Publications by authors named "Robert Reenan"

46Publications

Age-dependent degeneration of an identified adult leg motor neuron in a SOD1 model of ALS.

Biol Open 2020 Oct 21;9(10). Epub 2020 Oct 21.

Department of Biology, Rhode Island College, 600 Mt. Pleasant Ave., Providence, RI, 02908 USA

View Article and Find Full Text PDF
October 2020

Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis.

Neuroscience 2019 01;396:A3-A20

Department of Neuroscience, Brown University, Providence, Rhode Island 02912, United States; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912, United States. Electronic address:

View Article and Find Full Text PDF
January 2019

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan.

Cell Rep 2018 05;23(7):1915-1921

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA. Electronic address:

View Article and Find Full Text PDF
May 2018

Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible.

BMC Genomics 2017 07 10;18(1):522. Epub 2017 Jul 10.

Division of Applied Mathematics, Brown University, Providence, 02912, RI, USA.

View Article and Find Full Text PDF
July 2017

Human SOD1 ALS Mutations in a Drosophila Knock-In Model Cause Severe Phenotypes and Reveal Dosage-Sensitive Gain- and Loss-of-Function Components.

Genetics 2017 02 14;205(2):707-723. Epub 2016 Dec 14.

Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912

View Article and Find Full Text PDF
February 2017

Reprogramming, Circular Reasoning and Self versus Non-self: One-Stop Shopping with RNA Editing.

Front Genet 2016 7;7:100. Epub 2016 Jun 7.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence RI, USA.

View Article and Find Full Text PDF
July 2016

Genome-Wide Analysis of A-to-I RNA Editing.

Methods Mol Biol 2016 ;1358:255-68

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02912, USA.

View Article and Find Full Text PDF
July 2016

Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current.

J Neurophysiol 2014 Aug 7;112(4):903-12. Epub 2014 May 7.

Department of Developmental and Cell Biology, University of California, Irvine, California; Department of Anatomy and Neurobiology, University of California, Irvine, California;

View Article and Find Full Text PDF
August 2014

Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion.

Aging (Albany NY) 2014 Jan;6(1):58-69

Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912.

View Article and Find Full Text PDF
January 2014

Correcting mutations by RNA repair.

Authors:
Robert Reenan

N Engl J Med 2014 Jan;370(2):172-4

View Article and Find Full Text PDF
January 2014

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells.

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):337-42. Epub 2013 Dec 23.

Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

View Article and Find Full Text PDF
January 2014

RNA editing regulates transposon-mediated heterochromatic gene silencing.

Nat Commun 2013 ;4:2745

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 185 Meeting Street, Providence, Rhode Island 02912, USA.

View Article and Find Full Text PDF
June 2014

Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila.

Nat Struct Mol Biol 2013 Nov 29;20(11):1333-9. Epub 2013 Sep 29.

1] Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA. [2] St. Laurent Institute, Cambridge, Massachusetts, USA.

View Article and Find Full Text PDF
November 2013

Tertiary structural elements determine the extent and specificity of messenger RNA editing.

Nat Commun 2013 ;4:2232

Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.

View Article and Find Full Text PDF
February 2014

The ADAR protein family.

Genome Biol 2012 Dec 28;13(12):252. Epub 2012 Dec 28.

View Article and Find Full Text PDF
December 2012

Mutations to the piRNA pathway component aubergine enhance meiotic drive of segregation distorter in Drosophila melanogaster.

Genetics 2013 Mar 24;193(3):771-84. Epub 2012 Dec 24.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article and Find Full Text PDF
March 2013

RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue.

Channels (Austin) 2012 Nov-Dec;6(6):443-52. Epub 2012 Oct 12.

Department of Molecular Physiology & Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, PA, USA.

View Article and Find Full Text PDF
July 2013

A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure.

J Neurosci 2012 Oct;32(41):14145-55

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California 92697-1280, USA.

View Article and Find Full Text PDF
October 2012

Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila.

Nat Commun 2012 Apr 24;3:790. Epub 2012 Apr 24.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.

View Article and Find Full Text PDF
April 2012

Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging.

Fly (Austin) 2012 Jan-Mar;6(1):57-67. Epub 2012 Jan 1.

Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.

View Article and Find Full Text PDF
August 2012

Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system.

Nat Methods 2011 Dec 25;9(2):189-94. Epub 2011 Dec 25.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.

