Robert Lane

Robert Lane

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Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.

Elife 2020 Jan 27;9. Epub 2020 Jan 27.

Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.52189DOI Listing
January 2020

sp. nov., a novel species of the complex, occupying a basal position to North American species.

Int J Syst Evol Microbiol 2019 Dec 3. Epub 2019 Dec 3.

University of California, Department of Environmental Science, Policy and Management, Berkeley, CA, USA.

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http://dx.doi.org/10.1099/ijsem.0.003833DOI Listing
December 2019

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D Receptor.

J Med Chem 2019 Nov 23;62(21):9488-9520. Epub 2019 Oct 23.

School of Pharmacy, Centre for Biomolecular Sciences , University of Nottingham , Nottingham NG7 2RD , U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00864DOI Listing
November 2019

Early Online Attention Can Predict Citation Counts for Urological Publications: The #UroSoMe_Score.

Eur Urol Focus 2019 Nov 5. Epub 2019 Nov 5.

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Department of Urology, Churchill Hospital Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

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http://dx.doi.org/10.1016/j.euf.2019.10.015DOI Listing
November 2019

Bioinformatics Discovery of Putative Enhancers within Mouse Odorant Receptor Gene Clusters.

Chem Senses 2019 Oct;44(9):705-720

Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, CT, USA.

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http://dx.doi.org/10.1093/chemse/bjz043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821260PMC
October 2019

Adverse early-life environment impairs postnatal lung development in mice.

Physiol Genomics 2019 09 2;51(9):462-470. Epub 2019 Aug 2.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin and.

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http://dx.doi.org/10.1152/physiolgenomics.00016.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766700PMC
September 2019

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

ACS Chem Biol 2019 08 5;14(8):1780-1792. Epub 2019 Aug 5.

Division of Pharmacology, Physiology and Neuroscience, School of Life Sciences, Queen's Medical Centre , University of Nottingham , Nottingham NG7 2UH , U.K.

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http://dx.doi.org/10.1021/acschembio.9b00342DOI Listing
August 2019

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1.

Int J Mol Sci 2019 May 15;20(10). Epub 2019 May 15.

Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.

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http://dx.doi.org/10.3390/ijms20102417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566870PMC
May 2019

Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D receptor.

Eur J Med Chem 2019 Apr 11;168:474-490. Epub 2019 Feb 11.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.061DOI Listing
April 2019

Frequent and biased odorant receptor (OR) re-selection in an olfactory placode-derived cell line.

PLoS One 2018 26;13(9):e0204604. Epub 2018 Sep 26.

Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204604PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157871PMC
March 2019

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1.

J Biol Chem 2019 03 19;294(10):3464-3475. Epub 2018 Dec 19.

From the Infection and Immunity Program, Monash Biomedicine Discovery Institute, and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006535
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http://dx.doi.org/10.1074/jbc.RA118.006535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416418PMC
March 2019

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D Receptor.

J Med Chem 2019 01 15;62(1):174-206. Epub 2018 May 15.

Department of Biological Sciences, Bridge Institute , University of Southern California , Los Angeles , California 90089 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01565
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http://dx.doi.org/10.1021/acs.jmedchem.7b01565DOI Listing
January 2019

Spatial Determination of Neuronal Diversification in the Olfactory Epithelium.

J Neurosci 2019 01 10;39(5):814-832. Epub 2018 Dec 10.

Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts 02111,

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http://dx.doi.org/10.1523/JNEUROSCI.3594-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382982PMC
January 2019

Performance of Cold Chains for Chesapeake Bay Farmed Oysters and Modeled Growth of Vibrio parahaemolyticus.

J Food Prot 2019 01;82(1):168-178

6 Pacific Shellfish Institute, 120 State Avenue N.E. #1056, Olympia, Washington 98501, USA.

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http://dx.doi.org/10.4315/0362-028X.JFP-18-044DOI Listing
January 2019

Adverse maternal environment leads to cardiac fibrosis in adult male mice.

Birth Defects Res 2018 12;110(20):1551-1555

Department of Pediatrics, Division of Neonatology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1002/bdr2.1428DOI Listing
December 2018

Prevalence and Incidence of Immune Thrombocytopenia in Patients With Prostate Cancer.

Am J Med Sci 2018 11 5;356(5):499-500. Epub 2018 May 5.

Division of Hematology/Oncology; Hematology and Oncology Section. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2018.05.003DOI Listing
November 2018

Adverse early life environment induces anxiety-like behavior and increases expression of FKBP5 mRNA splice variants in mouse brain.

