Robert Langer

Robert Langer

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Robert Langer

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Trends in Therapeutic Conjugates: Bench to Clinic.

Authors:
Arnab Rudra Junwei Li Rameen Shakur Sachin Bhagchandani Robert Langer

Bioconjug Chem 2020 Feb 11. Epub 2020 Feb 11.

David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00828DOI Listing
February 2020

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs.

Authors:
Jicheng Yu Jinqiang Wang Yuqi Zhang Guojun Chen Weiwei Mao Yanqi Ye Anna R Kahkoska John B Buse Robert Langer Zhen Gu

Nat Biomed Eng 2020 Feb 3. Epub 2020 Feb 3.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.

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http://dx.doi.org/10.1038/s41551-019-0508-yDOI Listing
February 2020

Cyclodextrins in drug delivery: applications in gene and combination therapy.

Authors:
Rebecca M Haley Riccardo Gottardi Robert Langer Michael J Mitchell

Drug Deliv Transl Res 2020 Feb 19. Epub 2020 Feb 19.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s13346-020-00724-5DOI Listing
February 2020

Chiral Supraparticles for Controllable Nanomedicine.

Authors:
Jihyeon Yeom Pedro P G Guimaraes Hyo Min Ahn Bo-Kyeong Jung Quanyin Hu Kevin McHugh Michael J Mitchell Chae-Ok Yun Robert Langer Ana Jaklenec

Adv Mater 2020 Jan 5;32(1):e1903878. Epub 2019 Nov 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201903878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986383PMC
January 2020

From Molecule to Patient: A Biotech Perspective.

Authors:
Robert Langer Ana Jaklenec Giovanni Traverso Daniel Hartman

Clin Pharmacol Ther 2020 Jan 20;107(1):65-67. Epub 2019 Nov 20.

Global Health Division, Bill and Melinda Gates Foundation, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/cpt.1676DOI Listing
January 2020

Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery.

Authors:
Lisa R Volpatti Morgan A Matranga Abel B Cortinas Derfogail Delcassian Kevin B Daniel Robert Langer Daniel G Anderson

ACS Nano 2020 Jan 20;14(1):488-497. Epub 2019 Dec 20.

Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsnano.9b06395DOI Listing
January 2020

Light-degradable hydrogels as dynamic triggers for gastrointestinal applications.

Authors:
Ritu Raman Tiffany Hua Declan Gwynne Joy Collins Siddartha Tamang Jianlin Zhou Tina Esfandiary Vance Soares Simo Pajovic Alison Hayward Robert Langer Giovanni Traverso

Sci Adv 2020 01 17;6(3):eaay0065. Epub 2020 Jan 17.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/sciadv.aay0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968934PMC
January 2020

Injectable Polymer-Nanoparticle Hydrogels for Local Immune Cell Recruitment.

Authors:
Owen S Fenton Mark W Tibbitt Eric A Appel Siddharth Jhunjhunwala Matthew J Webber Robert Langer

Biomacromolecules 2019 Dec 4;20(12):4430-4436. Epub 2019 Nov 4.

Department of Chemical and Biomolecular Engineering , University of Notre Dame , Notre Dame , Indiana 46556 , United States.

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http://dx.doi.org/10.1021/acs.biomac.9b01129DOI Listing
December 2019

A once-a-month oral contraceptive.

Authors:
Ameya R Kirtane Tiffany Hua Alison Hayward Ambika Bajpayee Aniket Wahane Aaron Lopes Taylor Bensel Lihong Ma Frank Z Stanczyk Sierra Brooks Declan Gwynne Jacob Wainer Joy Collins Siddartha M Tamang Robert Langer Giovanni Traverso

Sci Transl Med 2019 Dec;11(521)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay2602DOI Listing
December 2019

Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination.

Authors:
Kevin J McHugh Lihong Jing Sean Y Severt Mache Cruz Morteza Sarmadi Hapuarachchige Surangi N Jayawardena Collin F Perkinson Fridrik Larusson Sviatlana Rose Stephanie Tomasic Tyler Graf Stephany Y Tzeng James L Sugarman Daniel Vlasic Matthew Peters Nels Peterson Lowell Wood Wen Tang Jihyeon Yeom Joe Collins Philip A Welkhoff Ari Karchin Megan Tse Mingyuan Gao Moungi G Bawendi Robert Langer Ana Jaklenec

Sci Transl Med 2019 Dec;11(523)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay7162DOI Listing
December 2019

Enhancing the defect contrast in ECCI through angular filtering of BSEs.

Authors:
Han Han Thomas Hantschel Andreas Schulze Libor Strakos Tomas Vystavel Roger Loo Bernardette Kunert Robert Langer Wilfried Vandervorst Matty Caymax

Ultramicroscopy 2019 Dec 24;210:112922. Epub 2019 Dec 24.

imec, Kapeldreef 75, Leuven 3001, Belgium.

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http://dx.doi.org/10.1016/j.ultramic.2019.112922DOI Listing
December 2019

Application of electron channeling contrast imaging to 3D semiconductor structures through proper detector configurations.

Authors:
Han Han Thomas Hantschel Libor Strakos Tomas Vystavel Marina Baryshnikova Yves Mols Bernardette Kunert Robert Langer Wilfried Vandervorst Matty Caymax

Ultramicroscopy 2019 Dec 30;210:112928. Epub 2019 Dec 30.

imec, Kapeldreef 75, Leuven 3001, Belgium.

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http://dx.doi.org/10.1016/j.ultramic.2019.112928DOI Listing
December 2019

A heat-stable microparticle platform for oral micronutrient delivery.

Authors:
Aaron C Anselmo Xian Xu Simone Buerkli Yingying Zeng Wen Tang Kevin J McHugh Adam M Behrens Evan Rosenberg Aranda R Duan James L Sugarman Jia Zhuang Joe Collins Xueguang Lu Tyler Graf Stephany Y Tzeng Sviatlana Rose Sarah Acolatse Thanh D Nguyen Xiao Le Ana Sofia Guerra Lisa E Freed Shelley B Weinstock Christopher B Sears Boris Nikolic Lowell Wood Philip A Welkhoff James D Oxley Diego Moretti Michael B Zimmermann Robert Langer Ana Jaklenec

Sci Transl Med 2019 Nov;11(518)

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaw3680DOI Listing
November 2019

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.

