Robert Stockley

Robert Stockley

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Robert Stockley

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Neutrophil phenotypes in chronic lung disease.

Expert Rev Respir Med 2019 Oct 21;13(10):951-967. Epub 2019 Aug 21.

Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/17476348.2019.1654377DOI Listing
October 2019

Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease?

Drugs Aging 2019 09;36(9):823-840

Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, B15 2GW, UK.

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http://dx.doi.org/10.1007/s40266-019-00684-7DOI Listing
September 2019

Reply to Pouwels : Confounding Factors Affecting sRAGE as a Biomarker for Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2019 Jul;200(1):114-115

4 Manchester University NHS Foundation Hospital Trust Manchester, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201903-0573LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603060PMC
July 2019

Getting stuck or choosing to stay? Neutrophil transit times in the lung in acute inflammation and COPD.

Thorax 2019 Jul 16;74(7):631-632. Epub 2019 May 16.

Respiratory Medicine, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2018-213000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585287PMC
July 2019

Corporate Memory and Rediscovering the Wheel.

Am J Respir Crit Care Med 2019 Jul;200(1):2-4

1 University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital Birmingham Birmingham, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201901-0066EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603050PMC
July 2019

Chronic Obstructive Pulmonary Disease Biomarkers and Their Interpretation.

Am J Respir Crit Care Med 2019 May;199(10):1195-1204

4 Medicines Evaluation Unit, University of Manchester, Manchester University NHS Foundation Hospital Trust, Manchester, United Kingdom.

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https://www.atsjournals.org/doi/10.1164/rccm.201810-1860SO
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http://dx.doi.org/10.1164/rccm.201810-1860SODOI Listing
May 2019

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019.

Eur Respir J 2019 May 18;53(5). Epub 2019 May 18.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1183/13993003.00164-2019DOI Listing
May 2019

The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Eur Respir J 2019 Feb 14;53(2). Epub 2019 Feb 14.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1183/13993003.00138-2019DOI Listing
February 2019

ICS Use May Modify FEV1 Decline in α1-Antitrypsin Deficiency Patients with Relatively High Blood Eosinophils.

Respiration 2018;95(2):114-121. Epub 2017 Dec 18.

Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1159/000481867DOI Listing
October 2018

Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.

Respir Res 2018 Sep 20;19(1):180. Epub 2018 Sep 20.

University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 2GW, UK.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0883-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149181PMC
September 2018

Health status decline in α-1 antitrypsin deficiency: a feasible outcome for disease modifying therapies?

Respir Res 2018 07 20;19(1):137. Epub 2018 Jul 20.

Institute of Applied Health Research, University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1186/s12931-018-0844-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053712PMC
July 2018

Small airways disease: time for a revisit?

Int J Chron Obstruct Pulmon Dis 2017 7;12:2343-2353. Epub 2017 Aug 7.

Institute of Inflammation and Ageing, Centre for Translational Inflammation Research, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.2147/COPD.S138540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557120PMC
May 2018

Pharmacological treatment of COPD: the devil is always in the detail.

Eur Respir J 2018 04 19;51(4). Epub 2018 Apr 19.

Hospital Clínic, Universitat de Barcelona, Ciberes, Barcelona, Spain.

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http://dx.doi.org/10.1183/13993003.00263-2018DOI Listing
April 2018

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

Int J Chron Obstruct Pulmon Dis 2017 4;12:1339-1349. Epub 2017 May 4.

University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.2147/COPD.S127802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422335PMC
March 2018

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α-antitrypsin deficiency.

Eur Respir J 2017 11 30;50(5). Epub 2017 Nov 30.

Lung Investigation Unit Medicine - University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, UK

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http://dx.doi.org/10.1183/13993003.00610-2017DOI Listing
November 2017

Patterns and characterization of COPD exacerbations using real-time data collection.

Int J Chron Obstruct Pulmon Dis 2017 25;12:427-434. Epub 2017 Jan 25.

Centre for Translational Inflammation Research, University of Birmingham; ADAPT Project, University Hospital Birmingham, Birmingham, UK.

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http://dx.doi.org/10.2147/COPD.S126158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279955PMC
October 2017

Individualized lung function trends in alpha-1-antitrypsin deficiency: a need for patience in order to provide patient centered management?

