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2008

Targeting the mTOR signaling network in cancer.

Trends Mol Med 2007 Oct 1;13(10):433-42. Epub 2007 Oct 1.

Program in Signal Transduction, Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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October 2007

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.

Mol Cancer Ther 2007 Sep 31;6(9):2505-14. Epub 2007 Aug 31.

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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September 2007

The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy.

Clin Cancer Res 2007 Jun;13(11):3109-14

Department of Oncology Discovery, Wyeth, Pearl River, New York 10960, USA.

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June 2007

The FRB domain of mTOR: NMR solution structure and inhibitor design.

Biochemistry 2006 Aug;45(34):10294-302

Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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August 2006

Signalomic signatures enlighten drug profiling.

Authors:
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Nat Chem Biol 2006 Jun;2(6):295-6

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June 2006

The functional role of Cdc6 in S-G2/M in mammalian cells.

EMBO Rep 2006 Apr 27;7(4):425-30. Epub 2006 Jan 27.

The Burnham Institute, La Jolla, California 92037, USA.

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April 2006

Turning the replication checkpoint on and off.

Cell Cycle 2006 Jan 16;5(2):125-8. Epub 2006 Jan 16.

Molecular and Cellular Biology, The Salk Institute, La Jolla, California, USA.

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January 2006

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

Mol Cell 2005 Sep;19(5):607-18

Signal Transduction Program, The Burnham Institute, La Jolla, California 92037, USA.

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September 2005

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

J Biol Chem 2005 Jul 16;280(27):25485-90. Epub 2005 May 16.

Program in Signal Transduction Research, The Burnham Institute, La Jolla, California 92037, USA.

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July 2005

Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

Nat Immunol 2005 Jun 1;6(6):608-17. Epub 2005 May 1.

Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 94143, USA.

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June 2005

Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer.

Cancer Res 2005 Jun;65(12):5325-36

Program in Signal Transduction Research, The Burnham Institute, La Jolla, California 92037, USA.

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June 2005

Cell biology. Guiding ATM to broken DNA.

Science 2005 Apr;308(5721):510-1

Signal Transduction Program, The Burnham Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1112069DOI Listing
April 2005

Part-time cop nabs deviant DNA.

Authors:
Robert T Abraham

Nat Med 2005 Mar;11(3):257-8

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March 2005

PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways.

Authors:
Robert T Abraham

DNA Repair (Amst) 2004 Aug-Sep;3(8-9):883-7

Program in Signal Transduction Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA.

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February 2005

The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.

Authors:
Robert T Abraham

DNA Repair (Amst) 2004 Aug-Sep;3(8-9):919-25

Program in Signal Transduction Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA.

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February 2005

TOR signaling: an odyssey from cellular stress to the cell growth machinery.

Authors:
Robert T Abraham

Curr Biol 2005 Feb;15(4):R139-41

Signal Transduction Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.cub.2005.02.015DOI Listing
February 2005

MAPKAP kinase-2: three's company at the G(2) checkpoint.

Authors:
Robert T Abraham

Mol Cell 2005 Jan;17(2):163-4

Signal Transduction Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2005

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.

EMBO J 2004 Nov 11;23(23):4660-9. Epub 2004 Nov 11.

Program in Signal Transduction Research, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533049PMC
November 2004

Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family.

Methods Mol Biol 2004 ;281:125-41

Program in Signal Transduction Research, The Burnham Institute, La Jolla, CA, USA.

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September 2004

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.

Bioorg Med Chem 2004 Sep;12(17):4749-59

Program in Chemistry and Chemical Biology, University of California-San Francisco, San Francisco, CA 94143, USA.

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September 2004

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.

EMBO J 2004 Aug 29;23(15):3164-74. Epub 2004 Jul 29.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514932PMC
August 2004

Jurkat T cells and development of the T-cell receptor signalling paradigm.

