Robert Plenge

Robert Plenge

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Robert Plenge

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Priority index for human genetics and drug discovery.

Authors:
Robert M Plenge

Nat Genet 2019 Jul;51(7):1073-1075

Research & Early Development, Celgene Corporation, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-019-0460-5DOI Listing
July 2019

Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients.

Authors:
Soha R Dargham Sumeja Zahirovic Mohammed Hammoudeh Samar Al Emadi Basel K Masri Hussein Halabi Humeira Badsha Imad Uthman Ziyad R Mahfoud Hadil Ashour Wissam Gad El Haq Karim Bayoumy Marianthi Kapiri Richa Saxena Robert M Plenge Layla Kazkaz Thurayya Arayssi

PLoS One 2018 19;13(12):e0208240. Epub 2018 Dec 19.

Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208240PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300286PMC
May 2019

Correction: Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients.

Authors:
Soha R Dargham Sumeja Zahirovic Mohammed Hammoudeh Samar Al Emadi Basel K Masri Hussein Halabi Humeira Badsha Imad Uthman Ziyad R Mahfoud Hadil Ashour Wissam Gad El Haq Karim Bayoumy Marianthi Kapiri Richa Saxena Robert M Plenge Layla Kazkaz Thurayya Arayssi

PLoS One 2019 18;14(3):e0214258. Epub 2019 Mar 18.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214258PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422291PMC
March 2019

Phenome-wide association studies across large population cohorts support drug target validation.

Authors:
Dorothée Diogo Chao Tian Christopher S Franklin Mervi Alanne-Kinnunen Michael March Chris C A Spencer Ciara Vangjeli Michael E Weale Hannele Mattsson Elina Kilpeläinen Patrick M A Sleiman Dermot F Reilly Joshua McElwee Joseph C Maranville Arnaub K Chatterjee Aman Bhandari Khanh-Dung H Nguyen Karol Estrada Mary-Pat Reeve Janna Hutz Nan Bing Sally John Daniel G MacArthur Veikko Salomaa Samuli Ripatti Hakon Hakonarson Mark J Daly Aarno Palotie David A Hinds Peter Donnelly Caroline S Fox Aaron G Day-Williams Robert M Plenge Heiko Runz

Nat Commun 2018 10 16;9(1):4285. Epub 2018 Oct 16.

Merck Sharp & Dohme, Boston, MA, 02115, USA.

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http://www.nature.com/articles/s41467-018-06540-3
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http://dx.doi.org/10.1038/s41467-018-06540-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191429PMC
October 2018

Genomic atlas of the human plasma proteome.

Authors:
Benjamin B Sun Joseph C Maranville James E Peters David Stacey James R Staley James Blackshaw Stephen Burgess Tao Jiang Ellie Paige Praveen Surendran Clare Oliver-Williams Mihir A Kamat Bram P Prins Sheri K Wilcox Erik S Zimmerman An Chi Narinder Bansal Sarah L Spain Angela M Wood Nicholas W Morrell John R Bradley Nebojsa Janjic David J Roberts Willem H Ouwehand John A Todd Nicole Soranzo Karsten Suhre Dirk S Paul Caroline S Fox Robert M Plenge John Danesh Heiko Runz Adam S Butterworth

Nature 2018 06 6;558(7708):73-79. Epub 2018 Jun 6.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41586-018-0175-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697541PMC
June 2018

Large Scale Metabolic Profiling identifies Novel Steroids linked to Rheumatoid Arthritis.

Authors:
Noha A Yousri Karim Bayoumy Wessam Gad Elhaq Robert P Mohney Samar Al Emadi Mohammed Hammoudeh Hussein Halabi Basel Masri Humeira Badsha Imad Uthman Robert Plenge Richa Saxena Karsten Suhre Thurayya Arayssi

Sci Rep 2017 08 22;7(1):9137. Epub 2017 Aug 22.

Department of Medicine, Weill Cornell Medical College-Qatar, Education City, Doha, Qatar.

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http://dx.doi.org/10.1038/s41598-017-05439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567269PMC
August 2017

A Multinational Arab Genome-Wide Association Study Identifies New Genetic Associations for Rheumatoid Arthritis.

Authors:
Richa Saxena Robert M Plenge Andrew C Bjonnes Hassan S Dashti Yukinori Okada Wessam Gad El Haq Mohammed Hammoudeh Samar Al Emadi Basel K Masri Hussein Halabi Humeira Badsha Imad W Uthman Lauren Margolin Namrata Gupta Ziyad R Mahfoud Marianthi Kapiri Soha R Dargham Grace Aranki Layla A Kazkaz Thurayya Arayssi

Arthritis Rheumatol 2017 05 31;69(5):976-985. Epub 2017 Mar 31.

Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.

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http://dx.doi.org/10.1002/art.40051DOI Listing
May 2017

Biomedicine: Human genes lost and their functions found.

Authors:
Robert M Plenge

Nature 2017 04;544(7649):171-172

Translational Medicine Department, Merck, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/544171aDOI Listing
April 2017

Brief Report: The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis.

Authors:
Jing Cui Dorothee Diogo Eli A Stahl Helena Canhao Xavier Mariette Jeffrey D Greenberg Yukinori Okada Dimitrios A Pappas Robert S Fulton Paul P Tak Michael T Nurmohamed Annette Lee David E Larson Fina Kurreeman Tracie L Deluca Michelle O'Laughlin Catrina C Fronick Lucinda L Fulton Elaine R Mardis Irene E van der Horst-Bruinsma Gert-Jan Wolbink Peter K Gregersen Joel M Kremer J Bart A Crusius Niek de Vries Tom W J Huizinga João Eurico Fonseca Corinne Miceli-Richard Elizabeth W Karlson Marieke J H Coenen Anne Barton Robert M Plenge Soumya Raychaudhuri

Arthritis Rheumatol 2017 04;69(4):735-741

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, Broad Institute, Cambridge, Massachusetts, and Centre for Musculoskeletal Research, University of Manchester and Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.

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http://dx.doi.org/10.1002/art.39966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669377PMC
April 2017

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Authors:
Solveig K Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O Falcao Christine Suver Bruce Hoff Venkat S K Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-Ud-Din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R Kramer Pekka Marttinen Aziz M Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P Tak Danielle Gerlag Tom W J Huizinga Fina Kurreeman Cornelia F Allaart S Louis Bridges Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M Mangravite

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.

Authors:
Gang Li Pierre Cunin Di Wu Dorothée Diogo Yu Yang Yukinori Okada Robert M Plenge Peter A Nigrovic

PLoS Genet 2016 09 14;12(9):e1006292. Epub 2016 Sep 14.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023119PMC
September 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Authors:
Solveig K Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O Falcao Christine Suver Bruce Hoff Venkat S K Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-Ud-Din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R Kramer Pekka Marttinen Aziz M Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P Tak Danielle Gerlag Tom W J Huizinga Fina Kurreeman Cornelia F Allaart S Louis Bridges Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M Mangravite

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

Disciplined approach to drug discovery and early development.

Authors:
Robert M Plenge

Sci Transl Med 2016 07;8(349):349ps15

Merck Research Laboratories, Boston, MA 02115, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aaf2608DOI Listing
July 2016

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Authors:
Paul L Klarenbeek Marieke E Doorenspleet Rebecca E E Esveldt Barbera D C van Schaik Neubury Lardy Antoine H C van Kampen Paul P Tak Robert M Plenge Frank Baas Paul I W de Bakker Niek de Vries

PLoS One 2015 30;10(10):e0140815. Epub 2015 Oct 30.

Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140815PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627806PMC
June 2016

Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts.

Authors:
Katherine P Liao Ashwin N Ananthakrishnan Vishesh Kumar Zongqi Xia Andrew Cagan Vivian S Gainer Sergey Goryachev Pei Chen Guergana K Savova Denis Agniel Susanne Churchill Jaeyoung Lee Shawn N Murphy Robert M Plenge Peter Szolovits Isaac Kohane Stanley Y Shaw Elizabeth W Karlson Tianxi Cai

PLoS One 2015 24;10(8):e0136651. Epub 2015 Aug 24.

Children's Hospital Informatics Program, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136651PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547801PMC
May 2016

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

Authors:
Dorothée Diogo Lisa Bastarache Katherine P Liao Robert R Graham Robert S Fulton Jeffrey D Greenberg Steve Eyre John Bowes Jing Cui Annette Lee Dimitrios A Pappas Joel M Kremer Anne Barton Marieke J H Coenen Barbara Franke Lambertus A Kiemeney Xavier Mariette Corrine Richard-Miceli Helena Canhão João E Fonseca Niek de Vries Paul P Tak J Bart A Crusius Michael T Nurmohamed Fina Kurreeman Ted R Mikuls Yukinori Okada Eli A Stahl David E Larson Tracie L Deluca Michelle O'Laughlin Catrina C Fronick Lucinda L Fulton Roman Kosoy Michael Ransom Tushar R Bhangale Ward Ortmann Andrew Cagan Vivian Gainer Elizabeth W Karlson Isaac Kohane Shawn N Murphy Javier Martin Alexandra Zhernakova Lars Klareskog Leonid Padyukov Jane Worthington Elaine R Mardis Michael F Seldin Peter K Gregersen Timothy Behrens Soumya Raychaudhuri Joshua C Denny Robert M Plenge

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388675PMC
March 2016

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.

