Robert Plenge

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, Broad Institute, Cambridge, Massachusetts, and Centre for Musculoskeletal Research, University of Manchester and Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.

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April 2017

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Authors:

Solveig K Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O Falcao Christine Suver Bruce Hoff Venkat S K Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-Ud-Din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R Kramer Pekka Marttinen Aziz M Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P Tak Danielle Gerlag Tom W J Huizinga Fina Kurreeman Cornelia F Allaart S Louis Bridges Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M Mangravite

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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October 2016

The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.

Authors:

Gang Li Pierre Cunin Di Wu Dorothée Diogo Yu Yang Yukinori Okada Robert M Plenge Peter A Nigrovic

PLoS Genet 2016 09 14;12(9):e1006292. Epub 2016 Sep 14.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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September 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Authors:

Solveig K Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O Falcao Christine Suver Bruce Hoff Venkat S K Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-Ud-Din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R Kramer Pekka Marttinen Aziz M Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P Tak Danielle Gerlag Tom W J Huizinga Fina Kurreeman Cornelia F Allaart S Louis Bridges Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M Mangravite

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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August 2016

Disciplined approach to drug discovery and early development.

Authors:

Robert M Plenge

Sci Transl Med 2016 07;8(349):349ps15

Merck Research Laboratories, Boston, MA 02115, USA. Email:

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July 2016

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Authors:

Paul L Klarenbeek Marieke E Doorenspleet Rebecca E E Esveldt Barbera D C van Schaik Neubury Lardy Antoine H C van Kampen Paul P Tak Robert M Plenge Frank Baas Paul I W de Bakker Niek de Vries

PLoS One 2015 30;10(10):e0140815. Epub 2015 Oct 30.

Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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June 2016

Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.

Authors:

Annie Yarwood Sebastien Viatte Yukinori Okada Robert Plenge Kazuhiko Yamamoto Anne Barton Deborah Symmons Soumya Raychaudhuri Lars Klareskog Peter Gregersen Jane Worthington Steve Eyre

Ann Rheum Dis 2016 Jan 17;75(1):317-20. Epub 2015 Sep 17.

Faculty of Medical and Human Sciences, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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January 2016

Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts.

Authors:

Katherine P Liao Ashwin N Ananthakrishnan Vishesh Kumar Zongqi Xia Andrew Cagan Vivian S Gainer Sergey Goryachev Pei Chen Guergana K Savova Denis Agniel Susanne Churchill Jaeyoung Lee Shawn N Murphy Robert M Plenge Peter Szolovits Isaac Kohane Stanley Y Shaw Elizabeth W Karlson Tianxi Cai

PLoS One 2015 24;10(8):e0136651. Epub 2015 Aug 24.

Children's Hospital Informatics Program, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.

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May 2016

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:

S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

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October 2015

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.

Eur J Hum Genet 2016 Feb 13;24(2):263-70. Epub 2015 May 13.

Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

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February 2016

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

Authors:

Dorothée Diogo Lisa Bastarache Katherine P Liao Robert R Graham Robert S Fulton Jeffrey D Greenberg Steve Eyre John Bowes Jing Cui Annette Lee Dimitrios A Pappas Joel M Kremer Anne Barton Marieke J H Coenen Barbara Franke Lambertus A Kiemeney Xavier Mariette Corrine Richard-Miceli Helena Canhão João E Fonseca Niek de Vries Paul P Tak J Bart A Crusius Michael T Nurmohamed Fina Kurreeman Ted R Mikuls Yukinori Okada Eli A Stahl David E Larson Tracie L Deluca Michelle O'Laughlin Catrina C Fronick Lucinda L Fulton Roman Kosoy Michael Ransom Tushar R Bhangale Ward Ortmann Andrew Cagan Vivian Gainer Elizabeth W Karlson Isaac Kohane Shawn N Murphy Javier Martin Alexandra Zhernakova Lars Klareskog Leonid Padyukov Jane Worthington Elaine R Mardis Michael F Seldin Peter K Gregersen Timothy Behrens Soumya Raychaudhuri Joshua C Denny Robert M Plenge

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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March 2016

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