Nat Rev Immunol 2004 Apr;4(4):301-8

Program in Signal Transduction Research at The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://www.nature.com/articles/nri1330
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April 2004

Differential regulation of TCR-mediated gene transcription by Vav family members.

J Exp Med 2004 Feb;199(3):429-34

Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1084/jem.20031228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211790PMC
February 2004

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.

Genes Dev 2004 Feb;18(3):249-54

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC338278PMC
February 2004

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.

Cancer Res 2003 Dec;63(23):8451-60

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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December 2003

Rap1 redux.

Authors:
Robert T Abraham

Nat Immunol 2003 Aug;4(8):725-7

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http://dx.doi.org/10.1038/ni0803-725DOI Listing
August 2003

Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase.

Authors:
Robert T Abraham

Bioessays 2003 Jul;25(7):627-30

Program in Signal Transduction Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA.

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http://doi.wiley.com/10.1002/bies.10310
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July 2003

Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin.

Mol Cancer Ther 2003 Jun;2(6):517-26

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA.

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June 2003

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.

Nat Cell Biol 2003 Apr;5(4):309-19

Department of Pharmacology and Cancer Biology Duke University Medical Center Durham, NC 27710, USA.

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http://dx.doi.org/10.1038/ncb949DOI Listing
April 2003

Tyrosine phosphorylation of VHR phosphatase by ZAP-70.

Nat Immunol 2003 Jan 25;4(1):44-8. Epub 2002 Nov 25.

Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/ni856DOI Listing
January 2003

Checkpoint signalling: focusing on 53BP1.

Authors:
Robert T Abraham

Nat Cell Biol 2002 Dec;4(12):E277-9

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http://dx.doi.org/10.1038/ncb1202-e277DOI Listing
December 2002

Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation.

Mol Cell 2002 Dec;10(6):1269-81

Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00728-1DOI Listing
December 2002

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.

Mol Cell Biol 2002 Nov;22(21):7428-38

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1128/mcb.22.21.7428-7438.2002DOI Listing
November 2002

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

Mol Cell Biol 2002 Oct;22(20):7004-14

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1128/mcb.22.20.7004-7014.2002DOI Listing
October 2002

Identification of TOR signaling complexes: more TORC for the cell growth engine.

Authors:
Robert T Abraham

Cell 2002 Oct;111(1):9-12

Program in Signal Transduction Research, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)01009-7DOI Listing
October 2002

Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

EMBO J 2002 Sep;21(18):4809-19

Department of Pharmacology and Cancer Biology and Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126295PMC
http://dx.doi.org/10.1093/emboj/cdf499DOI Listing
September 2002

Distinct requirements for Ras oncogenesis in human versus mouse cells.

Genes Dev 2002 Aug;16(16):2045-57

Department of Pharmacology, Division of Neurology, Duke University Medical Center, Durham North Carolina 27710, USA.

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http://dx.doi.org/10.1101/gad.993902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186434PMC
August 2002

Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).

J Biol Chem 2002 Jul 25;277(27):24220-4. Epub 2002 Apr 25.

Program of Signal Transduction, La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M202885200DOI Listing
July 2002

Protein tyrosine phosphorylation in T cell signaling.

Front Biosci 2002 Apr 1;7:d918-69. Epub 2002 Apr 1.

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA.

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April 2002

Hypoxia links ATR and p53 through replication arrest.

Mol Cell Biol 2002 Mar;22(6):1834-43

Center for Clinical Sciences Research, Department of Radiation Oncology, Stanford University, Stanford, CA 94303-5152, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135616PMC
http://dx.doi.org/10.1128/mcb.22.6.1834-1843.2002DOI Listing
March 2002

Antigen receptors rap to integrin receptors.

Authors:
Robert T Abraham

Nat Immunol 2002 Mar;3(3):212-3

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http://dx.doi.org/10.1038/ni0302-212DOI Listing
March 2002

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases.

Bioorg Med Chem 2002 Jan;10(1):167-74

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1016/s0968-0896(01)00260-7DOI Listing
January 2002