Int J Chron Obstruct Pulmon Dis 2016 1;11:1745-56. Epub 2016 Aug 1.

Department of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.2147/COPD.S111508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976906PMC
August 2017

COPD10: Birmingham,United Kingdom, July 2016.

Chronic Obstr Pulm Dis 2017 Jul 15;4(3):225-246. Epub 2017 Jul 15.

Queen Elizabeth Hospital, Birmingham, United Kingdom.

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http://dx.doi.org/10.15326/jcopdf.4.3.2017.0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556914PMC
July 2017

Post Hoc: Two (or More) for the Price of One.

Am J Respir Crit Care Med 2017 04;195(7):844-846

1 University Hospitals Birmingham National Health Service Foundation Trust Queen Elizabeth Hospital Birmingham Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201610-2132EDDOI Listing
April 2017

TNF- Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF- Receptors Support the Concept of Selective TNFR1 Blockade .

J Immunol Res 2016 22;2016:1079851. Epub 2016 Sep 22.

Department of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham, UK.

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https://www.hindawi.com/journals/jir/2016/1079851/
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http://dx.doi.org/10.1155/2016/1079851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055993PMC
March 2017

Maximal mid-expiratory flow detects early lung disease in α-antitrypsin deficiency.

Eur Respir J 2017 03 29;49(3). Epub 2017 Mar 29.

Institute of Inflammation and Ageing, Centre for Translational Inflammation Research, University of Birmingham, Birmingham, UK

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http://dx.doi.org/10.1183/13993003.02055-2016DOI Listing
March 2017

Lung Transplantation in Alpha-1-Antitrypsin Deficiency.

COPD 2016 21;13(2):146-52. Epub 2015 Oct 21.

a 1 ADAPT Project, Lung Function and Sleep Department, Queen Elizabeth Hospital Birmingham , Edgbaston , Birmingham , United Kingdom.

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http://dx.doi.org/10.3109/15412555.2015.1048850DOI Listing
January 2017

Alpha-1 Antitrypsin Deficiency: Phenotypes and Quality of Life.

Ann Am Thorac Soc 2016 08;13 Suppl 4:S332-5

Lung Investigation Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201507-436KVDOI Listing
August 2016

COPD service delivery in the UK.

Lancet Respir Med 2016 06 13;4(6):426-8. Epub 2016 May 13.

Lung Investigation Unit, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham B15 2GW, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(16)30082-0DOI Listing
June 2016

Pulmonary Physiology of Chronic Obstructive Pulmonary Disease, Cystic Fibrosis, and Alpha-1 Antitrypsin Deficiency.

Ann Am Thorac Soc 2016 04;13 Suppl 2:S118-22

Lung Investigation Unit, Medicine-University Hospitals Birmingham, National Health Service Foundation Trust, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201504-224KVDOI Listing
April 2016

Free light chains: potential biomarker and predictor of mortality in alpha-1-antitrypsin deficiency and usual COPD.

Respir Res 2016 Mar 31;17:34. Epub 2016 Mar 31.

Centre for Translational Inflammation Research, University of Birmingham, Birmingham, B15 2WB, UK.

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http://dx.doi.org/10.1186/s12931-016-0348-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815123PMC
March 2016

Pathophysiology of Emphysema and Implications.

Chronic Obstr Pulm Dis 2016 Jan 15;3(1):454-458. Epub 2016 Jan 15.

Department of Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom.

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http://dx.doi.org/10.15326/jcopdf.3.1.2015.0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559126PMC
January 2016

A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis.

Eur Respir J 2015 Oct 4;46(4):1021-32. Epub 2015 Sep 4.

Respiratory Department, Queen Elizabeth Hospital, Birmingham, UK.

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http://dx.doi.org/10.1183/13993003.00148-2015DOI Listing
October 2015

The Relationship of the Fibrinogen Cleavage Biomarker Aα-Val360 With Disease Severity and Activity in α1-Antitrypsin Deficiency.

Chest 2015 Aug;148(2):382-388

Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, England; ADAPT Project, Lung Function and Sleep, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, England. Electronic address:

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http://dx.doi.org/10.1378/chest.14-0520DOI Listing
August 2015

Relationship between Change in Lung Density and Long-Term Progression of Lung Function.