Physiol Genomics 2018 11 21;50(11):973-981. Epub 2018 Sep 21.

Division of Neonatology, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, Wisconsin.

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https://www.physiology.org/doi/10.1152/physiolgenomics.00054
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http://dx.doi.org/10.1152/physiolgenomics.00054.2018DOI Listing
November 2018

Rickettsia Species Isolated from Dermacentor occidentalis (Acari: Ixodidae) from California.

J Med Entomol 2018 10;55(6):1555-1560

Vector-Borne Disease Section, Division of Communicable Disease Control, California Department of Public Health, Richmond, CA.

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http://dx.doi.org/10.1093/jme/tjy100DOI Listing
October 2018

Identification of Positive Allosteric Modulators of the D Dopamine Receptor That Act at Diverse Binding Sites.

Mol Pharmacol 2018 10 1;94(4):1197-1209. Epub 2018 Aug 1.

Molecular Neuropharmacology Section, National Institute of Neurologic Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland (K.D.L., J.L.C., R.B.F., M.S.-S., A.E.M., B.K.A.W., L.A.H., D.R.S.); NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland (N.S., M.F., S.T.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (T.J.F., J.R.L.); KU Specialized Chemistry Center, University of Kansas, Lawrence, Kansas (P.J., J.A., K.J.F.); and Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.A., K.J.F.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.113175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117505PMC
October 2018

Reply to 'Antipsychotics with similar association kinetics at dopamine D receptors differ in extrapyramidal side-effects'.

Nat Commun 2018 09 3;9(1):3568. Epub 2018 Sep 3.

School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1038/s41467-018-05678-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120895PMC
September 2018

Modeling Climate Suitability of the Western Blacklegged Tick in California.

J Med Entomol 2018 08;55(5):1133-1142

Department of Environmental Science, Policy and Management, University of California, Berkeley, CA.

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http://dx.doi.org/10.1093/jme/tjy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119120PMC
August 2018

An Evaluation of the Role of Simulation Training for Teaching Surgical Skills in Sub-Saharan Africa.

World J Surg 2018 04;42(4):923-929

Department of Urology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1007/s00268-017-4261-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843670PMC
April 2018

Modeling impacts of sea-level rise, oil price, and management strategy on the costs of sustaining Mississippi delta marshes with hydraulic dredging.

Sci Total Environ 2018 Mar 27;618:1547-1559. Epub 2017 Oct 27.

Department of Environmental Sciences, College of the Coast and Environment, Louisiana State University, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1016/j.scitotenv.2017.09.314DOI Listing
March 2018

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D receptor.

Biochem Pharmacol 2018 02 9;148:315-328. Epub 2018 Jan 9.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus), 399 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952183000
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http://dx.doi.org/10.1016/j.bcp.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800995PMC
February 2018

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

PLoS Comput Biol 2018 01 16;14(1):e1005948. Epub 2018 Jan 16.

Computational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland, United States.

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http://dx.doi.org/10.1371/journal.pcbi.1005948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786319PMC
January 2018

Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance).

Authors:
Adil Haider John W Scott Colin D Gause Mira Meheš Grace Hsiung Albulena Prelvukaj Dana Yanocha Lauren M Baumann Faheem Ahmed Na'eem Ahmed Sara Anderson Herve Angate Lisa Arfaa Horacio Asbun Tigistu Ashengo Kisembo Asuman Ruben Ayala Stephen Bickler Saul Billingsley Peter Bird Matthijs Botman Marilyn Butler Jo Buyske Angelo Capozzi Kathleen Casey Charles Clayton James Cobey Michael Cotton Dan Deckelbaum Miliard Derbew Catherine deVries Jeanne Dillner Max Downham Natalie Draisin David Echinard Sohier Elneil Ahmed ElSayed Abigail Estelle Allen Finley Erica Frenkel Philip K Frykman Florin Gheorghe Julian Gore-Booth Richard Henker Jaymie Henry Orion Henry Laura Hoemeke David Hoffman Iko Ibanga Eric V Jackson Pankaj Jani Walter Johnson Andrew Jones Zeina Kassem Asuman Kisembo Abbey Kocan Sanjay Krishnaswami Robert Lane Asad Latif Barbara Levy Dimitrios Linos Peter Linz Louis A Listwa Declan Magee Emmanuel Makasa Michael L Marin Claude Martin Kelly McQueen Jamie Morgan Richard Moser Robert Neighbor William M Novick Stephen Ogendo Akinyinka Omigbodun Bisola Onajin-Obembe Neil Parsan Beverly K Philip Raymond Price Shahnawaz Rasheed Marjorie Ratel Cheri Reynolds Steven M Roser Jackie Rowles Lubna Samad John Sampson Harshadkumar Sanghvi Marchelle L Sellers David Sigalet Bruce C Steffes Erin Stieber Mamta Swaroop John Tarpley Asha Varghese Julie Varughese Richard Wagner Benjamin Warf Neil Wetzig Susan Williamson Joshua Wood Anne Zeidan Lewis Zirkle Brendan Allen Fizan Abdullah

