Robert Mecham

Robert Mecham

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Robert Mecham

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Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development.

Circ Res 2019 Nov 8;125(11):1006-1018. Epub 2019 Oct 8.

Department of Mechanical Engineering and Materials Science (M.C.S., J.Z.H., J.E.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315348DOI Listing
November 2019

Elastic fiber ultrastructure and assembly.

Matrix Biol 2019 Nov 24;84:31-40. Epub 2019 Oct 24.

Department of Cell Biology and Physiology, Washington University School of Medicine, Campus Box 8228, 660 South Euclid Ave, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.10.002DOI Listing
November 2019

Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis.

Curr Top Dev Biol 2018 ;130:193-216

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2018.02.001DOI Listing
July 2019

Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy.

Exp Eye Res 2019 Jul 6;184:221-226. Epub 2019 May 6.

Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625661PMC
July 2019

Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.

Biomech Model Mechanobiol 2019 Jul 3. Epub 2019 Jul 3.

Department of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA.

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http://dx.doi.org/10.1007/s10237-019-01198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940555PMC
July 2019

MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations.

FEBS J 2018 12 1;285(23):4394-4412. Epub 2018 Nov 1.

CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies, Univ. Lille, France.

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http://dx.doi.org/10.1111/febs.14680DOI Listing
December 2018

Measurement of elastin, collagen, and total protein levels in tissues.

Methods Cell Biol 2018 6;143:133-146. Epub 2017 Nov 6.

Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0091679X173012
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http://dx.doi.org/10.1016/bs.mcb.2017.08.008DOI Listing
November 2018

Elastin purification and solubilization.

Methods Cell Biol 2018 6;143:207-222. Epub 2017 Nov 6.

Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mcb.2017.08.012DOI Listing
November 2018

Preface.

Authors:
Robert P Mecham

Methods Cell Biol 2018 ;143:xix-xxi

St. Louis, Missouri, U.S.A.

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https://linkinghub.elsevier.com/retrieve/pii/S0091679X173016
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http://dx.doi.org/10.1016/S0091-679X(17)30166-8DOI Listing
November 2018

Elastin in lung development and disease pathogenesis.

Authors:
Robert P Mecham

Matrix Biol 2018 11 11;73:6-20. Epub 2018 Jan 11.

Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041195PMC
November 2018

Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.

Matrix Biol 2018 10 7;71-72:100-111. Epub 2018 Mar 7.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128786PMC
October 2018

Multifunctional, JNK-inhibiting nanotherapeutics for augmented elastic matrix regenerative repair in aortic aneurysms.

Drug Deliv Transl Res 2018 08;8(4):964-984

Department of Biomedical Engineering, The Cleveland Clinic, 9500 Euclid Avenue, ND 20, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s13346-017-0419-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837892PMC
August 2018

Maintaining Elastogenicity of Mesenchymal Stem Cell-Derived Smooth Muscle Cells in Two-Dimensional Culture.

Tissue Eng Part A 2018 06 2;24(11-12):979-989. Epub 2018 Feb 2.

1 Department of Biomedical Engineering, Cleveland Clinic , Cleveland, Ohio.

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http://dx.doi.org/10.1089/ten.TEA.2017.0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984560PMC
June 2018

Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development.

Sci Rep 2018 05 29;8(1):8334. Epub 2018 May 29.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.

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http://dx.doi.org/10.1038/s41598-018-26673-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974327PMC
May 2018

Phenotype-based selection of bone marrow mesenchymal stem cell-derived smooth muscle cells for elastic matrix regenerative repair in abdominal aortic aneurysms.

J Tissue Eng Regen Med 2018 01 25;12(1):e60-e70. Epub 2017 Apr 25.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1002/term.2349DOI Listing
January 2018

FGF receptors control alveolar elastogenesis.

Development 2017 12 9;144(24):4563-4572. Epub 2017 Nov 9.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA

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http://dx.doi.org/10.1242/dev.149443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769617PMC
December 2017

Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration.

J Biomech Eng 2017 Nov;139(11)

Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130.

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http://dx.doi.org/10.1115/1.4037932DOI Listing
November 2017

Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.

Am J Physiol Heart Circ Physiol 2017 Aug 26;313(2):H446-H456. Epub 2017 May 26.

Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, Missouri; and

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http://dx.doi.org/10.1152/ajpheart.00712.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582924PMC
August 2017

Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.