Am J Respir Crit Care Med 2015 Jul;192(1):114-6

1 Leiden University Medical Center Leiden, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201502-0370LEDOI Listing
July 2015

The multiple facets of alpha-1-antitrypsin.

Ann Transl Med 2015 Jun;3(10):130

Lung Investigation Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn way, Edgbaston, Birmingham B15 2WB, UK.

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http://www.atmjournal.org/article/view/6399/7571
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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.04.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486914PMC
June 2015

Antitrypsin Deficiency Assessment and Programme for Treatment (ADAPT): The United Kingdom Registry.

COPD 2015 May;12 Suppl 1:63-8

ADAPT Project, Queen Elizabeth Hospital Birmingham , Birmingham , United Kingdom.

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http://dx.doi.org/10.3109/15412555.2015.1021911DOI Listing
May 2015

α1-antitrypsin: a polyfunctional protein?

Lancet Respir Med 2015 May;3(5):341-3

Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, B15 2WB, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(15)00094-6DOI Listing
May 2015

COPD9: Birmingham, United Kingdom, June 2014.

Chronic Obstr Pulm Dis 2015 Apr 1;2(2):152-176. Epub 2015 Apr 1.

Queen Elizabeth Hospital, Birmingham, United Kingdom.

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http://dx.doi.org/10.15326/jcopdf.2.2.2014.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556969PMC
April 2015

Immune modulation by α1-antitrypsin. A nice concept, but does it influence outcome?

Am J Respir Crit Care Med 2015 Feb;191(4):363-4

1 Queen Elizabeth Hospital Birmingham Birmingham, United Kingdom.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201412-2129E
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http://dx.doi.org/10.1164/rccm.201412-2129EDDOI Listing
February 2015

Prevention of Exacerbations in Chronic Obstructive Pulmonary Disease: Knowns and Unknowns.

Chronic Obstr Pulm Dis 2014 Sep 25;1(2):166-184. Epub 2014 Sep 25.

Airways Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom.

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http://dx.doi.org/10.15326/jcopdf.1.2.2014.0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556862PMC
September 2014

Biomarkers in chronic obstructive pulmonary disease: confusing or useful?

Int J Chron Obstruct Pulmon Dis 2014 7;9:163-77. Epub 2014 Feb 7.

Queen Elizabeth Hospital Birmingham, Lung Function and Sleep Department, Birmingham, UK.

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http://dx.doi.org/10.2147/COPD.S42362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923613PMC
August 2014

Disease 'activity', 'severity' and 'impact': interrelationships in COPD; is a measure of disease 'activity' the Holy Grail for COPD, or a variable impossible to quantify?

COPD 2014 Aug 25;11(4):363-7. Epub 2014 Feb 25.

1Centre for Translational Inflammation Research, University of Birmingham Research Laboratories , Birmingham , United Kingdom.

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http://dx.doi.org/10.3109/15412555.2013.808616DOI Listing
August 2014

The significance of the F variant of alpha-1-antitrypsin and unique case report of a PiFF homozygote.

BMC Pulm Med 2014 Aug 7;14:132. Epub 2014 Aug 7.

Centre for Translational Inflammation Research, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1186/1471-2466-14-132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131482PMC
August 2014

Red, amber and green: the role of the lung in de-priming active systemic neutrophils.

Thorax 2014 Jul;69(7):606-8

Department of Respiratory Medicine, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2014-205438DOI Listing
July 2014

Spirometric and gas transfer discordance in a α1 -antitrypsin deficiency. patient characteristics and progression.

Chest 2014 Jun;145(6):1316-1324

Lung Function and Sleep Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, England. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00123692153480
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http://dx.doi.org/10.1378/chest.13-1886DOI Listing
June 2014

Alpha1-antitrypsin review.

Clin Chest Med 2014 Mar 12;35(1):39-50. Epub 2013 Dec 12.

ADAPT Project, Lung Function & Sleep Department, Queen Elizabeth Hospital Birmingham, Ground Floor, Out-patients Area 3, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccm.2013.10.001DOI Listing
March 2014

α-1-Antitrypsin deficiency: clinical variability, assessment, and treatment.

Trends Mol Med 2014 Feb 28;20(2):105-15. Epub 2013 Dec 28.

University of Birmingham, Queen Elizabeth Hospital Birmingham Research Laboratories, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2013.11.006DOI Listing
February 2014

Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD.