Authors:
Lude Franke Hanane el Bannoudi Diahann T S L Jansen Klaas Kok Gosia Trynka Dorothee Diogo Morris Swertz Karin Fransen Rachel Knevel Javier Gutierrez-Achury Lisbeth Ärlestig Jeffrey D Greenberg Joel Kremer Dimitrios A Pappas Alexandros Kanterakis Rinse K Weersma Annette H M van der Helm-van Mil Viktor Guryev Solbritt Rantapää-Dahlqvist Peter K Gregersen Robert M Plenge Cisca Wijmenga Tom W-J Huizinga Andreea Ioan-Facsinay Rene E M Toes Alexandra Zhernakova

Eur J Hum Genet 2016 Feb 13;24(2):263-70. Epub 2015 May 13.

Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2015.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717214PMC
February 2016

Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.

Authors:
Annie Yarwood Sebastien Viatte Yukinori Okada Robert Plenge Kazuhiko Yamamoto Anne Barton Deborah Symmons Soumya Raychaudhuri Lars Klareskog Peter Gregersen Jane Worthington Steve Eyre

Ann Rheum Dis 2016 Jan 17;75(1):317-20. Epub 2015 Sep 17.

Faculty of Medical and Human Sciences, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-207210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717396PMC
January 2016

TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.

Authors:
Helena Canhão Ana Maria Rodrigues Maria José Santos Diana Carmona-Fernandes Bruno F Bettencourt Jing Cui Fabiana L Rocha José Canas Silva Joaquim Polido-Pereira José Alberto Pereira Silva José António Costa Domingos Araujo Cândida Silva Helena Santos Cátia Duarte Rafael Cáliz Ileana Filipescu Fernando Pimentel-Santos Jaime Branco Juan Sainz Robert M Plenge Daniel H Solomon Jácome Bruges-Armas José António P Da Silva João Eurico Fonseca Elizabeth W Karlson

Biomed Res Int 2015 5;2015:490295. Epub 2015 Mar 5.

Division of Rheumatology, Allergy and Immunology, Section of Clinical Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1155/2015/490295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365300PMC
December 2015

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:
S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

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http://dx.doi.org/10.1093/ije/dyv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881824PMC
October 2015

Lack of gene-diuretic interactions on the risk of incident gout: the Nurses' Health Study and Health Professionals Follow-up Study.

Authors:
Ying Bao Gary Curhan Tony Merriman Robert Plenge Peter Kraft Hyon K Choi

Ann Rheum Dis 2015 Jul 9;74(7):1394-8. Epub 2015 Feb 9.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2014-206534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016261PMC
July 2015

Allele-specific methylation occurs at genetic variants associated with complex disease.

Authors:
John N Hutchinson Towfique Raj Jes Fagerness Eli Stahl Fernando T Viloria Alexander Gimelbrant Johanna Seddon Mark Daly Andrew Chess Robert Plenge

PLoS One 2014 9;9(6):e98464. Epub 2014 Jun 9.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098464PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049588PMC
June 2015

(Epi)Genetic analyses of age-related macular degeneration: case-control and discordant twin studies.

Authors:
John N Hutchinson Jes Fagerness Andrew Kirby Robyn Reynolds Alex Zak Alexander Gimelbrant Robert Plenge Mark Daly Andrew Chess Johanna M Seddon

Hum Hered 2014 12;78(2):59-72. Epub 2014 Jul 12.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000362814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476332PMC
April 2015

Accuracy of the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as a research tool for identification of patients with uveitis and scleritis.

Authors:
Eduardo Uchiyama Sepideh Faez Humzah Nasir Sebastian H Unizony Robert Plenge George N Papaliodis Lucia Sobrin

Ophthalmic Epidemiol 2015 Apr;22(2):139-41

Uveitis and Ocular Immunology Division, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston, MA , USA .

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http://www.tandfonline.com/doi/full/10.3109/09286586.2015.10
Publisher Site
http://dx.doi.org/10.3109/09286586.2015.1012274DOI Listing
April 2015

Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.

Authors:
Steven Gazal Karim Sacre Yannick Allanore Maria Teruel Alison H Goodall Shigeto Tohma Lars Alfredsson Yukinori Okada Gang Xie Arnaud Constantin Alejandro Balsa Aya Kawasaki Pascale Nicaise Christopher Amos Luis Rodriguez-Rodriguez Gilles Chiocchia Catherine Boileau Jinyi Zhang Olivier Vittecoq Thomas Barnetche Miguel A Gonzalez Gay Hiroshi Furukawa Alain Cantagrel Xavier Le Loët Takayuki Sumida Margarita Hurtado-Nedelec Christophe Richez Sylvie Chollet-Martin Thierry Schaeverbeke Bernard Combe Liliane Khoryati Baptiste Coustet Jammel El-Benna Katherine Siminovitch Robert Plenge Leonid Padyukov Javier Martin Naoyuki Tsuchiya Philippe Dieudé

Ann Rheum Dis 2015 Mar 21;74(3):e19. Epub 2014 Jan 21.

Department of Rheumatology, DHU FIRE, Assistance Publique Hôpitaux de Paris, Bichat Hospital, Université Paris Diderot, PRES Sorbonne Paris Cité, Paris, France Bichat Faculty of Medicine, INSERM U699, Université Paris Diderot, PRES Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1136/annrheumdis-2013-204581DOI Listing
March 2015

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

Authors:
Kwangwoo Kim So-Young Bang Hye-Soon Lee Soo-Kyung Cho Chan-Bum Choi Yoon-Kyoung Sung Tae-Hwan Kim Jae-Bum Jun Dae Hyun Yoo Young Mo Kang Seong-Kyu Kim Chang-Hee Suh Seung-Cheol Shim Shin-Seok Lee Jisoo Lee Won Tae Chung Jung-Yoon Choe Hyoung Doo Shin Jong-Young Lee Bok-Ghee Han Swapan K Nath Steve Eyre John Bowes Dimitrios A Pappas Joel M Kremer Miguel A Gonzalez-Gay Luis Rodriguez-Rodriguez Lisbeth Ärlestig Yukinori Okada Dorothée Diogo Katherine P Liao Elizabeth W Karlson Soumya Raychaudhuri Solbritt Rantapää-Dahlqvist Javier Martin Lars Klareskog Leonid Padyukov Peter K Gregersen Jane Worthington Jeffrey D Greenberg Robert M Plenge Sang-Cheol Bae

Ann Rheum Dis 2015 Mar 14;74(3):e13. Epub 2014 Feb 14.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.

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http://dx.doi.org/10.1136/annrheumdis-2013-204749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986PMC
March 2015

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.

Authors:
Annie Yarwood Buhm Han Soumya Raychaudhuri John Bowes Mark Lunt Dimitrios A Pappas Joel Kremer Jeffrey D Greenberg Robert Plenge Jane Worthington Anne Barton Steve Eyre

Ann Rheum Dis 2015 Jan 3;74(1):170-6. Epub 2013 Oct 3.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20413
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http://dx.doi.org/10.1136/annrheumdis-2013-204133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283663PMC
January 2015

Genomic architecture of pharmacological efficacy and adverse events.

Authors:
Aparna Chhibber Deanna L Kroetz Kelan G Tantisira Michael McGeachie Cheng Cheng Robert Plenge Eli Stahl Wolfgang Sadee Marylyn D Ritchie Sarah A Pendergrass

Pharmacogenomics 2014 Dec;15(16):2025-48

Department of Bioengineering & Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.2217/pgs.14.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308414PMC
December 2014

HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues.

Authors:
Richard J Reynolds Altan F Ahmed Maria I Danila Laura B Hughes Peter K Gregersen Soumya Raychaudhuri Robert M Plenge S Louis Bridges

Arthritis Rheumatol 2014 Dec;66(12):3274-82

University of Alabama at, Birmingham.

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http://dx.doi.org/10.1002/art.38855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273668PMC
December 2014

Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.

Authors:
Jennifer A Sinnott Wei Dai Katherine P Liao Stanley Y Shaw Ashwin N Ananthakrishnan Vivian S Gainer Elizabeth W Karlson Susanne Churchill Peter Szolovits Shawn Murphy Isaac Kohane Robert Plenge Tianxi Cai

Hum Genet 2014 Nov 26;133(11):1369-82. Epub 2014 Jul 26.

Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA,

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http://dx.doi.org/10.1007/s00439-014-1466-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185241PMC
November 2014

A role for noncoding variation in schizophrenia.

Authors:
Panos Roussos Amanda C Mitchell Georgios Voloudakis John F Fullard Venu M Pothula Jonathan Tsang Eli A Stahl Anastasios Georgakopoulos Douglas M Ruderfer Alexander Charney Yukinori Okada Katherine A Siminovitch Jane Worthington Leonid Padyukov Lars Klareskog Peter K Gregersen Robert M Plenge Soumya Raychaudhuri Menachem Fromer Shaun M Purcell Kristen J Brennand Nikolaos K Robakis Eric E Schadt Schahram Akbarian Pamela Sklar

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

Authors:
Yukinori Okada Dorothee Diogo Jeffrey D Greenberg Faten Mouassess Walid A L Achkar Robert S Fulton Joshua C Denny Namrata Gupta Daniel Mirel Stacy Gabriel Gang Li Joel M Kremer Dimitrios A Pappas Robert J Carroll Anne E Eyler Gosia Trynka Eli A Stahl Jing Cui Richa Saxena Marieke J H Coenen Henk-Jan Guchelaar Tom W J Huizinga Philippe Dieudé Xavier Mariette Anne Barton Helena Canhão João E Fonseca Niek de Vries Paul P Tak Larry W Moreland S Louis Bridges Corinne Miceli-Richard Hyon K Choi Yoichiro Kamatani Pilar Galan Mark Lathrop Towfique Raj Philip L De Jager Soumya Raychaudhuri Jane Worthington Leonid Padyukov Lars Klareskog Katherine A Siminovitch Peter K Gregersen Elaine R Mardis Thurayya Arayssi Layla A Kazkaz Robert M Plenge

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

Modeling disease severity in multiple sclerosis using electronic health records.

Authors:
Zongqi Xia Elizabeth Secor Lori B Chibnik Riley M Bove Suchun Cheng Tanuja Chitnis Andrew Cagan Vivian S Gainer Pei J Chen Katherine P Liao Stanley Y Shaw Ashwin N Ananthakrishnan Peter Szolovits Howard L Weiner Elizabeth W Karlson Shawn N Murphy Guergana K Savova Tianxi Cai Susanne E Churchill Robert M Plenge Isaac S Kohane Philip L De Jager

PLoS One 2013 11;8(11):e78927. Epub 2013 Nov 11.

Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America ; Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823928PMC
August 2014

Quantifying missing heritability at known GWAS loci.

Authors:
Alexander Gusev Gaurav Bhatia Noah Zaitlen Bjarni J Vilhjalmsson Dorothée Diogo Eli A Stahl Peter K Gregersen Jane Worthington Lars Klareskog Soumya Raychaudhuri Robert M Plenge Bogdan Pasaniuc Alkes L Price

PLoS Genet 2013 26;9(12):e1003993. Epub 2013 Dec 26.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873246PMC
August 2014

Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.

Authors:
Katherine P Liao Dorothée Diogo Jing Cui Tianxi Cai Yukinori Okada Vivian S Gainer Shawn N Murphy Namrata Gupta Daniel Mirel Ashwin N Ananthakrishnan Peter Szolovits Stanley Y Shaw Soumya Raychaudhuri Susanne Churchill Isaac Kohane Elizabeth W Karlson Robert M Plenge

Ann Rheum Dis 2014 Jun 28;73(6):1170-5. Epub 2013 May 28.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, , Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2012-203202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815491PMC
June 2014

Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records.

Authors:
Chen Lin Elizabeth W Karlson Helena Canhao Timothy A Miller Dmitriy Dligach Pei Jun Chen Raul Natanael Guzman Perez Yuanyan Shen Michael E Weinblatt Nancy A Shadick Robert M Plenge Guergana K Savova

PLoS One 2013 16;8(8):e69932. Epub 2013 Aug 16.

Informatics Program, Boston Children's Hospital, Boston, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745469PMC
April 2014

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Authors:
Buhm Han Dorothée Diogo Steve Eyre Henrik Kallberg Alexandra Zhernakova John Bowes Leonid Padyukov Yukinori Okada Miguel A González-Gay Solbritt Rantapää-Dahlqvist Javier Martin Tom W J Huizinga Robert M Plenge Jane Worthington Peter K Gregersen Lars Klareskog Paul I W de Bakker Soumya Raychaudhuri

Am J Hum Genet 2014 Apr 20;94(4):522-32. Epub 2014 Mar 20.

Division of Genetics, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA; Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980428PMC
April 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Authors:
Yukinori Okada Di Wu Gosia Trynka Towfique Raj Chikashi Terao Katsunori Ikari Yuta Kochi Koichiro Ohmura Akari Suzuki Shinji Yoshida Robert R Graham Arun Manoharan Ward Ortmann Tushar Bhangale Joshua C Denny Robert J Carroll Anne E Eyler Jeffrey D Greenberg Joel M Kremer Dimitrios A Pappas Lei Jiang Jian Yin Lingying Ye Ding-Feng Su Jian Yang Gang Xie Ed Keystone Harm-Jan Westra Tõnu Esko Andres Metspalu Xuezhong Zhou Namrata Gupta Daniel Mirel Eli A Stahl Dorothée Diogo Jing Cui Katherine Liao Michael H Guo Keiko Myouzen Takahisa Kawaguchi Marieke J H Coenen Piet L C M van Riel Mart A F J van de Laar Henk-Jan Guchelaar Tom W J Huizinga Philippe Dieudé Xavier Mariette S Louis Bridges Alexandra Zhernakova Rene E M Toes Paul P Tak Corinne Miceli-Richard So-Young Bang Hye-Soon Lee Javier Martin Miguel A Gonzalez-Gay Luis Rodriguez-Rodriguez Solbritt Rantapää-Dahlqvist Lisbeth Arlestig Hyon K Choi Yoichiro Kamatani Pilar Galan Mark Lathrop Steve Eyre John Bowes Anne Barton Niek de Vries Larry W Moreland Lindsey A Criswell Elizabeth W Karlson Atsuo Taniguchi Ryo Yamada Michiaki Kubo Jun S Liu Sang-Cheol Bae Jane Worthington Leonid Padyukov Lars Klareskog Peter K Gregersen Soumya Raychaudhuri Barbara E Stranger Philip L De Jager Lude Franke Peter M Visscher Matthew A Brown Hisashi Yamanaka Tsuneyo Mimori Atsushi Takahashi Huji Xu Timothy W Behrens Katherine A Siminovitch Shigeki Momohara Fumihiko Matsuda Kazuhiko Yamamoto Robert M Plenge

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.

Authors:
Dorothée Diogo Yukinori Okada Robert M Plenge

Curr Opin Rheumatol 2014 Jan;26(1):85-92

aDivision of Rheumatology, Immunology bDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston cMedical and Population Genetics Program, Broad Institute, Cambridge dMerck Research Laboratories, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000012DOI Listing
January 2014

Lipid and lipoprotein levels and trend in rheumatoid arthritis compared to the general population.

Authors:
Katherine P Liao Tianxi Cai Vivian S Gainer Andrew Cagan Shawn N Murphy Chihchin Liu Susanne Churchill Stanley Y Shaw Isaac Kohane Daniel H Solomon Robert M Plenge Elizabeth W Karlson

Arthritis Care Res (Hoboken) 2013 Dec;65(12):2046-50

Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/acr.22091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060244PMC
December 2013

Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data.

Authors:
Kate McAllister Annie Yarwood John Bowes Gisela Orozco Sebastian Viatte Dorothée Diogo Lynne J Hocking Sophia Steer Paul Wordsworth A G Wilson Ann W Morgan Joel M Kremer Dimitrios Pappas Peter Gregersen Lars Klareskog Robert Plenge Anne Barton Jeffrey Greenberg Jane Worthington Stephen Eyre

Arthritis Rheum 2013 Dec;65(12):3058-62

University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, and Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/art.38183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034583PMC
December 2013

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.

Authors:
Maša Umiċeviċ Mirkov Jing Cui Sita H Vermeulen Eli A Stahl Erik J M Toonen Remco R Makkinje Annette T Lee Tom W J Huizinga Renee Allaart Anne Barton Xavier Mariette Corinne Richard Miceli Lindsey A Criswell Paul P Tak Niek de Vries Saedis Saevarsdottir Leonid Padyukov S Louis Bridges Dirk-Jan van Schaardenburg Tim L Jansen Ellen A J Dutmer Mart A F J van de Laar Pilar Barrera Timothy R D J Radstake Piet L C M van Riel Hans Scheffer Barbara Franke Han G Brunner Robert M Plenge Peter K Gregersen Henk-Jan Guchelaar Marieke J H Coenen

Ann Rheum Dis 2013 Aug 11;72(8):1375-81. Epub 2012 Dec 11.

