Robert S Mittler

Robert S Mittler

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Robert S Mittler

Robert S Mittler

Publications by authors named "Robert S Mittler"

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Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy.

Front Immunol 2019 7;10:2566. Epub 2019 Nov 7.

Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853870PMC
November 2019

Recombinant soluble CD137 prevents type one diabetes in nonobese diabetic mice.

J Autoimmun 2013 Dec 18;47:94-103. Epub 2013 Oct 18.

Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, USA.

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http://dx.doi.org/10.1016/j.jaut.2013.09.002DOI Listing
December 2013

TLR2 signaling in tubular epithelial cells regulates NK cell recruitment in kidney ischemia-reperfusion injury.

J Immunol 2013 Sep 31;191(5):2657-64. Epub 2013 Jul 31.

Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 682-714, Korea.

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http://dx.doi.org/10.4049/jimmunol.1300358DOI Listing
September 2013

Host CD25+CD4+Foxp3+ regulatory T cells primed by anti-CD137 mAbs inhibit graft-versus-host disease.

Biol Blood Marrow Transplant 2012 Jan 28;18(1):44-54. Epub 2011 Sep 28.

Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Korea.

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http://dx.doi.org/10.1016/j.bbmt.2011.09.004DOI Listing
January 2012

Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation.

Proc Natl Acad Sci U S A 2012 Jan 12;109(1):E13-22. Epub 2011 Dec 12.

School of Biological Sciences, Department of Internal Medicine, University of Ulsan, Ulsan 680-749, Korea.

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http://dx.doi.org/10.1073/pnas.1112256109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252952PMC
January 2012

Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death.

J Immunol 2010 May 29;184(9):4770-8. Epub 2010 Mar 29.

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0902713
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http://dx.doi.org/10.4049/jimmunol.0902713DOI Listing
May 2010

Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity.

Vaccine 2010 Feb 26;28(5):1300-9. Epub 2009 Nov 26.

Department of Microbiology and Immunology, Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X090178
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http://dx.doi.org/10.1016/j.vaccine.2009.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814905PMC
February 2010

A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity.

Vaccine 2009 Dec 29;28(2):512-22. Epub 2009 Oct 29.

Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, KY 40202, United States.

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http://dx.doi.org/10.1016/j.vaccine.2009.09.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805442PMC
December 2009

Hypercostimulation through 4-1BB distorts homeostasis of immune cells.

J Immunol 2009 Jun;182(11):6753-62

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.0803241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713069PMC
June 2009

Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.

Int Arch Allergy Immunol 2009 11;148(4):305-10. Epub 2008 Nov 11.

Department of Ophthalmology, Kochi Medical School, Kohasu Oko-cho, Nankoku City, Japan.

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http://dx.doi.org/10.1159/000170384DOI Listing
April 2009

Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy.

Mol Cancer Ther 2009 Feb 3;8(2):469-78. Epub 2009 Feb 3.

Division of Cell and Immunobiology, and R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan, Goyang, Kyounggi-do, Korea.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0993DOI Listing
February 2009

The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death.

J Leukoc Biol 2009 Jan 15;85(1):175-85. Epub 2008 Oct 15.

Department of Immunology, Center for Immunotherapy of Cancer and Infectious Diseases, MC1319, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06032, USA.

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http://dx.doi.org/10.1189/jlb.0408248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626763PMC
January 2009

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.

Nat Immunol 2008 Aug 6;9(8):917-26. Epub 2008 Jul 6.

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.

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http://www.nature.com/articles/ni.1632
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http://dx.doi.org/10.1038/ni.1632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561255PMC
August 2008

CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells.

J Immunol 2008 Apr;180(8):5267-74

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768524PMC
http://dx.doi.org/10.4049/jimmunol.180.8.5267DOI Listing
April 2008

Distinct approaches to investigate the importance of the murine 4-1BB 4-1BBL interaction in the antibody response to Streptococcus pneumoniae.

J Leukoc Biol 2007 Sep 5;82(3):638-44. Epub 2007 Jun 5.

Department of Molecular Cell Biology, Faculty of Medicine, Catholic University Leuven, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1189/jlb.1006628DOI Listing
September 2007

CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent.

J Immunol 2007 Aug;179(4):2203-14

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2203DOI Listing
August 2007

T cell costimulatory and inhibitory receptors as therapeutic targets for inducing anti-tumor immunity.