Authors:
Elena M Smekalova Maxim V Gerashchenko Patrick B F O'Connor Charles A Whittaker Kevin J Kauffman Anna S Fefilova Timofei S Zatsepin Roman L Bogorad Pavel V Baranov Robert Langer Vadim N Gladyshev Daniel G Anderson Victor Koteliansky

Mol Ther Nucleic Acids 2019 Nov 18;19:252-266. Epub 2019 Nov 18.

Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926209PMC
November 2019

Lewis Acid Transition-Metal-Catalyzed Hydrogen Activation: Structures, Mechanisms, and Reactivities.

Authors:
Yinwu Li Jiahao Liu Xiao Huang Ling-Bo Qu Cunyuan Zhao Robert Langer Zhuofeng Ke

Chemistry 2019 Oct 20;25(60):13785-13798. Epub 2019 Sep 20.

School of Materials Science & Engineering, PCFM Lab, Department of Chemistry, Sun Yat-sen University, Guangzhou, 510275, P. R. China.

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http://dx.doi.org/10.1002/chem.201903193DOI Listing
October 2019

Using Large Datasets to Understand Nanotechnology.

Authors:
Kalina Paunovska David Loughrey Cory D Sago Robert Langer James E Dahlman

Adv Mater 2019 Oct 20;31(43):e1902798. Epub 2019 Aug 20.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2019027
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http://dx.doi.org/10.1002/adma.201902798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810779PMC
October 2019

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation.

Authors:
Lei Miao Linxian Li Yuxuan Huang Derfogail Delcassian Jasdave Chahal Jinsong Han Yunhua Shi Kaitlyn Sadtler Wenting Gao Jiaqi Lin Joshua C Doloff Robert Langer Daniel G Anderson

Nat Biotechnol 2019 10 30;37(10):1174-1185. Epub 2019 Sep 30.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0247-3DOI Listing
October 2019

Can Fish and Cell Phones Teach Us about Our Health?

Authors:
Michael A Lee Carlos M Duarte Víctor M Eguíluz Daniel A Heller Robert Langer Mark G Meekan Hadley D Sikes Mani Srivastava Michael S Strano Rory P Wilson

ACS Sens 2019 Oct 2;4(10):2566-2570. Epub 2019 Oct 2.

Department of Biosciences, College of Science , Swansea University , Swansea , Wales , SA2 8PP , United Kingdom.

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http://dx.doi.org/10.1021/acssensors.9b00947DOI Listing
October 2019

A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults.

Authors:
Melaney Bouthillette Daniela Beccati Ariya Akthakul Nithin Ramadurai Amir Nashat Robert Langer R Rox Anderson Fernanda H Sakamoto

J Am Acad Dermatol 2019 Oct 4. Epub 2019 Oct 4.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.09.073DOI Listing
October 2019

A luminal unfolding microneedle injector for oral delivery of macromolecules.

Authors:
Alex Abramson Ester Caffarel-Salvador Vance Soares Daniel Minahan Ryan Yu Tian Xiaoya Lu David Dellal Yuan Gao Soyoung Kim Jacob Wainer Joy Collins Siddartha Tamang Alison Hayward Tadayuki Yoshitake Hsiang-Chieh Lee James Fujimoto Johannes Fels Morten Revsgaard Frederiksen Ulrik Rahbek Niclas Roxhed Robert Langer Giovanni Traverso

Nat Med 2019 10 7;25(10):1512-1518. Epub 2019 Oct 7.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41591-019-0598-9DOI Listing
October 2019

Endoscopically Injectable Shear-Thinning Hydrogels Facilitating Polyp Removal.

Authors:
Yan Pang Jinyao Liu Zaina L Moussa Joy E Collins Shane McDonnell Alison M Hayward Kunal Jajoo Robert Langer Giovanni Traverso

Adv Sci (Weinh) 2019 Oct 30;6(19):1901041. Epub 2019 Jul 30.

Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.

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http://dx.doi.org/10.1002/advs.201901041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774062PMC
October 2019

Steerable Microinvasive Probes for Localized Drug Delivery to Deep Tissue.

Authors:
Max J Cotler Erin B Rousseau Khalil B Ramadi Joshua Fang Ann M Graybiel Robert Langer Michael J Cima

Small 2019 Sep 11;15(37):e1901459. Epub 2019 Jun 11.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/smll.201901459DOI Listing
September 2019

A New Approach for Microfabrication of Printed Circuit Boards with Ultrafine Traces.

Authors:
Seyed M Mirvakili Kurt Broderick Robert S Langer

ACS Appl Mater Interfaces 2019 Sep 13;11(38):35376-35381. Epub 2019 Sep 13.

Langer Lab , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsami.9b08761DOI Listing
September 2019

Flexible Multielectrode Array for Skeletal Muscle Conditioning, Acetylcholine Receptor Stabilization and Epimysial Recording After Critical Peripheral Nerve Injury.

Authors:
Malia McAvoy Jonathan K Tsosie Keval N Vyas Omar F Khan Kaitlyn Sadtler Robert Langer Daniel G Anderson

Theranostics 2019 21;9(23):7099-7107. Epub 2019 Sep 21.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.7150/thno.35436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815960PMC
September 2019

Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds.

Authors:
Benjamin L Larson Sarah N Yu Hyoungshin Park Bradley T Estes Franklin T Moutos Cameron J Bloomquist Patrick B Wu Jean F Welter Robert Langer Farshid Guilak Lisa E Freed

J Tissue Eng Regen Med 2019 08 18;13(8):1453-1465. Epub 2019 Jul 18.

Institute for Medical Engineering and Science, David H. Koch Institute for Integrative Cancer Research, and Media Lab, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1002/term.2899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715532PMC
August 2019

Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations.

