Robert Seeger

Robert Seeger

UNVERIFIED PROFILE

Are you Robert Seeger?   Register this Author

Register author
Robert Seeger

Robert Seeger

Publications by authors named "Robert Seeger"

Are you Robert Seeger?   Register this Author

79Publications

1944Reads

14Profile Views

Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms.

Cancer Res 2019 Mar 12;79(6):1151-1164. Epub 2018 Dec 12.

Children's Center for Cancer and Blood Diseases and Divisions of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, USC-Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-18-0779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428417PMC
March 2019

Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells.

J Extracell Vesicles 2019 12;8(1):1588538. Epub 2019 Mar 12.

Children's Center for Cancer and Blood Diseases and Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20013078.2019.1588538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419691PMC
March 2019

Phase I trial of dasatinib, lenalidomide, and temozolomide in children with relapsed or refractory central nervous system tumors.

J Neurooncol 2018 May 9;138(1):199-207. Epub 2018 Feb 9.

Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, 4650 Sunset Boulevard, MS #54, Los Angeles, CA, 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11060-018-2791-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930136PMC
May 2018

Biological roles and potential applications of immune cell-derived extracellular vesicles.

J Extracell Vesicles 2017 22;6(1):1400370. Epub 2017 Nov 22.

Department of Pediatrics, Children's Center for Cancer and Blood Diseases and Divisions of Hematology, Oncology, Blood and Marrow Transplantation.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20013078.2017.1400370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706476PMC
November 2017

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.

Cancer Res 2017 09 7;77(18):5142-5157. Epub 2017 Jul 7.

Division of Hematology, Oncology and Blood and Marrow Transplantation, Keck School of Medicine of the University of Southern California, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-2586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600847PMC
September 2017

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells.

J Extracell Vesicles 2017 28;6(1):1294368. Epub 2017 Feb 28.

Children's Center for Cancer and Blood Diseases and Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, USC-Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20013078.2017.1294368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345580PMC
February 2017

More than the genes, the tumor microenvironment in neuroblastoma.

Cancer Lett 2016 09 17;380(1):304-14. Epub 2015 Nov 17.

Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2015.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558454PMC
September 2016

A novel minimal residual disease model of neuroblastoma in mice.

J Pediatr Surg 2016 Jun 4;51(6):991-4. Epub 2016 Mar 4.

Division of Pediatric Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2016.02.066DOI Listing
June 2016

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.

Cancer Cell 2015 Nov 17;28(5):599-609. Epub 2015 Oct 17.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643330PMC
November 2015

Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma.

Pediatr Blood Cancer 2015 Oct 7;62(10):1739-46. Epub 2015 Jul 7.

Cancer Center and Departments of Cell Biology & Biochemistry, Pediatrics and Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.25594DOI Listing
October 2015

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.

Cancer Res 2015 Aug 22;75(15):3155-66. Epub 2015 Jun 22.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-3613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526355PMC
August 2015

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy.

J Natl Cancer Inst 2015 Jul 13;107(7). Epub 2015 May 13.

Children's Center for Cancer and Blood Diseases and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA; and Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (KBC, PMW, PN, HC, MM, MF); Division of Medical Oncology, Department of Internal Medicine, University of Southern California Keck School of Medicine and Norris Comprehensive Cancer Center, Los Angeles, CA (TX, AG); Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA (RK, MH, AJ, RCS, SA); Departments of Experimental Therapeutics and Leukemia and The Center for RNA interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX (CI, GAC); Department of Gynecologic Oncology and Reproductive Medicine and The Center for RNA interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX (XZ); Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) s.r.l., IRCCS, Gene Therapy Unit, Meldola (FC) 47014, Italy (IV, FF, DA); Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA (HS, SA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djv135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651042PMC
July 2015

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group.

Pediatr Dev Pathol 2014 Nov-Dec;17(6):441-9. Epub 2014 Sep 10.

1 Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, and University of Southern California Keck School of Medicine, 4650 Sunset Boulevard, MS #43, Los Angeles, CA 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2350/14-06-1505-OA.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340697PMC
March 2015

Drugging MYCN through an allosteric transition in Aurora kinase A.

Cancer Cell 2014 Sep 28;26(3):414-427. Epub 2014 Aug 28.

Department of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA 94158, USA; Departments of Neurology and Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160413PMC
September 2014

Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1.

Cancer Immunol Immunother 2013 Oct 27;62(10):1637-48. Epub 2013 Aug 27.

Division of Hematology/Oncology, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #57, Los Angeles, CA, 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00262-013-1466-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907789PMC
October 2013

Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma.

Cancer Res 2013 Jul 30;73(13):3852-64. Epub 2013 Apr 30.

Division of Hematology-Oncology, Department of Pediatrics, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-2353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740971PMC
July 2013

Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells.

J Immunother 2013 Jun;36(5):319-29

Division of Hematology/Oncology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CJI.0b013e31829b4493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064791PMC
June 2013

Growth and activation of natural killer cells ex vivo from children with neuroblastoma for adoptive cell therapy.

