Robert Landsiedel, PD Dr. rer. nat. , ERT, DABT, FellowATS - BASF SE, Experimental Toxicology and Ecology - VP

Robert Landsiedel

PD Dr. rer. nat. , ERT, DABT, FellowATS

BASF SE, Experimental Toxicology and Ecology

VP

Ludwigshafen am Rhein | Germany

Main Specialties: Chemistry, Pharmacology

Additional Specialties: Toxicology

ORCID logohttps://orcid.org/0000-0003-3756-1904

Robert Landsiedel, PD Dr. rer. nat. , ERT, DABT, FellowATS - BASF SE, Experimental Toxicology and Ecology - VP

Robert Landsiedel

PD Dr. rer. nat. , ERT, DABT, FellowATS

Introduction

Dr. Robert Landsiedel earned a Ph.D. (Dr. rer. nat.) in chemistry and a postgraduate degree in toxicology. After a postdoc position at the toxicology department of the German institute of human nutrition in Potsdam, he started working for BASF in Ludwigshafen am Rhein, Germany, in 1999. After assignments in product development and product safety in North Carolina, USA and Tokyo, Japan, he returned to Ludwigshafen in 2006.
He is now Vice President of an experimental toxicology unit. His team is performing more than 500 toxicological studies per year for regulatory and screening purposes according to Good Laboratory Practice (GLP), Good In Vitro Method Practice (GIVIMP) and ISO 17020. Moreover, they are developing new methods in toxicology and performing research on the safety of new materials (nanomaterials). His team has participated in more than 10 publicly-funded research projects and published more than 100 highly-cited (>10 citations) scientific papers.
In 2012 they received the BASF Innovation Award and in 2013 the Research Award of the state of Rhineland-Palatinate as well as the German Federal Research Award for the development of alternative methods; in 2016 Robert received the German Toxicology Award and in 2018 his team received the European Responsible Care Award by the European Chemical Industry Council(Cefic).
He is Vice-chairman of the German Society of Toxicology and member of the Scientific Committee on Occupational Exposure Limits (SCOEL) of the EU Commission; he is lecturer (Privatdozent) in toxicology at the Free University of Berlin (FU Berlin) and the Medical school of the University of Leipzig.

Primary Affiliation: BASF SE, Experimental Toxicology and Ecology - Ludwigshafen am Rhein , Germany

Specialties:

Additional Specialties:

Research Interests:

Education

Jan 2013 - May 2017
Free University of Berlin
Habilitation, Privatdozent
Biology, Chemistry and Pharmacy
Aug 1994 - Dec 1997
Johannes Gutenberg University of Mainz, University of Kaiserslautern
Dr. rer. nat.
Chemistry
Jan 1994 - Jan 1996
University of Leipzig
Fachchemiker für Toxikologie (Postgraduate Degree)
Faculty of Medicine

Experience

Jan 2016
BASF SE
Vice President
Experimental Toxicology and Ecology
Mar 2014
European Commission Scientific Committee on Occupational Exposure Level (SCOEL)
Full member
EU Scientific Committee on Occupational Exposure Level (SCOEL)
Jan 2008
German Toxicology Society
Vice chairman
Board
Jan 2006 - Jan 2006
BASF SE
Senior research manager
Experimental Toxicology and Ecology
Sep 2004 - May 2004
BASF Agro Japan
Manager
Development and Registration
Jan 2002 - Jan 2002
BASF Corporation
Senior scientist
Agrochemicals
Jan 1999 - Jan 1999
BASF Aktiengesellschaft
Scientist
Hauptlabor
Dec 1997 - Aug 1994
German Institute of Human Nutrition (DIfE)
PostDoc
Toxicology
Jul 1993
Environmental Ministry of Rhineland-Palatinate
charted chemist (Staatsexamen Lebensmittelchemie)
Chemisches Untersuchungsamt in Mainz

Publications

104Publications

2802Reads

698Profile Views

1001PubMed Central Citations

Letter to the editor regarding the article by Roberts, 2018.

Authors:
Andreas Natsch Robert Landsiedel

Regul Toxicol Pharmacol 2019 03 7;102:115-116. Epub 2019 Jan 7.

BASF SE, RB/TB - Z470, D-67056, Ludwigshafen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S02732300193000
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http://dx.doi.org/10.1016/j.yrtph.2019.01.005DOI Listing
March 2019
4 Reads
2.031 Impact Factor

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds.

Authors:
Eric Fabian Caroline Gomes Barbara Birk Tabitha Williford Tzutzuy Ramirez Hernandez Christian Haase Rene Zbranek Bennard van Ravenzwaay Robert Landsiedel

Arch Toxicol 2019 Feb 14;93(2):401-416. Epub 2018 Dec 14.

