Robert Rottapel

Robert Rottapel

Robert Rottapel

Robert Rottapel

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Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.

J Bone Miner Res 2020 Feb 24;35(2):382-395. Epub 2019 Oct 24.

Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN, USA.

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http://dx.doi.org/10.1002/jbmr.3882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012678PMC
February 2020

Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils.

Small GTPases 2020 Jan 30;11(1):23-31. Epub 2017 Nov 30.

Princess Margaret Cancer Center, Toronto Medical Discovery Tower, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1080/21541248.2017.1332505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959313PMC
January 2020

Bone dynamics and inflammation: lessons from rare diseases.

Immunol Med 2020 Jan 30:1-4. Epub 2020 Jan 30.

Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1080/25785826.2020.1720104DOI Listing
January 2020

Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.

Small GTPases 2019 11 11;10(6):441-448. Epub 2017 Jul 11.

Princess Margaret Cancer Centre, University Health Network, Toronto Medical Discovery Tower, University of Toronto , Toronto , Canada.

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http://dx.doi.org/10.1080/21541248.2017.1337545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748365PMC
November 2019

Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma.

Cancer Res 2019 Nov 17;79(21):5536-5549. Epub 2019 Sep 17.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3029DOI Listing
November 2019

Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer.

Oncotarget 2019 Apr 26;10(31):2947-2958. Epub 2019 Apr 26.

Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18632/oncotarget.26893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508206PMC
April 2019

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8 T Cell Expansion and Differentiation.

Cell Rep 2018 07;24(5):1123-1135

Princess Margaret Cancer Center, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701191PMC
July 2018

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Cell Rep 2017 03;18(10):2343-2358

Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.028DOI Listing
March 2017

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

Oncotarget 2017 Jan;8(3):4484-4500

Princess Margaret Cancer Centre, University Health Network, Toronto Medical Discovery Tower, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18632/oncotarget.13152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354848PMC
January 2017

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

J Cell Biol 2016 Oct;215(1):107-119

Princess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1L7, Canada Department of Immunology, University of Toronto, Toronto, Ontario M5S 1L7, Canada Department of Medicine, University of Toronto, Toronto, Ontario M5S 1L7, Canada Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada

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http://dx.doi.org/10.1083/jcb.201603109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057286PMC
October 2016

Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1.

Mol Cancer Res 2016 Mar 8;14(3):267-77. Epub 2016 Jan 8.

Princess Margaret Cancer Centre, University Health Network, Toronto Medical Discovery Tower, University of Toronto, Toronto, Ontario, Canada. Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. Department of Medical Biophysics, St. Michael's Hospital, Toronto, Ontario, Canada. Department of Immunology, St. Michael's Hospital, Toronto, Ontario, Canada. Division of Rheumatology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794362PMC
March 2016

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.

Nat Commun 2014 Sep 11;5:4857. Epub 2014 Sep 11.

1] Princess Margaret Cancer Centre, University Health Network, University of Toronto, 101 College Street, Room 12-704, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7 [2] Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 [3] Department of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 [4] Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 [5] Division of Rheumatology, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.

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http://sites.utoronto.ca/rottapel/documents/meiri2014.pdf
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http://www.nature.com/doifinder/10.1038/ncomms5857
Publisher Site
http://dx.doi.org/10.1038/ncomms5857DOI Listing
September 2014

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics.

Mol Syst Biol 2014 Jul 1;10:733. Epub 2014 Jul 1.

Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299491PMC
http://dx.doi.org/10.15252/msb.20145216DOI Listing
July 2014

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

Cancer Res 2014 Apr 31;74(7):2119-30. Epub 2014 Jan 31.

Authors' Affiliations: Division of Advanced Diagnostics, Toronto General Research Institute-University Health Network; Medicinal Chemistry Platform, Ontario Institute for Cancer Research; The Donnelly Centre, University of Toronto; Program in Developmental and Stem Cell Biology, Department of Molecular Genetics, The Hospital for Sick Children; Ontario Cancer Institute, University of Toronto, and Drug Discovery Program, Department of Pharmacology and Toxicology; Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/74/7/2119.full.pdf
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-2138DOI Listing
April 2014

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.

Cancer Cell 2014 Feb;25(2):181-95

Princess Margaret Cancer Center, University Health Network, 101 College Street, Room 8-703, Toronto Medical Discovery Tower, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108140003
Publisher Site
http://dx.doi.org/10.1016/j.ccr.2014.01.025DOI Listing
February 2014

The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.

J Immunol 2012 Sep 18;189(5):2138-50. Epub 2012 Jul 18.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 148, Canada.

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http://dx.doi.org/10.4049/jimmunol.1103184DOI Listing
September 2012

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.

Methods 2012 Aug 28;57(4):473-85. Epub 2012 Jun 28.

Ontario Cancer Institute and The Campbell Family Cancer Research Institute, University Health Network, 101 College Street, Rm 4-804 Toronto Medical Discovery Tower, MaRS Building, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1016/j.ymeth.2012.06.014DOI Listing
August 2012

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

Mol Cell 2012 Mar;45(5):642-55

Ontario Cancer Institute and the Campbell Family Cancer Research Institute, 101 College Street, Room 8-703 Toronto Medical Discovery Tower, University of Toronto, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.01.027DOI Listing
March 2012

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.

Cell 2011 Dec;147(6):1324-39

Ontario Cancer Institute and the Campbell Family Cancer Research Institute, 101 College Street, Rm 8-703, Toronto Medical Discovery Tower, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.cell.2011.10.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475183PMC
December 2011

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.

