Robert M Plenge

Robert M Plenge

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Robert M Plenge

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Priority index for human genetics and drug discovery.

Authors:
Robert M Plenge

Nat Genet 2019 Jul;51(7):1073-1075

Research & Early Development, Celgene Corporation, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-019-0460-5DOI Listing
July 2019

Biomedicine: Human genes lost and their functions found.

Authors:
Robert M Plenge

Nature 2017 04;544(7649):171-172

Translational Medicine Department, Merck, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/544171aDOI Listing
April 2017

The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.

PLoS Genet 2016 09 14;12(9):e1006292. Epub 2016 Sep 14.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023119PMC
September 2016

Disciplined approach to drug discovery and early development.

Authors:
Robert M Plenge

Sci Transl Med 2016 07;8(349):349ps15

Merck Research Laboratories, Boston, MA 02115, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aaf2608DOI Listing
July 2016

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

PLoS One 2015 30;10(10):e0140815. Epub 2015 Oct 30.

Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140815PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627806PMC
June 2016

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388675PMC
March 2016

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:
S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

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http://dx.doi.org/10.1093/ije/dyv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881824PMC
October 2015

A role for noncoding variation in schizophrenia.

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00869-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400869
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http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

Modeling disease severity in multiple sclerosis using electronic health records.

PLoS One 2013 11;8(11):e78927. Epub 2013 Nov 11.

Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America ; Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823928PMC
August 2014

Quantifying missing heritability at known GWAS loci.

PLoS Genet 2013 26;9(12):e1003993. Epub 2013 Dec 26.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873246PMC
August 2014

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Am J Hum Genet 2014 Apr 20;94(4):522-32. Epub 2014 Mar 20.

Division of Genetics, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA; Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140007
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http://dx.doi.org/10.1016/j.ajhg.2014.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980428PMC
April 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.

Curr Opin Rheumatol 2014 Jan;26(1):85-92

aDivision of Rheumatology, Immunology bDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston cMedical and Population Genetics Program, Broad Institute, Cambridge dMerck Research Laboratories, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000012DOI Listing
January 2014

Validating therapeutic targets through human genetics.

Nat Rev Drug Discov 2013 Aug 19;12(8):581-94. Epub 2013 Jul 19.

Division of Rheumatology, Immunology and Allergy, Brigham And Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd4051DOI Listing
August 2013

Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.

Ann Rheum Dis 2013 Jul 6;72(7):1249-54. Epub 2012 Dec 6.

Mount Sinai Hospital Samuel Lunenfeld Research Institute and Toronto General Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/annrheumdis-2012-202076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686260PMC
July 2013

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.

Pharmacogenet Genomics 2013 Jun;23(6):324-8

Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283607acfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767309PMC
June 2013

Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis.

Inflammation 2013 Apr;36(2):279-84

Division of Rheumatology, Department of Medicine, New York Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, P&S Building, Suite 10-455, New York, NY 10032, USA.

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http://dx.doi.org/10.1007/s10753-012-9544-4DOI Listing
April 2013

