Robert R Langley

Robert R Langley

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Robert R Langley

Robert R Langley

Publications by authors named "Robert R Langley"

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Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel.

Neuro Oncol 2016 Apr;18(4):486-96

Department of Cancer Biology, Metastasis Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas (H.J.L., M.H., S.-J.K., H.Y., M.S.K., J.H., R.R.L., I.J.F.); Actelion Pharmaceuticals, Ltd., Allschwil, Switzerland (F.L., U.R.).

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http://dx.doi.org/10.1093/neuonc/now037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799693PMC
April 2016

Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer.

Mol Cancer Ther 2015 Dec 29;14(12):2677-86. Epub 2015 Oct 29.

Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674355PMC
December 2015

Modulation of the cancer cell transcriptome by culture media formulations and cell density.

Int J Oncol 2015 May 17;46(5):2067-75. Epub 2015 Mar 17.

Department of Cancer Biology, Metastasis Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.3892/ijo.2015.2930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383016PMC
May 2015

Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.

Neuro Oncol 2014 Dec 9;16(12):1585-98. Epub 2014 Jul 9.

Department of Cancer Biology, Metastasis Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.W.K., H.J.C., H.-J.L., J.H., Q.W., R.R.L., I.J.F., S.-J.K.).

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http://dx.doi.org/10.1093/neuonc/nou128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232084PMC
December 2014

DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway.

Cell Rep 2013 Jun 20;3(6):2100-12. Epub 2013 Jun 20.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796289PMC
June 2013

The biology of brain metastasis.

Clin Chem 2013 Jan 31;59(1):180-9. Epub 2012 Oct 31.

Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1373/clinchem.2012.193342DOI Listing
January 2013

Crosstalk between the DNA damage response pathway and microRNAs.

Cell Mol Life Sci 2012 Sep 20;69(17):2895-906. Epub 2012 Mar 20.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://link.springer.com/10.1007/s00018-012-0959-8
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http://dx.doi.org/10.1007/s00018-012-0959-8DOI Listing
September 2012

Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse.

Int Immunopharmacol 2011 Jul 18;11(7):862-72. Epub 2011 Jan 18.

Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.intimp.2011.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086935PMC
July 2011

The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs.

Int J Cancer 2011 Jun 25;128(11):2527-35. Epub 2011 Mar 25.

Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/ijc.26031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075088PMC
June 2011

Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar.

Am J Pathol 2011 May;178(5):2357-66

Department of Cancer Biology-Cancer Metastasis Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.01.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081177PMC
May 2011

Nitric oxide-mediated tumoricidal activity of murine microglial cells.

Transl Oncol 2010 Dec 1;3(6):380-8. Epub 2010 Dec 1.

Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000463PMC
http://dx.doi.org/10.1593/tlo.10208DOI Listing
December 2010

Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma.

Neoplasia 2010 Feb;12(2):173-82

Department of Surgical and Radiological Sciences, University of California Davis School of Medicine, Davis, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814355PMC
http://dx.doi.org/10.1593/neo.91604DOI Listing
February 2010

Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis.

Int J Oncol 2009 Oct;35(4):665-72

Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882684PMC
http://dx.doi.org/10.3892/ijo_00000378DOI Listing
October 2009

Estrous cycle modulates ovarian carcinoma growth.

Clin Cancer Res 2009 May 21;15(9):2971-8. Epub 2009 Apr 21.

Department of Gynecologic Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743312PMC
May 2009

Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.

Clin Exp Metastasis 2008 7;25(4):477-89. Epub 2008 Mar 7.

Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10585-008-9153-7DOI Listing
August 2008

Impact of vessel maturation on antiangiogenic therapy in ovarian cancer.

Am J Obstet Gynecol 2008 Apr;198(4):477.e1-9; discussion 477.e9-10

Department of Gynecologic Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ajog.2007.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346589PMC
April 2008

Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.

Mol Cancer Ther 2007 Oct 3;6(10):2652-63. Epub 2007 Oct 3.

Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0759DOI Listing
October 2007

The role of the organ microenvironment in the biology and therapy of cancer metastasis.

J Cell Biochem 2007 Jul;101(4):927-36

Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/jcb.21148DOI Listing
July 2007

Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis.

Endocr Rev 2007 May 4;28(3):297-321. Epub 2007 Apr 4.

Department of Cancer Biology, Unit 173, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1210/er.2006-0027DOI Listing
May 2007

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade.

Mol Cancer Ther 2007 Feb;6(2):471-83

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Unit 97, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0416DOI Listing
February 2007

High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.

Cancer Res 2006 Apr;66(8):4198-207

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3842DOI Listing
April 2006

Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine.

Cancer Res 2005 Dec;65(23):10794-800

Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77230-1429, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534114PMC
December 2005

Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.

Neoplasia 2005 Dec;7(12):1065-72

Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501175PMC
http://dx.doi.org/10.1593/neo.05553DOI Listing
December 2005

Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells.

Clin Exp Metastasis 2004 ;21(8):747-53

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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August 2005

Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells.

Cancer Res 2004 Jun;64(11):3727-30

Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-3863DOI Listing
June 2004

Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis.

Cancer Res 2003 Jun;63(11):2971-6

Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

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June 2003