BASF SE, Experimental Toxicology and Ecology, Carl Bosch Straße 38, 67056, Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/s00204-018-2372-zDOI Listing
February 2019
3 Reads
5.980 Impact Factor

Correction to: Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:
F Oesch E Fabian Robert Landsiedel

Arch Toxicol 2018 Nov;92(11):3439

Experimental Toxicology and Ecology, GV/TB, Z470, BASF SE, Carl-Bosch-Str. 38, 67056, Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/s00204-018-2301-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208944PMC
November 2018
3 Reads
5.980 Impact Factor

Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms.

Authors:
Susan Dekkers Lan Ma-Hock Iseult Lynch Mike Russ Mark R Miller Roel P F Schins Jana Keller Isabella Römer Karin Küttler Volker Strauss Wim H De Jong Robert Landsiedel Flemming R Cassee

Inhal Toxicol 2018 Oct 4:1-14. Epub 2018 Oct 4.

a National Institute for Public Health and the Environment , Bilthoven , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1516834DOI Listing
October 2018
11 Reads
2.260 Impact Factor

Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:
F Oesch E Fabian Robert Landsiedel

Arch Toxicol 2018 Aug 18;92(8):2411-2456. Epub 2018 Jun 18.

Experimental Toxicology and Ecology, GV/TB, Z470, BASF SE, Carl-Bosch-Str. 38, 67056, Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/s00204-018-2232-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063329PMC
August 2018
30 Reads
5.980 Impact Factor

In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO₂.

Authors:
Martin Wiemann Ursula G Sauer Antje Vennemann Sandra Bäcker Johannes-Georg Keller Lan Ma-Hock Wendel Wohlleben Robert Landsiedel

Nanomaterials (Basel) 2018 Mar 13;8(3). Epub 2018 Mar 13.

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.3390/nano8030160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869651PMC
March 2018
10 Reads
1 Citation

A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing.

Authors:
Andrea Vassallo Michela Chiappalone Ricardo De Camargos Lopes Bibiana Scelfo Antonio Novellino Enrico Defranchi Taina Palosaari Timo Weisschu Tzutzuy Ramirez Sergio Martinoia Andrew F M Johnstone Cina M Mack Robert Landsiedel Maurice Whelan Anna Bal-Price Timothy J Shafer

Neurotoxicology 2017 May 29;60:280-292. Epub 2016 Mar 29.

National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.03.019DOI Listing
May 2017
51 Reads
5 Citations
3.380 Impact Factor

A protocol to determine dermal absorption of xenobiotica through human skin in vitro.

Authors:
Eric Fabian Franz Oesch Katharina Ott Robert Landsiedel Bennard van Ravenzwaay

Arch Toxicol 2017 Mar 5;91(3):1497-1511. Epub 2016 Jul 5.

Experimental Toxicology and Ecology, BASF SE, 67056, Ludwigshafen am Rhein, Germany.

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http://dx.doi.org/10.1007/s00204-016-1782-zDOI Listing
March 2017
41 Reads
5.980 Impact Factor

No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2 or BaSO4 nanomaterials.

Authors:
Eugenia Cordelli Jana Keller Patrizia Eleuteri Paola Villani Lan Ma-Hock Markus Schulz Robert Landsiedel Francesca Pacchierotti

Mutagenesis 2017 01 9;32(1):13-22. Epub 2016 Feb 9.

Experimental Toxicology and Ecology, BASF SE, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1093/mutage/gew005DOI Listing
January 2017
5 Reads
4 Citations
2.793 Impact Factor

Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles.

Authors:
Mathilde Delaval Wendel Wohlleben Robert Landsiedel Armelle Baeza-Squiban Sonja Boland

Arch Toxicol 2017 Jan 8;91(1):163-177. Epub 2016 Apr 8.

Unit of Functional and Adaptive Biology (BFA), Lab of Molecular and Cellular Responses to Xenobiotics, UMR CNRS 8251, Univ-Paris-Diderot (Sorbonne Paris Cité), 5 rue Thomas Mann, 75205, Paris Cedex 13, France.

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http://dx.doi.org/10.1007/s00204-016-1701-3DOI Listing
January 2017
18 Reads
1 Citation
5.980 Impact Factor

Concern-driven integrated approaches for the grouping, testing and assessment of nanomaterials.

Authors:
Robert Landsiedel

Environ Pollut 2016 Nov 14;218:1376-1380. Epub 2015 Nov 14.