Am J Physiol Lung Cell Mol Physiol 2014 Jan 1;306(1):L80-7. Epub 2013 Nov 1.

Lung Function and Sleep Dept., ADAPT Office (Office 4 Queen Elizabeth Hospital Birmingham, B15 2WB, UK.

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http://dx.doi.org/10.1152/ajplung.00221.2013DOI Listing
January 2014

α1-antitrypsin deficiency: what has it ever done for us?

Chest 2013 Dec;144(6):1923-1929

Lung Function and Sleep Department, ADAPT Project, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, England. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00123692154870
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http://dx.doi.org/10.1378/chest.13-1901DOI Listing
December 2013

Children must be protected from the tobacco industry's marketing tactics.

Authors:
Nicholas Hopkinson Colin Wallis Bernard Higgins Stephen Gaduzo Rebecca Sherrington Sarah Keilty Myra Stern John Britton Andrew Bush John Moxham Karl Sylvester Valerie Griffiths Tim Sutherland Iain Crossingham Raghu Raju Charlotte Spencer Shahideh Safavi Paul Deegan John Seymour Katherine Hickman John Hughes Jason Wieboldt Fizah Shaheen Clive Peedell Nesta Mackenzie David Nicholl Caroline Jolley Gillian Crooks Gillian Crooks Claire Dow Pete Deveson Oliver Bintcliffe Barry Gray Sanjay Kumar Sarah Haney Marianne Docherty Angela Thomas Felix Chua Akshay Dwarakanath Geoffrey Summers Keith Prowse Stephen Lytton Yee Ean Ong Jennifer Graves Tushar Banerjee Peter English Andrew Leonard Martin Brunet Nauman Chaudhry Robert Ian Ketchell Natalie Cummings Jenny Lebus Charles Sharp Chris Meadows Amelie Harle Tara Stewart Diane Parry Suzanne Templeton-Wright John Moore-Gillon James Stratford- Martin Sarvesh Saini Simon Matusiewicz Simon Merritt Lee Dowson Karnan Satkunam Luke Hodgson Eui-Sik Suh Hannah Durrington Emma Browne Nicola Walters Joerg Steier Simon Barry Mark Griffiths Nicholas Hart Marko Nikolic Matthew Berry Ajit Thomas Joy Miller Diarmuid McNicholl Paul Marsden Geoffrey Warwick Laura Barr David Adeboyeku Mohd Shahrin Mohd Noh Paul Griffiths Lisa Davies Jennifer Quint Rebecca Lyall Jonathan Shribman Andrea Collins Jon Goldman Susannah Bloch Alison Gill William Man Anne Christopher Razouqi Yasso Ashwin Rajhan Dinesh Shrikrishna Caroline Moore Gareth Absalom Richard Booton Robert William Fowler Carolyn Mackinlay Elizabeth Sapey Sara Lock Paul Walker Akhilesh Jha Imran Satia Bethia Bradley Naveed Mustfa Raana Haqqee Matt Thomas Anant Patel Anthony Redington Anilkumar Pillai Niall Keaney Stephen Fowler Lesley Lowe Amanda Brennan Douglas Morrison Clare Murray Jenny Hankinson P Dutta Matthew Maddocks Martino Pengo Katrina Curtis Gerrard Rafferty John Hutchinson Ruth Whitfield Steve Turner Ronan Breen Shams-un-nisa Naveed Chris Goode Georgina Esterbrook Liju Ahmed Woolf Walker David Ford Gary Connett Philip Davidson Will Elston Andrew Stanton David Morgan James Myerson David Maxwell Ann Harrris Sonia Parmar Catherine Houghton Robert Winter Zudin Puthucheary Fiona Thomson Sharon Sturney John Harvey Patricia L Haslam Irem Patel David Jennings Simon Range Brendan Mallia-Milanes Anne Collett Paul Tate Richard Russell Johanna Feary Ronan O'Driscoll James Eaden Jonathan Round Emma Sharkey Mary Montgomery Sophie Vaughan Kate Scheele Anna Lithgow Samuel Partridge Richard Chavasse Louise Restrick Sanjay Agrawal Said Abdallah Amruta Lacy-Colson Nick Adams Sally Mitchell Helmy Haja Mydin Ann Ward Sarah Denniston Mark Steel Dipansu Ghosh Stephen Connellan Lucy Rigge Ruth Williams Alison Grove Sadia Anwar Lee Dobson