Authors:
Shady Farah Joshua C Doloff Peter Müller Atieh Sadraei Hye Jung Han Katy Olafson Keval Vyas Hok Hei Tam Jennifer Hollister-Lock Piotr S Kowalski Marissa Griffin Ashley Meng Malia McAvoy Adam C Graham James McGarrigle Jose Oberholzer Gordon C Weir Dale L Greiner Robert Langer Daniel G Anderson

Nat Mater 2019 Aug 24;18(8):892-904. Epub 2019 Jun 24.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41563-019-0377-5DOI Listing
August 2019

Biohybrid Design Gets Personal: New Materials for Patient-Specific Therapy.

Authors:
Ritu Raman Robert Langer

Adv Mater 2019 Jul 4:e1901969. Epub 2019 Jul 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St., Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1002/adma.201901969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942246PMC
July 2019

Steroid pretreatment of organ donors does not impact on early rejection and long-term kidney allograft survival: Results from a multicenter randomized, controlled trial.

Authors:
Roman Reindl-Schwaighofer Alexander Kainz Kira Jelencsics Andreas Heinzel Gabriela Berlakovich Ádám Remport Georg Heinze Robert Langer Rainer Oberbauer

Am J Transplant 2019 06 1;19(6):1770-1776. Epub 2019 Feb 1.

Department of Nephrology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/ajt.15252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563104PMC
June 2019

Ultra-rapid drug delivery in the oral cavity using ultrasound.

Authors:
Marion M France Tony Del Rio Hannah Travers Erin Raftery Katherine Xu Robert Langer Giovanni Traverso Jochen K Lennerz Carl M Schoellhammer

J Control Release 2019 Jun 27;304:1-6. Epub 2019 Apr 27.

Suono Bio, Inc., 501 Massachusetts Avenue, Cambridge, MA 02139, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.04.037DOI Listing
June 2019

Outlooks on Three-Dimensional Printing for Ocular Biomaterials Research.

Authors:
Owen S Fenton Marion Paolini Jason L Andresen Florence J Müller Robert Langer

J Ocul Pharmacol Ther 2020 Jan/Feb;36(1):7-17. Epub 2019 Jun 18.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/jop.2018.0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985767PMC
June 2019

Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering.

Authors:
Tyler Hoffman Ali Khademhosseini Robert Langer

Tissue Eng Part A 2019 05;25(9-10):679-687

7 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/ten.TEA.2019.0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533781PMC
May 2019

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Authors:
Qiujun Yu Yi-Yin Tai Ying Tang Jingsi Zhao Vinny Negi Miranda K Culley Jyotsna Pilli Wei Sun Karin Brugger Johannes Mayr Rajeev Saggar Rajan Saggar W Dean Wallace David J Ross Aaron B Waxman Stacy G Wendell Steven J Mullett John Sembrat Mauricio Rojas Omar F Khan James E Dahlman Masataka Sugahara Nobuyuki Kagiyama Taijyu Satoh Manling Zhang Ning Feng John Gorcsan Sara O Vargas Kathleen J Haley Rahul Kumar Brian B Graham Robert Langer Daniel G Anderson Bing Wang Sruti Shiva Thomas Bertero Stephen Y Chan

Circulation 2019 05;139(19):2238-2255

Center for Pulmonary Vascular Biology and Medicine, Center for Metabolism and Mitochondrial Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (Q.Y., Y.-Y.T., Y.T., J.Z., V.N., M.K.C., J.P., W.S., J.S., M.R., M.S., N.K., T.S., M.Z., N.F., S.S., S.Y.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519484PMC
May 2019

Quantifying the Donor Strength of Ligand-Stabilized Main Group Fragments.

Authors:
Leon Maser Christian Schneider Lisa Vondung Lukas Alig Robert Langer

J Am Chem Soc 2019 May 25;141(18):7596-7604. Epub 2019 Apr 25.

Department of Chemistry , Philipps-Universität Marburg , Hans-Meerwein-Str. 4 , 35032 Marburg , Germany.

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http://pubs.acs.org/doi/10.1021/jacs.9b02598
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http://dx.doi.org/10.1021/jacs.9b02598DOI Listing
May 2019

Microbial therapeutics: New opportunities for drug delivery.

Authors:
Miguel Jimenez Robert Langer Giovanni Traverso

J Exp Med 2019 May 26;216(5):1005-1009. Epub 2019 Apr 26.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA

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http://dx.doi.org/10.1084/jem.20190609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504217PMC
May 2019

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.

Authors:
Vikash P Chauhan Ivy X Chen Rong Tong Mei Rosa Ng John D Martin Kamila Naxerova Michelle W Wu Peigen Huang Yves Boucher Daniel S Kohane Robert Langer Rakesh K Jain

Proc Natl Acad Sci U S A 2019 May 30;116(22):10674-10680. Epub 2019 Apr 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1819889116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561160PMC
May 2019

Polymers for extended-release administration.

Authors:
Marion S Paolini Owen S Fenton Chandrabali Bhattacharya Jason L Andresen Robert Langer

Biomed Microdevices 2019 04 8;21(2):45. Epub 2019 Apr 8.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1007/s10544-019-0386-9DOI Listing
April 2019

Temperature-responsive biometamaterials for gastrointestinal applications.

Authors:
Sahab Babaee Simo Pajovic Ameya R Kirtane Jiuyun Shi Ester Caffarel-Salvador Kaitlyn Hess Joy E Collins Siddartha Tamang Aniket V Wahane Alison M Hayward Hormoz Mazdiyasni Robert Langer Giovanni Traverso

Sci Transl Med 2019 04;11(488)

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aau8581DOI Listing
April 2019

Drug delivery across length scales.

Authors:
Derfogail Delcassian Asha K Patel Abel B Cortinas Robert Langer

J Drug Target 2019 Mar 20;27(3):229-243. Epub 2018 Feb 20.

a David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , MA , USA.