Department of Human Genetics, Radboud University Nijmegen Medical Centre, , Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2012-202405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169706PMC
August 2013

Editorial: entering the age of whole-exome sequencing in rheumatic diseases: novel insights into disease pathogenicity.

Authors:
Yukinori Okada Robert M Plenge

Arthritis Rheum 2013 Aug;65(8):1975-9

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http://dx.doi.org/10.1002/art.38011DOI Listing
August 2013

Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease.

Authors:
Ashwin N Ananthakrishnan Andrew Cagan Vivian S Gainer Tianxi Cai Su-Chun Cheng Guergana Savova Pei Chen Peter Szolovits Zongqi Xia Philip L De Jager Stanley Y Shaw Susanne Churchill Elizabeth W Karlson Isaac Kohane Robert M Plenge Shawn N Murphy Katherine P Liao

Inflamm Bowel Dis 2013 Aug;19(9):1921-7

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1097/MIB.0b013e3182902ad9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720838PMC
August 2013

Validating therapeutic targets through human genetics.

Authors:
Robert M Plenge Edward M Scolnick David Altshuler

Nat Rev Drug Discov 2013 Aug 19;12(8):581-94. Epub 2013 Jul 19.

Division of Rheumatology, Immunology and Allergy, Brigham And Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd4051DOI Listing
August 2013

Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.

Authors:
Gang Xie Yue Lu Ye Sun Steven Shiyang Zhang Edward Clark Keystone Peter K Gregersen Robert M Plenge Christopher I Amos Katherine A Siminovitch

Ann Rheum Dis 2013 Jul 6;72(7):1249-54. Epub 2012 Dec 6.

Mount Sinai Hospital Samuel Lunenfeld Research Institute and Toronto General Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/annrheumdis-2012-202076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686260PMC
July 2013

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.

Authors:
H Benjamin Larman Uri Laserson Luis Querol Katrijn Verhaeghen Nicole L Solimini George Jing Xu Paul L Klarenbeek George M Church David A Hafler Robert M Plenge Peter A Nigrovic Philip L De Jager Ilse Weets Geert A Martens Kevin C O'Connor Stephen J Elledge

J Autoimmun 2013 Jun 13;43:1-9. Epub 2013 Mar 13.

Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.jaut.2013.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677742PMC
June 2013

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.

Authors:
Michael J McGeachie Eli A Stahl Blanca E Himes Sarah A Pendergrass John J Lima Charles G Irvin Stephen P Peters Marylyn D Ritchie Robert M Plenge Kelan G Tantisira

Pharmacogenet Genomics 2013 Jun;23(6):324-8

Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283607acfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767309PMC
June 2013

Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach.

Authors:
Ashwin N Ananthakrishnan Tianxi Cai Guergana Savova Su-Chun Cheng Pei Chen Raul Guzman Perez Vivian S Gainer Shawn N Murphy Peter Szolovits Zongqi Xia Stanley Shaw Susanne Churchill Elizabeth W Karlson Isaac Kohane Robert M Plenge Katherine P Liao

Inflamm Bowel Dis 2013 Jun;19(7):1411-20

Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1097/MIB.0b013e31828133fdDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665760PMC
June 2013

Informed conditioning on clinical covariates increases power in case-control association studies.

Authors:
Noah Zaitlen Sara Lindström Bogdan Pasaniuc Marilyn Cornelis Giulio Genovese Samuela Pollack Anne Barton Heike Bickeböller Donald W Bowden Steve Eyre Barry I Freedman David J Friedman John K Field Leif Groop Aage Haugen Joachim Heinrich Brian E Henderson Pamela J Hicks Lynne J Hocking Laurence N Kolonel Maria Teresa Landi Carl D Langefeld Loic Le Marchand Michael Meister Ann W Morgan Olaide Y Raji Angela Risch Albert Rosenberger David Scherf Sophia Steer Martin Walshaw Kevin M Waters Anthony G Wilson Paul Wordsworth Shanbeh Zienolddiny Eric Tchetgen Tchetgen Christopher Haiman David J Hunter Robert M Plenge Jane Worthington David C Christiani Debra A Schaumberg Daniel I Chasman David Altshuler Benjamin Voight Peter Kraft Nick Patterson Alkes L Price

PLoS Genet 2012 8;8(11):e1003032. Epub 2012 Nov 8.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493452PMC
May 2013

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.

Authors:
Robert M Plenge Jeffrey D Greenberg Lara M Mangravite Jonathan M J Derry Eli A Stahl Marieke J H Coenen Anne Barton Leonid Padyukov Lars Klareskog Peter K Gregersen Xavier Mariette Larry W Moreland S Louis Bridges Niek de Vries Tom W J Huizinga Henk-Jan Guchelaar Stephen H Friend Gustavo Stolovitzky

Nat Genet 2013 May;45(5):468-9

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http://dx.doi.org/10.1038/ng.2623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084858PMC
May 2013

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

Authors:
Gang Li Dorothée Diogo Di Wu Jim Spoonamore Vlado Dancik Lude Franke Fina Kurreeman Elizabeth J Rossin Grant Duclos Cathy Hartland Xuezhong Zhou Kejie Li Jun Liu Philip L De Jager Katherine A Siminovitch Alexandra Zhernakova Soumya Raychaudhuri John Bowes Steve Eyre Leonid Padyukov Peter K Gregersen Jane Worthington Namrata Gupta Paul A Clemons Eli Stahl Nicola Tolliday Robert M Plenge

PLoS Genet 2013 May 16;9(5):e1003487. Epub 2013 May 16.

Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656093PMC
May 2013

Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis.

Authors:
Dimitrios A Pappas Cheongeun Oh Robert M Plenge Joel M Kremer Jeffrey D Greenberg

Inflammation 2013 Apr;36(2):279-84

Division of Rheumatology, Department of Medicine, New York Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, P&S Building, Suite 10-455, New York, NY 10032, USA.

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http://dx.doi.org/10.1007/s10753-012-9544-4DOI Listing
April 2013

Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis.

Authors:
Ashwin N Ananthakrishnan Vivian S Gainer Tianxi Cai Raul Guzman Perez Su-Chun Cheng Guergana Savova Pei Chen Peter Szolovits Zongqi Xia Philip L De Jager Stanley Shaw Susanne Churchill Elizabeth W Karlson Isaac Kohane Roy H Perlis Robert M Plenge Shawn N Murphy Katherine P Liao

Am J Gastroenterol 2013 Apr 22;108(4):594-601. Epub 2013 Jan 22.

Crohn's and Colitis Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/ajg.2012.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627544PMC
April 2013

Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls.

Authors:
Katherine P Liao Fina Kurreeman Gang Li Grant Duclos Shawn Murphy Raul Guzman Tianxi Cai Namrata Gupta Vivian Gainer Peter Schur Jing Cui Joshua C Denny Peter Szolovits Susanne Churchill Isaac Kohane Elizabeth W Karlson Robert M Plenge

Arthritis Rheum 2013 Mar;65(3):571-81

Brigham and Women's Hospital, 75 Francis Street, PBB-B3, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/art.37801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582761PMC
March 2013

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.

Authors:
Jing Cui Eli A Stahl Saedis Saevarsdottir Corinne Miceli Dorothee Diogo Gosia Trynka Towfique Raj Maša Umiċeviċ Mirkov Helena Canhao Katsunori Ikari Chikashi Terao Yukinori Okada Sara Wedrén Johan Askling Hisashi Yamanaka Shigeki Momohara Atsuo Taniguchi Koichiro Ohmura Fumihiko Matsuda Tsuneyo Mimori Namrata Gupta Manik Kuchroo Ann W Morgan John D Isaacs Anthony G Wilson Kimme L Hyrich Marieke Herenius Marieke E Doorenspleet Paul-Peter Tak J Bart A Crusius Irene E van der Horst-Bruinsma Gert Jan Wolbink Piet L C M van Riel Mart van de Laar Henk-Jan Guchelaar Nancy A Shadick Cornelia F Allaart Tom W J Huizinga Rene E M Toes Robert P Kimberly S Louis Bridges Lindsey A Criswell Larry W Moreland João Eurico Fonseca Niek de Vries Barbara E Stranger Philip L De Jager Soumya Raychaudhuri Michael E Weinblatt Peter K Gregersen Xavier Mariette Anne Barton Leonid Padyukov Marieke J H Coenen Elizabeth W Karlson Robert M Plenge

PLoS Genet 2013 Mar 28;9(3):e1003394. Epub 2013 Mar 28.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610685PMC
March 2013