Cell 2011 Dec;147(6):1340-54

Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.cell.2011.10.046DOI Listing
December 2011

Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.

J Immunol 2011 Oct 26;187(7):3499-510. Epub 2011 Aug 26.

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.4049/jimmunol.1100424DOI Listing
October 2011

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions.

J Clin Invest 2011 Aug 18;121(8):3244-57. Epub 2011 Jul 18.

Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI45843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148735PMC
August 2011

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.

J Immunol 2010 Jun 17;184(12):7196-206. Epub 2010 May 17.

Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.4049/jimmunol.0901404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999618PMC
June 2010

Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation.

Mol Cell Biol 2009 Nov 10;29(21):5963-73. Epub 2009 Aug 10.

Ontario Cancer Institute, Toronto Medical Discovery Tower, MaRS East Tower, 101 College St., Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1128/MCB.01268-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772734PMC
November 2009

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.

Nat Neurosci 2009 Jun 17;12(6):735-44. Epub 2009 May 17.

Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nn.2339DOI Listing
June 2009

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

Blood 2008 Feb 15;111(3):1464-71. Epub 2007 Nov 15.

Laboratory of Lymphocyte Signaling and Development, Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2007-08-108050DOI Listing
February 2008

The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response.

Mol Cell Biol 2007 Apr 5;27(8):3109-22. Epub 2007 Feb 5.

Princess Margaret Hospital/Ontario Cancer Institute, Room 10-105, University Ave., Toronto, ON, Canada.

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http://dx.doi.org/10.1128/MCB.01014-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899947PMC
April 2007

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.

Int Immunol 2007 Mar 17;19(3):267-76. Epub 2007 Jan 17.

Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1093/intimm/dxl143DOI Listing
March 2007

The adapter 3BP2: how it plugs into leukocyte signaling.

Adv Exp Med Biol 2006 ;584:107-14

INSERM Unit 576 and Hopital de l'Archet, Nice, France.

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http://dx.doi.org/10.1007/0-387-34132-3_8DOI Listing
October 2006

Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis.

J Immunol 2006 Apr;176(7):4029-41

Immunology Division, Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Canada.

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http://dx.doi.org/10.4049/jimmunol.176.7.4029DOI Listing
April 2006

The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis.

Proc Natl Acad Sci U S A 2005 Jul 23;102(27):9529-34. Epub 2005 Jun 23.

Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1073/pnas.0504190102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1157106PMC
July 2005

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway.

J Immunol 2005 Jan;174(1):180-94

Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.174.1.180DOI Listing
January 2005

Regulation of the immune system by SOCS family adaptor proteins.

Semin Immunol 2004 Dec;16(6):351-65

Faculty of Medicine, Immunology Division, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Que., Canada J1H 5N4.

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http://dx.doi.org/10.1016/j.smim.2004.08.015DOI Listing
December 2004

The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse.

J Exp Med 2004 Nov;200(9):1167-77

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, c/o Dr. Bohr Gasse 3-5, A-1030 Vienna, Austria.

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http://dx.doi.org/10.1084/jem.20032246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211862PMC
November 2004

Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.

Mol Cell Biol 2004 Jul;24(13):6067-75

Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada H2W 1R7.

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http://dx.doi.org/10.1128/MCB.24.13.6067-6075.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC480883PMC
July 2004

A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling.

Blood 2004 Feb 9;103(4):1398-407. Epub 2003 Oct 9.

Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, QC H3A 1A1, Canada.

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http://dx.doi.org/10.1182/blood-2003-07-2617DOI Listing
February 2004

Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes.

Blood 2003 Dec 7;102(12):4115-22. Epub 2003 Aug 7.

Rm 10-108, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Ave, Toronto M5G 2M9, Canada.

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http://dx.doi.org/10.1182/blood-2003-01-0175DOI Listing
December 2003

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

Mol Cell 2003 Dec;12(6):1413-26

Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00490-8DOI Listing
December 2003

Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease.

J Biol Chem 2003 Oct 12;278(43):41871-80. Epub 2003 Aug 12.

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto M5G 2M9, Canada.

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http://dx.doi.org/10.1074/jbc.M308382200DOI Listing
October 2003

Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.

J Immunol 2003 Sep;171(5):2435-45

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.4049/jimmunol.171.5.2435DOI Listing
September 2003

Signal transduction by several KIT juxtamembrane domain mutations.

Oncogene 2003 Jul;22(30):4710-22

Molecular and Functional Hematopoiesis Laboratory, U119 INSERM, 27 Bd Leï Roure 13009 Marseille, France.

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http://dx.doi.org/10.1038/sj.onc.1206587DOI Listing
July 2003

Flow cytometric analysis of cytokine receptor signal transduction.

J Immunol Methods 2003 Jul;278(1-2):221-34

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1016/s0022-1759(03)00177-7DOI Listing
July 2003

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

Mol Cell Biol 2003 May;23(9):3067-78

Division of Experimental Therapeutics, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario M5G 2M9, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153186PMC
http://dx.doi.org/10.1128/mcb.23.9.3067-3078.2003DOI Listing
May 2003

Regulation of cytokine receptor signaling by SOCS1.

Immunol Rev 2003 Apr;192:196-211

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00020.xDOI Listing
April 2003

Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence.

Cancer Res 2002 Sep;62(17):5076-82

Institute of Medical Science, University of Toronto, Ontario, Canada.

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September 2002

The tumor suppressor activity of SOCS-1.

Oncogene 2002 Jun;21(28):4351-62

Department of Immunology, University of Toronto, Canada.

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http://dx.doi.org/10.1038/sj.onc.1205537DOI Listing
June 2002