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Authors:
Anna Köttgen Eva Albrecht Alexander Teumer Veronique Vitart Jan Krumsiek Claudia Hundertmark Giorgio Pistis Daniela Ruggiero Conall M O'Seaghdha Toomas Haller Qiong Yang Toshiko Tanaka Andrew D Johnson Zoltán Kutalik Albert V Smith Julia Shi Maksim Struchalin Rita P S Middelberg Morris J Brown Angelo L Gaffo Nicola Pirastu Guo Li Caroline Hayward Tatijana Zemunik Jennifer Huffman Loic Yengo Jing Hua Zhao Ayse Demirkan Mary F Feitosa Xuan Liu Giovanni Malerba Lorna M Lopez Pim van der Harst Xinzhong Li Marcus E Kleber Andrew A Hicks Ilja M Nolte Asa Johansson Federico Murgia Sarah H Wild Stephan J L Bakker John F Peden Abbas Dehghan Maristella Steri Albert Tenesa Vasiliki Lagou Perttu Salo Massimo Mangino Lynda M Rose Terho Lehtimäki Owen M Woodward Yukinori Okada Adrienne Tin Christian Müller Christopher Oldmeadow Margus Putku Darina Czamara Peter Kraft Laura Frogheri Gian Andri Thun Anne Grotevendt Gauti Kjartan Gislason Tamara B Harris Lenore J Launer Patrick McArdle Alan R Shuldiner Eric Boerwinkle Josef Coresh Helena Schmidt Michael Schallert Nicholas G Martin Grant W Montgomery Michiaki Kubo Yusuke Nakamura Toshihiro Tanaka Patricia B Munroe Nilesh J Samani David R Jacobs Kiang Liu Pio D'Adamo Sheila Ulivi Jerome I Rotter Bruce M Psaty Peter Vollenweider Gerard Waeber Susan Campbell Olivier Devuyst Pau Navarro Ivana Kolcic Nicholas Hastie Beverley Balkau Philippe Froguel Tõnu Esko Andres Salumets Kay Tee Khaw Claudia Langenberg Nicholas J Wareham Aaron Isaacs Aldi Kraja Qunyuan Zhang Philipp S Wild Rodney J Scott Elizabeth G Holliday Elin Org Margus Viigimaa Stefania Bandinelli Jeffrey E Metter Antonio Lupo Elisabetta Trabetti Rossella Sorice Angela Döring Eva Lattka Konstantin Strauch Fabian Theis Melanie Waldenberger H-Erich Wichmann Gail Davies Alan J Gow Marcel Bruinenberg Ronald P Stolk Jaspal S Kooner Weihua Zhang Bernhard R Winkelmann Bernhard O Boehm Susanne Lucae Brenda W Penninx Johannes H Smit Gary Curhan Poorva Mudgal Robert M Plenge Laura Portas Ivana Persico Mirna Kirin James F Wilson Irene Mateo Leach Wiek H van Gilst Anuj Goel Halit Ongen Albert Hofman Fernando Rivadeneira Andre G Uitterlinden Medea Imboden Arnold von Eckardstein Francesco Cucca Ramaiah Nagaraja Maria Grazia Piras Matthias Nauck Claudia Schurmann Kathrin Budde Florian Ernst Susan M Farrington Evropi Theodoratou Inga Prokopenko Michael Stumvoll Antti Jula Markus Perola Veikko Salomaa So-Youn Shin Tim D Spector Cinzia Sala Paul M Ridker Mika Kähönen Jorma Viikari Christian Hengstenberg Christopher P Nelson James F Meschia Michael A Nalls Pankaj Sharma Andrew B Singleton Naoyuki Kamatani Tanja Zeller Michel Burnier John Attia Maris Laan Norman Klopp Hans L Hillege Stefan Kloiber Hyon Choi Mario Pirastu Silvia Tore Nicole M Probst-Hensch Henry Völzke Vilmundur Gudnason Afshin Parsa Reinhold Schmidt John B Whitfield Myriam Fornage Paolo Gasparini David S Siscovick Ozren Polašek Harry Campbell Igor Rudan Nabila Bouatia-Naji Andres Metspalu Ruth J F Loos Cornelia M van Duijn Ingrid B Borecki Luigi Ferrucci Giovanni Gambaro Ian J Deary Bruce H R Wolffenbuttel John C Chambers Winfried März Peter P Pramstaller Harold Snieder Ulf Gyllensten Alan F Wright Gerjan Navis Hugh Watkins Jacqueline C M Witteman Serena Sanna Sabine Schipf Malcolm G Dunlop Anke Tönjes Samuli Ripatti Nicole Soranzo Daniela Toniolo Daniel I Chasman Olli Raitakari W H Linda Kao Marina Ciullo Caroline S Fox Mark Caulfield Murielle Bochud Christian Gieger

Nat Genet 2013 Feb 23;45(2):145-54. Epub 2012 Dec 23.

Renal Division, Freiburg University Hospital, Freiburg, Germany.

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http://dx.doi.org/10.1038/ng.2500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663712PMC
February 2013

GWAS implicates a role for quantitative immune traits and threshold effects in risk for human autoimmune disorders.

Curr Opin Immunol 2012 Oct 28;24(5):538-43. Epub 2012 Sep 28.

Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, United States.

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http://dx.doi.org/10.1016/j.coi.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758732PMC
October 2012

Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.

PLoS One 2011 12;6(9):e24380. Epub 2011 Sep 12.

Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024380PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171415PMC
January 2012

Recommendations for publication of genetic association studies in Arthritis & Rheumatism.

Arthritis Rheum 2011 Oct;63(10):2839-47

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/art.30509DOI Listing
October 2011

Genomic technology applied to pharmacological traits.

JAMA 2011 Aug;306(6):652-3

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2011.1125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295228PMC
August 2011

Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.