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Authors:
Anna Köttgen Eva Albrecht Alexander Teumer Veronique Vitart Jan Krumsiek Claudia Hundertmark Giorgio Pistis Daniela Ruggiero Conall M O'Seaghdha Toomas Haller Qiong Yang Toshiko Tanaka Andrew D Johnson Zoltán Kutalik Albert V Smith Julia Shi Maksim Struchalin Rita P S Middelberg Morris J Brown Angelo L Gaffo Nicola Pirastu Guo Li Caroline Hayward Tatijana Zemunik Jennifer Huffman Loic Yengo Jing Hua Zhao Ayse Demirkan Mary F Feitosa Xuan Liu Giovanni Malerba Lorna M Lopez Pim van der Harst Xinzhong Li Marcus E Kleber Andrew A Hicks Ilja M Nolte Asa Johansson Federico Murgia Sarah H Wild Stephan J L Bakker John F Peden Abbas Dehghan Maristella Steri Albert Tenesa Vasiliki Lagou Perttu Salo Massimo Mangino Lynda M Rose Terho Lehtimäki Owen M Woodward Yukinori Okada Adrienne Tin Christian Müller Christopher Oldmeadow Margus Putku Darina Czamara Peter Kraft Laura Frogheri Gian Andri Thun Anne Grotevendt Gauti Kjartan Gislason Tamara B Harris Lenore J Launer Patrick McArdle Alan R Shuldiner Eric Boerwinkle Josef Coresh Helena Schmidt Michael Schallert Nicholas G Martin Grant W Montgomery Michiaki Kubo Yusuke Nakamura Toshihiro Tanaka Patricia B Munroe Nilesh J Samani David R Jacobs Kiang Liu Pio D'Adamo Sheila Ulivi Jerome I Rotter Bruce M Psaty Peter Vollenweider Gerard Waeber Susan Campbell Olivier Devuyst Pau Navarro Ivana Kolcic Nicholas Hastie Beverley Balkau Philippe Froguel Tõnu Esko Andres Salumets Kay Tee Khaw Claudia Langenberg Nicholas J Wareham Aaron Isaacs Aldi Kraja Qunyuan Zhang Philipp S Wild Rodney J Scott Elizabeth G Holliday Elin Org Margus Viigimaa Stefania Bandinelli Jeffrey E Metter Antonio Lupo Elisabetta Trabetti Rossella Sorice Angela Döring Eva Lattka Konstantin Strauch Fabian Theis Melanie Waldenberger H-Erich Wichmann Gail Davies Alan J Gow Marcel Bruinenberg Ronald P Stolk Jaspal S Kooner Weihua Zhang Bernhard R Winkelmann Bernhard O Boehm Susanne Lucae Brenda W Penninx Johannes H Smit Gary Curhan Poorva Mudgal Robert M Plenge Laura Portas Ivana Persico Mirna Kirin James F Wilson Irene Mateo Leach Wiek H van Gilst Anuj Goel Halit Ongen Albert Hofman Fernando Rivadeneira Andre G Uitterlinden Medea Imboden Arnold von Eckardstein Francesco Cucca Ramaiah Nagaraja Maria Grazia Piras Matthias Nauck Claudia Schurmann Kathrin Budde Florian Ernst Susan M Farrington Evropi Theodoratou Inga Prokopenko Michael Stumvoll Antti Jula Markus Perola Veikko Salomaa So-Youn Shin Tim D Spector Cinzia Sala Paul M Ridker Mika Kähönen Jorma Viikari Christian Hengstenberg Christopher P Nelson James F Meschia Michael A Nalls Pankaj Sharma Andrew B Singleton Naoyuki Kamatani Tanja Zeller Michel Burnier John Attia Maris Laan Norman Klopp Hans L Hillege Stefan Kloiber Hyon Choi Mario Pirastu Silvia Tore Nicole M Probst-Hensch Henry Völzke Vilmundur Gudnason Afshin Parsa Reinhold Schmidt John B Whitfield Myriam Fornage Paolo Gasparini David S Siscovick Ozren Polašek Harry Campbell Igor Rudan Nabila Bouatia-Naji Andres Metspalu Ruth J F Loos Cornelia M van Duijn Ingrid B Borecki Luigi Ferrucci Giovanni Gambaro Ian J Deary Bruce H R Wolffenbuttel John C Chambers Winfried März Peter P Pramstaller Harold Snieder Ulf Gyllensten Alan F Wright Gerjan Navis Hugh Watkins Jacqueline C M Witteman Serena Sanna Sabine Schipf Malcolm G Dunlop Anke Tönjes Samuli Ripatti Nicole Soranzo Daniela Toniolo Daniel I Chasman Olli Raitakari W H Linda Kao Marina Ciullo Caroline S Fox Mark Caulfield Murielle Bochud Christian Gieger

Nat Genet 2013 Feb 23;45(2):145-54. Epub 2012 Dec 23.

Renal Division, Freiburg University Hospital, Freiburg, Germany.

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http://dx.doi.org/10.1038/ng.2500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663712PMC
February 2013

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

Authors:
Dorothée Diogo Fina Kurreeman Eli A Stahl Katherine P Liao Namrata Gupta Jeffrey D Greenberg Manuel A Rivas Brendan Hickey Jason Flannick Brian Thomson Candace Guiducci Stephan Ripke Ivan Adzhubey Anne Barton Joel M Kremer Lars Alfredsson Shamil Sunyaev Javier Martin Alexandra Zhernakova John Bowes Steve Eyre Katherine A Siminovitch Peter K Gregersen Jane Worthington Lars Klareskog Leonid Padyukov Soumya Raychaudhuri Robert M Plenge

Am J Hum Genet 2013 Jan 20;92(1):15-27. Epub 2012 Dec 20.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542467PMC
January 2013

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

Authors:
Steve Eyre John Bowes Dorothée Diogo Annette Lee Anne Barton Paul Martin Alexandra Zhernakova Eli Stahl Sebastien Viatte Kate McAllister Christopher I Amos Leonid Padyukov Rene E M Toes Tom W J Huizinga Cisca Wijmenga Gosia Trynka Lude Franke Harm-Jan Westra Lars Alfredsson Xinli Hu Cynthia Sandor Paul I W de Bakker Sonia Davila Chiea Chuen Khor Khai Koon Heng Robert Andrews Sarah Edkins Sarah E Hunt Cordelia Langford Deborah Symmons Pat Concannon Suna Onengut-Gumuscu Stephen S Rich Panos Deloukas Miguel A Gonzalez-Gay Luis Rodriguez-Rodriguez Lisbeth Ärlsetig Javier Martin Solbritt Rantapää-Dahlqvist Robert M Plenge Soumya Raychaudhuri Lars Klareskog Peter K Gregersen Jane Worthington

Nat Genet 2012 Dec 11;44(12):1336-40. Epub 2012 Nov 11.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1038/ng.2462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761PMC
December 2012

Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.

Authors:
Sharon A Chung Gang Xie Delnaz Roshandel Richard Sherva Jeffrey C Edberg Megan Kravitz Paul F Dellaripa Gary S Hoffman Alfred D Mahr Philip Seo Ulrich Specks Robert F Spiera E William St Clair John H Stone Robert M Plenge Katherine A Siminovitch Peter A Merkel Paul A Monach

Arthritis Rheum 2012 Oct;64(10):3463-71

University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1002/art.34496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425721PMC
October 2012

GWAS implicates a role for quantitative immune traits and threshold effects in risk for human autoimmune disorders.

Authors:
Peter K Gregersen Betty Diamond Robert M Plenge

Curr Opin Immunol 2012 Oct 28;24(5):538-43. Epub 2012 Sep 28.

Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, United States.

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http://dx.doi.org/10.1016/j.coi.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758732PMC
October 2012

Portability of an algorithm to identify rheumatoid arthritis in electronic health records.

Authors:
Robert J Carroll Will K Thompson Anne E Eyler Arthur M Mandelin Tianxi Cai Raquel M Zink Jennifer A Pacheco Chad S Boomershine Thomas A Lasko Hua Xu Elizabeth W Karlson Raul G Perez Vivian S Gainer Shawn N Murphy Eric M Ruderman Richard M Pope Robert M Plenge Abel Ngo Kho Katherine P Liao Joshua C Denny

J Am Med Inform Assoc 2012 Jun 28;19(e1):e162-9. Epub 2012 Feb 28.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1136/amiajnl-2011-000583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392871PMC
June 2012

JAK and STAT signaling molecules in immunoregulation and immune-mediated disease.

Authors:
John J O'Shea Robert Plenge

Immunity 2012 Apr;36(4):542-50

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499974PMC
April 2012

Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.