World J Surg 2017 10;41(10):2426-2434

Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Ave, Box 63, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s00268-017-4028-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596034PMC
October 2017

Erratum to: Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance).

Authors:
Adil Haider John W Scott Colin D Gause Mira Meheš Grace Hsiung Albulena Prelvukaj Dana Yanocha Lauren M Baumann Faheem Ahmed Na'eem Ahmed Sara Anderson Herve Angate Lisa Arfaa Horacio Asbun Tigistu Ashengo Kisembo Asuman Ruben Ayala Stephen Bickler Saul Billingsley Peter Bird Matthijs Botman Marilyn Butler Jo Buyske Angelo Capozzi Kathleen Casey Charles Clayton James Cobey Michael Cotton Dan Deckelbaum Miliard Derbew Catherine deVries Jeanne Dillner Max Downham Natalie Draisin David Echinard Sohier Elneil Ahmed ElSayed Abigail Estelle Allen Finley Erica Frenkel Philip K Frykman Florin Gheorghe Julian Gore-Booth Richard Henker Jaymie Henry Orion Henry Laura Hoemeke David Hoffman Iko Ibanga Eric V Jackson Pankaj Jani Walter Johnson Andrew Jones Zeina Kassem Asuman Kisembo Abbey Kocan Sanjay Krishnaswami Robert Lane Asad Latif Barbara Levy Dimitrios Linos Peter Linz Louis A Listwa Declan Magee Emmanuel Makasa Michael L Marin Claude Martin Kelly McQueen Jamie Morgan Richard Moser Robert Neighbor William M Novick Stephen Ogendo Akinyinka Omigbodun Bisola Onajin-Obembe Neil Parsan Beverly K Philip Raymond Price Shahnawaz Rasheed Marjorie Ratel Cheri Reynolds Steven M Roser Jackie Rowles Lubna Samad John Sampson Harshadkumar Sanghvi Marchelle L Sellers David Sigalet Bruce C Steffes Erin Stieber Mamta Swaroop John Tarpley Asha Varghese Julie Varughese Richard Wagner Benjamin Warf Neil Wetzig Susan Williamson Joshua Wood Anne Zeidan Lewis Zirkle Brendan Allen Fizan Abdullah

World J Surg 2017 10;41(10):2423-2425

Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Ave, Box 63, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s00268-017-4067-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828096PMC
October 2017

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D receptors.

Nat Commun 2017 10 2;8(1):763. Epub 2017 Oct 2.

School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1038/s41467-017-00716-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624946PMC
October 2017

DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes.

Sci Rep 2017 10 10;7(1):12879. Epub 2017 Oct 10.

University of Nevada, Department of Agriculture, Nutrition, and Veterinary Sciences, Reno, Reno, Nevada, 89557, USA.

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http://dx.doi.org/10.1038/s41598-017-12861-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635013PMC
October 2017

A kinetic view of GPCR allostery and biased agonism.

Nat Chem Biol 2017 Aug;13(9):929-937

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/nchembio.2431DOI Listing
August 2017

Lysine-specific demethylase-1 (LSD1) depletion disrupts monogenic and monoallelic odorant receptor (OR) expression in an olfactory neuronal cell line.

Mol Cell Neurosci 2017 07 13;82:1-11. Epub 2017 Apr 13.

Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, CT 06457, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.04.005DOI Listing
July 2017

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

Sci Signal 2017 May 23;10(480). Epub 2017 May 23.

Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aai8
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http://dx.doi.org/10.1126/scisignal.aai8529DOI Listing
May 2017

A Molecular Survey for Francisella tularensis and Rickettsia spp. in Haemaphysalis leporispalustris (Acari: Ixodidae) in Northern California.

