Robert Langer

Robert Langer

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Robert Langer

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Trends in Therapeutic Conjugates: Bench to Clinic.

Bioconjug Chem 2020 Feb 11. Epub 2020 Feb 11.

David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00828DOI Listing
February 2020

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs.

Nat Biomed Eng 2020 Feb 3. Epub 2020 Feb 3.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.

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http://dx.doi.org/10.1038/s41551-019-0508-yDOI Listing
February 2020

Cyclodextrins in drug delivery: applications in gene and combination therapy.

Drug Deliv Transl Res 2020 Feb 19. Epub 2020 Feb 19.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s13346-020-00724-5DOI Listing
February 2020

Chiral Supraparticles for Controllable Nanomedicine.

Adv Mater 2020 Jan 5;32(1):e1903878. Epub 2019 Nov 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201903878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986383PMC
January 2020

From Molecule to Patient: A Biotech Perspective.

Clin Pharmacol Ther 2020 Jan 20;107(1):65-67. Epub 2019 Nov 20.

Global Health Division, Bill and Melinda Gates Foundation, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/cpt.1676DOI Listing
January 2020

Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery.

ACS Nano 2020 Jan 20;14(1):488-497. Epub 2019 Dec 20.

Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsnano.9b06395DOI Listing
January 2020

Light-degradable hydrogels as dynamic triggers for gastrointestinal applications.

Sci Adv 2020 01 17;6(3):eaay0065. Epub 2020 Jan 17.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/sciadv.aay0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968934PMC
January 2020

Injectable Polymer-Nanoparticle Hydrogels for Local Immune Cell Recruitment.

Biomacromolecules 2019 Dec 4;20(12):4430-4436. Epub 2019 Nov 4.

Department of Chemical and Biomolecular Engineering , University of Notre Dame , Notre Dame , Indiana 46556 , United States.

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http://dx.doi.org/10.1021/acs.biomac.9b01129DOI Listing
December 2019

A once-a-month oral contraceptive.

Sci Transl Med 2019 Dec;11(521)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay2602DOI Listing
December 2019

Lewis Acid Transition-Metal-Catalyzed Hydrogen Activation: Structures, Mechanisms, and Reactivities.

Chemistry 2019 Oct 20;25(60):13785-13798. Epub 2019 Sep 20.

School of Materials Science & Engineering, PCFM Lab, Department of Chemistry, Sun Yat-sen University, Guangzhou, 510275, P. R. China.

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http://dx.doi.org/10.1002/chem.201903193DOI Listing
October 2019

Using Large Datasets to Understand Nanotechnology.

Adv Mater 2019 Oct 20;31(43):e1902798. Epub 2019 Aug 20.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2019027
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http://dx.doi.org/10.1002/adma.201902798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810779PMC
October 2019

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation.

Nat Biotechnol 2019 10 30;37(10):1174-1185. Epub 2019 Sep 30.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0247-3DOI Listing
October 2019

Can Fish and Cell Phones Teach Us about Our Health?

ACS Sens 2019 Oct 2;4(10):2566-2570. Epub 2019 Oct 2.

Department of Biosciences, College of Science , Swansea University , Swansea , Wales , SA2 8PP , United Kingdom.

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http://dx.doi.org/10.1021/acssensors.9b00947DOI Listing
October 2019

A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults.

J Am Acad Dermatol 2019 Oct 4. Epub 2019 Oct 4.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.09.073DOI Listing
October 2019

Endoscopically Injectable Shear-Thinning Hydrogels Facilitating Polyp Removal.

Adv Sci (Weinh) 2019 Oct 30;6(19):1901041. Epub 2019 Jul 30.

Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.

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http://dx.doi.org/10.1002/advs.201901041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774062PMC
October 2019

Steerable Microinvasive Probes for Localized Drug Delivery to Deep Tissue.

Small 2019 Sep 11;15(37):e1901459. Epub 2019 Jun 11.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/smll.201901459DOI Listing
September 2019

A New Approach for Microfabrication of Printed Circuit Boards with Ultrafine Traces.

ACS Appl Mater Interfaces 2019 Sep 13;11(38):35376-35381. Epub 2019 Sep 13.

Langer Lab , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsami.9b08761DOI Listing
September 2019

Flexible Multielectrode Array for Skeletal Muscle Conditioning, Acetylcholine Receptor Stabilization and Epimysial Recording After Critical Peripheral Nerve Injury.