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.envpol.2015.10.060DOI Listing
November 2016
21 Reads
2 Citations
4.143 Impact Factor

The way forward for risk assessment of nanomaterials in solid media.

Authors:
Janeck J Scott-Fordsmand Willie Peijnenburg Mónica J B Amorim Robert Landsiedel Koen Oorts

Environ Pollut 2016 Nov 14;218:1363-1364. Epub 2015 Dec 14.

ARCHE (Assessing Risks of CHEmicals), Stapelplein 70 box 104, 9000 Gent, Belgium.

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http://dx.doi.org/10.1016/j.envpol.2015.11.048DOI Listing
November 2016
9 Reads
2 Citations
4.143 Impact Factor

Acute oral toxicity testing: Scientific evidence and practicability should govern Three Rs activities.

Authors:
Roland Buesen Uwe Oberholz Ursula G Sauer Robert Landsiedel

Altern Lab Anim 2016 Sep;44(4):391-398

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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September 2016
18 Reads
1.592 Impact Factor

Comparative short-term inhalation toxicity of five organic diketopyrrolopyrrole pigments and two inorganic iron-oxide-based pigments.

Authors:
Thomas Hofmann Lan Ma-Hock Volker Strauss Silke Treumann Maria Rey Moreno Nicole Neubauer Wendel Wohlleben Sibylle Gröters Karin Wiench Ulrich Veith Wera Teubner Bennard van Ravenzwaay Robert Landsiedel

Inhal Toxicol 2016 08 7;28(10):463-79. Epub 2016 Jul 7.

a Department of Experimental Toxicology and Ecology .

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http://dx.doi.org/10.1080/08958378.2016.1200698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020341PMC
August 2016
26 Reads
1 Citation
2.260 Impact Factor

Evaluation of non-animal methods for assessing skin sensitisation hazard: A Bayesian Value-of-Information analysis.

Authors:
Maria Leontaridou Silke Gabbert Ekko C Van Ierland Andrew P Worth Robert Landsiedel

Altern Lab Anim 2016 Jul;44(3):255-69

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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July 2016
58 Reads
1.592 Impact Factor

Local tolerance testing under REACH: Accepted non-animal methods are not on equal footing with animal tests.

Authors:
Ursula G Sauer Erin H Hill Rodger D Curren Hans A Raabe Susanne N Kolle Wera Teubner Annette Mehling Robert Landsiedel

Altern Lab Anim 2016 Jul;44(3):281-99

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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July 2016
95 Reads
1.592 Impact Factor

Activities of xenobiotic metabolizing enzymes in rat placenta and liver in vitro.

Authors:
Eric Fabian Xinyi Wang Franziska Engel Hequn Li Robert Landsiedel Bennard van Ravenzwaay

Toxicol In Vitro 2016 Jun 2;33:174-9. Epub 2016 Mar 2.

BASF SE, Experimental Toxicology and Ecology, GV/TB-/470, 67056 Ludwigshafen am Rhein, Germany; Division of Toxicology, Wageningen University, Tuinlaan 5, 6700 HE Wageningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2016.02.024DOI Listing
June 2016
25 Reads
2.903 Impact Factor

Assessment of Pre- and Pro-haptens Using Nonanimal Test Methods for Skin Sensitization.

Authors:
Daniel Urbisch Matthias Becker Naveed Honarvar Susanne Noreen Kolle Annette Mehling Wera Teubner Britta Wareing Robert Landsiedel

Chem Res Toxicol 2016 05 29;29(5):901-13. Epub 2016 Apr 29.

Experimental Toxicology and Ecology, BASF SE , Ludwigshafen, Germany.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00055DOI Listing
May 2016
57 Reads
1 Citation
3.530 Impact Factor

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay.

Authors:
Susanne N Kolle Ursula G Sauer Maria C Rey Moreno Wera Teubner Wendel Wohlleben Robert Landsiedel

Part Fibre Toxicol 2016 Apr 15;13:18. Epub 2016 Apr 15.

BASF SE, Experimental Toxicology and Ecology, GB/TB - Z470, 67056, Ludwigshafen, Germany.

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http://dx.doi.org/10.1186/s12989-016-0128-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833924PMC
April 2016
78 Reads
3 Citations
7.113 Impact Factor

Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice.

Authors:
Josje H E Arts Muhammad-Adeel Irfan Athena M Keene Reinhard Kreiling Delina Lyon Monika Maier Karin Michel Nicole Neubauer Thomas Petry Ursula G Sauer David Warheit Karin Wiench Wendel Wohlleben Robert Landsiedel

Regul Toxicol Pharmacol 2016 Apr 10;76:234-61. Epub 2015 Dec 10.