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https://www.tandfonline.com/doi/full/10.1080/1061186X.2018.1
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http://dx.doi.org/10.1080/1061186X.2018.1438440DOI Listing
March 2019

Drug loading augmentation in polymeric nanoparticles using a coaxial turbulent jet mixer: Yong investigator perspective.

Authors:
Jong-Min Lim Truong Cai Stefan Mandaric Sunandini Chopra Hyeonwoo Han Seokkyu Jang Won Il Choi Robert Langer Omid C Farokhzad Rohit Karnik

J Colloid Interface Sci 2019 Mar 10;538:45-50. Epub 2018 Nov 10.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00219797183134
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http://dx.doi.org/10.1016/j.jcis.2018.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360111PMC
March 2019

Delivery technologies for cancer immunotherapy.

Authors:
Rachel S Riley Carl H June Robert Langer Michael J Mitchell

Nat Rev Drug Discov 2019 03;18(3):175-196

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41573-018-0006-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410566PMC
March 2019

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.

Authors:
Ivy X Chen Vikash P Chauhan Jessica Posada Mei R Ng Michelle W Wu Pichet Adstamongkonkul Peigen Huang Neal Lindeman Robert Langer Rakesh K Jain

Proc Natl Acad Sci U S A 2019 Mar 30;116(10):4558-4566. Epub 2019 Jan 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1815515116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410779PMC
March 2019

Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

Authors:
Virginia Spanoudaki Joshua C Doloff Wei Huang Samuel R Norcross Shady Farah Robert Langer Daniel G Anderson

Proc Natl Acad Sci U S A 2019 03 26;116(11):4861-4870. Epub 2019 Feb 26.

David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1815909116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421446PMC
March 2019

A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.

Authors:
Malvika Verma Karan Vishwanath Feyisope Eweje Niclas Roxhed Tyler Grant Macy Castaneda Christoph Steiger Hormoz Mazdiyasni Taylor Bensel Daniel Minahan Vance Soares John A F Salama Aaron Lopes Kaitlyn Hess Cody Cleveland Daniel J Fulop Alison Hayward Joy Collins Siddartha M Tamang Tiffany Hua Chinonyelum Ikeanyi Gal Zeidman Elizabeth Mule Sooraj Boominathan Ellena Popova Jonathan B Miller Andrew M Bellinger David Collins Dalia Leibowitz Shelly Batra Sandeep Ahuja Manju Bajiya Sonali Batra Rohit Sarin Upasna Agarwal Sunil D Khaparde Neeraj K Gupta Deepak Gupta Anuj K Bhatnagar Kamal K Chopra Nandini Sharma Ashwani Khanna Jayeeta Chowdhury Robert Stoner Alexander H Slocum Michael J Cima Jennifer Furin Robert Langer Giovanni Traverso

Sci Transl Med 2019 03;11(483)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aau6267DOI Listing
March 2019

Polyimide Electrode-Based Electrical Stimulation Impedes Early Stage Muscle Graft Regeneration.

Authors:
Shriya Srinivasan Keval Vyas Malia McAvoy Peter Calvaresi Omar F Khan Robert Langer Daniel G Anderson Hugh Herr

Front Neurol 2019 22;10:252. Epub 2019 Mar 22.

Center for Extreme Bionics, Massachusetts Institute of Technology, Cambridge, MA, United States.

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https://www.frontiersin.org/article/10.3389/fneur.2019.00252
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http://dx.doi.org/10.3389/fneur.2019.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438882PMC
March 2019

Ligands Based on Phosphine-Stabilized Aluminum(I), Boron(I), and Carbon(0).

Authors:
Lisa Vondung Paul Jerabek Robert Langer

Chemistry 2019 Feb 29;25(12):3068-3076. Epub 2019 Jan 29.

Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Str. 4, 35032, Marburg, Germany.

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February 2019

Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer.

Authors:
Tovi Shapira-Furman Riccardo Serra Noah Gorelick Marisol Doglioli Valentina Tagliaferri Arba Cecia Michael Peters Awanish Kumar Yakir Rottenberg Robert Langer Henry Brem Betty Tyler Abraham J Domb

J Control Release 2019 02 31;295:93-101. Epub 2018 Dec 31.

Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.12.048DOI Listing
February 2019

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium.

Authors:
Asha Kumari Patel James C Kaczmarek Suman Bose Kevin J Kauffman Faryal Mir Michael W Heartlein Frank DeRosa Robert Langer Daniel G Anderson

Adv Mater 2019 Feb 4;31(8):e1805116. Epub 2019 Jan 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201805116DOI Listing
February 2019

An ingestible self-orienting system for oral delivery of macromolecules.

Authors:
Alex Abramson Ester Caffarel-Salvador Minsoo Khang David Dellal David Silverstein Yuan Gao Morten Revsgaard Frederiksen Andreas Vegge František Hubálek Jorrit J Water Anders V Friderichsen Johannes Fels Rikke Kaae Kirk Cody Cleveland Joy Collins Siddartha Tamang Alison Hayward Tomas Landh Stephen T Buckley Niclas Roxhed Ulrik Rahbek Robert Langer Giovanni Traverso

Science 2019 02;363(6427):611-615

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.aau2277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430586PMC
February 2019

Making the case: developing innovative adherence solutions for the treatment of tuberculosis.

Authors:
Malvika Verma Jennifer Furin Robert Langer Giovanni Traverso

BMJ Glob Health 2019 1;4(1):e001323. Epub 2019 Feb 1.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1136/bmjgh-2018-001323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361324PMC
February 2019

Nanofibrillar Patches of Commensal Skin Bacteria.

Authors:
Karine Glinel Adam Behrens Robert S Langer Ana Jaklenec Alain M Jonas

Biomacromolecules 2019 01 19;20(1):102-108. Epub 2018 Jul 19.

Institute of Condensed Matter and Nanosciences , Université Catholique de Louvain , Croix du Sud 1/L7.04.02 , Louvain-la-Neuve , 1348 , Belgium.

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http://dx.doi.org/10.1021/acs.biomac.8b00735DOI Listing
January 2019

Intracochlear drug delivery: Fluorescent tracer evaluation for quantification of distribution in the cochlear partition.