J Biomech 2017 08 25;61:199-207. Epub 2017 Jul 25.

Dept. of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jbiomech.2017.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581218PMC
August 2017

Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.

Arterioscler Thromb Vasc Biol 2017 05 2;37(5):930-941. Epub 2017 Mar 2.

From the Department of Surgery, Yale University School of Medicine, New Haven, CT (Y.J., G.L., L.Q., Q.L., W.L., G.T.); Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China (Y.J., Q.L., W.L.); Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, People's Republic of China (G.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (A.K., A.W.C., M.R.B., J.D.H.); Department of Cell Biology, Washington University School of Medicine, St Louis, MO (R.P.M.); Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine (J.D.H., G.T.); and Veterans Affairs Connecticut Healthcare System, West Haven (G.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501334PMC
May 2017

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.

Sci Adv 2017 May 3;3(5):e1602532. Epub 2017 May 3.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/sciadv.1602532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415335PMC
May 2017

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis.

Invest Ophthalmol Vis Sci 2017 05;58(5):2725-2731

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States 2Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1167/iovs.16-21340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444550PMC
May 2017

Magnetically-responsive, multifunctional drug delivery nanoparticles for elastic matrix regenerative repair.

Acta Biomater 2017 04 21;52:171-186. Epub 2016 Nov 21.

Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue, ND 20, Cleveland, OH 44195, USA; Department of Cell Biology and Physiology, Washington University, St. Louis, MO, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2016.11.048DOI Listing
April 2017

Pro-elastogenic effects of bone marrow mesenchymal stem cell-derived smooth muscle cells on cultured aneurysmal smooth muscle cells.

J Tissue Eng Regen Med 2017 03 6;11(3):679-693. Epub 2014 Nov 6.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.

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http://doi.wiley.com/10.1002/term.1964
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http://dx.doi.org/10.1002/term.1964DOI Listing
March 2017

Characterization of metabolic health in mouse models of fibrillin-1 perturbation.

Matrix Biol 2016 09 21;55:63-76. Epub 2016 Feb 21.

Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992667PMC
September 2016

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.

Proc Natl Acad Sci U S A 2016 08 18;113(31):8759-64. Epub 2016 Jul 18.

Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1073/pnas.1601442113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978273PMC
August 2016

Albumin contributes to kidney disease progression in Alport syndrome.

Am J Physiol Renal Physiol 2016 07 4;311(1):F120-30. Epub 2016 May 4.

Division of Nephrology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1152/ajprenal.00456.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967167PMC
July 2016

Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.

Front Endocrinol (Lausanne) 2016 30;7:87. Epub 2016 Jun 30.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Bone and Mineral Diseases Division, Washington University School of Medicine, St. Louis, MO, USA.

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http://journal.frontiersin.org/Article/10.3389/fendo.2016.00
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http://dx.doi.org/10.3389/fendo.2016.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928449PMC
July 2016

Sterilization of Lung Matrices by Supercritical Carbon Dioxide.

Tissue Eng Part C Methods 2016 Mar 29;22(3):260-9. Epub 2016 Jan 29.

1 Department of Biomedical Engineering, Yale University School of Medicine , New Haven, Connecticut.

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http://dx.doi.org/10.1089/ten.TEC.2015.0449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782026PMC
March 2016

The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.

Matrix Biol 2015 Sep 8;47:13-33. Epub 2015 May 8.

School of Medical Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.

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http://dx.doi.org/10.1016/j.matbio.2015.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154765PMC
September 2015

Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.

Am J Physiol Heart Circ Physiol 2015 Sep 31;309(5):H1008-16. Epub 2015 Jul 31.

Departments of Pediatrics Washington University School of Medicine, St. Louis, Missouri; and

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http://dx.doi.org/10.1152/ajpheart.00288.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591401PMC
September 2015

Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.

J Biol Chem 2015 Aug 15;290(35):21443-59. Epub 2015 Jul 15.

From the Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,

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http://dx.doi.org/10.1074/jbc.M115.640425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571872PMC
August 2015

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

Dis Model Mech 2015 May 11;8(5):487-99. Epub 2015 Mar 11.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

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http://dx.doi.org/10.1242/dmm.017046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415891PMC
May 2015

Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency.