BASF SE, Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2015.11.020DOI Listing
April 2016
40 Reads
11 Citations
2.031 Impact Factor

Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers.

Authors:
Tzutzuy Ramirez Nadine Stein Alexandra Aumann Tina Remus Amber Edwards Kimberly G Norman Cindy Ryan Jackie E Bader Markus Fehr Florence Burleson Leslie Foertsch Xiaohong Wang Frank Gerberick Paul Beilstein Sebastian Hoffmann Annette Mehling Bennard van Ravenzwaay Robert Landsiedel

Toxicol In Vitro 2016 Apr 12;32:278-86. Epub 2016 Jan 12.

BASF SE, Experimental Toxicology and Ecology, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2016.01.004DOI Listing
April 2016
41 Reads
2 Citations
2.903 Impact Factor

An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials.

Authors:
Martin Wiemann Antje Vennemann Ursula G Sauer Karin Wiench Lan Ma-Hock Robert Landsiedel

J Nanobiotechnology 2016 Mar 5;14:16. Epub 2016 Mar 5.

BASF SE, Experimental Toxicology and Ecology, GB/TB - Z470, 67056, Ludwigshafen, Germany.

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http://dx.doi.org/10.1186/s12951-016-0164-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779246PMC
March 2016
27 Reads
12 Citations
4.080 Impact Factor

Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making.

Authors:
Hilary Godwin Catherine Nameth David Avery Lynn L Bergeson Daniel Bernard Elizabeth Beryt William Boyes Scott Brown Amy J Clippinger Yoram Cohen Maria Doa Christine Ogilvie Hendren Patricia Holden Keith Houck Agnes B Kane Frederick Klaessig Toivo Kodas Robert Landsiedel Iseult Lynch Timothy Malloy Mary Beth Miller Julie Muller Gunter Oberdorster Elijah J Petersen Richard C Pleus Philip Sayre Vicki Stone Kristie M Sullivan Jutta Tentschert Philip Wallis Andre E Nel

ACS Nano 2015 20;9(4):3409-17. Epub 2015 Mar 20.

▲▲SouthWest NanoTechnologies, Norman, Oklahoma 73071, United States.

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http://dx.doi.org/10.1021/acsnano.5b00941DOI Listing
February 2016
20 Reads
29 Citations
12.881 Impact Factor

In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials.

Authors:
Elena Maser Markus Schulz Ursula G Sauer Martin Wiemann Lan Ma-Hock Wendel Wohlleben Andrea Hartwig Robert Landsiedel

Mutat Res Genet Toxicol Environ Mutagen 2015 Dec 31;794:57-74. Epub 2015 Oct 31.

Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mrgentox.2015.10.005DOI Listing
December 2015
21 Reads
9 Citations
2.420 Impact Factor

Read-across for hazard assessment: the ugly duckling is growing up.

Authors:
Wera Teubner Robert Landsiedel

Altern Lab Anim 2015 Dec;43(6):P67-71

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany.

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December 2015
12 Reads
1 Citation
1.592 Impact Factor

The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials.

Authors:
Peter M J Bos Stefania Gottardo Janeck J Scott-Fordsmand Martie van Tongeren Elena Semenzin Teresa F Fernandes Danail Hristozov Kerstin Hund-Rinke Neil Hunt Muhammad-Adeel Irfan Robert Landsiedel Willie J G M Peijnenburg Araceli Sánchez Jiménez Petra C E van Kesteren Agnes G Oomen

Int J Environ Res Public Health 2015 Nov 27;12(12):15007-21. Epub 2015 Nov 27.

National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands.

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http://dx.doi.org/10.3390/ijerph121214961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690897PMC
November 2015
43 Reads
8 Citations
2.063 Impact Factor

Alternatives for skin sensitisation: Hazard identification and potency categorisation: Report from an EPAA/CEFIC LRI/Cosmetics Europe cross sector workshop, ECHA Helsinki, April 23rd and 24th 2015.

Authors:
David Basketter Takao Ashikaga Silvia Casati Bruno Hubesch Joanna Jaworska Joop de Knecht Robert Landsiedel Irene Manou Annette Mehling Dirk Petersohn Emiel Rorije Laura H Rossi Winfried Steiling Silvia Teissier Andrew Worth

Regul Toxicol Pharmacol 2015 Nov 9;73(2):660-6. Epub 2015 Oct 9.

EURL ECVAM, Ispra, Italy.

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http://dx.doi.org/10.1016/j.yrtph.2015.10.005DOI Listing
November 2015
135 Reads
2 Citations
2.031 Impact Factor

Grouping and Read-Across Approaches for Risk Assessment of Nanomaterials.