J Med Entomol 2017 03;54(2):492-495

Department of Medicine and Epidemiology, University of California, Davis, CA 95616

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http://dx.doi.org/10.1093/jme/tjw202DOI Listing
March 2017

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D Receptor (DR).

J Med Chem 2017 02 10;60(4):1478-1494. Epub 2017 Feb 10.

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health , 333 Cassell Drive, Baltimore, Maryland 21224, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325712PMC
February 2017

Adverse early life environment increases hippocampal microglia abundance in conjunction with decreased neural stem cells in juvenile mice.

Int J Dev Neurosci 2016 Dec 22;55:56-65. Epub 2016 Sep 22.

Division of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.

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http://dx.doi.org/10.1016/j.ijdevneu.2016.09.010DOI Listing
December 2016

β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.

Brain Behav Immun 2016 Oct 16;57:106-115. Epub 2016 Jun 16.

Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Cousins Center for PNI, UCLA Semel Institute, Jonsson Comprehensive Cancer Center, and UCLA AIDS Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5060133PMC
http://dx.doi.org/10.1016/j.bbi.2016.06.011DOI Listing
October 2016

Human behaviors elevating the risk of exposure to Ixodes ricinus larvae and nymphs in two types of lowland coniferous forests in west-central Poland.

Ticks Tick Borne Dis 2016 10 1;7(6):1180-1185. Epub 2016 Aug 1.

Department of Environmental Science, Policy and Management, University of California, Berkeley, CA, 94720, USA.

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http://dx.doi.org/10.1016/j.ttbdis.2016.07.018DOI Listing
October 2016

Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex.

BMC Genomics 2016 09 15;17(1):734. Epub 2016 Sep 15.

National Reference Centre for Borrelia at the Bavarian Health and Food Safety Authority, Veterinärstr. 2, 85764, Oberschleissheim, Germany.

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http://dx.doi.org/10.1186/s12864-016-3016-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025617PMC
September 2016

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

Biochem Pharmacol 2016 08 7;113:70-87. Epub 2016 Jun 7.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.05.014DOI Listing
August 2016

Lysine-specific demethylase-1 (LSD1) is compartmentalized at nuclear chromocenters in early post-mitotic cells of the olfactory sensory neuronal lineage.

Mol Cell Neurosci 2016 07 4;74:58-70. Epub 2016 Mar 4.

Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, CT 06457, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935602PMC
July 2016

Diapause in ticks of the medically important Ixodes ricinus species complex.

Ticks Tick Borne Dis 2016 07 17;7(5):992-1003. Epub 2016 May 17.

Department of Fisheries & Wildlife and Large Animal Clinical Sciences, Michigan State University, USA.

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http://dx.doi.org/10.1016/j.ttbdis.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659180PMC
July 2016

Differential associations of Borrelia species with European badgers (Meles meles) and raccoon dogs (Nyctereutes procyonoides) in western Poland.

Ticks Tick Borne Dis 2016 07 20;7(5):1010-1016. Epub 2016 May 20.

Department of Game Management and Forest Protection, Faculty of Forestry, Poznań University of Life Sciences, Poznań, Poland.

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http://dx.doi.org/10.1016/j.ttbdis.2016.05.008DOI Listing
July 2016

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.

Future Med Chem 2016 07 30;8(11):1349-72. Epub 2016 Jun 30.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.4155/fmc-2016-0010DOI Listing
July 2016

Diversity of rickettsial pathogens in Columbian black-tailed deer and their associated keds (Diptera: Hippoboscidae) and ticks (Acari: Ixodidae).

J Vector Ecol 2016 06;41(1):41-7

Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, U.S.A.

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http://dx.doi.org/10.1111/jvec.12192DOI Listing
June 2016

Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex.

BMC Genomics 2016 09 15;17(1):734. Epub 2016 Sep 15.

National Reference Centre for Borrelia at the Bavarian Health and Food Safety Authority, Veterinärstr. 2, 85764, Oberschleissheim, Germany.

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http://dx.doi.org/10.1186/s12864-016-3016-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025617PMC
September 2016

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.

ACS Chem Neurosci 2016 05 3;7(5):647-61. Epub 2016 Mar 3.

Medicinal Chemistry and ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville 3052, Victoria Australia.

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http://dx.doi.org/10.1021/acschemneuro.6b00018DOI Listing
May 2016

The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.

FASEB J 2016 Mar 17;30(3):1144-54. Epub 2015 Nov 17.

*Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Cousins Center, UCLA Semel Institute for Neuroscience and Human Behavior, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California USA; and Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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http://dx.doi.org/10.1096/fj.15-277798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750412PMC
March 2016

sp. nov. and sp. nov. prevail in diverse enzootic transmission cycles.