Authors:
Fina A S Kurreeman Eli A Stahl Yukinori Okada Katherine Liao Dorothée Diogo Soumya Raychaudhuri Jan Freudenberg Yuta Kochi Nikolaos A Patsopoulos Namrata Gupta Cynthia Sandor So-Young Bang Hye-Soon Lee Leonid Padyukov Akari Suzuki Kathy Siminovitch Jane Worthington Peter K Gregersen Laura B Hughes Richard J Reynolds S Louis Bridges Sang-Cheol Bae Kazuhiko Yamamoto Robert M Plenge

Am J Hum Genet 2012 Mar 23;90(3):524-32. Epub 2012 Feb 23.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309197PMC
March 2012

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.

Authors:
Eli A Stahl Daniel Wegmann Gosia Trynka Javier Gutierrez-Achury Ron Do Benjamin F Voight Peter Kraft Robert Chen Henrik J Kallberg Fina A S Kurreeman Sekar Kathiresan Cisca Wijmenga Peter K Gregersen Lars Alfredsson Katherine A Siminovitch Jane Worthington Paul I W de Bakker Soumya Raychaudhuri Robert M Plenge

Nat Genet 2012 Mar 25;44(5):483-9. Epub 2012 Mar 25.

Division of Rheumatology Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560362PMC
March 2012

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.

Authors:
Yukinori Okada Chikashi Terao Katsunori Ikari Yuta Kochi Koichiro Ohmura Akari Suzuki Takahisa Kawaguchi Eli A Stahl Fina A S Kurreeman Nao Nishida Hiroko Ohmiya Keiko Myouzen Meiko Takahashi Tetsuji Sawada Yuichi Nishioka Masao Yukioka Tsukasa Matsubara Shigeyuki Wakitani Ryota Teshima Shigeto Tohma Kiyoshi Takasugi Kota Shimada Akira Murasawa Shigeru Honjo Keitaro Matsuo Hideo Tanaka Kazuo Tajima Taku Suzuki Takuji Iwamoto Yoshiya Kawamura Hisashi Tanii Yuji Okazaki Tsukasa Sasaki Peter K Gregersen Leonid Padyukov Jane Worthington Katherine A Siminovitch Mark Lathrop Atsuo Taniguchi Atsushi Takahashi Katsushi Tokunaga Michiaki Kubo Yusuke Nakamura Naoyuki Kamatani Tsuneyo Mimori Robert M Plenge Hisashi Yamanaka Shigeki Momohara Ryo Yamada Fumihiko Matsuda Kazuhiko Yamamoto

Nat Genet 2012 Mar 25;44(5):511-6. Epub 2012 Mar 25.

Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan.

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http://dx.doi.org/10.1038/ng.2231DOI Listing
March 2012

Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.

Authors:
Lori B Chibnik Brendan T Keenan Jing Cui Katherine P Liao Karen H Costenbader Robert M Plenge Elizabeth W Karlson

PLoS One 2011 12;6(9):e24380. Epub 2011 Sep 12.

Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171415PMC
January 2012

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

Authors:
Soumya Raychaudhuri Cynthia Sandor Eli A Stahl Jan Freudenberg Hye-Soon Lee Xiaoming Jia Lars Alfredsson Leonid Padyukov Lars Klareskog Jane Worthington Katherine A Siminovitch Sang-Cheol Bae Robert M Plenge Peter K Gregersen Paul I W de Bakker

Nat Genet 2012 Jan 29;44(3):291-6. Epub 2012 Jan 29.

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/ng.1076
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http://dx.doi.org/10.1038/ng.1076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288335PMC
January 2012

Recommendations for publication of genetic association studies in Arthritis & Rheumatism.

Authors:
Robert M Plenge S Louis Bridges Tom W J Huizinga Lindsey A Criswell Peter K Gregersen

Arthritis Rheum 2011 Oct;63(10):2839-47

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/art.30509DOI Listing
October 2011

Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets.

Authors:
Xinli Hu Hyun Kim Eli Stahl Robert Plenge Mark Daly Soumya Raychaudhuri

Am J Hum Genet 2011 Oct 29;89(4):496-506. Epub 2011 Sep 29.

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188838PMC
October 2011

Genomic technology applied to pharmacological traits.

Authors:
Jun J Yang Robert M Plenge

JAMA 2011 Aug;306(6):652-3

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2011.1125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295228PMC
August 2011

Personalized medicine in rheumatoid arthritis: miles to go before we sleep.

Authors:
Robert M Plenge S Louis Bridges

Arthritis Rheum 2011 Mar;63(3):590-3

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http://doi.wiley.com/10.1002/art.30126
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http://dx.doi.org/10.1002/art.30126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036067PMC
March 2011

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

Authors:
Alexandra Zhernakova Eli A Stahl Gosia Trynka Soumya Raychaudhuri Eleanora A Festen Lude Franke Harm-Jan Westra Rudolf S N Fehrmann Fina A S Kurreeman Brian Thomson Namrata Gupta Jihane Romanos Ross McManus Anthony W Ryan Graham Turner Elisabeth Brouwer Marcel D Posthumus Elaine F Remmers Francesca Tucci Rene Toes Elvira Grandone Maria Cristina Mazzilli Anna Rybak Bozena Cukrowska Marieke J H Coenen Timothy R D J Radstake Piet L C M van Riel Yonghong Li Paul I W de Bakker Peter K Gregersen Jane Worthington Katherine A Siminovitch Lars Klareskog Tom W J Huizinga Cisca Wijmenga Robert M Plenge

PLoS Genet 2011 Feb 24;7(2):e1002004. Epub 2011 Feb 24.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1002004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044685PMC
February 2011

Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study.

Authors:
Christine K Iannaccone Yvonne C Lee Jing Cui Michelle L Frits Roberta J Glass Robert M Plenge Daniel H Solomon Michael E Weinblatt Nancy A Shadick

Rheumatology (Oxford) 2011 Jan 16;50(1):40-6. Epub 2010 Sep 16.

Department of Medicine, Brigham and Women's Hospital, PBB-B3, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/rheumatology/keq263DOI Listing
January 2011

Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.

Authors:
Fina Kurreeman Katherine Liao Lori Chibnik Brendan Hickey Eli Stahl Vivian Gainer Gang Li Lynn Bry Scott Mahan Kristin Ardlie Brian Thomson Peter Szolovits Susanne Churchill Shawn N Murphy Tianxi Cai Soumya Raychaudhuri Isaac Kohane Elizabeth Karlson Robert M Plenge