Theranostics 2019 21;9(23):7099-7107. Epub 2019 Sep 21.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.7150/thno.35436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815960PMC
September 2019

Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds.

J Tissue Eng Regen Med 2019 08 18;13(8):1453-1465. Epub 2019 Jul 18.

Institute for Medical Engineering and Science, David H. Koch Institute for Integrative Cancer Research, and Media Lab, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1002/term.2899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715532PMC
August 2019

Biohybrid Design Gets Personal: New Materials for Patient-Specific Therapy.

Adv Mater 2019 Jul 4:e1901969. Epub 2019 Jul 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St., Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1002/adma.201901969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942246PMC
July 2019

Ultra-rapid drug delivery in the oral cavity using ultrasound.

J Control Release 2019 Jun 27;304:1-6. Epub 2019 Apr 27.

Suono Bio, Inc., 501 Massachusetts Avenue, Cambridge, MA 02139, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.04.037DOI Listing
June 2019

Outlooks on Three-Dimensional Printing for Ocular Biomaterials Research.

J Ocul Pharmacol Ther 2020 Jan/Feb;36(1):7-17. Epub 2019 Jun 18.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/jop.2018.0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985767PMC
June 2019

Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering.

Tissue Eng Part A 2019 05;25(9-10):679-687

7 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/ten.TEA.2019.0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533781PMC
May 2019

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation 2019 05;139(19):2238-2255

Center for Pulmonary Vascular Biology and Medicine, Center for Metabolism and Mitochondrial Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (Q.Y., Y.-Y.T., Y.T., J.Z., V.N., M.K.C., J.P., W.S., J.S., M.R., M.S., N.K., T.S., M.Z., N.F., S.S., S.Y.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519484PMC
May 2019

Quantifying the Donor Strength of Ligand-Stabilized Main Group Fragments.

J Am Chem Soc 2019 May 25;141(18):7596-7604. Epub 2019 Apr 25.

Department of Chemistry , Philipps-Universität Marburg , Hans-Meerwein-Str. 4 , 35032 Marburg , Germany.

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http://pubs.acs.org/doi/10.1021/jacs.9b02598
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http://dx.doi.org/10.1021/jacs.9b02598DOI Listing
May 2019

Microbial therapeutics: New opportunities for drug delivery.

J Exp Med 2019 May 26;216(5):1005-1009. Epub 2019 Apr 26.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA

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http://dx.doi.org/10.1084/jem.20190609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504217PMC
May 2019

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.

Proc Natl Acad Sci U S A 2019 May 30;116(22):10674-10680. Epub 2019 Apr 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1819889116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561160PMC
May 2019

Polymers for extended-release administration.

Biomed Microdevices 2019 04 8;21(2):45. Epub 2019 Apr 8.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1007/s10544-019-0386-9DOI Listing
April 2019

Temperature-responsive biometamaterials for gastrointestinal applications.

Sci Transl Med 2019 04;11(488)

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aau8581DOI Listing
April 2019

Drug delivery across length scales.

J Drug Target 2019 Mar 20;27(3):229-243. Epub 2018 Feb 20.

a David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , MA , USA.

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https://www.tandfonline.com/doi/full/10.1080/1061186X.2018.1
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http://dx.doi.org/10.1080/1061186X.2018.1438440DOI Listing
March 2019

Delivery technologies for cancer immunotherapy.

Nat Rev Drug Discov 2019 03;18(3):175-196

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41573-018-0006-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410566PMC
March 2019

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.

Proc Natl Acad Sci U S A 2019 Mar 30;116(10):4558-4566. Epub 2019 Jan 30.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1815515116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410779PMC
March 2019

Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

Proc Natl Acad Sci U S A 2019 03 26;116(11):4861-4870. Epub 2019 Feb 26.

David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1815909116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421446PMC
March 2019

Ligands Based on Phosphine-Stabilized Aluminum(I), Boron(I), and Carbon(0).

Chemistry 2019 Feb 29;25(12):3068-3076. Epub 2019 Jan 29.

Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Str. 4, 35032, Marburg, Germany.

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http://dx.doi.org/10.1002/chem.201805123DOI Listing
February 2019

Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer.

J Control Release 2019 02 31;295:93-101. Epub 2018 Dec 31.

Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183075
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http://dx.doi.org/10.1016/j.jconrel.2018.12.048DOI Listing
February 2019

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium.