Curr Cancer Drug Targets 2007 Feb;7(1):55-70

Department of Pediatrics, Hematology and Oncology and Center for Cell and Gene Therapy, Martin Luther University, Halle-Wittenburg, Germany.

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http://dx.doi.org/10.2174/156800907780006841DOI Listing
February 2007

Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes.

Diabetes 2007 Jan;56(1):186-96

Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, PA, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-07
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http://dx.doi.org/10.2337/db06-0793DOI Listing
January 2007

TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.

J Immunol 2006 Nov;177(9):6091-7

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.177.9.6091DOI Listing
November 2006

Costimulatory molecules as immunotherapeutic targets in systemic lupus erythematosus.

Springer Semin Immunopathol 2006 Oct 2;28(2):153-62. Epub 2006 Sep 2.

Department of Pediatrics, Hematology and Oncology, Martin Luther University, Halle-Wittenburg, Germany.

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http://dx.doi.org/10.1007/s00281-006-0039-yDOI Listing
October 2006

Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.

Hum Gene Ther 2006 Aug;17(8):798-806

Division of Hematology/Oncology and Blood and Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, AFLAC Cancer Center and Blood Disorders Services, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1089/hum.2006.17.798DOI Listing
August 2006

Eradication of established tumors in mice by a combination antibody-based therapy.

Nat Med 2006 Jun 7;12(6):693-8. Epub 2006 May 7.

Department of Immunology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1038/nm1405DOI Listing
June 2006

CD137-mediated immunotherapy for allergic asthma.

J Clin Invest 2006 Apr 9;116(4):1025-36. Epub 2006 Mar 9.

Division of Pediatric Pulmonology and Neonatology, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1172/JCI23792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395480PMC
April 2006

Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells.

Int Immunol 2006 Feb 22;18(2):325-33. Epub 2005 Dec 22.

Department of Immunology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1093/intimm/dxh371DOI Listing
February 2006

Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice.

J Immunol 2005 Oct;175(8):4897-903

Department of Ophthalmology, Kochi Medical School, Nankoku-city, Japan.

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http://dx.doi.org/10.4049/jimmunol.175.8.4897DOI Listing
October 2005

Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.

J Immunol 2005 Jun;174(12):7625-32

Division of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.174.12.7625DOI Listing
June 2005

Anti-CD137 antibodies in the treatment of autoimmune disease and cancer.

Immunol Res 2004 ;29(1-3):197-208

Department of Surgery and Emory Vaccine Research Center, Emory University School of Medicine, 954 Gatewood Road, Atlanta, GA 30329, USA.

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http://link.springer.com/content/pdf/10.1385/IR:29:1-3:197.p
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http://link.springer.com/10.1385/IR:29:1-3:197
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http://dx.doi.org/10.1385/IR:29:1-3:197DOI Listing
December 2004

Suppressing the self in rheumatoid arthritis.

Authors:
Robert S Mittler

Nat Med 2004 Oct;10(10):1047-9

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http://www.nature.com/articles/nm1004-1047
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http://dx.doi.org/10.1038/nm1004-1047DOI Listing
October 2004

4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.

J Immunol 2004 Sep;173(5):3002-12

Division of Immunology, University of Connecticut Health Center, Farmington 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.173.5.3002DOI Listing
September 2004

4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.

Immunology 2004 Aug;112(4):559-66

Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2004.01917.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782516PMC
August 2004

Role of 4-1BB in allograft rejection mediated by CD8+ T cells.

Am J Transplant 2003 May;3(5):543-51

Emory Transplant Center and the Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1034/j.1600-6143.2003.00088.xDOI Listing
May 2003

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering.

Proc Natl Acad Sci U S A 2003 Apr 14;100(9):5348-53. Epub 2003 Apr 14.

Division of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.1073/pnas.0837611100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154348PMC
April 2003

4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae.

Infect Immun 2003 Jan;71(1):196-204

Department of Pathology. Biomedical Instrumentation Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC143421PMC
http://dx.doi.org/10.1128/iai.71.1.196-204.2003DOI Listing
January 2003

4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells.

Int Immunol 2002 Oct;14(10):1155-67

Barbara Ann Karmanos Cancer Institute, Department of Immunology Microbiology, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1093/intimm/dxf080DOI Listing
October 2002