Robert N Lightowlers

Robert N Lightowlers

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Robert N Lightowlers

Publications by authors named "Robert N Lightowlers"

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Rescuing stalled mammalian mitoribosomes - what can we learn from bacteria?

J Cell Sci 2020 Jan 2;133(1). Epub 2020 Jan 2.

The Wellcome Centre for Mitochondrial Research, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK

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http://dx.doi.org/10.1242/jcs.231811DOI Listing
January 2020

Mammalian mitochondrial translation - revealing consequences of divergent evolution.

Biochem Soc Trans 2019 Oct;47(5):1429-1436

The Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.

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http://dx.doi.org/10.1042/BST20190265DOI Listing
October 2019

How much does a disrupted mitochondrial network influence neuronal dysfunction?

EMBO Mol Med 2019 01;11(1)

Wellcome Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.15252/emmm.201809899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328938PMC
January 2019

Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome.

Essays Biochem 2018 07 20;62(3):455-465. Epub 2018 Jul 20.

Wellcome Centre for Mitochondrial Research, Newcastle upon Tyne, U.K.

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http://dx.doi.org/10.1042/EBC20170113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056713PMC
July 2018

Defective mitochondrial protease LonP1 can cause classical mitochondrial disease.

Hum Mol Genet 2018 05;27(10):1743-1753

Wellcome Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/hmg/ddy080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932559PMC
May 2018

Using mitoribosomal profiling to investigate human mitochondrial translation.

Wellcome Open Res 2017 11;2:116. Epub 2017 Dec 11.

The Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.13119.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771143PMC
December 2017

Human mitochondrial nucleases.

FEBS J 2017 06 1;284(12):1767-1777. Epub 2017 Feb 1.

The Wellcome Trust Centre for Mitochondrial Research, The Medical School, Newcastle University, UK.

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http://dx.doi.org/10.1111/febs.13981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484287PMC
June 2017

The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.

Biochem J 2017 06 13;474(13):2145-2158. Epub 2017 Jun 13.

Institute for Cell and Molecular Bioscience, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.

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http://dx.doi.org/10.1042/BCJ20170256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468982PMC
June 2017

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives.

Interface Focus 2017 Apr;7(2):20160117

The Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences , The Medical School, Newcastle University , Newcastle upon Tyne , UK.

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http://dx.doi.org/10.1098/rsfs.2016.0117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311907PMC
April 2017

The process of mammalian mitochondrial protein synthesis.

Cell Tissue Res 2017 Jan 14;367(1):5-20. Epub 2016 Jul 14.

Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00441-016-2456-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203842PMC
January 2017

Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons.

Nat Commun 2016 11 17;7:13495. Epub 2016 Nov 17.

Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/ncomms13495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118542PMC
November 2016

Human mitochondrial ribosomes can switch their structural RNA composition.

Proc Natl Acad Sci U S A 2016 10 11;113(43):12198-12201. Epub 2016 Oct 11.

The Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom; The Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom

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http://dx.doi.org/10.1073/pnas.1609338113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087001PMC
October 2016

SLIRP stabilizes LRPPRC via an RRM-PPR protein interface.

Nucleic Acids Res 2016 08 28;44(14):6868-82. Epub 2016 Jun 28.

Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden

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http://dx.doi.org/10.1093/nar/gkw575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001613PMC
August 2016

Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry.

Chembiochem 2016 07 25;17(14):1312-6. Epub 2016 May 25.

The Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/cbic.201600188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973694PMC
July 2016

Applying the Airbrakes: Treating Mitochondrial Disease with Hypoxia.

Mol Cell 2016 Apr;62(1):5-6

Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.027DOI Listing
April 2016

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.

Mitochondrion 2015 Nov 5;25:17-27. Epub 2015 Sep 5.

Grupo GIBE, Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade da Coruña (UDC), Campus Zapateira s/n, 15071 A Coruña, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2015.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665369PMC
November 2015

Mutations causing mitochondrial disease: What is new and what challenges remain?

Science 2015 Sep 24;349(6255):1494-9. Epub 2015 Sep 24.

Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences and Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1126/science.aac7516DOI Listing
September 2015

Human pentatricopeptide proteins: only a few and what do they do?

RNA Biol 2013 23;10(9):1433-8. Epub 2013 Apr 23.

The Wellcome Trust Centre for Mitochondrial Research; Institute for Ageing and Health; Newcastle University; The Medical School; Framlington Place; Newcastle upon Tyne, UK.

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http://dx.doi.org/10.4161/rna.24770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858426PMC
May 2015

Mitochondrial protein synthesis: figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation.