Authors:
Andrew M Ayoob Marcello Peppi Vishal Tandon Robert Langer Jeffrey T Borenstein

Eur J Pharm Sci 2019 Jan 7;126:49-58. Epub 2018 Sep 7.

Biomedical Engineering Center, Charles Stark Draper Laboratory, 555 Technology Square, Cambridge, MA 02139, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2018.09.007DOI Listing
January 2019

Reactive Dimerization of an N-Heterocyclic Plumbylene: C-H Activation with Pb.

Authors:
Robin Guthardt Jan Oetzel Julia I Schweizer Clemens Bruhn Robert Langer Martin Maurer Jan Vícha Pavletta Shestakova Max C Holthausen Ulrich Siemeling

Angew Chem Int Ed Engl 2019 Jan 3;58(5):1387-1391. Epub 2019 Jan 3.

Institut für Chemie, Universität Kassel, Heinrich-Plett-Strasse 40, 34132, Kassel, Germany.

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http://doi.wiley.com/10.1002/anie.201811559
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January 2019

Circulating Magnetic Microbubbles for Localized Real-Time Control of Drug Delivery by Ultrasonography-Guided Magnetic Targeting and Ultrasound.

Authors:
Beata Chertok Robert Langer

Theranostics 2018 1;8(2):341-357. Epub 2018 Jan 1.

Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.7150/thno.20781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743552PMC
December 2018

β-Aminoacrylate Synthetic Hydrogels: Easily Accessible and Operationally Simple Biomaterials Networks.

Authors:
Owen S Fenton Jason L Andresen Marion Paolini Robert Langer

Angew Chem Int Ed Engl 2018 12 8;57(49):16026-16029. Epub 2018 Nov 8.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201808452DOI Listing
December 2018

Biofilm-Inspired Encapsulation of Probiotics for the Treatment of Complex Infections.

Authors:
Zhihao Li Adam M Behrens Nitzan Ginat Stephany Y Tzeng Xueguang Lu Sarit Sivan Robert Langer Ana Jaklenec

Adv Mater 2018 Dec 17;30(51):e1803925. Epub 2018 Oct 17.

David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main Street, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/adma.201803925
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December 2018

Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer.

Authors:
Xi Xie Joshua C Doloff Volkan Yesilyurt Atieh Sadraei James J McGarrigle Mustafa Omami Omid Veiseh Shady Farah Douglas Isa Sofia Ghani Ira Joshi Arturo Vegas Jie Li Weiheng Wang Andrew Bader Hok Hei Tam Jun Tao Hui-Jiuan Chen Boru Yang Katrina Ann Williamson Jose Oberholzer Robert Langer Daniel G Anderson

Nat Biomed Eng 2018 12 30;2(12):894-906. Epub 2018 Jul 30.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41551-018-0273-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436621PMC
December 2018

Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.

Authors:
Mohammad Ariful Islam Yingjie Xu Wei Tao Jessalyn M Ubellacker Michael Lim Daniel Aum Gha Young Lee Kun Zhou Harshal Zope Mikyung Yu Wuji Cao James Trevor Oswald Meshkat Dinarvand Morteza Mahmoudi Robert Langer Philip W Kantoff Omid C Farokhzad Bruce R Zetter Jinjun Shi

Nat Biomed Eng 2018 Dec;2(12):968

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41551-018-0331-xDOI Listing
December 2018

Nanomaterial Interactions with Human Neutrophils.

Authors:
Paul W Bisso Stephanie Gaglione Pedro P G Guimarães Michael J Mitchell Robert Langer

ACS Biomater Sci Eng 2018 Dec 5;4(12):4255-4265. Epub 2018 Nov 5.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsbiomaterials.8b01062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731026PMC
December 2018

3D-Printed Gastric Resident Electronics.

Authors:
Yong Lin Kong Xingyu Zou Caitlin A McCandler Ameya R Kirtane Shen Ning Jianlin Zhou Abubakar Abid Mousa Jafari Jaimie Rogner Daniel Minahan Joy E Collins Shane McDonnell Cody Cleveland Taylor Bensel Siid Tamang Graham Arrick Alla Gimbel Tiffany Hua Udayan Ghosh Vance Soares Nancy Wang Aniket Wahane Alison Hayward Shiyi Zhang Brian R Smith Robert Langer Giovanni Traverso

Adv Mater Technol 2019 13;4(3):1800490. Epub 2018 Dec 13.

Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1002/admt.201800490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988123PMC
December 2018

Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes.

Authors:
Pedro P G Guimaraes Mingchee Tan Tuomas Tammela Katherine Wu Amanda Chung Matthias Oberli Karin Wang Roman Spektor Rachel S Riley Celso T R Viana Tyler Jacks Robert Langer Michael J Mitchell

J Control Release 2018 11 2;290:75-87. Epub 2018 Oct 2.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441337PMC
November 2018

Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.

Authors:
Michael J Mitchell Rakesh K Jain Robert Langer

Nat Rev Cancer 2018 11;18(11):720

Department of Chemical Engineering, David H. Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA.

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http://www.nature.com/articles/s41568-018-0072-x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357229PMC
November 2018

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques.

Authors:
Matthew A Bochenek Omid Veiseh Arturo J Vegas James J McGarrigle Meirigeng Qi Enza Marchese Mustafa Omami Joshua C Doloff Joshua Mendoza-Elias Mohammad Nourmohammadzadeh Arshad Khan Chun-Chieh Yeh Yuan Xing Douglas Isa Sofia Ghani Jie Li Casey Landry Andrew R Bader Karsten Olejnik Michael Chen Jennifer Hollister-Lock Yong Wang Dale L Greiner Gordon C Weir Berit Løkensgard Strand Anne Mari A Rokstad Igor Lacik Robert Langer Daniel G Anderson Jose Oberholzer

Nat Biomed Eng 2018 Nov 13;2(11):810-821. Epub 2018 Aug 13.

Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41551-018-0275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413527PMC
November 2018

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.