View Article and Find Full Text PDF
December 2011

The intricate relationship between RNA structure, editing, and splicing.

Semin Cell Dev Biol 2012 May 8;23(3):281-8. Epub 2011 Dec 8.

Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

View Article and Find Full Text PDF
May 2012

Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein.

Nat Neurosci 2011 Oct 30;14(12):1517-24. Epub 2011 Oct 30.

Department of Genetics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article and Find Full Text PDF
October 2011

Perturbing A-to-I RNA editing using genetics and homologous recombination.

Methods Mol Biol 2011 ;718:41-73

Molecular Biology Cellular Biology and Biochemistry, Brown University, Providence, RI, USA.

View Article and Find Full Text PDF
June 2011

Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets.

J Biol Chem 2011 Mar 15;286(10):8325-37. Epub 2010 Nov 15.

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.

View Article and Find Full Text PDF
March 2011

Channels get in an HUFA: RNA editing gets them out of a jam.

EMBO J 2010 Jul;29(13):2097-8

Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, PA, USA.

View Article and Find Full Text PDF
July 2010

Unraveling pleiotropic functions of A-to-I RNA editing in Drosophila.

Fly (Austin) 2010 Apr-Jun;4(2):154-8. Epub 2010 Apr 17.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.

View Article and Find Full Text PDF
September 2010

Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila.

J Biol Chem 2009 Nov 15;284(45):31391-400. Epub 2009 Sep 15.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.

View Article and Find Full Text PDF
November 2009

Enhancing non-coding RNA information content with ADAR editing.

Neurosci Lett 2009 Dec 12;466(2):89-98. Epub 2009 Sep 12.

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

View Article and Find Full Text PDF
December 2009

Regulated RNA editing and functional epistasis in Shaker potassium channels.

J Gen Physiol 2009 Jan;133(1):17-27

Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, PA 19107, USA.

View Article and Find Full Text PDF
January 2009

Characterization of five RNA editing sites in Shab potassium channels.

Channels (Austin) 2008 May-Jun;2(3):202-9. Epub 2008 May 2.

Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.

View Article and Find Full Text PDF
October 2010

Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila.

Aging Cell 2008 Mar 15;7(2):179-86. Epub 2008 Jan 15.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

View Article and Find Full Text PDF
March 2008

RNA editing in regulating gene expression in the brain.

Biochim Biophys Acta 2008 Aug 3;1779(8):459-70. Epub 2007 Dec 3.

Department of Molecular Biology, Cell Biology and Biochemistry, SFH Life Sciences Building, Brown University, 185 Meeting Street, Providence, RI 02912, USA.

View Article and Find Full Text PDF
August 2008

Evolution of genes and genomes on the Drosophila phylogeny.