FEBS Lett 2014 Aug 6;588(15):2496-503. Epub 2014 Jun 6.

The Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.05.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099522PMC
August 2014

Overcoming stalled translation in human mitochondria.

Front Microbiol 2014 18;5:374. Epub 2014 Jul 18.

Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School Newcastle upon Tyne, UK.

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http://dx.doi.org/10.3389/fmicb.2014.00374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103422PMC
August 2014

Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?

EMBO Mol Med 2014 Jun 6;6(6):705-7. Epub 2014 Apr 6.

Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences Medical School Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.15252/emmm.201404179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203349PMC
June 2014

The role of TDP1 and APTX in mitochondrial DNA repair.

Biochimie 2014 May 22;100:121-4. Epub 2013 Oct 22.

The Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1016/j.biochi.2013.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356151PMC
May 2014

Analysis of 953 human proteins from a mitochondrial HEK293 fraction by complexome profiling.

PLoS One 2013 23;8(7):e68340. Epub 2013 Jul 23.

Department of Laboratory Medicine, Laboratory of Genetic Endocrine and Metabolic Disorders, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068340PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720734PMC
March 2014

REXO2 is an oligoribonuclease active in human mitochondria.

PLoS One 2013 31;8(5):e64670. Epub 2013 May 31.

The Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064670PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669425PMC
February 2014

Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutations.

EMBO Mol Med 2014 02 10;6(2):183-93. Epub 2014 Jan 10.

The Wellcome Trust Centre for Mitochondrial Research Institute for Ageing and Health The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/emmm.201303202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927954PMC
February 2014

Mutation of the human mitochondrial phenylalanine-tRNA synthetase causes infantile-onset epilepsy and cytochrome c oxidase deficiency.

Biochim Biophys Acta 2014 Jan 24;1842(1):56-64. Epub 2013 Oct 24.

Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2013.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898479PMC
January 2014

GRSF1 regulates RNA processing in mitochondrial RNA granules.

Cell Metab 2013 Mar;17(3):399-410

Department of Cell Biology, University of Geneva, 30 Quai Ernest-Ansermet, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1016/j.cmet.2013.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593211PMC
March 2013

The mystery of mitochondrial RNases.

Biochem Soc Trans 2012 Aug;40(4):865-9

Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1042/BST20120022DOI Listing
August 2012

Recombinant human MDM2 oncoprotein shows sequence composition selectivity for binding to both RNA and DNA.

Int J Oncol 2012 Mar 21;40(3):851-9. Epub 2011 Nov 21.

Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.3892/ijo.2011.1267DOI Listing
March 2012

DNA delivery to mitochondria: sequence specificity and energy enhancement.

Pharm Res 2011 Nov 12;28(11):2871-82. Epub 2011 Jul 12.

Institut de Biologie Moléculaire des Plantes, CNRS and Université de Strasbourg, 12 rue du Général Zimmer, 67084 Strasbourg, France.

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http://link.springer.com/10.1007/s11095-011-0516-4
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http://dx.doi.org/10.1007/s11095-011-0516-4DOI Listing
November 2011

Termination of protein synthesis in mammalian mitochondria.

J Biol Chem 2011 Oct 26;286(40):34479-85. Epub 2011 Aug 26.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.R111.290585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186377PMC
October 2011

Mitochondrial transfection for studying organellar DNA repair, genome maintenance and aging.

Mech Ageing Dev 2011 Aug 27;132(8-9):412-23. Epub 2011 May 27.

Institut de Biologie Moléculaire des Plantes, CNRS/Université de Strasbourg, 12 rue du Général Zimmer, 67084 Strasbourg, France.

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http://dx.doi.org/10.1016/j.mad.2011.05.002DOI Listing
August 2011

Designing an organellar postal service: delivery of macromolecules to mitochondria in intact cells.

Mol Ther 2011 Aug;19(8):1404-5

Mitochondrial Research Group, Institute for Ageing, Medical School, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1038/mt.2011.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149165PMC
August 2011

Mitochondrial transformation: time for concerted action.

EMBO Rep 2011 Jun;12(6):480-1

the Institute for Ageing and Health, Newcastle University, UK.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2011.93
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http://dx.doi.org/10.1038/embor.2011.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128293PMC
June 2011

Altering the balance between healthy and mutated mitochondrial DNA.

J Inherit Metab Dis 2011 Apr 27;34(2):309-13. Epub 2010 May 27.

Mitochondrial Research Group, Institute of Ageing and Health, Medical School, Framlington Place, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s10545-010-9122-6DOI Listing
April 2011

Terminating human mitochondrial protein synthesis: a shift in our thinking.