Harold Hosker David Stableforth Neil Greening Tim Howell Georgina Casswell Sarah Davies Georgia Tunnicliffe Philip Mitchelmore Elpida Phitidis Louise Robinson Keith Prowse Mona Bafadhel Grace Robinson Alison Boland Marc Lipman Stephen Bourke Sundeep Kaul Calvin Cowie Ian Forrest Elizabeth Starren Hannah Burke John Furness Angshu Bhowmik Caroline Everett Douglas Seaton Steve Holmes Simon Doe Samuel Parker Annika Graham Ian Paterson Usman Maqsood Chandra Ohri Peter Iles Samuel Kemp Ahsan Iftikhar Chris Carlin Tim Fletcher Peter Emerson Victoria Beasley Michelle Ramsay Robert Buttery Sarah Mungall Stephen Crooks John Ridyard David Ross Alison Guadagno Emma Holden Ian Coutts Kathy Cullen Sally O'Connor Jack Barker Katherine Sloper John Watson Peter Smith Paul Anderson Louise Brown Cyril Nyman Heather Milburn Amelia Clive Matthew Serlin Charlotte Bolton Jonathan Fuld Helen Powell Mark Dayer Ian Woolhouse Adamantia Georgiadi Helen Leonard James Dodd Ian Campbell Gary Ruiz Andrew Zurek James Y Paton Adam Malin Fraser Wood Gareth Hynes David Connell David Spencer Sarah Brown David Smith David Cooper Cecilia O'Kane Alex Hicks Ben Creagh-Brown James Lordan Annabel Nickol Robert Primhak Louise Fleming Duncan Powrie Joanna Brown Zaid Zoumot Sarah Elkin Joanna Szram Anthony Scaffardi Robert Marshall Ian Macdonald Darren Lightbody Ray Farmer Iain Wheatley Paul Radnan Ian Lane Andrew Booth Sean Tilbrook Toby Capstick Lee Hewitt Martin McHugh Christopher Nelson Patrick Wilson Vijay Padmanaban John White John Davison Una O'Callaghan Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Rosalind Backham Kim Randall Tracey Mathieson Alex Long Marilyn Parkes Sarah Clarke Bev Allen Carol Connelly Georgia Forster Jacky Hoadley Katharine Martin Kate Barnham Katie Khan Maureen Munday Catherine Edwards Doreen O'Hara Sally Turner Sue Pieri-Davies Kate Ford Tracey Daniels Joanne Wright Rebecca Towns Karen Fern Jane Butcher Karen Burgin Barbara Winter Debbie Freeman Sandra Olive Linda Gray Kathy Pye Debbie Roots Nicola Cox Carol-Anne Davies Jacquelyne Wicker Kay Hilton Jananee Lloyd Vicky MacBean Marion Wood Julia Kowal Janis Downs Helen Ryan Fran Guyatt Debby Nicoll Elizabeth Lyons Divya Narasimhan Anne Rodman Sandy Walmsley Alison Newey Maria Buxton Maria Dewar Angela Cooper Jacqui Reilly Julie Lloyd Alison Bennett Macmillan Debbie Roots Amy Olley Nia Voase Sarah Martin Iona McCarvill Anne Christensen Rowan Agate Karen Heslop Amber Timlett Karen Hailes Claire Davey Barbara Pawulska Amber Lane Shona Ioakim Alexandra Hough Jo Treharne Helen Jones Alice Winter-Burke Lauren Miller Bronwen Connolly Lyn Bingham Una Fraser Julia Bott Carol Johnston Alison Graham Denise Curry Helen Sumner Carol Ann Costello Charlotte Bartoszewicz Ros Badman Kathryn Williamson Amy Taylor Helen Purcell Emma Barnett Alanna Molloy Laura Crawfurd Nicola Collins Valerie Monaghan Misbah Mir Victoria Lord Janet Stocks Adrian Edwards Trish Greenhalgh Warren Lenney Martin McKee Danny McAuley Azeem Majeed John Cookson Emma Baker Sam Janes Wisia Wedzicha David Lomas Dean Brian Harrison Tony Davison Peter Calverley Robert Wilson Robert Stockley Jon Ayres John Gibson John Simpson Sherwood Burge John Warner Warren Lenney Neil Thomson Peter Davies Ashley Woodcock Mark Woodhead Stephen Spiro Lawrence Ormerod Graham Bothamley Martyn Partridge Michael Shields Hugh Montgomery Anita Simonds Peter Barnes Stephen Durham Sarah Malone Gilda Arabnia Sharon Olivier Karen Gardiner Sheila Edwards

BMJ 2013 Dec 9;347:f7358. Epub 2013 Dec 9.