Authors:
Andrew G Clark Michael B Eisen Douglas R Smith Casey M Bergman Brian Oliver Therese A Markow Thomas C Kaufman Manolis Kellis William Gelbart Venky N Iyer Daniel A Pollard Timothy B Sackton Amanda M Larracuente Nadia D Singh Jose P Abad Dawn N Abt Boris Adryan Montserrat Aguade Hiroshi Akashi Wyatt W Anderson Charles F Aquadro David H Ardell Roman Arguello Carlo G Artieri Daniel A Barbash Daniel Barker Paolo Barsanti Phil Batterham Serafim Batzoglou Dave Begun Arjun Bhutkar Enrico Blanco Stephanie A Bosak Robert K Bradley Adrianne D Brand Michael R Brent Angela N Brooks Randall H Brown Roger K Butlin Corrado Caggese Brian R Calvi A Bernardo de Carvalho Anat Caspi Sergio Castrezana Susan E Celniker Jean L Chang Charles Chapple Sourav Chatterji Asif Chinwalla Alberto Civetta Sandra W Clifton Josep M Comeron James C Costello Jerry A Coyne Jennifer Daub Robert G David Arthur L Delcher Kim Delehaunty Chuong B Do Heather Ebling Kevin Edwards Thomas Eickbush Jay D Evans Alan Filipski Sven Findeiss Eva Freyhult Lucinda Fulton Robert Fulton Ana C L Garcia Anastasia Gardiner David A Garfield Barry E Garvin Greg Gibson Don Gilbert Sante Gnerre Jennifer Godfrey Robert Good Valer Gotea Brenton Gravely Anthony J Greenberg Sam Griffiths-Jones Samuel Gross Roderic Guigo Erik A Gustafson Wilfried Haerty Matthew W Hahn Daniel L Halligan Aaron L Halpern Gillian M Halter Mira V Han Andreas Heger LaDeana Hillier Angie S Hinrichs Ian Holmes Roger A Hoskins Melissa J Hubisz Dan Hultmark Melanie A Huntley David B Jaffe Santosh Jagadeeshan William R Jeck Justin Johnson Corbin D Jones William C Jordan Gary H Karpen Eiko Kataoka Peter D Keightley Pouya Kheradpour Ewen F Kirkness Leonardo B Koerich Karsten Kristiansen Dave Kudrna Rob J Kulathinal Sudhir Kumar Roberta Kwok Eric Lander Charles H Langley Richard Lapoint Brian P Lazzaro So-Jeong Lee Lisa Levesque Ruiqiang Li Chiao-Feng Lin Michael F Lin Kerstin Lindblad-Toh Ana Llopart Manyuan Long Lloyd Low Elena Lozovsky Jian Lu Meizhong Luo Carlos A Machado Wojciech Makalowski Mar Marzo Muneo Matsuda Luciano Matzkin Bryant McAllister Carolyn S McBride Brendan McKernan Kevin McKernan Maria Mendez-Lago Patrick Minx Michael U Mollenhauer Kristi Montooth Stephen M Mount Xu Mu Eugene Myers Barbara Negre Stuart Newfeld Rasmus Nielsen Mohamed A F Noor Patrick O'Grady Lior Pachter Montserrat Papaceit Matthew J Parisi Michael Parisi Leopold Parts Jakob S Pedersen Graziano Pesole Adam M Phillippy Chris P Ponting Mihai Pop Damiano Porcelli Jeffrey R Powell Sonja Prohaska Kim Pruitt Marta Puig Hadi Quesneville Kristipati Ravi Ram David Rand Matthew D Rasmussen Laura K Reed Robert Reenan Amy Reily Karin A Remington Tania T Rieger Michael G Ritchie Charles Robin Yu-Hui Rogers Claudia Rohde Julio Rozas Marc J Rubenfield Alfredo Ruiz Susan Russo Steven L Salzberg Alejandro Sanchez-Gracia David J Saranga Hajime Sato Stephen W Schaeffer Michael C Schatz Todd Schlenke Russell Schwartz Carmen Segarra Rama S Singh Laura Sirot Marina Sirota Nicholas B Sisneros Chris D Smith Temple F Smith John Spieth Deborah E Stage Alexander Stark Wolfgang Stephan Robert L Strausberg Sebastian Strempel David Sturgill Granger Sutton Granger G Sutton Wei Tao Sarah Teichmann Yoshiko N Tobari Yoshihiko Tomimura Jason M Tsolas Vera L S Valente Eli Venter J Craig Venter Saverio Vicario Filipe G Vieira Albert J Vilella Alfredo Villasante Brian Walenz Jun Wang Marvin Wasserman Thomas Watts Derek Wilson Richard K Wilson Rod A Wing Mariana F Wolfner Alex Wong Gane Ka-Shu Wong Chung-I Wu Gabriel Wu Daisuke Yamamoto Hsiao-Pei Yang Shiaw-Pyng Yang James A Yorke Kiyohito Yoshida Evgeny Zdobnov Peili Zhang Yu Zhang Aleksey V Zimin Jennifer Baldwin Amr Abdouelleil Jamal Abdulkadir Adal Abebe Brikti Abera Justin Abreu St Christophe Acer Lynne Aftuck Allen Alexander Peter An Erica Anderson Scott Anderson Harindra Arachi Marc Azer Pasang Bachantsang Andrew Barry Tashi Bayul Aaron Berlin Daniel Bessette Toby Bloom Jason Blye Leonid Boguslavskiy Claude Bonnet Boris Boukhgalter Imane Bourzgui Adam Brown Patrick Cahill Sheridon Channer Yama Cheshatsang Lisa Chuda Mieke Citroen Alville Collymore Patrick Cooke Maura Costello Katie D'Aco Riza Daza Georgius De Haan Stuart DeGray Christina DeMaso Norbu Dhargay Kimberly Dooley Erin Dooley Missole Doricent Passang Dorje Kunsang Dorjee Alan Dupes Richard Elong Jill Falk Abderrahim Farina Susan Faro Diallo Ferguson Sheila Fisher Chelsea D Foley Alicia Franke Dennis Friedrich Loryn Gadbois Gary Gearin Christina R Gearin Georgia Giannoukos Tina Goode Joseph Graham Edward Grandbois Sharleen Grewal Kunsang Gyaltsen Nabil Hafez Birhane Hagos Jennifer Hall Charlotte Henson Andrew Hollinger Tracey Honan Monika D Huard Leanne Hughes Brian Hurhula M Erii Husby Asha Kamat Ben Kanga Seva Kashin Dmitry Khazanovich Peter Kisner Krista Lance Marcia Lara William Lee Niall Lennon Frances Letendre Rosie LeVine Alex Lipovsky Xiaohong Liu Jinlei Liu Shangtao Liu Tashi Lokyitsang Yeshi Lokyitsang Rakela Lubonja Annie Lui Pen MacDonald Vasilia Magnisalis Kebede Maru Charles Matthews William McCusker Susan McDonough Teena Mehta James Meldrim Louis Meneus Oana Mihai Atanas Mihalev Tanya Mihova Rachel Mittelman Valentine Mlenga Anna Montmayeur Leonidas Mulrain Adam Navidi Jerome Naylor Tamrat Negash Thu Nguyen Nga Nguyen Robert Nicol Choe Norbu Nyima Norbu Nathaniel Novod Barry O'Neill Sahal Osman Eva Markiewicz Otero L Oyono Christopher Patti Pema Phunkhang Fritz Pierre Margaret Priest Sujaa Raghuraman Filip Rege Rebecca Reyes Cecil Rise Peter Rogov Keenan Ross Elizabeth Ryan Sampath Settipalli Terry Shea Ngawang Sherpa Lu Shi Diana Shih Todd Sparrow Jessica Spaulding John Stalker Nicole Stange-Thomann Sharon Stavropoulos Catherine Stone Christopher Strader Senait Tesfaye Talene Thomson Yama Thoulutsang Dawa Thoulutsang Kerri Topham Ira Topping Tsamla Tsamla Helen Vassiliev Andy Vo Tsering Wangchuk Tsering Wangdi Michael Weiand Jane Wilkinson Adam Wilson Shailendra Yadav Geneva Young Qing Yu Lisa Zembek Danni Zhong Andrew Zimmer Zac Zwirko David B Jaffe Pablo Alvarez Will Brockman Jonathan Butler CheeWhye Chin Sante Gnerre Manfred Grabherr Michael Kleber Evan Mauceli Iain MacCallum