Am J Hum Genet 2011 Jan;88(1):57-69

Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014362PMC
January 2011

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Authors:
Florencia Pereyra Xiaoming Jia Paul J McLaren Amalio Telenti Paul I W de Bakker Bruce D Walker Stephan Ripke Chanson J Brumme Sara L Pulit Mary Carrington Carl M Kadie Jonathan M Carlson David Heckerman Robert R Graham Robert M Plenge Steven G Deeks Lauren Gianniny Gabriel Crawford Jordan Sullivan Elena Gonzalez Leela Davies Amy Camargo Jamie M Moore Nicole Beattie Supriya Gupta Andrew Crenshaw Noël P Burtt Candace Guiducci Namrata Gupta Xiaojiang Gao Ying Qi Yuko Yuki Alicja Piechocka-Trocha Emily Cutrell Rachel Rosenberg Kristin L Moss Paul Lemay Jessica O'Leary Todd Schaefer Pranshu Verma Ildiko Toth Brian Block Brett Baker Alissa Rothchild Jeffrey Lian Jacqueline Proudfoot Donna Marie L Alvino Seanna Vine Marylyn M Addo Todd M Allen Marcus Altfeld Matthew R Henn Sylvie Le Gall Hendrik Streeck David W Haas Daniel R Kuritzkes Gregory K Robbins Robert W Shafer Roy M Gulick Cecilia M Shikuma Richard Haubrich Sharon Riddler Paul E Sax Eric S Daar Heather J Ribaudo Brian Agan Shanu Agarwal Richard L Ahern Brady L Allen Sherly Altidor Eric L Altschuler Sujata Ambardar Kathryn Anastos Ben Anderson Val Anderson Ushan Andrady Diana Antoniskis David Bangsberg Daniel Barbaro William Barrie J Bartczak Simon Barton Patricia Basden Nesli Basgoz Suzane Bazner Nicholaos C Bellos Anne M Benson Judith Berger Nicole F Bernard Annette M Bernard Christopher Birch Stanley J Bodner Robert K Bolan Emilie T Boudreaux Meg Bradley James F Braun Jon E Brndjar Stephen J Brown Katherine Brown Sheldon T Brown Jedidiah Burack Larry M Bush Virginia Cafaro Omobolaji Campbell John Campbell Robert H Carlson J Kevin Carmichael Kathleen K Casey Chris Cavacuiti Gregory Celestin Steven T Chambers Nancy Chez Lisa M Chirch Paul J Cimoch Daniel Cohen Lillian E Cohn Brian Conway David A Cooper Brian Cornelson David T Cox Michael V Cristofano George Cuchural Julie L Czartoski Joseph M Dahman Jennifer S Daly Benjamin T Davis Kristine Davis Sheila M Davod Edwin DeJesus Craig A Dietz Eleanor Dunham Michael E Dunn Todd B Ellerin Joseph J Eron John J W Fangman Claire E Farel Helen Ferlazzo Sarah Fidler Anita Fleenor-Ford Renee Frankel Kenneth A Freedberg Neel K French Jonathan D Fuchs Jon D Fuller Jonna Gaberman Joel E Gallant Rajesh T Gandhi Efrain Garcia Donald Garmon Joseph C Gathe Cyril R Gaultier Wondwoosen Gebre Frank D Gilman Ian Gilson Paul A Goepfert Michael S Gottlieb Claudia Goulston Richard K Groger T Douglas Gurley Stuart Haber Robin Hardwicke W David Hardy P Richard Harrigan Trevor N Hawkins Sonya Heath Frederick M Hecht W Keith Henry Melissa Hladek Robert P Hoffman James M Horton Ricky K Hsu Gregory D Huhn Peter Hunt Mark J Hupert Mark L Illeman Hans Jaeger Robert M Jellinger Mina John Jennifer A Johnson Kristin L Johnson Heather Johnson Kay Johnson Jennifer Joly Wilbert C Jordan Carol A Kauffman Homayoon Khanlou Robert K Killian Arthur Y Kim David D Kim Clifford A Kinder Jeffrey T Kirchner Laura Kogelman Erna Milunka Kojic P Todd Korthuis Wayne Kurisu Douglas S Kwon Melissa LaMar Harry Lampiris Massimiliano Lanzafame Michael M Lederman David M Lee Jean M L Lee Marah J Lee Edward T Y Lee Janice Lemoine Jay A Levy Josep M Llibre Michael A Liguori Susan J Little Anne Y Liu Alvaro J Lopez Mono R Loutfy Dawn Loy Debbie Y Mohammed Alan Man Michael K Mansour Vincent C Marconi Martin Markowitz Rui Marques Jeffrey N Martin Harold L Martin Kenneth Hugh Mayer M Juliana McElrath Theresa A McGhee Barbara H McGovern Katherine McGowan Dawn McIntyre Gavin X Mcleod Prema Menezes Greg Mesa Craig E Metroka Dirk Meyer-Olson Andy O Miller Kate Montgomery Karam C Mounzer Ellen H Nagami Iris Nagin Ronald G Nahass Margret O Nelson Craig Nielsen David L Norene David H O'Connor Bisola O Ojikutu Jason Okulicz Olakunle O Oladehin Edward C Oldfield Susan A Olender Mario Ostrowski William F Owen Eunice Pae Jeffrey Parsonnet Andrew M Pavlatos Aaron M Perlmutter Michael N Pierce Jonathan M Pincus Leandro Pisani Lawrence Jay Price Laurie Proia Richard C Prokesch Heather Calderon Pujet Moti Ramgopal Almas Rathod Michael Rausch J Ravishankar Frank S Rhame Constance Shamuyarira Richards Douglas D Richman Berta Rodes Milagros Rodriguez Richard C Rose Eric S Rosenberg Daniel Rosenthal Polly E Ross David S Rubin Elease Rumbaugh Luis Saenz Michelle R Salvaggio William C Sanchez Veeraf M Sanjana Steven Santiago Wolfgang Schmidt Hanneke Schuitemaker Philip M Sestak Peter Shalit William Shay Vivian N Shirvani Vanessa I Silebi James M Sizemore Paul R Skolnik Marcia Sokol-Anderson James M Sosman Paul Stabile Jack T Stapleton Sheree Starrett Francine Stein Hans-Jurgen Stellbrink F Lisa Sterman Valerie E Stone David R Stone Giuseppe Tambussi Randy A Taplitz Ellen M Tedaldi Amalio Telenti William Theisen Richard Torres Lorraine Tosiello Cecile Tremblay Marc A Tribble Phuong D Trinh Alice Tsao Peggy Ueda Anthony Vaccaro Emilia Valadas Thanes J Vanig Isabel Vecino Vilma M Vega Wenoah Veikley Barbara H Wade Charles Walworth Chingchai Wanidworanun Douglas J Ward Daniel A Warner Robert D Weber Duncan Webster Steve Weis David A Wheeler David J White Ed Wilkins Alan Winston Clifford G Wlodaver Angelique van't Wout David P Wright Otto O Yang David L Yurdin Brandon W Zabukovic Kimon C Zachary Beth Zeeman Meng Zhao

