Robert Lyle

Robert Lyle

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J Pediatr 2019 Jun 8;209:257-258. Epub 2019 Mar 8.

University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, Arkansas.

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http://dx.doi.org/10.1016/j.jpeds.2019.02.007DOI Listing
June 2019

Long-Term Neurodevelopment of Low-Birthweight, Preterm Infants with Patent Ductus Arteriosus.

J Pediatr 2018 12 26;203:170-176.e1. Epub 2018 Sep 26.

Arkansas Children's Research Institute, Little Rock, AR; Section of Developmental Pediatrics, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR.

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http://dx.doi.org/10.1016/j.jpeds.2018.08.004DOI Listing
December 2018

Health-care spending and utilization for children discharged from a neonatal intensive care unit.

J Perinatol 2018 06 15;38(6):734-741. Epub 2018 Feb 15.

Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1038/s41372-018-0055-5DOI Listing
June 2018

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.

Clin Epigenetics 2017 2;9:77. Epub 2017 Aug 2.

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1186/s13148-017-0376-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540511PMC
April 2018

Care System Redesign for Preterm Children After Discharge From the NICU.

Pediatrics 2017 Apr 1;139(4). Epub 2017 Mar 1.

Children's Hospital Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1542/peds.2016-2969DOI Listing
April 2017

Degradation in forensic trace DNA samples explored by massively parallel sequencing.

Forensic Sci Int Genet 2017 03 3;27:160-166. Epub 2017 Jan 3.

Department of Forensic Biology, Norwegian Institute of Public Health, Oslo, Norway; Department of Forensic Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.fsigen.2017.01.002DOI Listing
March 2017

Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.

Authors:
Asbjørg Stray-Pedersen Hanne Sørmo Sorte Pubudu Samarakoon Tomasz Gambin Ivan K Chinn Zeynep H Coban Akdemir Hans Christian Erichsen Lisa R Forbes Shen Gu Bo Yuan Shalini N Jhangiani Donna M Muzny Olaug Kristin Rødningen Ying Sheng Sarah K Nicholas Lenora M Noroski Filiz O Seeborg Carla M Davis Debra L Canter Emily M Mace Timothy J Vece Carl E Allen Harshal A Abhyankar Philip M Boone Christine R Beck Wojciech Wiszniewski Børre Fevang Pål Aukrust Geir E Tjønnfjord Tobias Gedde-Dahl Henrik Hjorth-Hansen Ingunn Dybedal Ingvild Nordøy Silje F Jørgensen Tore G Abrahamsen Torstein Øverland Anne Grete Bechensteen Vegard Skogen Liv T N Osnes Mari Ann Kulseth Trine E Prescott Cecilie F Rustad Ketil R Heimdal John W Belmont Nicholas L Rider Javier Chinen Tram N Cao Eric A Smith Maria Soledad Caldirola Liliana Bezrodnik Saul Oswaldo Lugo Reyes Francisco J Espinosa Rosales Nina Denisse Guerrero-Cursaru Luis Alberto Pedroza Cecilia M Poli Jose L Franco Claudia M Trujillo Vargas Juan Carlos Aldave Becerra Nicola Wright Thomas B Issekutz Andrew C Issekutz Jordan Abbott Jason W Caldwell Diana K Bayer Alice Y Chan Alessandro Aiuti Caterina Cancrini Eva Holmberg Christina West Magnus Burstedt Ender Karaca Gözde Yesil Hasibe Artac Yavuz Bayram Mehmed Musa Atik Mohammad K Eldomery Mohammad S Ehlayel Stephen Jolles Berit Flatø Alison A Bertuch I Celine Hanson Victor W Zhang Lee-Jun Wong Jianhong Hu Magdalena Walkiewicz Yaping Yang Christine M Eng Eric Boerwinkle Richard A Gibbs William T Shearer Robert Lyle Jordan S Orange James R Lupski

J Allergy Clin Immunol 2017 01 16;139(1):232-245. Epub 2016 Jul 16.

Baylor-Hopkins Center for Mendelian Genomics of the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex; Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, Tex; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Tex. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222743PMC
January 2017

A potential founder variant in in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction.

Mol Genet Genomic Med 2016 Nov 17;4(6):604-616. Epub 2016 Sep 17.

Baylor-Hopkins Center for Mendelian Genomics (BHCMG) of the Department of Molecular and Human GeneticsBaylor College of MedicineHoustonTexas; Norwegian National Unit for Newborn ScreeningDivision of Children and Adolescent MedicineOslo University HospitalOsloNorway.

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http://dx.doi.org/10.1002/mgg3.237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118205PMC
November 2016

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study.

Front Immunol 2016 17;7:510. Epub 2016 Nov 17.