Am J Physiol Heart Circ Physiol 2014 Mar 10;306(5):H654-66. Epub 2014 Jan 10.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri;

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http://www.physiology.org/doi/10.1152/ajpheart.00601.2013
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http://dx.doi.org/10.1152/ajpheart.00601.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949062PMC
March 2014

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

Invest Ophthalmol Vis Sci 2013 Dec 23;54(13):8337-44. Epub 2013 Dec 23.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

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http://dx.doi.org/10.1167/iovs.13-13121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875392PMC
December 2013

Ocular phenotype of Fbn2-null mice.

Invest Ophthalmol Vis Sci 2013 Nov 1;54(12):7163-73. Epub 2013 Nov 1.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1167/iovs.13-12687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816615PMC
November 2013

Zap70 inhibits Syk-mediated osteoclast function.

J Cell Biochem 2013 Aug;114(8):1871-8

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/jcb.24531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977572PMC
August 2013

Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.

J Am Heart Assoc 2013 Aug 23;2(4):e000365. Epub 2013 Aug 23.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO.

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http://dx.doi.org/10.1161/JAHA.113.000365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828800PMC
August 2013

A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta.

Biomech Model Mechanobiol 2013 Jun 12;12(3):497-510. Epub 2012 Jul 12.

Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/s10237-012-0420-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661750PMC
June 2013

Development, composition, and structural arrangements of the ciliary zonule of the mouse.

Invest Ophthalmol Vis Sci 2013 Apr 1;54(4):2504-15. Epub 2013 Apr 1.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1167/iovs.13-11619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621578PMC
April 2013

Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.

J Biol Chem 2013 Feb 7;288(8):5268-77. Epub 2013 Jan 7.

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M112.446054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581369PMC
February 2013

Paxillin contracts the osteoclast cytoskeleton.

J Bone Miner Res 2012 Dec;27(12):2490-500

Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/jbmr.1706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494816PMC
December 2012

Overview of extracellular matrix.

Authors:
Robert P Mecham

Curr Protoc Cell Biol 2012 Dec;Chapter 10:Unit 10.1

Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/0471143030.cb1001s57DOI Listing
December 2012

Elastin in large artery stiffness and hypertension.

J Cardiovasc Transl Res 2012 Jun;5(3):264-73

Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, St Louis, MO 63103, USA.

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http://dx.doi.org/10.1007/s12265-012-9349-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383658PMC
June 2012

Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.

Arterioscler Thromb Vasc Biol 2012 Mar 17;32(3):756-9. Epub 2011 Nov 17.

Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.238113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288647PMC
March 2012

Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.

J Cell Biochem 2012 Jan;113(1):93-9

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/jcb.23331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245339PMC
January 2012

Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation.

Mol Genet Metab 2011 Dec 24;104(4):608-19. Epub 2011 Aug 24.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ymgme.2011.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283036PMC
December 2011

Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.

J Biol Chem 2011 Dec 2;286(52):44926-36. Epub 2011 Nov 2.

Departments of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M111.274779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248007PMC
December 2011

Characterization of erectile function in elastin haploinsufficicent mice.

J Sex Med 2011 Nov 30;8(11):3075-85. Epub 2011 Aug 30.

Department of Urology, University of Washington, Seattle, WA 98104, USA.

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http://dx.doi.org/10.1111/j.1743-6109.2011.02454.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765001PMC
November 2011

Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice.

Am J Physiol Heart Circ Physiol 2011 Jul 2;301(1):H221-9. Epub 2011 May 2.

Dept. of Biomedical Engineering, Saint Louis Univ., 3507 Lindell Blvd., St. Louis, MO 63103, USA.

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http://dx.doi.org/10.1152/ajpheart.00119.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129922PMC
July 2011

Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas.

J Neurooncol 2011 Jun 8;103(2):207-19. Epub 2010 Sep 8.

Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8057, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s11060-010-0379-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732656PMC
June 2011

Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.

J Biol Chem 2011 Apr 14;286(15):13574-82. Epub 2011 Feb 14.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.192088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075703PMC
April 2011

Evidence for heterozygous abnormalities of the elastin gene (ELN) affecting the quantity of vocal fold elastic fibers: a pilot study.

J Voice 2011 Mar 6;25(2):e85-90. Epub 2010 Oct 6.

Department of Communication Sciences & Disorders, Texas Christian University, Fort Worth, Texas, USA.

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http://dx.doi.org/10.1016/j.jvoice.2010.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765004PMC
March 2011

Tropoelastin and fibulin overexpression in the subepithelial connective tissue of human pterygium.