Int J Syst Evol Microbiol 2016 Mar 22;66(3):1447-1452. Epub 2016 Jan 22.

German National Reference Centre for Borrelia at the Bavarian Health and Food Safety Authority, Veterinärstr. 2, Oberschleissheim, Germany.

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http://dx.doi.org/10.1099/ijsem.0.000897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801759PMC
March 2016

sp. nov. and sp. nov. prevail in diverse enzootic transmission cycles.

Int J Syst Evol Microbiol 2016 Mar 22;66(3):1447-1452. Epub 2016 Jan 22.

German National Reference Centre for Borrelia at the Bavarian Health and Food Safety Authority, Veterinärstr. 2, Oberschleissheim, Germany.

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http://dx.doi.org/10.1099/ijsem.0.000897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801759PMC
March 2016

Aboveground Net Primary Productivity in a Riparian Wetland Following Restoration of Hydrology.

Biology (Basel) 2016 Feb 4;5(1). Epub 2016 Feb 4.

Department of Biological Sciences, The University of Memphis, Memphis, TN 38152, USA.

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http://dx.doi.org/10.3390/biology5010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810167PMC
February 2016

The role of kinetic context in apparent biased agonism at GPCRs.

Nat Commun 2016 Feb 24;7:10842. Epub 2016 Feb 24.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/ncomms10842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770093PMC
February 2016

Borrelia burgdorferi sensu lato spirochetes in wild birds in northwestern California: associations with ecological factors, bird behavior and tick infestation.

PLoS One 2015 25;10(2):e0118146. Epub 2015 Feb 25.

Department of Environmental Science, Policy, and Management, University of California, 130 Mulford Hall, Berkeley, CA 94720, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340631PMC
January 2016

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

J Med Chem 2016 Jan 31;59(1):388-409. Epub 2015 Dec 31.

Medicinal Chemistry and ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville 3052, Victoria Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01562DOI Listing
January 2016

Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene.

Physiol Genomics 2015 Dec 20;47(12):634-43. Epub 2015 Oct 20.

Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; and.

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http://dx.doi.org/10.1152/physiolgenomics.00082.2015DOI Listing
December 2015

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

Breast Cancer Res 2015 Nov 25;17(1):145. Epub 2015 Nov 25.

Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1186/s13058-015-0655-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660629PMC
November 2015

The relationship between early-life environment, the epigenome and the microbiota.

Epigenomics 2015 Oct 20;7(7):1173-84. Epub 2015 Nov 20.

Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.2217/epi.15.74DOI Listing
October 2015

Sequestration within nuclear chromocenters is not a requirement for silencing olfactory receptor transcription in a placode-derived cell line.

Nucleus 2014 Jul-Aug;5(4):318-30

a Department of Molecular Biology and Biochemistry; Wesleyan University; Middletown, CT USA.

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http://dx.doi.org/10.4161/nucl.29343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152346PMC
September 2015

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

J Med Chem 2015 Sep 28;58(17):6819-43. Epub 2015 Aug 28.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville 3052, Victoria Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00585DOI Listing
September 2015

Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor.

Mol Pharmacol 2015 Aug 26;88(2):335-46. Epub 2015 May 26.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (G.L.T., J.R.L., T.C., P.M.S., A.C., M.C.); and Defence Science and Technology Organisation, Department of Defence, Fishermans Bend, Victoria, Australia (G.L.T.)

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http://dx.doi.org/10.1124/mol.115.098848DOI Listing
August 2015

IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling.

Pediatr Res 2015 Jul 31;78(1):14-23. Epub 2015 Mar 31.

Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1038/pr.2015.70DOI Listing
July 2015

IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus.

Am J Physiol Regul Integr Comp Physiol 2015 Jul 13;309(2):R119-27. Epub 2015 May 13.

Division of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin;

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http://dx.doi.org/10.1152/ajpregu.00495.2014DOI Listing
July 2015

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.

J Med Chem 2015 Jul 24;58(13):5287-307. Epub 2015 Jun 24.

†Medicinal Chemistry, and ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00581DOI Listing
July 2015

In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.

Birth Defects Res A Clin Mol Teratol 2015 Jul 14;103(7):583-8. Epub 2015 Jul 14.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/bdra.23395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821574PMC
July 2015

The Amsterdam Declaration on Essential Surgical Care.