Adv Mater 2019 Feb 4;31(8):e1805116. Epub 2019 Jan 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201805116DOI Listing
February 2019

Making the case: developing innovative adherence solutions for the treatment of tuberculosis.

BMJ Glob Health 2019 1;4(1):e001323. Epub 2019 Feb 1.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1136/bmjgh-2018-001323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361324PMC
February 2019

Nanofibrillar Patches of Commensal Skin Bacteria.

Biomacromolecules 2019 01 19;20(1):102-108. Epub 2018 Jul 19.

Institute of Condensed Matter and Nanosciences , Université Catholique de Louvain , Croix du Sud 1/L7.04.02 , Louvain-la-Neuve , 1348 , Belgium.

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http://dx.doi.org/10.1021/acs.biomac.8b00735DOI Listing
January 2019

Intracochlear drug delivery: Fluorescent tracer evaluation for quantification of distribution in the cochlear partition.

Eur J Pharm Sci 2019 Jan 7;126:49-58. Epub 2018 Sep 7.

Biomedical Engineering Center, Charles Stark Draper Laboratory, 555 Technology Square, Cambridge, MA 02139, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2018.09.007DOI Listing
January 2019

Reactive Dimerization of an N-Heterocyclic Plumbylene: C-H Activation with Pb.

Angew Chem Int Ed Engl 2019 Jan 3;58(5):1387-1391. Epub 2019 Jan 3.

Institut für Chemie, Universität Kassel, Heinrich-Plett-Strasse 40, 34132, Kassel, Germany.

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http://doi.wiley.com/10.1002/anie.201811559
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http://dx.doi.org/10.1002/anie.201811559DOI Listing
January 2019

Circulating Magnetic Microbubbles for Localized Real-Time Control of Drug Delivery by Ultrasonography-Guided Magnetic Targeting and Ultrasound.

Theranostics 2018 1;8(2):341-357. Epub 2018 Jan 1.

Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.7150/thno.20781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743552PMC
December 2018

β-Aminoacrylate Synthetic Hydrogels: Easily Accessible and Operationally Simple Biomaterials Networks.

Angew Chem Int Ed Engl 2018 12 8;57(49):16026-16029. Epub 2018 Nov 8.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201808452DOI Listing
December 2018

Biofilm-Inspired Encapsulation of Probiotics for the Treatment of Complex Infections.

Adv Mater 2018 Dec 17;30(51):e1803925. Epub 2018 Oct 17.

David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main Street, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/adma.201803925
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http://dx.doi.org/10.1002/adma.201803925DOI Listing
December 2018

Nanomaterial Interactions with Human Neutrophils.

ACS Biomater Sci Eng 2018 Dec 5;4(12):4255-4265. Epub 2018 Nov 5.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsbiomaterials.8b01062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731026PMC
December 2018

Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.

Nat Rev Cancer 2018 11;18(11):720

Department of Chemical Engineering, David H. Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA.

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http://www.nature.com/articles/s41568-018-0072-x
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http://dx.doi.org/10.1038/s41568-018-0072-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357229PMC
November 2018

A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery.

Hear Res 2018 10 5;368:41-48. Epub 2018 Apr 5.

Biomedical Engineering Center, Charles Stark Draper Laboratory, 555 Technology Square, Cambridge MA 02139, United States. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2018.03.026DOI Listing
October 2018

[The first five years of Hungary's Eurotransplant membership].

Authors:
Róbert Langer

Orv Hetil 2018 10;159(42):1695-1699

Krankenhaus der Elisabethinen, Chirurgie, Ordensklinikum Linz Fadingerstrasse 1., A-4020 Linz, Austria.

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http://dx.doi.org/10.1556/650.2018.31230DOI Listing
October 2018

Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model.

Commun Biol 2018 12;1:144. Epub 2018 Sep 12.

McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s42003-018-0147-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135761PMC
September 2018

Umpolung at Boron: Ancillary-Ligand-Induced Formation of Boron-Based Donor Ligands from Phosphine-Boranes.

Chemistry 2018 Aug 22;24(47):12346-12353. Epub 2018 Mar 22.

Fachbereich Chemie, Philipps-Universität, Hans-Meerwein-Strasse 4, 35032, Marburg, Germany.

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http://dx.doi.org/10.1002/chem.201705847DOI Listing
August 2018

Carbodiphosphorane-based nickel pincer complexes and their (de)protonated analogues: dimerisation, ligand tautomers and proton affinities.