Am J Ophthalmol 2011 Jan 20;151(1):44-52. Epub 2010 Nov 20.

Department of Ophthalmology, University Hospital Principe de Asturias, University of Alcalá, Alcalá de Henares, Madrid, Spain.

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http://dx.doi.org/10.1016/j.ajo.2010.07.012DOI Listing
January 2011

The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix.

Macromol Biosci 2010 Nov;10(11):1338-44

Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church St. SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1002/mabi.201000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157317PMC
November 2010

Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro.

J Biol Chem 2010 Nov 16;285(48):37396-404. Epub 2010 Sep 16.

Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988345PMC
November 2010

Mechanisms of emphysema in autosomal dominant cutis laxa.

Matrix Biol 2010 Sep 28;29(7):621-8. Epub 2010 Jun 28.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.matbio.2010.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606561PMC
September 2010

Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts.

J Cell Sci 2010 Sep;123(Pt 17):2955-63

Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/jcs.069872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923570PMC
September 2010

Discrete contributions of elastic fiber components to arterial development and mechanical compliance.

Arterioscler Thromb Vasc Biol 2009 Dec 22;29(12):2083-9. Epub 2009 Oct 22.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.193227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797476PMC
December 2009

Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing.

Clin Exp Pharmacol Physiol 2009 Oct 26;36(10):988-94. Epub 2009 Mar 26.

Laboratory of Vascular Physiopathologies: Cellular Interactions, Signalling and Ageing, Joseph Fourier University, Grenoble, F-38041, France.

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http://dx.doi.org/10.1111/j.1440-1681.2009.05174.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765003PMC
October 2009

Vascular extracellular matrix and arterial mechanics.

Physiol Rev 2009 Jul;89(3):957-89

Department of Biomedical Engineering, Saint Louis University, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1152/physrev.00041.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775470PMC
July 2009

Reduced vessel elasticity alters cardiovascular structure and function in newborn mice.

Circ Res 2009 May 16;104(10):1217-24. Epub 2009 Apr 16.

Department of Cell Biology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.192054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800958PMC
May 2009

Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure.

J Appl Physiol (1985) 2008 Nov 4;105(5):1610-9. Epub 2008 Sep 4.

Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1152/japplphysiol.90563.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584846PMC
November 2008

Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis.

Dev Dyn 2008 Oct;237(10):2844-61

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/dvdy.21705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081706PMC
October 2008

Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin.

Matrix Biol 2008 Sep 17;27(7):631-9. Epub 2008 Jun 17.

Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.matbio.2008.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586719PMC
September 2008

Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.

J Biol Chem 2008 Sep 14;283(37):25533-43. Epub 2008 Jul 14.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/jbc.M709962200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533084PMC
September 2008

Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle?

Mol Genet Genomics 2008 Aug 29;280(2):127-37. Epub 2008 May 29.

Institution for Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, Bruna stråket 16, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00438-008-0349-yDOI Listing
August 2008

Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.

Mol Genet Metab 2008 Jul 13;94(3):298-304. Epub 2008 May 13.

Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ymgme.2008.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775334PMC
July 2008

Methods in elastic tissue biology: elastin isolation and purification.

Authors:
Robert P Mecham

Methods 2008 May;45(1):32-41

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ymeth.2008.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2405817PMC
May 2008

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

Am J Respir Cell Mol Biol 2008 Apr 15;38(4):435-45. Epub 2007 Nov 15.

Department of Veterans Affairs Research Service and University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

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http://dx.doi.org/10.1165/rcmb.2007-0281OCDOI Listing
April 2008

Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils.

J Biol Chem 2008 Apr 4;283(15):9513-22. Epub 2008 Jan 4.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/jbc.M706239200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442305PMC
April 2008

Fibulin-2 is dispensable for mouse development and elastic fiber formation.

Mol Cell Biol 2008 Feb 10;28(3):1061-7. Epub 2007 Dec 10.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1128/MCB.01876-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223402PMC
February 2008

The intracellular form of human MAGP1 elicits a complex and specific transcriptional response.

Int J Biochem Cell Biol 2007 27;39(12):2303-13. Epub 2007 Jul 27.

Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.biocel.2007.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083557PMC
January 2008

New insights into elastic fiber assembly.

Birth Defects Res C Embryo Today 2007 Dec;81(4):229-40

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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December 2007

Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease.

Circ Res 2007 Aug 12;101(5):523-31. Epub 2007 Jul 12.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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August 2007