Nature 2007 Nov;450(7167):203-18

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.

View Article and Find Full Text PDF
November 2007

Genetic approaches to studying adenosine-to-inosine RNA editing.

Methods Enzymol 2007 ;424:265-87

Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA.

View Article and Find Full Text PDF
September 2007

Comparative genomic and bioinformatic approaches for the identification of new adenosine-to-inosine substrates.

Methods Enzymol 2007 ;424:245-64

Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA.

View Article and Find Full Text PDF
September 2007

A model genetic system for testing the in vivo function of peptide toxins.

Peptides 2007 Jan 1;28(1):51-6. Epub 2006 Dec 1.

Department of Molecular, Microbial & Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

View Article and Find Full Text PDF
January 2007

Tuning of RNA editing by ADAR is required in Drosophila.

EMBO J 2005 Jun 26;24(12):2183-93. Epub 2005 May 26.

MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

View Article and Find Full Text PDF
June 2005

Molecular determinants and guided evolution of species-specific RNA editing.

Authors:
Robert A Reenan

Nature 2005 Mar;434(7031):409-13

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

View Article and Find Full Text PDF
March 2005

Identification of alternative splicing regulators by RNA interference in Drosophila.

Proc Natl Acad Sci U S A 2004 Nov 18;101(45):15974-9. Epub 2004 Oct 18.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3301, USA.

View Article and Find Full Text PDF
November 2004

Control of human potassium channel inactivation by editing of a small mRNA hairpin.

Nat Struct Mol Biol 2004 Oct 7;11(10):950-6. Epub 2004 Sep 7.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

View Article and Find Full Text PDF
October 2004

Nervous system targets of RNA editing identified by comparative genomics.

Science 2003 Aug;301(5634):832-6

Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

View Article and Find Full Text PDF
August 2003