Publications by authors named "Robert Plumb"

90Publications

UHPLC-MS-Based Lipidomic and Metabonomic Investigation of the Metabolic Phenotypes of Wild Type and Hepatic CYP Reductase Null (HRN) Mice.

J Pharm Biomed Anal 2020 Jul 18;186:113318. Epub 2020 Apr 18.

Division of Computational and Systems Medicine, Dept. of Metabolism, Digestion and Reproduction, Imperial College, London, SW7 2AZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2020.113318DOI Listing
July 2020

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC-MS.

Bioanalysis 2020 Apr 28;12(7):485-500. Epub 2020 Apr 28.

Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio-2020-0015DOI Listing
April 2020

Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish.

J Endocrinol 2020 04;245(1):39-51

Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JOE-19-0413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040496PMC
April 2020

Rapid profiling method for the analysis of lipids in human plasma using ion mobility enabled-reversed phase-ultra high performance liquid chromatography/mass spectrometry.

J Chromatogr A 2020 Jan 4;1611:460597. Epub 2019 Oct 4.

Dept Metabolism, Digestion and Reproduction, Imperial College, South Kensington, London, SW7 2AZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2019.460597DOI Listing
January 2020

Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-Treated Liver-Humanized PXB Mice.

J Proteome Res 2019 11 8;18(11):4055-4064. Epub 2019 Oct 8.

Waters Corporation , 34 Maple Street , Milford , Massachusetts 01757 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.9b00334DOI Listing
November 2019

Untargeted LC/MS-based metabolic phenotyping (metabonomics/metabolomics): The state of the art.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jun 8;1117:136-147. Epub 2019 Apr 8.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2019.04.009DOI Listing
June 2019

Development of a rapid profiling method for the analysis of polar analytes in urine using HILIC-MS and ion mobility enabled HILIC-MS.

Metabolomics 2019 01 22;15(2):17. Epub 2019 Jan 22.

Separations Science and Metabolomics laboratory, Murdoch University, South Street, 6150, Murdoch, WA, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-019-1474-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342856PMC
January 2019

A validated UPLC-MS/MS assay for the quantification of amino acids and biogenic amines in rat urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Feb 29;1106-1107:50-57. Epub 2018 Dec 29.

Australian National Phenome Centre, Murdoch University, Harry Perkins Building, Perth, WA, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2018.12.028DOI Listing
February 2019

The metabolic fate and effects of 2-Bromophenol in male Sprague-Dawley rats.

Xenobiotica 2019 Nov 22;49(11):1352-1359. Epub 2019 Feb 22.

Department of Surgery and Cancer Faculty of Medicine, Imperial College London, South Kensington Campus, London, United Kingdom.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/00498254.2018.1
Publisher Site
http://dx.doi.org/10.1080/00498254.2018.1559376DOI Listing
November 2019

Capillary ultra performance liquid chromatography-tandem mass spectrometry analysis of tienilic acid metabolites in urine following intravenous administration to the rat.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jun 26;1087-1088:142-148. Epub 2018 Apr 26.

Waters Corporation, Milford, MA, 01757, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2018.04.034DOI Listing
June 2018

Ion mobility spectrometry combined with ultra performance liquid chromatography/mass spectrometry for metabolic phenotyping of urine: Effects of column length, gradient duration and ion mobility spectrometry on metabolite detection.

Anal Chim Acta 2017 Aug 19;982:1-8. Epub 2017 Jun 19.

Waters Corporation, Milford, MA, 01757, USA; Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2017.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533171PMC
August 2017

High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.

Anal Chem 2017 02 7;89(4):2478-2487. Epub 2017 Feb 7.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b04623DOI Listing
February 2017

Analysis of polar urinary metabolites for metabolic phenotyping using supercritical fluid chromatography and mass spectrometry.

J Chromatogr A 2016 Jun 19;1449:141-55. Epub 2016 Apr 19.

