Publications by authors named "Robert Sebra"

100Publications

Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of Expanded Human Hematopoietic Stem Cells.

Front Cell Dev Biol 2020 15;8:592348. Epub 2020 Dec 15.

Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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December 2020

SARS-CoV-2 Transmission among Marine Recruits during Quarantine.

N Engl J Med 2020 12 11;383(25):2407-2416. Epub 2020 Nov 11.

From the Naval Medical Research Center, Silver Spring (A.G.L., C.G., D.L.W., L.E., W.D.G., R.G., F.J., J.M., E.N., B.L.P., C.P., J.R., E.S.A., M.P.S., V.S., C.W.) and the Infectious Disease Clinical Research Program, Uniformed Services University (E.V.M.), Bethesda - both in Maryland; the Naval Medical Research Unit 6, Lima, Peru (R.L., S.L.); the Departments of Neurology (I.R., Y.G., M.-C.G., A.K., N.M., V.D.N., G.N., S.R., A.S.-S., S.V., S.C.S.) and Genetics and Genomic Sciences (A.O., J.D., E.E., A.S.G.-R., A.G., R.S., H.B.), Icahn Institute for Data Science and Genomic Technology (E.E., R.S., H.B.), the Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai (R.S.), and the Center for Computational Biology, Flatiron Institute (R.S.G.S., O.G.T.) - all in New York; the University of Alabama at Birmingham Center for Exercise Medicine, University of Alabama Medical School, Birmingham (M.M.B.); Sema4, Stamford, CT (R.S.); the Navy Medicine Readiness and Training Command Beaufort, Beaufort, SC (M.T.); and the Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ (O.G.T.).

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December 2020

COVID-19: Staging of a New Disease.

Cancer Cell 2020 11 10;38(5):594-597. Epub 2020 Oct 10.

Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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November 2020

Application of Single-Cell Sequencing to Immunotherapy.

Urol Clin North Am 2020 Nov 9;47(4):475-485. Epub 2020 Sep 9.

Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA.

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November 2020

Peritumoral edema correlates with mutational burden in meningiomas.

Neuroradiology 2021 Jan 12;63(1):73-80. Epub 2020 Aug 12.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

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January 2021

Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.

Cell Rep 2020 07;32(1):107871

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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July 2020

Familial Hypercholesterolemia in a Healthy Elderly Population.

Circ Genom Precis Med 2020 Aug 10;13(4):e002938. Epub 2020 Jun 10.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia (P.L., M.R., J.T., A.B., R.L.W., A.M.T., C.M.R., J.J.M.).

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August 2020

STK11 mutation status is associated with decreased survival in meningiomas.

Neurol Sci 2020 Sep 7;41(9):2585-2589. Epub 2020 Apr 7.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

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September 2020

Epigenetic preconditioning with decitabine sensitizes glioblastoma to temozolomide via induction of MLH1.

J Neurooncol 2020 May 19;147(3):557-566. Epub 2020 Mar 19.

Departments of Neurosurgery and Oncological Sciences, Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, Box 1136, New York, NY, 10029, USA.

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May 2020

A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles.

Genome Med 2020 02 28;12(1):24. Epub 2020 Feb 28.

Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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February 2020

Genetic associations with clozapine-induced myocarditis in patients with schizophrenia.

Transl Psychiatry 2020 01 27;10(1):37. Epub 2020 Jan 27.

MRC Centre for Drug Safety Science, Wolfson Centre for Personalised Medicine, University of Liverpool, The Royal Liverpool and Broadgreen University Hospitals NHS Trust, and Liverpool Health Partners, Liverpool, UK.

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January 2020

Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study.

Cold Spring Harb Mol Case Stud 2020 04 1;6(2). Epub 2020 Apr 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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April 2020

Elucidation of de novo small insertion/deletion biology with parent-of-origin phasing.

Hum Mutat 2020 04 16;41(4):800-806. Epub 2020 Jan 16.

Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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April 2020

Capture of complete ciliate chromosomes in single sequencing reads reveals widespread chromosome isoforms.

BMC Genomics 2019 Dec 30;20(1):1037. Epub 2019 Dec 30.

Departments of Biochemistry & Molecular Biophysics and Biological Sciences, Columbia University, New York, NY, 10032, USA.

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December 2019

Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival of .

NPJ Biofilms Microbiomes 2019;5(1):33. Epub 2019 Nov 5.

1The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, 700 Children's Drive, Columbus, OH 43205 USA.

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June 2020

Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review.

Alzheimers Dement 2019 12 7;15(12):1612-1623. Epub 2019 Sep 7.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

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December 2019

High-coverage, long-read sequencing of Han Chinese trio reference samples.

Sci Data 2019 06 14;6(1):91. Epub 2019 Jun 14.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Pl, New York, NY, 10029, USA.

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June 2019

Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.

Cell 2019 06 16;177(7):1781-1796.e25. Epub 2019 May 16.

