Publications by authors named "Robert S Illingworth"

19Publications

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.

Dev Cell 2020 Aug 10;54(3):317-332.e9. Epub 2020 Jul 10.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435699PMC
August 2020

A central role for canonical PRC1 in shaping the 3D nuclear landscape.

Genes Dev 2020 07 21;34(13-14):931-949. Epub 2020 May 21.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1101/gad.336487.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328521PMC
July 2020

Coolpup.py: versatile pile-up analysis of Hi-C data.

Bioinformatics 2020 05;36(10):2980-2985

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1093/bioinformatics/btaa073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214034PMC
May 2020

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency.

Cell Rep 2019 11;29(7):1974-1985.e6

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856714PMC
November 2019

Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation.

Mol Cell 2019 11 4;76(3):473-484.e7. Epub 2019 Sep 4.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838673PMC
November 2019

Chromatin folding and nuclear architecture: PRC1 function in 3D.

Curr Opin Genet Dev 2019 04 16;55:82-90. Epub 2019 Jul 16.

MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859790PMC
April 2019

Polycomb enables primitive endoderm lineage priming in embryonic stem cells.

Elife 2016 10 10;5. Epub 2016 Oct 10.

The Danish Stem Cell Centre - DanStem, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.7554/eLife.14926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056788PMC
October 2016

Polycomb-mediated chromatin compaction weathers the STORM.

Genome Biol 2016 Feb 25;17:35. Epub 2016 Feb 25.

MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1186/s13059-016-0899-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768414PMC
February 2016

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.

Genes Dev 2015 Sep;29(18):1897-902

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH42XU, United Kingdom.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.268151.115
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http://dx.doi.org/10.1101/gad.268151.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579347PMC
September 2015

Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization.

Genes Dev 2014 Dec;28(24):2778-91

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom;

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http://dx.doi.org/10.1101/gad.251694.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265680PMC
December 2014

Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells.

Science 2014 Dec;346(6214):1238-42

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1126/science.1259587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529354PMC
December 2014

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

PLoS One 2012 9;7(4):e34848. Epub 2012 Apr 9.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034848PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322156PMC
August 2012

Cell type-specific DNA methylation at intragenic CpG islands in the immune system.

Genome Res 2011 Jul 31;21(7):1074-86. Epub 2011 May 31.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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http://dx.doi.org/10.1101/gr.118703.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129250PMC
July 2011

Immunostaining of modified histones defines high-level features of the human metaphase epigenome.

Genome Biol 2010 15;11(11):R110. Epub 2010 Nov 15.

Chromatin and Gene Expression Group, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2010-11-11-r110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156949PMC
June 2011

CpG islands--'a rough guide'.

FEBS Lett 2009 Jun 18;583(11):1713-20. Epub 2009 Apr 18.

Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, United Kingdom.

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http://dx.doi.org/10.1016/j.febslet.2009.04.012DOI Listing
June 2009