Analytical and Environmental Sciences Division, Faculty of Life Sciences & Medicine, Franklin-Wilkins Building, King's College London, London SE1 9NH, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2016.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927693PMC
June 2016

Development of a Rapid Microbore Metabolic Profiling Ultraperformance Liquid Chromatography-Mass Spectrometry Approach for High-Throughput Phenotyping Studies.

Anal Chem 2016 06 9;88(11):5742-51. Epub 2016 May 9.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b00038DOI Listing
June 2016

Integration of microfluidic LC with HRMS for the analysis of analytes in biofluids: past, present and future.

Bioanalysis 2015 ;7(11):1397-411

Imperial College, Division of Surgery & Cancer, South Kensington, London, SW7 2AZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.15.68DOI Listing
March 2016

High-Throughput Microbore UPLC-MS Metabolic Phenotyping of Urine for Large-Scale Epidemiology Studies.

J Proteome Res 2015 Jun 11;14(6):2714-21. Epub 2015 May 11.

†Division of Computational and Systems Medicine, Department of Surgery and Cancer, South Kensington Campus, London, SW7 2AZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.5b00203DOI Listing
June 2015

Identification of a novel human circulating metabolite of tenofovir disoproxil fumarate with LC-MS/MS.

Bioanalysis 2015 ;7(6):643-52

Division of Computational & Systems Medicine, Department of Surgery & Cancer, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.14.300DOI Listing
January 2016

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation.

J Proteome Res 2014 Sep 15;13(9):4143-54. Epub 2014 Aug 15.

Department of Biochemistry and Molecular & Cellular Biology, Georgetown University , Washington DC 20057, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr5005295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156265PMC
September 2014

Ultra high resolution SFC-MS as a high throughput platform for metabolic phenotyping: application to metabolic profiling of rat and dog bile.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Sep 18;966:200-7. Epub 2014 Apr 18.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2014.04.017DOI Listing
September 2014

Current practice of liquid chromatography-mass spectrometry in metabolomics and metabonomics.

J Pharm Biomed Anal 2014 Jan 17;87:12-25. Epub 2013 Jul 17.

Department of Chemical Engineering, Aristotle University Thessaloniki, 541 24 Thessaloniki, Greece. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2013.06.032DOI Listing
January 2014

Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the quantification of ephedrines using medium-resolution accurate mass spectrometry.

J Chromatogr A 2013 May 19;1289:37-46. Epub 2013 Mar 19.

Waters Centre for Innovation in Separation Science, Analytical and Environmental Science Division, School of Biomedical Sciences, Franklin Wilkins-Building, King's College London, London SE1 9NH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2013.03.021DOI Listing
May 2013

Global metabolic profiling of animal and human tissues via UPLC-MS.

Nat Protoc 2013 Jan 6;8(1):17-32. Epub 2012 Dec 6.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2012.135DOI Listing
January 2013

Investigation of basic mobile phases with positive ESI LC-MS for metabonomics studies.

Bioanalysis 2012 Dec;4(23):2833-42

King's College London, School of Pharmacy, Stamford St, London SE1 9NH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.12.258DOI Listing
December 2012

Systematic evaluation of acetone and acetonitrile for use in hydrophilic interaction liquid chromatography coupled with electrospray ionization mass spectrometry of basic small molecules.

Rapid Commun Mass Spectrom 2011 Dec;25(24):3666-74

Pharmaceutical Science Division, School of Biomedical and Health Sciences, King's College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.5271DOI Listing
December 2011

Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling.

Anal Chem 2012 Mar 13;84(5):2424-32. Epub 2012 Feb 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, London, SW7 2AZ, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac203200xDOI Listing
March 2012

Comprehensive investigation of the influence of acidic, basic, and organic mobile phase compositions on bioanalytical assay sensitivity in positive ESI mode LC/MS/MS.

J Pharm Biomed Anal 2012 Feb 25;59:138-50. Epub 2011 Oct 25.

King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2011.10.021DOI Listing
February 2012

Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines.