Clin Cancer Res 2013 Apr 1;19(8):2132-43. Epub 2013 Feb 1.

Division of Hematology/Oncology and Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-12-1243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658308PMC
April 2013

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.

Cancer Biol Ther 2012 May 1;13(7):534-41. Epub 2012 May 1.

Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cbt.19603DOI Listing
May 2012

Immunology and immunotherapy of neuroblastoma.

Authors:
Robert C Seeger

Semin Cancer Biol 2011 Oct 28;21(4):229-37. Epub 2011 Sep 28.

Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA 90027, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2011.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658311PMC
October 2011

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Cell 2010 Jul;142(2):218-29

Divisions of Molecular Carcinogenesis and Molecular Genetics, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2010.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913027PMC
July 2010

Novel cancer vaccine based on genes of Salmonella pathogenicity island 2.

Int J Cancer 2010 Jun;126(11):2622-34

Division of Hematology-Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine and The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.24957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993175PMC
June 2010

ATM is down-regulated by N-Myc-regulated microRNA-421.

Proc Natl Acad Sci U S A 2010 Jan 4;107(4):1506-11. Epub 2010 Jan 4.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0907763107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824372PMC
January 2010

Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.

Pediatr Blood Cancer 2009 Oct;53(4):563-9

Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.22106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730988PMC
October 2009

Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.

J Clin Invest 2009 Jun;119(6):1524-36

Division of Hematology-Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine, and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI37869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689106PMC
June 2009

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

Cancer Cell 2009 Apr;15(4):328-40

Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2009.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693316PMC
April 2009

An integrated cross-platform prognosis study on neuroblastoma patients.

Genomics 2008 Oct 30;92(4):195-203. Epub 2008 Jul 30.

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20877, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2008.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562635PMC
October 2008

Cdc6 knockdown inhibits human neuroblastoma cell proliferation.

Mol Cell Biochem 2008 Apr 8;311(1-2):189-97. Epub 2008 Feb 8.

Division of Hematology and Oncology, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA.

View Article

Download full-text PDF

Source
http://www.rntein.com/downloads/Cdc6%20research.pdf
Web Search
http://link.springer.com/content/pdf/10.1007/s11010-008-9709
Web Search
http://link.springer.com/10.1007/s11010-008-9709-5
Publisher Site
http://dx.doi.org/10.1007/s11010-008-9709-5DOI Listing
April 2008

Sparse representation and Bayesian detection of genome copy number alterations from microarray data.

Bioinformatics 2008 Feb 18;24(3):309-18. Epub 2008 Jan 18.

Signal and Image Processing Institute, Ming Hsieh Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, EEB 400, 3740 McClintock Ave, Los Angeles, CA 90089-2564, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btm601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704547PMC
February 2008

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.

J Clin Invest 2007 Sep;117(9):2702-12

Division of Hematology-Oncology, Department of Pediatrics, Childrens Hospital Los Angeles (CHLA), Los Angeles, California 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI30751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940236PMC
September 2007

Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification.

J Natl Cancer Inst 2006 Sep;98(17):1193-203

Department of Pediatrics, Division of Hematology-Oncology, Childrens Hospital Los Angeles and Saban Research Institute, University of Southern California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djj330DOI Listing
September 2006

The MYCN enigma: significance of MYCN expression in neuroblastoma.

Cancer Res 2006 Mar;66(5):2826-33

AFLAC Cancer Center, Department of Pediatrics and Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-05-0854DOI Listing
March 2006

Chromosome 1p and 11q deletions and outcome in neuroblastoma.

N Engl J Med 2005 Nov;353(21):2243-53

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104-4318, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa052399DOI Listing
November 2005

Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study.

J Clin Oncol 2005 Sep 22;23(27):6474-80. Epub 2005 Aug 22.

Department of Pediatrics, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2005.05.183DOI Listing
September 2005

Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis index.

Cancer 2005 Jan;103(1):174-80

Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles/Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cncr.20717
Publisher Site
http://dx.doi.org/10.1002/cncr.20717DOI Listing
January 2005

TrkA expression in peripheral neuroblastic tumors: prognostic significance and biological relevance.

Cancer 2004 Oct;101(8):1873-81

Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.20557DOI Listing
October 2004

GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma.

J Clin Oncol 2004 Oct;22(20):4127-34

Department of Pediatrics, NRC-5, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2004.02.032DOI Listing
October 2004

Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2.

J Exp Med 2004 May;199(9):1213-21

Department of Pediatrics, Division of Hematology-Oncology, MS #57, Childrens Hospital Los Angeles, 4650 Sunset Blvd., Los Angeles, CA 90027, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20031462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211904PMC
May 2004

Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group study.

Int J Radiat Oncol Biol Phys 2003 May;56(1):28-39

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0360-3016(02)04506-6DOI Listing
May 2003