Departments of Biochemistry & Molecular Biophysics and Biological Sciences, Columbia University, New York, NY 10032, USA. Electronic address:

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June 2019

Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities.

ACS Infect Dis 2019 07 3;5(7):1239-1251. Epub 2019 May 3.

Department of Chemistry , Stony Brook University , 100 John S. Toll Drive , Stony Brook , New York 11794-3400 , United States.

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July 2019

Don't overlook the little guy: An evaluation of the frequency of small plasmids co-conjugating with larger carbapenemase gene containing plasmids.

Plasmid 2019 05 27;103:1-8. Epub 2019 Mar 27.

Division of Infectious Disease and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA; Clinical Microbiology Laboratory, Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA. Electronic address:

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May 2019

Provides a Window into Carbapenemase Gene Transfer, Plasmid Rearrangements, and Patient Interactions with the Hospital Environment.

Antimicrob Agents Chemother 2019 06 24;63(6). Epub 2019 May 24.

Modernizing Medical Microbiology Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.

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June 2019

Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence.

PLoS Pathog 2018 10 17;14(10):e1007355. Epub 2018 Oct 17.

The Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, Columbus, Ohio, United States of America.

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October 2018

Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy.

Cold Spring Harb Mol Case Stud 2018 12 17;4(6). Epub 2018 Dec 17.

Department of Obstetrics/Gynecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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December 2018

High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma.

Sci Rep 2018 08 1;8(1):11570. Epub 2018 Aug 1.

Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.

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August 2018

Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing.

Genome Res 2018 07 15;28(7):1067-1078. Epub 2018 May 15.

Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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July 2018

Treatment-associated DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma.

Oncotarget 2018 Jan 20;9(2):2603-2621. Epub 2017 Dec 20.

Departments of Neurosurgery and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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January 2018

Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.

Antimicrob Agents Chemother 2018 04 27;62(4). Epub 2018 Mar 27.

Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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April 2018

Using single-cell multiple omics approaches to resolve tumor heterogeneity.

Clin Transl Med 2017 Dec 28;6(1):46. Epub 2017 Dec 28.

Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

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December 2017

Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation.

Nat Biotechnol 2018 01 11;36(1):61-69. Epub 2017 Dec 11.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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January 2018

Characterization of drug-induced splicing complexity in prostate cancer cell line using long read technology.

Pac Symp Biocomput 2018 ;23:8-19

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA.

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August 2018

DNA sequencing at ultra-high fidelity.

Authors:
Robert Sebra

Nat Biotechnol 2017 12 30;35(12):1143-1144. Epub 2017 Oct 30.

Department of Genetics & Genomic Sciences & Icahn Institute for Genomics & Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA, and at Sema4, a Mount Sinai venture, Stamford, Connecticut, USA.

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December 2017

Identification of Differentially Expressed Splice Variants by the Proteogenomic Pipeline Splicify.

Mol Cell Proteomics 2017 10 26;16(10):1850-1863. Epub 2017 Jul 26.

From the ‡Translational Gastrointestinal Oncology, Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands;

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October 2017

Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR Populations with Stem Cell Properties.

Stem Cell Reports 2017 05 20;8(5):1421-1429. Epub 2017 Apr 20.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Friedman Brain Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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May 2017

Chromosomal Integration of the Klebsiella pneumoniae Carbapenemase Gene, , in Klebsiella Species Is Elusive but Not Rare.

Antimicrob Agents Chemother 2017 03 23;61(3). Epub 2017 Feb 23.

Modernizing Medical Microbiology Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.

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March 2017

Capturing pairwise and multi-way chromosomal conformations using chromosomal walks.

Nature 2016 12 30;540(7632):296-300. Epub 2016 Nov 30.

Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot 76100, Israel.

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December 2016

Genome-Wide Biases in the Rate and Molecular Spectrum of Spontaneous Mutations in Vibrio cholerae and Vibrio fischeri.

Mol Biol Evol 2017 01 15;34(1):93-109. Epub 2016 Oct 15.

Microbiology Graduate Program, University of New Hampshire, Durham, NH

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January 2017

Complete Sequencing of Plasmids Containing blaOXA-163 and blaOXA-48 in Escherichia coli Sequence Type 131.

Antimicrob Agents Chemother 2016 11 21;60(11):6948-6951. Epub 2016 Oct 21.

Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada.

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November 2016

First Report of blaIMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131.

Antimicrob Agents Chemother 2016 08 22;60(8):5068-71. Epub 2016 Jul 22.

Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.

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August 2016

Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC.

Antimicrob Agents Chemother 2016 06 23;60(6):3767-78. Epub 2016 May 23.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA Clinical Microbiology, Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA

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June 2016

Complete Genome Sequence of KPC-Producing Klebsiella pneumoniae Strain CAV1193.

Genome Announc 2016 Jan 28;4(1). Epub 2016 Jan 28.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA Clinical Microbiology, Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA

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January 2016