J Chromatogr A 2012 Mar 24;1228:329-37. Epub 2011 Sep 24.

Analytical and Environmental Sciences, School of Biomedical Sciences, King's College, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2011.09.026DOI Listing
March 2012

Addressing the challenge of limited sample volumes in in vitro studies with capillary-scale microfluidic LC-MS/MS.

Bioanalysis 2011 Apr;3(8):873-82

Kings College London, School of Pharmacy, Micro Separations Group, 150 Stamford Street, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.11.48DOI Listing
April 2011

Rapid analysis of dried blood spot samples with sub-2-µm LC-MS/MS.

Bioanalysis 2011 Feb;3(4):411-20

Waters Corporation, Pharmaceutical Business Operation, Milford, MA, USA.

View Article

Download full-text PDF

Source
http://www.future-science.com/doi/10.4155/bio.10.210
Publisher Site
http://dx.doi.org/10.4155/bio.10.210DOI Listing
February 2011

HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies.

Anal Chem 2011 Jan 13;83(1):382-90. Epub 2010 Dec 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac102523qDOI Listing
January 2011

A novel LC-MS approach for the detection of metabolites in DMPK studies.

Bioanalysis 2010 Oct;2(10):1767-78

Imperial College, Division of Surgery & Oncology, South Kensington, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio.10.115DOI Listing
October 2010

Development of a high sensitivity bioanalytical method for alprazolam using ultra-performance liquid chromatography/tandem mass spectrometry.

Drug Test Anal 2010 Jan;2(1):11-8

Pharmaceutical Business Operations, Waters Corporation, Milford, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dta.90DOI Listing
January 2010

Global metabolic profiling procedures for urine using UPLC-MS.

Nat Protoc 2010 Jun;5(6):1005-18

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2010.50DOI Listing
June 2010

Application of ultra performance liquid chromatography-mass spectrometry to profiling rat and dog bile.

J Proteome Res 2009 May;8(5):2495-500

Pharmaceutical Business Operations, Waters Corporation, Milford, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr801078aDOI Listing
May 2009

1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies.

Anal Chem 2008 Sep 14;80(18):6835-44. Epub 2008 Aug 14.

Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Sir Alexander Fleming Building, Imperial College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac801075mDOI Listing
September 2008

Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research.

J Sep Sci 2008 Apr;31(6-7):1015-26

Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, P. R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.200700650DOI Listing
April 2008

A rapid simple approach to screening pharmaceutical products using ultra-performance LC coupled to time-of-flight mass spectrometry and pattern recognition.

J Chromatogr Sci 2008 Mar;46(3):193-8

Imperial College, Faculty of Medicine, Sir Alexander Fleming Building, South Kensington, London, UK, SW7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/chromsci/46.3.193DOI Listing
March 2008

Genome-wide detection and characterization of positive selection in human populations.

Authors:
Pardis C Sabeti Patrick Varilly Ben Fry Jason Lohmueller Elizabeth Hostetter Chris Cotsapas Xiaohui Xie Elizabeth H Byrne Steven A McCarroll Rachelle Gaudet Stephen F Schaffner Eric S Lander Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda Todd A Johnson James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):913-8

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA.

View Article

Download full-text PDF

Source
https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/Le
Web Search
http://www.nature.com/doifinder/10.1038/nature06250
Publisher Site
http://dx.doi.org/10.1038/nature06250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687721PMC
October 2007

A second generation human haplotype map of over 3.1 million SNPs.

Authors:
Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):851-61

The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA.

View Article

Download full-text PDF

Source
https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/In
Web Search
http://www.nature.com/doifinder/10.1038/nature06258
Publisher Site
http://dx.doi.org/10.1038/nature06258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689609PMC
October 2007

The application of small porous particles, high temperatures, and high pressures to generate very high resolution LC and LC/MS separations.

J Sep Sci 2007 May;30(8):1158-66

Pharmaceutical Application and Development Manager, Waters Corporation, 34 Maple Street, M/S GC, Milford, MA 01757, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.200600492DOI Listing
May 2007

A metabonomic study of strain- and age-related differences in the Zucker rat.