Authors:
Mohammad Ariful Islam Yingjie Xu Wei Tao Jessalyn M Ubellacker Michael Lim Daniel Aum Gha Young Lee Kun Zhou Harshal Zope Mikyung Yu Wuji Cao James Trevor Oswald Meshkat Dinarvand Morteza Mahmoudi Robert Langer Philip W Kantoff Omid C Farokhzad Bruce R Zetter Jinjun Shi

Nat Biomed Eng 2018 11 17;2(11):850-864. Epub 2018 Sep 17.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41551-018-0284-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486184PMC
November 2018

A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery.

Authors:
Andrew M Ayoob Marcello Peppi Vishal Tandon Robert Langer Jeffrey T Borenstein

Hear Res 2018 10 5;368:41-48. Epub 2018 Apr 5.

Biomedical Engineering Center, Charles Stark Draper Laboratory, 555 Technology Square, Cambridge MA 02139, United States. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2018.03.026DOI Listing
October 2018

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy.

Authors:
Oliver Jonas Jeon Woong Kang Surya P Singh Alex Lammers Freddy T Nguyen Ramachandra R Dasari Peter T C So Robert Langer Michael J Cima

Analyst 2018 Oct;143(20):4836-4839

Department of Radiology, Brigham & Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1039/c8an00913aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175619PMC
October 2018

[The first five years of Hungary's Eurotransplant membership].

Authors:
Róbert Langer

Orv Hetil 2018 10;159(42):1695-1699

Krankenhaus der Elisabethinen, Chirurgie, Ordensklinikum Linz Fadingerstrasse 1., A-4020 Linz, Austria.

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http://dx.doi.org/10.1556/650.2018.31230DOI Listing
October 2018

Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop.

Authors:
Michael R Rickels Peter G Stock Eelco J P de Koning Lorenzo Piemonti Johann Pratschke Rodolfo Alejandro Melena D Bellin Thierry Berney Pratik Choudhary Paul R Johnson Raja Kandaswamy Thomas W H Kay Bart Keymeulen Yogish C Kudva Esther Latres Robert M Langer Roger Lehmann Barbara Ludwig James F Markmann Marjana Marinac Jon S Odorico François Pattou Peter A Senior James A M Shaw Marie-Christine Vantyghem Steven White

Transplantation 2018 09;102(9):1479-1486

Institute of Transplantation, The Freeman Hospital and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1097/TP.0000000000002158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408213PMC
September 2018

Genotype-targeted local therapy of glioma.

Authors:
Ganesh M Shankar Ameya R Kirtane Julie J Miller Hormoz Mazdiyasni Jaimie Rogner Tammy Tai Erik A Williams Fumi Higuchi Tareq A Juratli Kensuke Tateishi Mara V A Koerner Shilpa S Tummala Alexandria L Fink Tristan Penson Stephen P Schmidt Gregory R Wojtkiewicz Aymen Baig Joshua M Francis Mikael L Rinne Julie M Batten Tracy T Batchelor Priscilla K Brastianos William T Curry Fred G Barker Justin T Jordan A John Iafrate Andrew S Chi Jochen K Lennerz Matthew Meyerson Robert Langer Hiroaki Wakimoto Giovanni Traverso Daniel P Cahill

Proc Natl Acad Sci U S A 2018 09 6;115(36):E8388-E8394. Epub 2018 Aug 6.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1805751115
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http://dx.doi.org/10.1073/pnas.1805751115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130372PMC
September 2018

Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model.

Authors:
Helen N Schwerdt Elizabeth Zhang Min Jung Kim Tomoko Yoshida Lauren Stanwicks Satoko Amemori Huseyin E Dagdeviren Robert Langer Michael J Cima Ann M Graybiel

Commun Biol 2018 12;1:144. Epub 2018 Sep 12.

McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s42003-018-0147-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135761PMC
September 2018

Umpolung at Boron: Ancillary-Ligand-Induced Formation of Boron-Based Donor Ligands from Phosphine-Boranes.

Authors:
Lisa Vondung Lukas Alig Monika Ballmann Robert Langer

Chemistry 2018 Aug 22;24(47):12346-12353. Epub 2018 Mar 22.

Fachbereich Chemie, Philipps-Universität, Hans-Meerwein-Strasse 4, 35032, Marburg, Germany.

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http://dx.doi.org/10.1002/chem.201705847DOI Listing
August 2018

Carbodiphosphorane-based nickel pincer complexes and their (de)protonated analogues: dimerisation, ligand tautomers and proton affinities.

Authors:
Leon Maser Jan Herritsch Robert Langer

Dalton Trans 2018 Aug;47(31):10544-10552

Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35032 Marburg, Germany.

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http://dx.doi.org/10.1039/c7dt04930gDOI Listing
August 2018

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.

Authors:
Martin P Stewart Robert Langer Klavs F Jensen

Chem Rev 2018 08 27;118(16):7409-7531. Epub 2018 Jul 27.

Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acs.chemrev.7b00678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763210PMC
August 2018

Scalable Gastric Resident Systems for Veterinary Application.

Authors:
Alison Hayward Taylor Bensel Hormoz Mazdiyasni Jaimie Rogner Ameya R Kirtane Young-Ah Lucy Lee Tiffany Hua Ambika Bajpayee Joy Collins Shane McDonnell Cody Cleveland Aaron Lopes Aniket Wahane Robert Langer Giovanni Traverso

Sci Rep 2018 08 7;8(1):11816. Epub 2018 Aug 7.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1038/s41598-018-30212-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081402PMC
August 2018

Caffeine-catalyzed gels.

Authors:
Angela M DiCiccio Young-Ah Lucy Lee Dean L Glettig Elizabeth S E Walton Eva L de la Serna Veronica A Montgomery Tyler M Grant Robert Langer Giovanni Traverso

Biomaterials 2018 07 6;170:127-135. Epub 2018 Apr 6.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937912PMC
July 2018

Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold Chain.

Authors:
Shiran Ferber Adam M Behrens Kevin J McHugh Evan M Rosenberg Allison R Linehan James L Sugarman Hapuarachchige Surangi N Jayawardena Robert Langer Ana Jaklenec

Adv Healthc Mater 2018 07 7;7(14):e1800220. Epub 2018 May 7.