The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.3389/fimmu.2016.00510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112246PMC
November 2016

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.

Epigenetics Chromatin 2016 31;9:21. Epub 2016 May 31.

Nordic European Molecular Laboratory (EMBL) Partnership, Centre for Molecular Medicine Norway, University of Oslo, Blindern, P.O. Box 1137, 0318 Oslo, Norway ; Department of Haematology, Oslo University Hospital, Oslo, Norway ; Norwegian Center for Stem Cell Research, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1186/s13072-016-0070-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888655PMC
June 2016

Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas.

Neuro Endocrinol Lett 2015 ;36(2):136-42

Research Institute for Internal Medicine, Oslo University Hospital, Oslo, Norway.

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September 2015

microRNA Biomarker Discovery and High-Throughput DNA Sequencing Are Possible Using Long-term Archived Serum Samples.

Cancer Epidemiol Biomarkers Prev 2015 Sep 24;24(9):1381-7. Epub 2015 Jun 24.

Department of Research, Cancer Registry of Norway, Oslo, Norway.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-15-0289DOI Listing
September 2015

Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women.

J Bone Miner Res 2015 Feb;30(2):249-56

Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Lovisenberg Diakonale Hospital, Oslo, Norway; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1002/jbmr.2342DOI Listing
February 2015

Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.

Cell Rep 2014 Sep 21;8(5):1432-46. Epub 2014 Aug 21.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.035DOI Listing
September 2014

A dominant STIM1 mutation causes Stormorken syndrome.

Hum Mutat 2014 May 9;35(5):556-64. Epub 2014 Apr 9.

Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/humu.22544DOI Listing
May 2014

Epithelial splicing regulator protein 1 and alternative splicing in somatotroph adenomas.

Endocrinology 2013 Sep 3;154(9):3331-43. Epub 2013 Jul 3.

Section of Specialized Endocrinology and Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, University of Oslo, PO Box 4950 Nydalen, 0424 Oslo, Norway.

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http://dx.doi.org/10.1210/en.2013-1051DOI Listing
September 2013

Parent-reported outcomes of comprehensive care for children with medical complexity.

Fam Syst Health 2013 Jun;31(2):132-41

Center for Applied Research and Evaluation, Department of Pediatrics, University of Arkansas for Medical Sciences, AR, USA.

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http://dx.doi.org/10.1037/a0032341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941173PMC
June 2013

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.

Nucleic Acids Res 2013 Mar 15;41(5):2846-56. Epub 2013 Jan 15.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.

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http://dx.doi.org/10.1093/nar/gks1336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597645PMC
March 2013

The Norwegian Twin Registry from a public health perspective: a research update.

Twin Res Hum Genet 2013 Feb 28;16(1):285-95. Epub 2012 Nov 28.

Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1017/thg.2012.117DOI Listing
February 2013

Limitations and possibilities of low cell number ChIP-seq.

BMC Genomics 2012 Nov 21;13:645. Epub 2012 Nov 21.

Department of Medical Genetics, Oslo University Hospital, Norway.

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http://dx.doi.org/10.1186/1471-2164-13-645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533509PMC
November 2012

Diagnosis by sequencing: correction of misdiagnosis from FSHD2 to LGMD2A by whole-exome analysis.

Eur J Hum Genet 2012 Sep 29;20(9):999-1003. Epub 2012 Feb 29.

Centre for Genetics and Genomics, School of Biology, Queen's Medical Centre, The University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1038/ejhg.2012.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421126PMC
September 2012

Early life interventions to prevent allergy in the offspring: the role of maternal immunization and postnatal mucosal allergen exposure.

Int Arch Allergy Immunol 2012 2;158(3):261-75. Epub 2012 Mar 2.

Department of Environmental Immunology, Norwegian Institute of Public Health, Nydalen, Oslo, Norway.

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https://www.karger.com/Article/FullText/332963
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http://dx.doi.org/10.1159/000332963DOI Listing
August 2012

miR-511-3p modulates genetic programs of tumor-associated macrophages.

Cell Rep 2012 Feb 9;1(2):141-54. Epub 2012 Feb 9.

Angiogenesis and Tumor Targeting Unit, and HSR-TIGET, Division of Regenerative Medicine, San Raffaele Institute, 20132-Milan, Italy.

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http://dx.doi.org/10.1016/j.celrep.2011.12.005DOI Listing
February 2012

Extensive variation and low heritability of DNA methylation identified in a twin study.

Genome Res 2011 Nov 26;21(11):1813-21. Epub 2011 Sep 26.

Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0407 Oslo, Norway;

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http://dx.doi.org/10.1101/gr.119685.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205566PMC
November 2011

Exon trapping analysis of c.301-19G > A in intron 1 of the SHH gene in a patient with a microform of holoprosencephaly.