Rapid Commun Mass Spectrom 2007 ;21(13):2039-45

AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.3059DOI Listing
August 2007

Generation of ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities.

Anal Chem 2006 Oct;78(20):7278-83

Biological Chemistry, Division of Biomedical Sciences, Sir Alexander Fleming Building, Imperial College London, SW7 2AZ, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac060935jDOI Listing
October 2006

A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis.

Analyst 2006 Oct 15;131(10):1075-8. Epub 2006 Aug 15.

Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK SK10 4TG.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b604498kDOI Listing
October 2006

Statistical search space reduction and two-dimensional data display approaches for UPLC-MS in biomarker discovery and pathway analysis.

Anal Chem 2006 Jul;78(13):4398-408

Biological Chemistry, Division of Biomedical Sciences, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac060168oDOI Listing
July 2006

UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation.

Rapid Commun Mass Spectrom 2006 ;20(13):1989-94

Biological Chemistry, Biomedical Sciences Division, Faculty of Natural Sciences, Sir Alexander Fleming Building, Imperial College, London SW7 2AZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.2550DOI Listing
August 2007

Future costs for long-term care: cost projections for long-term care for older people in the United Kingdom.

Health Policy 2006 Jan 22;75(2):187-213. Epub 2005 Apr 22.

Faculty of Actuarial Science and Statistics Cass Business School, City University, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healthpol.2005.03.006DOI Listing
January 2006

Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS.

J Pharm Biomed Anal 2005 Sep;39(3-4):805-10

Waters Corporation, 34 Maple Street, M/S GC, Milford, MA 01757, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2005.04.048DOI Listing
September 2005

A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.

J Pharm Biomed Anal 2005 Jul 26;38(3):465-71. Epub 2005 Feb 26.

Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2005.01.013DOI Listing
July 2005

[Metabonomics and its applications].

Sheng Wu Gong Cheng Xue Bao 2005 Jan;21(1):1-5

National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116011, China.

View Article

Download full-text PDF

Source
January 2005

High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

J Proteome Res 2005 Mar-Apr;4(2):591-8

AstraZeneca, Dept of Drug Metabolism and Pharmacokinetics, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr049769rDOI Listing
July 2005

A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition.

Rapid Commun Mass Spectrom 2005 ;19(6):798-804

Waters Corporation (MS Technology Center), Floats Road, Manchester M23 9LZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.1855DOI Listing
May 2005

HPLC-MS-based methods for the study of metabonomics.

J Chromatogr B Analyt Technol Biomed Life Sci 2005 Mar;817(1):67-76

Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK104TG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2004.07.045DOI Listing
March 2005

Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences.

Analyst 2003 Jul;128(7):819-23

Life Sciences Research and Development, Waters Corporation, 34 Maple St, Milford, MA 01757, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b304296kDOI Listing
July 2003

Initial sequencing and comparative analysis of the mouse genome.