RNA Biol 2010 May-Jun;7(3):282-6. Epub 2010 May 8.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.4161/rna.7.3.12023DOI Listing
February 2011

Human mitochondrial mRNAs--like members of all families, similar but different.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1081-5. Epub 2010 Mar 6.

Mitochondrial Research Group, Medical School, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00052728100009
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http://dx.doi.org/10.1016/j.bbabio.2010.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003153PMC
January 2011

DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging.

Biochim Biophys Acta 2011 Jan 13;1813(1):186-200. Epub 2010 Oct 13.

Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.bbamcr.2010.10.002DOI Listing
January 2011

Could successful (mitochondrial) networking help prevent Huntington's disease?

EMBO Mol Med 2010 Dec;2(12):487-9

REQUIMTE, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1002/emmm.201000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377349PMC
December 2010

Translation termination in human mitochondrial ribosomes.

Biochem Soc Trans 2010 Dec;38(6):1523-6

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1042/BST0381523DOI Listing
December 2010

Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition.

Nucleic Acids Res 2010 Jun 9;38(11):3732-42. Epub 2010 Feb 9.

Mitochondrial Research Group, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkq068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887948PMC
June 2010

Membrane association of mitochondrial DNA facilitates base excision repair in mammalian mitochondria.

Nucleic Acids Res 2010 Mar 10;38(5):1478-88. Epub 2009 Dec 10.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkp1143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836570PMC
March 2010

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.

Brain 2010 Mar 15;133(Pt 3):797-807. Epub 2010 Feb 15.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1093/brain/awq015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842515PMC
March 2010

A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.

EMBO J 2010 Mar 25;29(6):1116-25. Epub 2010 Feb 25.

Mitochondrial Research Group, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/emboj.2010.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845271PMC
March 2010

Mitochondrial DNA mutations affect calcium handling in differentiated neurons.

Brain 2010 Mar 5;133(Pt 3):787-96. Epub 2010 Mar 5.

Mitochondrial Research Group, Institute for Ageing and Health Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, England.

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http://dx.doi.org/10.1093/brain/awq023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842518PMC
March 2010

Hungry codons promote frameshifting in human mitochondrial ribosomes.

Science 2010 Jan;327(5963):301

The Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1126/science.1180674DOI Listing
January 2010

Probing the orientation of yeast VDAC1 in vivo.

FEBS Lett 2009 Feb 29;583(4):739-42. Epub 2009 Jan 29.

The Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://doi.wiley.com/10.1016/j.febslet.2009.01.039
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http://dx.doi.org/10.1016/j.febslet.2009.01.039DOI Listing
February 2009

PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression.

Biochem J 2008 Nov;416(1):e5-6

Mitochondrial Research Group, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1042/BJ20081942DOI Listing
November 2008

The human mitochondrial ribosome recycling factor is essential for cell viability.

Nucleic Acids Res 2008 Oct 9;36(18):5787-99. Epub 2008 Sep 9.

Mitochondrial Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkn576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566884PMC
October 2008

Polyadenylation and degradation of mRNA in mammalian mitochondria: a missing link?

Biochem Soc Trans 2008 Jun;36(Pt 3):517-9

Mitochondrial Research Group, Institute of Neuroscience, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST0360517
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http://dx.doi.org/10.1042/BST0360517DOI Listing
June 2008

What causes mitochondrial DNA deletions in human cells?

Nat Genet 2008 Mar;40(3):275-9

Mitochondrial Research Group, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1038/ng.f.94DOI Listing
March 2008

Nature of mitochondrial DNA deletions in substantia nigra neurons.

Am J Hum Genet 2008 Jan;82(1):228-35

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.ajhg.2007.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253975PMC
January 2008

Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure.

Mol Pharmacol 2007 Apr 5;71(4):1006-14. Epub 2007 Jan 5.

The Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1124/mol.106.032953DOI Listing
April 2007

Mitochondrial DNA clonality in the dock: can surveillance swing the case?

Trends Genet 2006 Nov 18;22(11):603-7. Epub 2006 Sep 18.

Mitochondrial Research Group, School of Neurology, Neurobiology, and Psychiatry, The University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.tig.2006.09.004DOI Listing
November 2006

Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2.

Protein Sci 2006 Nov;15(11):2466-80

Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1110/ps.051818406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242420PMC
November 2006

Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.

Nucleic Acids Res 2006 Aug 2;34(13):e95. Epub 2006 Aug 2.