Am J Hum Genet 2011 Jan;88(1):57-69

Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014362PMC
January 2011

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Authors:
Florencia Pereyra Xiaoming Jia Paul J McLaren Amalio Telenti Paul I W de Bakker Bruce D Walker Stephan Ripke Chanson J Brumme Sara L Pulit Mary Carrington Carl M Kadie Jonathan M Carlson David Heckerman Robert R Graham Robert M Plenge Steven G Deeks Lauren Gianniny Gabriel Crawford Jordan Sullivan Elena Gonzalez Leela Davies Amy Camargo Jamie M Moore Nicole Beattie Supriya Gupta Andrew Crenshaw Noël P Burtt Candace Guiducci Namrata Gupta Xiaojiang Gao Ying Qi Yuko Yuki Alicja Piechocka-Trocha Emily Cutrell Rachel Rosenberg Kristin L Moss Paul Lemay Jessica O'Leary Todd Schaefer Pranshu Verma Ildiko Toth Brian Block Brett Baker Alissa Rothchild Jeffrey Lian Jacqueline Proudfoot Donna Marie L Alvino Seanna Vine Marylyn M Addo Todd M Allen Marcus Altfeld Matthew R Henn Sylvie Le Gall Hendrik Streeck David W Haas Daniel R Kuritzkes Gregory K Robbins Robert W Shafer Roy M Gulick Cecilia M Shikuma Richard Haubrich Sharon Riddler Paul E Sax Eric S Daar Heather J Ribaudo Brian Agan Shanu Agarwal Richard L Ahern Brady L Allen Sherly Altidor Eric L Altschuler Sujata Ambardar Kathryn Anastos Ben Anderson Val Anderson Ushan Andrady Diana Antoniskis David Bangsberg Daniel Barbaro William Barrie J Bartczak Simon Barton Patricia Basden Nesli Basgoz Suzane Bazner Nicholaos C Bellos Anne M Benson Judith Berger Nicole F Bernard Annette M Bernard Christopher Birch Stanley J Bodner Robert K Bolan Emilie T Boudreaux Meg Bradley James F Braun Jon E Brndjar Stephen J Brown Katherine Brown Sheldon T Brown Jedidiah Burack Larry M Bush Virginia Cafaro Omobolaji Campbell John Campbell Robert H Carlson J Kevin Carmichael Kathleen K Casey Chris Cavacuiti Gregory Celestin Steven T Chambers Nancy Chez Lisa M Chirch Paul J Cimoch Daniel Cohen Lillian E Cohn Brian Conway David A Cooper Brian Cornelson David T Cox Michael V Cristofano George Cuchural Julie L Czartoski Joseph M Dahman Jennifer S Daly Benjamin T Davis Kristine Davis Sheila M Davod Edwin DeJesus Craig A Dietz Eleanor Dunham Michael E Dunn Todd B Ellerin Joseph J Eron John J W Fangman Claire E Farel Helen Ferlazzo Sarah Fidler Anita Fleenor-Ford Renee Frankel Kenneth A Freedberg Neel K French Jonathan D Fuchs Jon D Fuller Jonna Gaberman Joel E Gallant Rajesh T Gandhi Efrain Garcia Donald Garmon Joseph C Gathe Cyril R Gaultier Wondwoosen Gebre Frank D Gilman Ian Gilson Paul A Goepfert Michael S Gottlieb Claudia Goulston Richard K Groger T Douglas Gurley Stuart Haber Robin Hardwicke W David Hardy P Richard Harrigan Trevor N Hawkins Sonya Heath Frederick M Hecht W Keith Henry Melissa Hladek Robert P Hoffman James M Horton Ricky K Hsu Gregory D Huhn Peter Hunt Mark J Hupert Mark L Illeman Hans Jaeger Robert M Jellinger Mina John Jennifer A Johnson Kristin L Johnson Heather Johnson Kay Johnson Jennifer Joly Wilbert C Jordan Carol A Kauffman Homayoon Khanlou Robert K Killian Arthur Y Kim David D Kim Clifford A Kinder Jeffrey T Kirchner Laura Kogelman Erna Milunka Kojic P Todd Korthuis Wayne Kurisu Douglas S Kwon Melissa LaMar Harry Lampiris Massimiliano Lanzafame Michael M Lederman David M Lee Jean M L Lee Marah J Lee Edward T Y Lee Janice Lemoine Jay A Levy Josep M Llibre Michael A Liguori Susan J Little Anne Y Liu Alvaro J Lopez Mono R Loutfy Dawn Loy Debbie Y Mohammed Alan Man Michael K Mansour Vincent C Marconi Martin Markowitz Rui Marques Jeffrey N Martin Harold L Martin Kenneth Hugh Mayer M Juliana McElrath Theresa A McGhee Barbara H McGovern Katherine McGowan Dawn McIntyre Gavin X Mcleod Prema Menezes Greg Mesa Craig E Metroka Dirk Meyer-Olson Andy O Miller Kate Montgomery Karam C Mounzer Ellen H Nagami Iris Nagin Ronald G Nahass Margret O Nelson Craig Nielsen David L Norene David H O'Connor Bisola O Ojikutu Jason Okulicz Olakunle O Oladehin Edward C Oldfield Susan A Olender Mario Ostrowski William F Owen Eunice Pae Jeffrey Parsonnet Andrew M Pavlatos Aaron M Perlmutter Michael N Pierce Jonathan M Pincus Leandro Pisani Lawrence Jay Price Laurie Proia Richard C Prokesch Heather Calderon Pujet Moti Ramgopal Almas Rathod Michael Rausch J Ravishankar Frank S Rhame Constance Shamuyarira Richards Douglas D Richman Berta Rodes Milagros Rodriguez Richard C Rose Eric S Rosenberg Daniel Rosenthal Polly E Ross David S Rubin Elease Rumbaugh Luis Saenz Michelle R Salvaggio William C Sanchez Veeraf M Sanjana Steven Santiago Wolfgang Schmidt Hanneke Schuitemaker Philip M Sestak Peter Shalit William Shay Vivian N Shirvani Vanessa I Silebi James M Sizemore Paul R Skolnik Marcia Sokol-Anderson James M Sosman Paul Stabile Jack T Stapleton Sheree Starrett Francine Stein Hans-Jurgen Stellbrink F Lisa Sterman Valerie E Stone David R Stone Giuseppe Tambussi Randy A Taplitz Ellen M Tedaldi Amalio Telenti William Theisen Richard Torres Lorraine Tosiello Cecile Tremblay Marc A Tribble Phuong D Trinh Alice Tsao Peggy Ueda Anthony Vaccaro Emilia Valadas Thanes J Vanig Isabel Vecino Vilma M Vega Wenoah Veikley Barbara H Wade Charles Walworth Chingchai Wanidworanun Douglas J Ward Daniel A Warner Robert D Weber Duncan Webster Steve Weis David A Wheeler David J White Ed Wilkins Alan Winston Clifford G Wlodaver Angelique van't Wout David P Wright Otto O Yang David L Yurdin Brandon W Zabukovic Kimon C Zachary Beth Zeeman Meng Zhao

Science 2010 Dec 4;330(6010):1551-7. Epub 2010 Nov 4.

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USA.

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http://dx.doi.org/10.1126/science.1195271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235490PMC
December 2010

Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.

Authors:
Laura B Hughes Richard J Reynolds Elizabeth E Brown James M Kelley Brian Thomson Doyt L Conn Beth L Jonas Andrew O Westfall Miguel A Padilla Leigh F Callahan Edwin A Smith Richard D Brasington Jeffrey C Edberg Robert P Kimberly Larry W Moreland Robert M Plenge S Louis Bridges

Arthritis Rheum 2010 Dec;62(12):3547-53

University of Alabama at Birmingham, 1530 3rd Avenue South, SHEL 210, Birmingham, AL 35294-2182, USA.

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http://dx.doi.org/10.1002/art.27732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030622PMC
December 2010

Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions.

Authors:
Timothy J Henrich Jonathan Z Li Donna Felsenstein Camille N Kotton Robert M Plenge Florencia Pereyra Francisco M Marty Nina H Lin Paul Grazioso Danielle M Crochiere Daniel Eggers Daniel R Kuritzkes Athe M N Tsibris

J Infect Dis 2010 Nov 11;202(10):1478-81. Epub 2010 Oct 11.

Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://ecdc.europa.eu/en/publications/Publications/111222_TE
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http://jid.oxfordjournals.org/lookup/doi/10.1086/657168
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http://dx.doi.org/10.1086/657168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957553PMC
November 2010

GWASs and the age of human as the model organism for autoimmune genetic research.

Authors:
Robert Plenge

Genome Biol 2010 5;11(5):212. Epub 2010 May 5.

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/gb-2010-11-5-212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898069PMC
September 2010

Electronic medical records for discovery research in rheumatoid arthritis.

Authors:
Katherine P Liao Tianxi Cai Vivian Gainer Sergey Goryachev Qing Zeng-treitler Soumya Raychaudhuri Peter Szolovits Susanne Churchill Shawn Murphy Isaac Kohane Elizabeth W Karlson Robert M Plenge

Arthritis Care Res (Hoboken) 2010 Aug;62(8):1120-7

Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://doi.wiley.com/10.1002/acr.20184
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http://dx.doi.org/10.1002/acr.20184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121049PMC
August 2010

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

Authors:
Jing Cui Saedis Saevarsdottir Brian Thomson Leonid Padyukov Annette H M van der Helm-van Mil Joanne Nititham Laura B Hughes Niek de Vries Soumya Raychaudhuri Lars Alfredsson Johan Askling Sara Wedrén Bo Ding Candace Guiducci Gert Jan Wolbink J Bart A Crusius Irene E van der Horst-Bruinsma Marieke Herenius Michael E Weinblatt Nancy A Shadick Jane Worthington Franak Batliwalla Marlena Kern Ann W Morgan Anthony G Wilson John D Isaacs Kimme Hyrich Michael F Seldin Larry W Moreland Timothy W Behrens Cornelia F Allaart Lindsey A Criswell Tom W J Huizinga Paul P Tak S Louis Bridges Rene E M Toes Anne Barton Lars Klareskog Peter K Gregersen Elizabeth W Karlson Robert M Plenge

Arthritis Rheum 2010 Jul;62(7):1849-61

Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/art.27457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652476PMC
July 2010

Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.

Authors:
Elizabeth W Karlson Lori B Chibnik Peter Kraft Jing Cui Brendan T Keenan Bo Ding Souyma Raychaudhuri Lars Klareskog Lars Alfredsson Robert M Plenge

Ann Rheum Dis 2010 Jun 16;69(6):1077-85. Epub 2010 Mar 16.

