Publications by authors named "Robert Langer"

979 Publications

Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study.

Otol Neurotol 2021 Feb 22. Epub 2021 Feb 22.

Frequency Therapeutics, Woburn, MA & Farmington, CT Department of Surgery, University of Connecticut School of Medicine, Farmington, CT Department of Otolaryngology, Central Institute for the Deaf, Fay and Carl Simons Center for Hearing and Deafness, Washington University School of Medicine, Saint Louis, MO Department of Otolaryngology and Cluster of Excellence of the German Research Foundation "Hearing4all", Hannover Medical School, Hannover, Germany Ear Medical Group Ear Institute of Texas, San Antonio, TX Alamo ENT Associates, San Antonio, TX Worldwide Clinical Trials, San Antonio, TX Forsythe and Bear LLC, Woodland Hills, CA Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear, Boston Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School Boston MA Harvard-MIT Division of Health Science and Technology Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA.

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February 2021

BBB pathophysiology-independent delivery of siRNA in traumatic brain injury.

Sci Adv 2021 Jan 1;7(1). Epub 2021 Jan 1.

Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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January 2021

Engineered drug delivery devices to address Global Health challenges.

J Control Release 2021 Jan 28;331:503-514. Epub 2021 Jan 28.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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January 2021

Controlled Delivery of Bile Acids to the Colon.

Clin Transl Gastroenterol 2020 Dec;11(12):e00229

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; 2Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; 3Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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December 2020

From carbones to carbenes and ylides in the coordination sphere of iridium.

Dalton Trans 2021 Jan 22;50(3):954-959. Epub 2020 Dec 22.

Institute of Chemistry, Faculty of Natural Sciences II, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. and Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Str., 35032 Marburg, Germany.

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January 2021

Polyphosphazene immunoadjuvants: Historical perspective and recent advances.

J Control Release 2021 Jan 5;329:299-315. Epub 2020 Dec 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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January 2021

Engineering precision nanoparticles for drug delivery.

Nat Rev Drug Discov 2021 Feb 4;20(2):101-124. Epub 2020 Dec 4.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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February 2021

Microgel encapsulated nanoparticles for glucose-responsive insulin delivery.

Biomaterials 2021 Jan 4;267:120458. Epub 2020 Nov 4.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

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January 2021

Inverse Pneumatic Artificial Muscles for Application in Low-Cost Ventilators.

Adv Intell Syst 2020 Oct 30:2000200. Epub 2020 Oct 30.

Koch Institute Massachusetts Institute of Technology Cambridge MA 02139 USA.

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October 2020

Analysis of the Human Plasma Proteome Using Multi-Nanoparticle Protein Corona for Detection of Alzheimer's Disease.

Adv Healthc Mater 2021 01 9;10(2):e2000948. Epub 2020 Nov 9.

Center for Nanomedicine, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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January 2021

Chemical Tuning of Fibers Drawn from Extensible Hyaluronic Acid Networks.

J Am Chem Soc 2020 11 3;142(46):19715-19721. Epub 2020 Nov 3.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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November 2020

A materials-science perspective on tackling COVID-19.

Nat Rev Mater 2020 Oct 14:1-14. Epub 2020 Oct 14.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.

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October 2020

Corrigendum to "Advanced multimodal nanoparticles delay tumor progression withclinical radiation therapy" [Journal of Controlled Release 238 (2016) 103-133].

J Control Release 2021 Jan 23;329:1283-1285. Epub 2020 Sep 23.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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January 2021

Ingestible transiently anchoring electronics for microstimulation and conductive signaling.

Sci Adv 2020 Aug 28;6(35):eaaz0127. Epub 2020 Aug 28.

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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August 2020

Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations.

Sci Adv 2020 Jul 8;6(28):eabb6594. Epub 2020 Jul 8.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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July 2020

Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury.

Front Neurol 2020 21;11:644. Epub 2020 Jul 21.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.

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July 2020

Advances in oligonucleotide drug delivery.

Nat Rev Drug Discov 2020 10 11;19(10):673-694. Epub 2020 Aug 11.

Department of Paediatrics, University of Oxford, Oxford, UK.

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October 2020

Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for CRISPR/Cas-Based Genome Editing.

ACS Nano 2020 08 22;14(8):9243-9262. Epub 2020 Jul 22.

Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.

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August 2020

Simultaneous recording and marking of brain microstructures.

J Neural Eng 2020 07 24;17(4):044001. Epub 2020 Jul 24.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. Harvard-MIT Health Sciences and Technology Division, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. These authors contributed equally to this work.

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July 2020

Parallel evolution of polymer chemistry and immunology: Integrating mechanistic biology with materials design.

Adv Drug Deliv Rev 2020 23;156:65-79. Epub 2020 Jun 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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June 2020

Computationally Guided Intracerebral Drug Delivery via Chronically Implanted Microdevices.

Cell Rep 2020 06;31(10):107734

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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June 2020

Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation.

Nano Lett 2020 07 9;20(7):4816-4822. Epub 2020 Jun 9.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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July 2020