Science 2010 Dec 4;330(6010):1551-7. Epub 2010 Nov 4.

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USA.

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http://dx.doi.org/10.1126/science.1195271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235490PMC
December 2010

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Nat Genet 2010 Jun 9;42(6):508-14. Epub 2010 May 9.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243840PMC
June 2010

Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

Rheum Dis Clin North Am 2010 May;36(2):259-70

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.rdc.2010.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879392PMC
May 2010

Unlocking the pathogenesis of celiac disease.

Authors:
Robert M Plenge

Nat Genet 2010 Apr;42(4):281-2

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http://www.nature.com/articles/ng0410-281
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http://dx.doi.org/10.1038/ng0410-281DOI Listing
April 2010

Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data.

BMC Proc 2009 Dec 15;3 Suppl 7:S2. Epub 2009 Dec 15.

Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795916PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s2DOI Listing
December 2009

Rheumatoid arthritis genetics: 2009 update.

Authors:
Robert M Plenge

Curr Rheumatol Rep 2009 Oct;11(5):351-6

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA.

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October 2009

Rare protection against type 1 diabetes.

Authors:
Robert M Plenge

Genome Biol 2009 15;10(5):219. Epub 2009 May 15.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2009-10-5-219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718509PMC
August 2009

Recent progress in rheumatoid arthritis genetics: one step towards improved patient care.

Authors:
Robert M Plenge

Curr Opin Rheumatol 2009 May;21(3):262-71

Division of Rheumatology, Immunology and Allergy, Brigham and Women's, Hospital, Harvard Medical School, Boston, USA.

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https://insights.ovid.com/crossref?an=00002281-200905000-000
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http://dx.doi.org/10.1097/BOR.0b013e32832a2e2dDOI Listing
May 2009

Defining the role of the MHC in autoimmunity: a review and pooled analysis.

PLoS Genet 2008 Apr 25;4(4):e1000024. Epub 2008 Apr 25.

Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291482PMC
April 2008

Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis: current challenges and future directions.

Curr Opin Rheumatol 2008 Mar;20(2):145-52

Division of Rheumatology, Immunology and Allergy, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1097/BOR.0b013e3282f5135bDOI Listing
March 2008