Mitochondrial Research Group, University of Newcastle upon Tyne, School of Neurology, Neurobiology and Psychiatry, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkl516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540737PMC
August 2006

Natural competence of mammalian mitochondria allows the molecular investigation of mitochondrial gene expression.

Hum Mol Genet 2006 Jan 1;15(1):143-54. Epub 2005 Dec 1.

Mitochondrial Research Group, Institutes of Neuroscience, University of Newcastle upon Tyne, UK.

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http://academic.oup.com/hmg/article/15/1/143/613180/Natural-
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http://dx.doi.org/10.1093/hmg/ddi435DOI Listing
January 2006

Accumulation of Nav1 mRNAs at differentiating postsynaptic sites in rat soleus muscles.

Mol Cell Neurosci 2005 Apr;28(4):694-702

School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.mcn.2004.11.015DOI Listing
April 2005

Serum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stability.

Nucleic Acids Res 2005 14;33(1):376-87. Epub 2005 Jan 14.

Department of Neurology, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gki169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546156PMC
February 2005

Strategies for treating disorders of the mitochondrial genome.

Biochim Biophys Acta 2004 Dec;1659(2-3):232-9

Mitochondrial Research Group, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S000527280400268
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http://dx.doi.org/10.1016/j.bbabio.2004.09.003DOI Listing
December 2004

Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells.

Hum Mol Genet 2004 Oct 18;13(20):2519-34. Epub 2004 Aug 18.

CNRS-FRE 2375, Institute of Physiology and Biological Chemistry, Université Louis Pasteur, 21 René Descartes, 67084 Strasbourg, France.

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http://dx.doi.org/10.1093/hmg/ddh267DOI Listing
October 2004

Sporadic mitochondrial myopathy due to a new mutation in the mitochondrial tRNASer(UCN) gene.

Neuromuscul Disord 2004 Jul;14(7):417-20

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.nmd.2004.03.004DOI Listing
July 2004

Messenger RNA stability in mitochondria: different means to an end.

Trends Genet 2004 Jun;20(6):260-7

IBMP CNRS, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1016/j.tig.2004.04.006DOI Listing
June 2004

Identification of the RAG-1 as a suitable mouse model for mitochondrial DNA disease.

Neuromuscul Disord 2004 May;14(5):329-36

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.nmd.2004.02.010DOI Listing
May 2004

Synthesis of trifunctional PNA-benzophenone derivatives for mitochondrial targeting, selective DNA binding, and photo-cross-linking.

Bioconjug Chem 2003 Sep-Oct;14(5):962-6

School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1021/bc034050fDOI Listing
April 2004

Neuropathological aspects of mitochondrial DNA disease.

Neurochem Res 2004 Mar;29(3):505-11

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1023/b:nere.0000014821.07269.8dDOI Listing
March 2004

Functional polypeptides can be synthesized from human mitochondrial transcripts lacking termination codons.

Biochem J 2004 Feb;377(Pt 3):725-31

School of Neurology, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, U.K.

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http://biochemj.org/lookup/doi/10.1042/bj20031556
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http://dx.doi.org/10.1042/BJ20031556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223913PMC
February 2004

Bridging PNAs can bind preferentially to a deleted mitochondrial DNA template but replication by mitochondrial DNA polymerase gamma in vitro is not impaired.

Biochim Biophys Acta 2003 Oct;1629(1-3):73-83

School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.bbaexp.2003.08.005DOI Listing
October 2003

Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria.

Hum Mol Genet 2003 Sep 22;12(18):2341-8. Epub 2003 Jul 22.

Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/hmg/ddg238DOI Listing
September 2003

Changes in the human mitochondrial genome after treatment of malignant disease.

Mutat Res 2003 Apr;525(1-2):19-27

Department of Neurology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/s0027-5107(02)00313-5DOI Listing
April 2003

Mismatch repair activity in mammalian mitochondria.

Nucleic Acids Res 2003 Feb;31(3):1052-8

School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149189PMC
http://dx.doi.org/10.1093/nar/gkg167DOI Listing
February 2003

A roundabout route to gene therapy.

Nat Genet 2002 Apr;30(4):345-6

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http://www.nature.com/articles/ng0402-345
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April 2002

A high frequency of mtDNA polymorphisms in HeLa cell sublines.

Mutat Res 2002 Apr;501(1-2):19-28

MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/s0027-5107(01)00304-9DOI Listing
April 2002

Multiple neonatal deaths due to a homoplasmic mitochondrial DNA mutation.

Nat Genet 2002 Feb 22;30(2):145-6. Epub 2002 Jan 22.

Departments of Neurology, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/ng819DOI Listing
February 2002