World J Surg 2015 Jun;39(6):1335-40

Netherlands Society for International Surgery, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00268-015-3057-xDOI Listing
June 2015

Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene.

FASEB J 2015 Apr 2;29(4):1176-84. Epub 2014 Dec 2.

*Division of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; and Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA

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http://dx.doi.org/10.1096/fj.14-258442DOI Listing
April 2015

Epigenetic contributions to the developmental origins of adult lung disease.

Biochem Cell Biol 2015 Apr 13;93(2):119-27. Epub 2014 Oct 13.

Division of Neonatology, Department of Pediatrics, University of Utah, P.O. Box 581289, Salt Lake City, UT 84158, USA.

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http://dx.doi.org/10.1139/bcb-2014-0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683896PMC
April 2015

Essential surgery: the way forward.

World J Surg 2015 Apr;39(4):822-32

International Collaboration for Essential Surgery (ICES), New York, USA.

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http://dx.doi.org/10.1007/s00268-014-2937-9DOI Listing
April 2015

Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.

FASEB J 2015 Mar 13;29(3):807-19. Epub 2014 Nov 13.

*Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA; Department of Internal Medicine, Department of Pediatrics, and Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, USA; Program in Cardiovascular and Metabolic Diseases, Duke-National University of Singapore Graduate Medical School, Singapore; and Department of Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA

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http://dx.doi.org/10.1096/fj.14-259614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422359PMC
March 2015

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.

J Med Chem 2015 Feb 30;58(3):1550-5. Epub 2015 Jan 30.

Medicinal Chemistry, and ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville 3052, Victoria, Australia.

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http://dx.doi.org/10.1021/jm5013243DOI Listing
February 2015

Seasonal activity patterns of the western black-legged tick, Ixodes pacificus, in relation to onset of human Lyme disease in northwestern California.

Ticks Tick Borne Dis 2014 Oct 10;5(6):790-6. Epub 2014 Aug 10.

Vector-borne Disease Section, California Department of Public Health, United States.

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http://dx.doi.org/10.1016/j.ttbdis.2014.05.002DOI Listing
October 2014

Fetal programming, epigenetics, and adult onset disease.

Authors:
Robert H Lane

Clin Perinatol 2014 Dec 23;41(4):815-31. Epub 2014 Sep 23.

Department of Pediatrics, Children's Hospital of Wisconsin, Medical College of Wisconsin, Suite 720, PO Box 1997, Milwaukee, WI 53201-1997, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clp.2014.08.006DOI Listing
December 2014

Preface. Current controversies in perinatology.

Clin Perinatol 2014 Dec 11;41(4):xix-xx. Epub 2014 Oct 11.

Department of Pediatrics, Children's Hospital of Wisconsin, Medical College of Wisconsin, Children's Corporate Center, 999 North 92nd Street, Suite 450, Milwaukee, WI 53222, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clp.2014.09.001DOI Listing
December 2014

Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats.

Pediatr Res 2014 Nov 13;76(5):432-40. Epub 2014 Aug 13.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1038/pr.2014.117DOI Listing
November 2014

Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment.

Expert Rev Endocrinol Metab 2014 Nov 14;9(6):605-614. Epub 2014 Aug 14.

b Children's Hospital of Wisconsin, Children's Corporate Center, Suite 525, PO Box 1997, Milwaukee, WI 53201-1997, USA.

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http://dx.doi.org/10.1586/17446651.2014.949241DOI Listing
November 2014

Patching the pipeline: creation and retention of the next generation of physician-scientists for child health research.

J Pediatr 2014 Nov 21;165(5):882-4.e1. Epub 2014 Oct 21.

Department of Pediatrics, University of Colorado School of Medicine.

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http://dx.doi.org/10.1016/j.jpeds.2014.07.037DOI Listing
November 2014

Seasonal activity patterns of the western black-legged tick, Ixodes pacificus, in relation to onset of human Lyme disease in northwestern California.

Ticks Tick Borne Dis 2014 Oct 10;5(6):790-6. Epub 2014 Aug 10.

Vector-borne Disease Section, California Department of Public Health, United States.

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http://dx.doi.org/10.1016/j.ttbdis.2014.05.002DOI Listing
October 2014

Remarkable diversity of tick or mammalian-associated Borreliae in the metropolitan San Francisco Bay Area, California.

Ticks Tick Borne Dis 2014 Oct 14;5(6):951-61. Epub 2014 Aug 14.

Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.ttbdis.2014.07.015DOI Listing
October 2014