David H. Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/adhm.201800220
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July 2018

Focal, remote-controlled, chronic chemical modulation of brain microstructures.

Authors:
Khalil B Ramadi Canan Dagdeviren Kevin C Spencer Pauline Joe Max Cotler Erin Rousseau Carlos Nunez-Lopez Ann M Graybiel Robert Langer Michael J Cima

Proc Natl Acad Sci U S A 2018 07 25;115(28):7254-7259. Epub 2018 Jun 25.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1804372115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048526PMC
July 2018

Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery.

Authors:
Piotr S Kowalski Umberto Capasso Palmiero Yuxuan Huang Arnab Rudra Robert Langer Daniel G Anderson

Adv Mater 2018 Jul 5:e1801151. Epub 2018 Jul 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://doi.wiley.com/10.1002/adma.201801151
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http://dx.doi.org/10.1002/adma.201801151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320729PMC
July 2018

Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response.

Authors:
Stephany Y Tzeng Kevin J McHugh Adam M Behrens Sviatlana Rose James L Sugarman Shiran Ferber Robert Langer Ana Jaklenec

Proc Natl Acad Sci U S A 2018 06 21;115(23):E5269-E5278. Epub 2018 May 21.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1720970115
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http://dx.doi.org/10.1073/pnas.1720970115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003376PMC
June 2018

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types.

Authors:
Benjamin E Mead Jose Ordovas-Montanes Alexandra P Braun Lauren E Levy Prerna Bhargava Matthew J Szucs Dustin A Ammendolia Melanie A MacMullan Xiaolei Yin Travis K Hughes Marc H Wadsworth Rushdy Ahmad Seth Rakoff-Nahoum Steven A Carr Robert Langer James J Collins Alex K Shalek Jeffrey M Karp

BMC Biol 2018 06 5;16(1):62. Epub 2018 Jun 5.

Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12915-018-0527-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989470PMC
June 2018

Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles.

Authors:
Omar F Khan Piotr S Kowalski Joshua C Doloff Jonathan K Tsosie Vasudevan Bakthavatchalu Caroline Bodi Winn Jennifer Haupt Morgan Jamiel Robert Langer Daniel G Anderson

Sci Adv 2018 06 27;4(6):eaar8409. Epub 2018 Jun 27.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/sciadv.aar8409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021147PMC
June 2018

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents.

Authors:
Kevin J McHugh Lihong Jing Adam M Behrens Surangi Jayawardena Wen Tang Mingyuan Gao Robert Langer Ana Jaklenec

Adv Mater 2018 May 22;30(18):e1706356. Epub 2018 Feb 22.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201706356DOI Listing
May 2018

Design and Synthesis of Waterborne Polyurethanes.

Authors:
Soo-Young Kang Zhaoxia Ji Ling-Fang Tseng Sara A Turner Dinara A Villanueva Rhiannon Johnson Ariana Albano Robert Langer

Adv Mater 2018 May 15;30(18):e1706237. Epub 2018 Mar 15.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201706237DOI Listing
May 2018

Corrigendum to "Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems" [J. Control. Release 262(2017) 284-295].

Authors:
Christian Schneider Robert Langer Donald Loveday Dirk Hair

J Control Release 2018 05;278:156-158

Celanese Corp., 4405 - 101 Avenue, Edmonton, AB T6A0L2, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2018.04.007DOI Listing
May 2018

Controlling the Growth of Staphylococcus epidermidis by Layer-By-Layer Encapsulation.

Authors:
Alain M Jonas Karine Glinel Adam Behrens Aaron C Anselmo Robert S Langer Ana Jaklenec

ACS Appl Mater Interfaces 2018 May 3;10(19):16250-16259. Epub 2018 May 3.

David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsami.8b01988DOI Listing
May 2018

Advances in Biomaterials for Drug Delivery.

Authors:
Owen S Fenton Katy N Olafson Padmini S Pillai Michael J Mitchell Robert Langer

Adv Mater 2018 May 7:e1705328. Epub 2018 May 7.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1002/adma.201705328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261797PMC
May 2018

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.

Authors:
Dewy C van der Valk Casper F T van der Ven Mark C Blaser Joshua M Grolman Pin-Jou Wu Owen S Fenton Lang H Lee Mark W Tibbitt Jason L Andresen Jennifer R Wen Anna H Ha Fabrizio Buffolo Alain van Mil Carlijn V C Bouten Simon C Body David J Mooney Joost P G Sluijter Masanori Aikawa Jesper Hjortnaes Robert Langer Elena Aikawa

Nanomaterials (Basel) 2018 May 3;8(5). Epub 2018 May 3.

Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.mdpi.com/2079-4991/8/5/296
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http://dx.doi.org/10.3390/nano8050296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977310PMC
May 2018

A new anthraquinoid ligand for the iron-catalyzed hydrosilylation of carbonyl compounds at room temperature: new insights and kinetics.

Authors:
Álvaro Raya-Barón Carmen P Galdeano-Ruano Pascual Oña-Burgos Antonio Rodríguez-Diéguez Robert Langer Rosalía López-Ruiz Roberto Romero-González Istemi Kuzu Ignacio Fernández

Dalton Trans 2018 May;47(21):7272-7281

Department of Chemistry and Physics, Research Centre CIAIMBITAL, Universidad de Almería, Ctra. Sacramento s/n, 04120 Almería, Spain.

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http://dx.doi.org/10.1039/c8dt01123kDOI Listing
May 2018

An ingestible bacterial-electronic system to monitor gastrointestinal health.

Authors:
Mark Mimee Phillip Nadeau Alison Hayward Sean Carim Sarah Flanagan Logan Jerger Joy Collins Shane McDonnell Richard Swartwout Robert J Citorik Vladimir Bulović Robert Langer Giovanni Traverso Anantha P Chandrakasan Timothy K Lu

Science 2018 05;360(6391):915-918

Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aas9315
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http://dx.doi.org/10.1126/science.aas9315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430580PMC
May 2018

Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop.

