Robert N DeHaven

Robert N DeHaven

UNVERIFIED PROFILE

Are you Robert N DeHaven?   Register this Author

Register author
Robert N DeHaven

Robert N DeHaven

Publications by authors named "Robert N DeHaven"

Are you Robert N DeHaven?   Register this Author

35Publications

446Reads

38Profile Views

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.

Bioorg Med Chem Lett 2009 Oct 21;19(20):5931-5. Epub 2009 Aug 21.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.08.063DOI Listing
October 2009

Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.

Bioorg Med Chem Lett 2009 Jul 3;19(13):3647-50. Epub 2009 May 3.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.04.105DOI Listing
July 2009

Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.

Bioorg Med Chem Lett 2008 Jun 4;18(12):3667-71. Epub 2007 Dec 4.

Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.11.116DOI Listing
June 2008

Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands.

Bioorg Med Chem Lett 2008 May 7;18(9):2830-5. Epub 2008 Apr 7.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.04.006DOI Listing
May 2008

The involvement of the mu-opioid receptor in gastrointestinal pathophysiology: therapeutic opportunities for antagonism at this receptor.

Pharmacol Ther 2008 Jan 16;117(1):162-87. Epub 2007 Oct 16.

Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2007.09.007DOI Listing
January 2008

Discovery of a series of aminopiperidines as novel iNOS inhibitors.

Bioorg Med Chem Lett 2008 Jan 25;18(1):336-43. Epub 2007 Oct 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.10.073DOI Listing
January 2008

Biaryl cannabinoid mimetics--synthesis and structure-activity relationship.

Bioorg Med Chem Lett 2007 Jul 25;17(13):3652-6. Epub 2007 Apr 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.04.059DOI Listing
July 2007

Further studies of tyrosine surrogates in opioid receptor peptide ligands.

Bioorg Med Chem Lett 2007 May 2;17(9):2656-60. Epub 2007 Feb 2.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.01.092DOI Listing
May 2007

Novel malonamide derivatives as potent kappa opioid receptor agonists.

Bioorg Med Chem Lett 2007 Apr 25;17(7):1951-5. Epub 2007 Jan 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.01.053DOI Listing
April 2007

Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.

J Med Chem 2006 Dec;49(25):7290-306

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm0604878DOI Listing
December 2006

Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.

Bioorg Med Chem Lett 2006 Feb 2;16(3):645-8. Epub 2005 Nov 2.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.10.034DOI Listing
February 2006

[(3)H]Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists.

Eur J Pharmacol 2005 Sep;520(1-3):29-36

Department of Pharmacology, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2005.08.008DOI Listing
September 2005

Pharmacological characterization of human kappa/mu opioid receptor chimeras that retain high affinity for dynorphin A.

Curr Top Med Chem 2005 ;5(3):303-13

Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341-1129, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568026053544542DOI Listing
June 2005

Amino acid conjugates as kappa opioid receptor agonists.

Bioorg Med Chem Lett 2005 Mar;15(5):1279-82

Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.01.038DOI Listing
March 2005

Azepinone as a conformational constraint in the design of kappa-opioid receptor agonists.

Bioorg Med Chem Lett 2004 Nov;14(22):5693-7

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.08.041DOI Listing
November 2004

(4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands.

Bioorg Med Chem Lett 2004 Jul;14(13):3545-8

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.04.039DOI Listing
July 2004

trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists.

Bioorg Med Chem Lett 2003 Dec;13(24):4459-62

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2003.09.012DOI Listing
December 2003

Structure-activity relationships of dynorphin analogs substituted in positions 2 and 3.

Biopolymers 2003 ;71(1):71-6

University of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla 92093-0343, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.10382DOI Listing
July 2003

Structure-activity relationships of dynorphin a analogues modified in the address sequence.

J Med Chem 2003 May;46(11):2104-9

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0343, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm020125+DOI Listing
May 2003

Antipruritic and antihyperalgesic actions of loperamide and analogs.

Life Sci 2002 Oct;71(23):2787-96

Department of Pharmacology, Adolor Corporation, 371 Phoenixville Pike, Malvern, PA 19355, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0024-3205(02)02102-1DOI Listing
October 2002

Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.

J Med Chem 2002 Aug;45(17):3746-54

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0343, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm020108kDOI Listing
August 2002

NMR and modeling studies of a synthetic extracellular loop II of the kappa opioid receptor in a DPC micelle.

Biochemistry 2002 Jan;41(1):61-8

Department of Chemistry and Biochemistry, University of California at San Diego, 6223 Pacific Hall, La Jolla, California 92093-0343, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0117955DOI Listing
January 2002