British Thoracic Society Chronic Obstructive Pulmonary Disease Specialist Advisory Group, National Heart and Lung Institute, Imperial College, London SW3 6NP, UK.

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http://dx.doi.org/10.1136/bmj.f7358DOI Listing
December 2013

Large chronic obstructive pulmonary disease cohorts: advantages and caution in biomarker discovery/validation.

Am J Respir Crit Care Med 2013 Dec;188(12):1387-8

1 Lung Function and Sleep Department Queen Elizabeth Hospital Birmingham Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201311-2001EDDOI Listing
December 2013

The link between chronic periodontitis and COPD: a common role for the neutrophil?

BMC Med 2013 Nov 13;11:241. Epub 2013 Nov 13.

Lung Investigation Unit, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK.

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http://dx.doi.org/10.1186/1741-7015-11-241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225606PMC
November 2013

Augmentation therapy for alpha-1 antitrypsin deficiency: towards a personalised approach.

Orphanet J Rare Dis 2013 Sep 24;8:149. Epub 2013 Sep 24.

Lung Investigation Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn way, Edgbaston, Birmingham B15 2WB, UK.

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http://dx.doi.org/10.1186/1750-1172-8-149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852071PMC
September 2013

Prevalence and radiological outcomes of lung nodules in alpha 1-antitrypsin deficiency.

Respir Med 2013 Jun 20;107(6):863-9. Epub 2013 Jan 20.

Department of Respiratory Medicine, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.

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http://dx.doi.org/10.1016/j.rmed.2012.12.021DOI Listing
June 2013

Recent advances in α-1-antitrypsin deficiency-related lung disease.

Expert Rev Respir Med 2013 Jun;7(3):213-29; quiz 230

The ADAPT Project, Lung Function and Sleep Department, University Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK.

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http://www.tandfonline.com/doi/full/10.1586/ers.13.20
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http://dx.doi.org/10.1586/ers.13.20DOI Listing
June 2013

Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD.

Eur Respir J 2013 May 30;41(5):1042-50. Epub 2012 Aug 30.

Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, UK.

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http://dx.doi.org/10.1183/09031936.00089712DOI Listing
May 2013

Authors' response to 'TAP deficiency is also a cause of bronchiectasis'.

Thorax 2013 May 23;68(5):491. Epub 2013 Jan 23.

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http://dx.doi.org/10.1136/thoraxjnl-2012-203138DOI Listing
May 2013

Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD.

Int J Chron Obstruct Pulmon Dis 2012 27;7:789-96. Epub 2012 Nov 27.

Lung Investigation Unit, University Hospital Birmingham NHS Trust, UK.

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http://dx.doi.org/10.2147/COPD.S31797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514009PMC
April 2013

Bronchiectasis in older patients with chronic obstructive pulmonary disease : prevalence, diagnosis and therapeutic management.

Drugs Aging 2013 Apr;30(4):215-25

Department of Lung Function and Sleep, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK.

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http://link.springer.com/10.1007/s40266-013-0053-4
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http://dx.doi.org/10.1007/s40266-013-0053-4DOI Listing
April 2013

Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.

Respir Med 2013 Apr 20;107(4):524-33. Epub 2013 Feb 20.

Lung Investigations Unit, Medicine - University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK.

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http://dx.doi.org/10.1016/j.rmed.2012.12.009DOI Listing
April 2013

Bronchiectasis with chronic obstructive pulmonary disease: association or a further phenotype?

Am J Respir Crit Care Med 2013 Apr;187(8):786-8

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http://dx.doi.org/10.1164/rccm.201302-0203EDDOI Listing
April 2013

Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies.

Respir Med 2013 Mar 29;107(3):387-93. Epub 2012 Dec 29.