Eur J Med Genet 2011 Mar-Apr;54(2):130-5. Epub 2010 Oct 31.

Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1016/j.ejmg.2010.10.011DOI Listing
August 2011

Effect of hospital-based comprehensive care clinic on health costs for Medicaid-insured medically complex children.

Arch Pediatr Adolesc Med 2011 May 7;165(5):392-8. Epub 2011 Feb 7.

Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, 1 Children's Way, Little Rock, AR 72202, USA.

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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archpediatrics.2011.5DOI Listing
May 2011

Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.

PLoS One 2011 Feb 28;6(2):e17316. Epub 2011 Feb 28.

Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017316PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046167PMC
February 2011

Increasing prevalence of medically complex children in US hospitals.

Pediatrics 2010 Oct 20;126(4):638-46. Epub 2010 Sep 20.

Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, 1 Children's Way, Slot 512-41, Little Rock, AR 72202, USA.

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2009-1658DOI Listing
October 2010

CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?

J Allergy Clin Immunol 2010 Jun 15;125(6):1361-8. Epub 2010 Apr 15.

Department of Pediatrics, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1016/j.jaci.2010.02.010DOI Listing
June 2010

CH medical home program for special needs children. A new medical era...

J Ark Med Soc 2009 Jan;105(7):163-5

University of Arkansas for Medical Sciences Arkansas Children's Hospital, Little Rock, Arkansas, USA.

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January 2009

Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.

Mamm Genome 2008 Apr 5;19(4):272-8. Epub 2008 Apr 5.

Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland.

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http://link.springer.com/10.1007/s00335-008-9106-0
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http://dx.doi.org/10.1007/s00335-008-9106-0DOI Listing
April 2008

Gene expression variation and expression quantitative trait mapping of human chromosome 21 genes.

Hum Mol Genet 2005 Dec 26;14(23):3741-9. Epub 2005 Oct 26.

Department of Genetic Medicine and Development, Geneva University Medical School, Geneva, Switzerland.

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http://dx.doi.org/10.1093/hmg/ddi404DOI Listing
December 2005

Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro.

Hum Mutat 2005 Jun;25(6):543-9

Department of Genetic Medicine and Development, University of Geneva Medical School and Geneva University Hospitals, Geneva, Switzerland.

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http://dx.doi.org/10.1002/humu.20172DOI Listing
June 2005

Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis.

Proc Natl Acad Sci U S A 2005 Mar 7;102(11):4068-73. Epub 2005 Mar 7.

Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0500702102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC552976PMC
March 2005

Chromosome 21 and down syndrome: from genomics to pathophysiology.

Nat Rev Genet 2004 Oct;5(10):725-38

Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland.

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http://www.nature.com/articles/nrg1448
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http://dx.doi.org/10.1038/nrg1448DOI Listing
October 2004

Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome.

Genome Res 2004 Jul;14(7):1268-74

Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1101/gr.2090904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC442141PMC
July 2004

The TPTE gene family: cellular expression, subcellular localization and alternative splicing.

Gene 2003 Dec;323:189-99

Division of Medical Genetics, Centre Medical Universitaire, University of Geneva Medical School, 1, Rue Michel Servet CH-1211, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.gene.2003.09.038DOI Listing
December 2003

Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes.

Proc Natl Acad Sci U S A 2003 Feb 27;100(3):1140-5. Epub 2003 Jan 27.

Research Group in Biomedical Informatics, Institut Municipal d'Investigació Mèdica/Universitat Pompeu Fabra/Centre de Regulació Genòmica, E08003 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1073/pnas.0337561100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298740PMC
February 2003

Numerous potentially functional but non-genic conserved sequences on human chromosome 21.

Nature 2002 Dec;420(6915):578-82

Division of Medical Genetics, 1 Rue Michel-Servet, University of Geneva Medical School and University Hospitals of Geneva, CH-1211 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nature01251DOI Listing
December 2002

Human chromosome 21 gene expression atlas in the mouse.

Nature 2002 Dec;420(6915):582-6

Division of Medical Genetics, University of Geneva Medical School and University Hospital of Geneva, CMU, 1, rue Michel Servet, 1211 Geneva, Switzerland.

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http://www.nature.com/articles/nature01178
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http://dx.doi.org/10.1038/nature01178DOI Listing
December 2002

Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.

Biochem Biophys Res Commun 2002 Jan;290(3):1066-71

Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas 72205, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0196291
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http://dx.doi.org/10.1006/bbrc.2001.6291DOI Listing
January 2002

Chromosome 21: a small land of fascinating disorders with unknown pathophysiology.

Int J Dev Biol 2002 Jan;46(1):89-96

Division of Medical Genetics, University of Geneva Medical School and University Hospitals, Switzerland.

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January 2002