Authors:
Michael R Rickels Peter G Stock Eelco J P de Koning Lorenzo Piemonti Johann Pratschke Rodolfo Alejandro Melena D Bellin Thierry Berney Pratik Choudhary Paul R Johnson Raja Kandaswamy Thomas W H Kay Bart Keymeulen Yogish C Kudva Esther Latres Robert M Langer Roger Lehmann Barbara Ludwig James F Markmann Marjana Marinac Jon S Odorico François Pattou Peter A Senior James A M Shaw Marie-Christine Vantyghem Steven White

Transpl Int 2018 04;31(4):343-352

Institute of Transplantation, The Freeman Hospital, Newcastle University, Newcastle upon Tyne, UK.

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http://doi.wiley.com/10.1111/tri.13138
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http://dx.doi.org/10.1111/tri.13138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867272PMC
April 2018

Convergence for Translation: Drug-Delivery Research in Multidisciplinary Teams.

Authors:
Giovanni Traverso Ameya R Kirtane Carl M Schoellhammer Robert Langer

Angew Chem Int Ed Engl 2018 04 9;57(16):4156-4163. Epub 2018 Mar 9.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201712512DOI Listing
April 2018

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

Authors:
Hao Yin Chun-Qing Song Sneha Suresh Suet-Yan Kwan Qiongqiong Wu Stephen Walsh Junmei Ding Roman L Bogorad Lihua Julie Zhu Scot A Wolfe Victor Koteliansky Wen Xue Robert Langer Daniel G Anderson

Nat Chem Biol 2018 03 29;14(3):311-316. Epub 2018 Jan 29.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902734PMC
March 2018

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Authors:
Kevin J Kauffman Matthias A Oberli J Robert Dorkin Juan E Hurtado James C Kaczmarek Shivani Bhadani Jeff Wyckoff Robert Langer Ana Jaklenec Daniel G Anderson

Mol Ther Nucleic Acids 2018 Mar 21;10:55-63. Epub 2017 Nov 21.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734870PMC
March 2018

Surface tension-assisted additive manufacturing.

Authors:
Héloïse Ragelle Mark W Tibbitt Shang-Yun Wu Michael A Castillo George Z Cheng Sidharta P Gangadharan Daniel G Anderson Michael J Cima Robert Langer

Nat Commun 2018 03 22;9(1):1184. Epub 2018 Mar 22.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St Cambridge, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1038/s41467-018-03391-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864961PMC
March 2018

Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy.

Authors:
Pedro P G Guimarães Stephanie Gaglione Tomasz Sewastianik Ruben D Carrasco Robert Langer Michael J Mitchell

ACS Nano 2018 02 6;12(2):912-931. Epub 2018 Feb 6.

Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/acsnano.7b05876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834400PMC
February 2018

Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices.

Authors:
Paulius Mikulskis Andrew Hook Adam A Dundas Derek Irvine Olutoba Sanni Daniel Anderson Robert Langer Morgan R Alexander Paul Williams David A Winkler

ACS Appl Mater Interfaces 2018 Jan 2;10(1):139-149. Epub 2018 Jan 2.

School of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acsami.7b14197
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http://dx.doi.org/10.1021/acsami.7b14197DOI Listing
January 2018

Molecular Rotors for Universal Quantitation of Nanoscale Hydrophobic Interfaces in Microplate Format.

Authors:
Paul W Bisso Michelle Tai Hari Katepalli Nicolas Bertrand Daniel Blankschtein Robert Langer

Nano Lett 2018 01 22;18(1):618-628. Epub 2017 Dec 22.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b04877DOI Listing
January 2018

Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy.

Authors:
Ameya R Kirtane Omar Abouzid Daniel Minahan Taylor Bensel Alison L Hill Christian Selinger Anna Bershteyn Morgan Craig Shirley S Mo Hormoz Mazdiyasni Cody Cleveland Jaimie Rogner Young-Ah Lucy Lee Lucas Booth Farhad Javid Sarah J Wu Tyler Grant Andrew M Bellinger Boris Nikolic Alison Hayward Lowell Wood Philip A Eckhoff Martin A Nowak Robert Langer Giovanni Traverso

Nat Commun 2018 01 9;9(1). Epub 2018 Jan 9.

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-02294-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760734PMC
January 2018

Miniaturized neural system for chronic, local intracerebral drug delivery.

Authors:
Canan Dagdeviren Khalil B Ramadi Pauline Joe Kevin Spencer Helen N Schwerdt Hideki Shimazu Sebastien Delcasso Ken-Ichi Amemori Carlos Nunez-Lopez Ann M Graybiel Michael J Cima Robert Langer

Sci Transl Med 2018 01;10(425)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aan2742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746310PMC
January 2018

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.

Authors:
Jatin Roper Tuomas Tammela Naniye Malli Cetinbas Adam Akkad Ali Roghanian Steffen Rickelt Mohammad Almeqdadi Katherine Wu Matthias A Oberli Francisco Sánchez-Rivera Yoona K Park Xu Liang George Eng Martin S Taylor Roxana Azimi Dmitriy Kedrin Rachit Neupane Semir Beyaz Ewa T Sicinska Yvelisse Suarez James Yoo Lillian Chen Lawrence Zukerberg Pekka Katajisto Vikram Deshpande Adam J Bass Philip N Tsichlis Jacqueline Lees Robert Langer Richard O Hynes Jianzhu Chen Arjun Bhutkar Tyler Jacks Ömer H Yilmaz

Nat Biotechnol 2017 12;35(12):1211

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http://dx.doi.org/10.1038/nbt1217-1211aDOI Listing
December 2017

Erratum: Glucose-responsive insulin by molecular and physical design.

Authors:
Naveed A Bakh Abel B Cortinas Michael A Weiss Robert S Langer Daniel G Anderson Zhen Gu Sanjoy Dutta Michael S Strano

Nat Chem 2017 12;10(1):109

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http://dx.doi.org/10.1038/nchem.2898DOI Listing
December 2017