University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1016/j.rmed.2012.12.003DOI Listing
March 2013

Alpha-1 antitrypsin deficiency: the European experience.

COPD 2013 Mar;10 Suppl 1:50-3

Lung Investigation Unit, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom.

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http://dx.doi.org/10.3109/15412555.2013.765838DOI Listing
March 2013

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

Am J Respir Crit Care Med 2013 Feb 9;187(4):347-65. Epub 2012 Aug 9.

Manchester Academic Sciences Health Centre, Respiratory Research Group, University of Manchester, University Hospital South Manchester, Southmoor Road, Manchester M23 9LT, UK.

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http://dx.doi.org/10.1164/rccm.201204-0596PPDOI Listing
February 2013

Polyclonal free light chains: a biomarker of inflammatory disease or treatment target?

F1000 Med Rep 2013 1;5. Epub 2013 Feb 1.

Lung Function and Sleep Department, Queen Elizabeth Hospital Mindelsohn Way, Edgbaston, Birmingham, B15 2WB.

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http://dx.doi.org/10.3410/M5-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564472PMC
February 2013

Aα-Val360: a marker of neutrophil elastase and COPD disease activity.

Eur Respir J 2013 Jan 20;41(1):31-8. Epub 2012 Apr 20.

University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1183/09031936.00197411DOI Listing
January 2013

Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission tomography.

Am J Respir Crit Care Med 2012 Dec 26;186(11):1125-32. Epub 2012 Jul 26.

Department of Respiratory Medicine, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.

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http://dx.doi.org/10.1164/rccm.201201-0051OCDOI Listing
December 2012

Immunity and bacterial colonisation in bronchiectasis.

Thorax 2012 Nov 20;67(11):1006-13. Epub 2011 Sep 20.

Queen Elizabeth Hospital, Lung Investigation and Sleep Department, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2011-200206DOI Listing
November 2012

Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency.

Eur Respir J 2012 Sep 14;40(3):561-9. Epub 2012 Jun 14.

School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, UK.

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http://erj.ersjournals.com/lookup/doi/10.1183/09031936.00162
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http://dx.doi.org/10.1183/09031936.00162811DOI Listing
September 2012

Mechanisms of neutrophil transmigration across the vascular endothelium in COPD.

Thorax 2012 Jun 4;67(6):553-61. Epub 2011 May 4.

Lung Function and Sleep Department, University Hospital Birmingham NHS Foundation Trust, (New) Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2011-200088DOI Listing
June 2012

A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency.

Mamm Genome 2012 Apr 11;23(3-4):241-9. Epub 2011 Nov 11.

Department of Respiratory Medicine, Centre for Translational Inflammation, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2WB, UK.

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http://dx.doi.org/10.1007/s00335-011-9370-2DOI Listing
April 2012

The cleavage specificity of an IgA1 protease from Haemophilus influenzae.

Virulence 2011 Mar-Apr;2(2):103-10. Epub 2011 Mar 1.

Respiratory Research, Cardiovascular and Respiratory Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.

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http://www.tandfonline.com/doi/abs/10.4161/viru.2.2.15401
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August 2011

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo.

Thorax 2011 Aug 26;66(8):686-91. Epub 2011 May 26.

Lung Function and Sleep Department, ADAPT Office (Office 4), Queen Elizabeth Hospital, Birmingham B15 2WB, UK.

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http://thorax.bmj.com/cgi/doi/10.1136/thx.2010.154690
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http://dx.doi.org/10.1136/thx.2010.154690DOI Listing
August 2011

Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2011 May 21;183(9):1176-86. Epub 2011 Jan 21.

Department of Clinical and Experimental Medicine, First Floor, Nuffield House, University of Birmingham, Edgbaston, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1164/rccm.201008-1285OCDOI Listing
May 2011

Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency.

Respir Res 2010 Dec 7;11:173. Epub 2010 Dec 7.

Section of Respiratory Medicine, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.1186/1465-9921-11-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004850PMC
December 2010

3-Chlorotyrosine in sputum of COPD patients: relationship with airway inflammation.

COPD 2010 Dec;7(6):411-7

DMPK, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, United Kingdom.

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http://dx.doi.org/10.3109/15412555.2010.528086DOI Listing
December 2010