75 Francis Street, Boston, MA 02115, USA.

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http://ard.bmj.com/cgi/doi/10.1136/ard.2009.120170
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933175PMC
June 2010

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Authors:
Eli A Stahl Soumya Raychaudhuri Elaine F Remmers Gang Xie Stephen Eyre Brian P Thomson Yonghong Li Fina A S Kurreeman Alexandra Zhernakova Anne Hinks Candace Guiducci Robert Chen Lars Alfredsson Christopher I Amos Kristin G Ardlie Anne Barton John Bowes Elisabeth Brouwer Noel P Burtt Joseph J Catanese Jonathan Coblyn Marieke J H Coenen Karen H Costenbader Lindsey A Criswell J Bart A Crusius Jing Cui Paul I W de Bakker Philip L De Jager Bo Ding Paul Emery Edward Flynn Pille Harrison Lynne J Hocking Tom W J Huizinga Daniel L Kastner Xiayi Ke Annette T Lee Xiangdong Liu Paul Martin Ann W Morgan Leonid Padyukov Marcel D Posthumus Timothy R D J Radstake David M Reid Mark Seielstad Michael F Seldin Nancy A Shadick Sophia Steer Paul P Tak Wendy Thomson Annette H M van der Helm-van Mil Irene E van der Horst-Bruinsma C Ellen van der Schoot Piet L C M van Riel Michael E Weinblatt Anthony G Wilson Gert Jan Wolbink B Paul Wordsworth Cisca Wijmenga Elizabeth W Karlson Rene E M Toes Niek de Vries Ann B Begovich Jane Worthington Katherine A Siminovitch Peter K Gregersen Lars Klareskog Robert M Plenge

Nat Genet 2010 Jun 9;42(6):508-14. Epub 2010 May 9.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243840PMC
June 2010

Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

Authors:
Robert M Plenge Soumya Raychaudhuri

Rheum Dis Clin North Am 2010 May;36(2):259-70

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.rdc.2010.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879392PMC
May 2010

Unlocking the pathogenesis of celiac disease.

Authors:
Robert M Plenge

Nat Genet 2010 Apr;42(4):281-2

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April 2010

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Authors:
Soumya Raychaudhuri Brian P Thomson Elaine F Remmers Stephen Eyre Anne Hinks Candace Guiducci Joseph J Catanese Gang Xie Eli A Stahl Robert Chen Lars Alfredsson Christopher I Amos Kristin G Ardlie Anne Barton John Bowes Noel P Burtt Monica Chang Jonathan Coblyn Karen H Costenbader Lindsey A Criswell J Bart A Crusius Jing Cui Phillip L De Jager Bo Ding Paul Emery Edward Flynn Pille Harrison Lynne J Hocking Tom W J Huizinga Daniel L Kastner Xiayi Ke Fina A S Kurreeman Annette T Lee Xiangdong Liu Yonghong Li Paul Martin Ann W Morgan Leonid Padyukov David M Reid Mark Seielstad Michael F Seldin Nancy A Shadick Sophia Steer Paul P Tak Wendy Thomson Annette H M van der Helm-van Mil Irene E van der Horst-Bruinsma Michael E Weinblatt Anthony G Wilson Gert Jan Wolbink Paul Wordsworth David Altshuler Elizabeth W Karlson Rene E M Toes Niek de Vries Ann B Begovich Katherine A Siminovitch Jane Worthington Lars Klareskog Peter K Gregersen Mark J Daly Robert M Plenge

Nat Genet 2009 Dec 8;41(12):1313-8. Epub 2009 Nov 8.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142887PMC
December 2009

Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data.

Authors:
Christopher I Amos Wei Vivien Chen Michael F Seldin Elaine F Remmers Kimberly E Taylor Lindsey A Criswell Annette T Lee Robert M Plenge Daniel L Kastner Peter K Gregersen

BMC Proc 2009 Dec 15;3 Suppl 7:S2. Epub 2009 Dec 15.

Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795916PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s2DOI Listing
December 2009

Rheumatoid arthritis genetics: 2009 update.

Authors:
Robert M Plenge

Curr Rheumatol Rep 2009 Oct;11(5):351-6

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA.

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October 2009

Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.

Authors:
Jing Cui Kimberly E Taylor Anita L Destefano Lindsey A Criswell Elena S Izmailova Alex Parker Ronenn Roubenoff Robert M Plenge Michael E Weinblatt Nancy A Shadick Elizabeth W Karlson

Mol Med 2009 May-Jun;15(5-6):136-43. Epub 2009 Mar 6.

Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654848PMC
September 2009

Rare protection against type 1 diabetes.

Authors:
Robert M Plenge

Genome Biol 2009 15;10(5):219. Epub 2009 May 15.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718509PMC
August 2009

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.

Authors:
Steven C Greenway Alexandre C Pereira Jennifer C Lin Steven R DePalma Samuel J Israel Sonia M Mesquita Emel Ergul Jessie H Conta Joshua M Korn Steven A McCarroll Joshua M Gorham Stacey Gabriel David M Altshuler Maria de Lourdes Quintanilla-Dieck Maria Alexandra Artunduaga Roland D Eavey Robert M Plenge Nancy A Shadick Michael E Weinblatt Philip L De Jager David A Hafler Roger E Breitbart Jonathan G Seidman Christine E Seidman

Nat Genet 2009 Aug 13;41(8):931-5. Epub 2009 Jul 13.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747103PMC
August 2009

REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

Authors:
Peter K Gregersen Chistopher I Amos Annette T Lee Yue Lu Elaine F Remmers Daniel L Kastner Michael F Seldin Lindsey A Criswell Robert M Plenge V Michael Holers Ted R Mikuls Tuulikki Sokka Larry W Moreland S Louis Bridges Gang Xie Ann B Begovich Katherine A Siminovitch

Nat Genet 2009 Jul 7;41(7):820-3. Epub 2009 Jun 7.

The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY, USA.

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http://dx.doi.org/10.1038/ng.395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705058PMC
July 2009

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Authors:
Soumya Raychaudhuri Robert M Plenge Elizabeth J Rossin Aylwin C Y Ng Shaun M Purcell Pamela Sklar Edward M Scolnick Ramnik J Xavier David Altshuler Mark J Daly

PLoS Genet 2009 Jun 26;5(6):e1000534. Epub 2009 Jun 26.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1000534
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694358PMC
June 2009

Recent progress in rheumatoid arthritis genetics: one step towards improved patient care.

Authors:
Robert M Plenge

Curr Opin Rheumatol 2009 May;21(3):262-71

Division of Rheumatology, Immunology and Allergy, Brigham and Women's, Hospital, Harvard Medical School, Boston, USA.

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https://insights.ovid.com/crossref?an=00002281-200905000-000
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http://dx.doi.org/10.1097/BOR.0b013e32832a2e2dDOI Listing
May 2009

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.

Authors:
Yvonne C Lee Soumya Raychaudhuri Jing Cui Immaculata De Vivo Bo Ding Lars Alfredsson Leonid Padyukov Karen H Costenbader Mark Seielstad Robert R Graham Lars Klareskog Peter K Gregersen Robert M Plenge Elizabeth W Karlson

Arthritis Rheum 2009 May;60(5):1250-4

Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://doi.wiley.com/10.1002/art.24468
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956274PMC
May 2009

Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.

Authors:
Katherine P Liao Marie Gunnarsson Henrik Källberg Bo Ding Robert M Plenge Leonid Padyukov Elizabeth W Karlson Lars Klareskog Johan Askling Lars Alfredsson

Arthritis Rheum 2009 Mar;60(3):653-60

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/art.24362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768389PMC
March 2009

Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.

Authors:
Bo Ding Leonid Padyukov Emeli Lundström Mark Seielstad Robert M Plenge Jorge R Oksenberg Peter K Gregersen Lars Alfredsson Lars Klareskog

Arthritis Rheum 2009 Jan;60(1):30-8

Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/art.24135
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874319PMC
January 2009

The chromosome 7q region association with rheumatoid arthritis in females in a British population is not replicated in a North American case-control series.

Authors:
Benjamin D Korman Michael F Seldin Kimberly E Taylor Julie M Le Annette T Lee Robert M Plenge Christopher I Amos Lindsey A Criswell Peter K Gregersen Daniel L Kastner Elaine F Remmers

Arthritis Rheum 2009 Jan;60(1):47-52

National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892-1849, USA.

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http://dx.doi.org/10.1002/art.24180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741408PMC
January 2009

Shared genetic risk factors for type 1 diabetes and celiac disease.

Authors:
Robert M Plenge

N Engl J Med 2008 Dec 10;359(26):2837-8. Epub 2008 Dec 10.

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http://www.nejm.org/doi/abs/10.1056/NEJMe0809719
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December 2008

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Authors:
Robert R Graham Chris Cotsapas Leela Davies Rachel Hackett Christopher J Lessard Joanlise M Leon Noel P Burtt Candace Guiducci Melissa Parkin Casey Gates Robert M Plenge Timothy W Behrens Joan E Wither John D Rioux Paul R Fortin Deborah Cunninghame Graham Andrew K Wong Timothy J Vyse Mark J Daly David Altshuler Kathy L Moser Patrick M Gaffney

Nat Genet 2008 Sep;40(9):1059-61

Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1038/ng.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772171PMC
September 2008