Authors:
Robert H Waterston Kerstin Lindblad-Toh Ewan Birney Jane Rogers Josep F Abril Pankaj Agarwal Richa Agarwala Rachel Ainscough Marina Alexandersson Peter An Stylianos E Antonarakis John Attwood Robert Baertsch Jonathon Bailey Karen Barlow Stephan Beck Eric Berry Bruce Birren Toby Bloom Peer Bork Marc Botcherby Nicolas Bray Michael R Brent Daniel G Brown Stephen D Brown Carol Bult John Burton Jonathan Butler Robert D Campbell Piero Carninci Simon Cawley Francesca Chiaromonte Asif T Chinwalla Deanna M Church Michele Clamp Christopher Clee Francis S Collins Lisa L Cook Richard R Copley Alan Coulson Olivier Couronne James Cuff Val Curwen Tim Cutts Mark Daly Robert David Joy Davies Kimberly D Delehaunty Justin Deri Emmanouil T Dermitzakis Colin Dewey Nicholas J Dickens Mark Diekhans Sheila Dodge Inna Dubchak Diane M Dunn Sean R Eddy Laura Elnitski Richard D Emes Pallavi Eswara Eduardo Eyras Adam Felsenfeld Ginger A Fewell Paul Flicek Karen Foley Wayne N Frankel Lucinda A Fulton Robert S Fulton Terrence S Furey Diane Gage Richard A Gibbs Gustavo Glusman Sante Gnerre Nick Goldman Leo Goodstadt Darren Grafham Tina A Graves Eric D Green Simon Gregory Roderic Guigó Mark Guyer Ross C Hardison David Haussler Yoshihide Hayashizaki LaDeana W Hillier Angela Hinrichs Wratko Hlavina Timothy Holzer Fan Hsu Axin Hua Tim Hubbard Adrienne Hunt Ian Jackson David B Jaffe L Steven Johnson Matthew Jones Thomas A Jones Ann Joy Michael Kamal Elinor K Karlsson Donna Karolchik Arkadiusz Kasprzyk Jun Kawai Evan Keibler Cristyn Kells W James Kent Andrew Kirby Diana L Kolbe Ian Korf Raju S Kucherlapati Edward J Kulbokas David Kulp Tom Landers J P Leger Steven Leonard Ivica Letunic Rosie Levine Jia Li Ming Li Christine Lloyd Susan Lucas Bin Ma Donna R Maglott Elaine R Mardis Lucy Matthews Evan Mauceli John H Mayer Megan McCarthy W Richard McCombie Stuart McLaren Kirsten McLay John D McPherson Jim Meldrim Beverley Meredith Jill P Mesirov Webb Miller Tracie L Miner Emmanuel Mongin Kate T Montgomery Michael Morgan Richard Mott James C Mullikin Donna M Muzny William E Nash Joanne O Nelson Michael N Nhan Robert Nicol Zemin Ning Chad Nusbaum Michael J O'Connor Yasushi Okazaki Karen Oliver Emma Overton-Larty Lior Pachter Genís Parra Kymberlie H Pepin Jane Peterson Pavel Pevzner Robert Plumb Craig S Pohl Alex Poliakov Tracy C Ponce Chris P Ponting Simon Potter Michael Quail Alexandre Reymond Bruce A Roe Krishna M Roskin Edward M Rubin Alistair G Rust Ralph Santos Victor Sapojnikov Brian Schultz Jörg Schultz Matthias S Schwartz Scott Schwartz Carol Scott Steven Seaman Steve Searle Ted Sharpe Andrew Sheridan Ratna Shownkeen Sarah Sims Jonathan B Singer Guy Slater Arian Smit Douglas R Smith Brian Spencer Arne Stabenau Nicole Stange-Thomann Charles Sugnet Mikita Suyama Glenn Tesler Johanna Thompson David Torrents Evanne Trevaskis John Tromp Catherine Ucla Abel Ureta-Vidal Jade P Vinson Andrew C Von Niederhausern Claire M Wade Melanie Wall Ryan J Weber Robert B Weiss Michael C Wendl Anthony P West Kris Wetterstrand Raymond Wheeler Simon Whelan Jamey Wierzbowski David Willey Sophie Williams Richard K Wilson Eitan Winter Kim C Worley Dudley Wyman Shan Yang Shiaw-Pyng Yang Evgeny M Zdobnov Michael C Zody Eric S Lander

Nature 2002 Dec;420(6915):520-62

Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature01262DOI Listing
December 2002

Multidimensional chromatography coupled to electrospray ionization time-of-flight mass spectrometry as an alternative to two-dimensional gels for the identification and analysis of complex mixtures of intact proteins.

J Chromatogr B Analyt Technol Biomed Life Sci 2002 Dec;782(1-2):267-89

Life Sciences R&D Group, Waters Corporation, 34 Maple Street, Mail Stop TG, Milford, MA 01757, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1570-0232(02)00554-8DOI Listing
December 2002