Dalton Trans 2018 Aug;47(31):10544-10552

Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35032 Marburg, Germany.

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http://dx.doi.org/10.1039/c7dt04930gDOI Listing
August 2018

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.

Chem Rev 2018 08 27;118(16):7409-7531. Epub 2018 Jul 27.

Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acs.chemrev.7b00678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763210PMC
August 2018

Scalable Gastric Resident Systems for Veterinary Application.

Sci Rep 2018 08 7;8(1):11816. Epub 2018 Aug 7.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1038/s41598-018-30212-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081402PMC
August 2018

Caffeine-catalyzed gels.

Biomaterials 2018 07 6;170:127-135. Epub 2018 Apr 6.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937912PMC
July 2018

Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold Chain.

Adv Healthc Mater 2018 07 7;7(14):e1800220. Epub 2018 May 7.

David H. Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/adhm.201800220
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http://dx.doi.org/10.1002/adhm.201800220DOI Listing
July 2018

Focal, remote-controlled, chronic chemical modulation of brain microstructures.

Proc Natl Acad Sci U S A 2018 07 25;115(28):7254-7259. Epub 2018 Jun 25.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1804372115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048526PMC
July 2018

Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery.

Adv Mater 2018 Jul 5:e1801151. Epub 2018 Jul 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://doi.wiley.com/10.1002/adma.201801151
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http://dx.doi.org/10.1002/adma.201801151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320729PMC
July 2018

Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response.

Proc Natl Acad Sci U S A 2018 06 21;115(23):E5269-E5278. Epub 2018 May 21.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1720970115
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http://dx.doi.org/10.1073/pnas.1720970115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003376PMC
June 2018

Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles.

Sci Adv 2018 06 27;4(6):eaar8409. Epub 2018 Jun 27.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/sciadv.aar8409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021147PMC
June 2018

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents.

Adv Mater 2018 May 22;30(18):e1706356. Epub 2018 Feb 22.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201706356DOI Listing
May 2018

Design and Synthesis of Waterborne Polyurethanes.

Adv Mater 2018 May 15;30(18):e1706237. Epub 2018 Mar 15.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201706237DOI Listing
May 2018

Controlling the Growth of Staphylococcus epidermidis by Layer-By-Layer Encapsulation.

ACS Appl Mater Interfaces 2018 May 3;10(19):16250-16259. Epub 2018 May 3.

David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsami.8b01988DOI Listing
May 2018

Advances in Biomaterials for Drug Delivery.

Adv Mater 2018 May 7:e1705328. Epub 2018 May 7.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1002/adma.201705328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261797PMC
May 2018

A new anthraquinoid ligand for the iron-catalyzed hydrosilylation of carbonyl compounds at room temperature: new insights and kinetics.

Dalton Trans 2018 May;47(21):7272-7281

Department of Chemistry and Physics, Research Centre CIAIMBITAL, Universidad de Almería, Ctra. Sacramento s/n, 04120 Almería, Spain.

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http://dx.doi.org/10.1039/c8dt01123kDOI Listing
May 2018

Convergence for Translation: Drug-Delivery Research in Multidisciplinary Teams.

Angew Chem Int Ed Engl 2018 04 9;57(16):4156-4163. Epub 2018 Mar 9.

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201712512DOI Listing
April 2018

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

Nat Chem Biol 2018 03 29;14(3):311-316. Epub 2018 Jan 29.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902734PMC
March 2018

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Mol Ther Nucleic Acids 2018 Mar 21;10:55-63. Epub 2017 Nov 21.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734870PMC
March 2018

Surface tension-assisted additive manufacturing.

Nat Commun 2018 03 22;9(1):1184. Epub 2018 Mar 22.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St Cambridge, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1038/s41467-018-03391-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864961PMC
March 2018

Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy.

ACS Nano 2018 02 6;12(2):912-931. Epub 2018 Feb 6.

Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/acsnano.7b05876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834400PMC
February 2018

Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices.

ACS Appl Mater Interfaces 2018 Jan 2;10(1):139-149. Epub 2018 Jan 2.

School of Pharmacy, University of Nottingham , Nottingham NG7 2RD, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acsami.7b14197
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http://dx.doi.org/10.1021/acsami.7b14197DOI Listing
January 2018

Molecular Rotors for Universal Quantitation of Nanoscale Hydrophobic Interfaces in Microplate Format.

Nano Lett 2018 01 22;18(1):618-628. Epub 2017 Dec 22.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b04877DOI Listing
January 2018