Authors:
Agnes G Oomen Eric A J Bleeker Peter M J Bos Fleur van Broekhuizen Stefania Gottardo Monique Groenewold Danail Hristozov Kerstin Hund-Rinke Muhammad-Adeel Irfan Antonio Marcomini Willie J G M Peijnenburg Kirsten Rasmussen Araceli Sánchez Jiménez Janeck J Scott-Fordsmand Martie van Tongeren Karin Wiench Wendel Wohlleben Robert Landsiedel

Int J Environ Res Public Health 2015 Oct 26;12(10):13415-34. Epub 2015 Oct 26.

BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany.

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http://dx.doi.org/10.3390/ijerph121013415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627040PMC
October 2015
24 Reads
15 Citations
2.063 Impact Factor

Integrated Testing Strategies (ITS) for safety assessment.

Authors:
Costanza Rovida Nathalie Alépée Anne M Api David A Basketter Frédéric Y Bois Francesca Caloni Emanuela Corsini Mardas Daneshian Chantra Eskes Janine Ezendam Horst Fuchs Patrick Hayden Christa Hegele-Hartung Sebastian Hoffmann Bruno Hubesch Miriam N Jacobs Joanna Jaworska André Kleensang Nicole Kleinstreuer Jon Lalko Robert Landsiedel Frédéric Lebreux Thomas Luechtefeld Monica Locatelli Annette Mehling Andreas Natsch Jonathan W Pitchford Donald Prater Pilar Prieto Andreas Schepky Gerrit Schüürmann Lena Smirnova Colleen Toole Erwin van Vliet Dirk Weisensee Thomas Hartung

ALTEX 2015 19;32(1):25-40. Epub 2014 Nov 19.

CAAT Europe, University of Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1411011DOI Listing
August 2015
37 Reads
17 Citations
5.470 Impact Factor

International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.

Authors:
Marc A T Teunis Sander W Spiekstra Mieke Smits Els Adriaens Tobias Eltze Valentina Galbiati Cyrille Krul Robert Landsiedel Raymond Pieters Judith Reinders Erwin Roggen Emanuela Corsini Susan Gibbs

ALTEX 2014 17;31(3):251-68. Epub 2014 Feb 17.

University of Applied Sciences, Utrecht, The Netherlands.

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http://dx.doi.org/10.14573/altex.1308021DOI Listing
August 2015
30 Reads
5.470 Impact Factor

Prenatal toxicity of synthetic amorphous silica nanomaterial in rats.

Authors:
Thomas Hofmann Steffen Schneider André Wolterbeek Han van de Sandt Robert Landsiedel Bennard van Ravenzwaay

Reprod Toxicol 2015 Aug 18;56:141-6. Epub 2015 Apr 18.

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.reprotox.2015.04.006DOI Listing
August 2015
6 Reads
4 Citations
3.230 Impact Factor

Evaluation of an optimized protocol using human peripheral blood monocyte derived dendritic cells for the in vitro detection of sensitizers: Results of a ring study in five laboratories.

Authors:
Hendrik Reuter Silke Gerlach Jochem Spieker Cindy Ryan Caroline Bauch Claire Mangez Petra Winkler Robert Landsiedel Marie Templier Aurelien Mignot Frank Gerberick Horst Wenck Pierre Aeby Andreas Schepky

Toxicol In Vitro 2015 Aug 10;29(5):976-86. Epub 2015 Apr 10.

Research and Development, Beiersdorf AG, Unnastrasse 48, D-20245 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.tiv.2015.03.021DOI Listing
August 2015
13 Reads
1 Citation
2.903 Impact Factor

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.

Authors:
Natalie Alépée Anthony Bahinski Mardas Daneshian Bart De Wever Ellen Fritsche Alan Goldberg Jan Hansmann Thomas Hartung John Haycock Helena Hogberg Lisa Hoelting Jens M Kelm Suzanne Kadereit Emily McVey Robert Landsiedel Marcel Leist Marc Lübberstedt Fozia Noor Christian Pellevoisin Dirk Petersohn Uwe Pfannenbecker Kerstin Reisinger Tzutzuy Ramirez Barbara Rothen-Rutishauser Monika Schäfer-Korting Katrin Zeilinger Marie-Gabriele Zurich

ALTEX 2014 14;31(4):441-77. Epub 2014 Jul 14.

L'Oréal R&I, Aulnay, France.

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http://dx.doi.org/10.14573/altex.1406111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783151PMC
August 2015
58 Reads
32 Citations
5.470 Impact Factor

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Authors:
Pavlos C Englezou Simon W Rothwell Joseph S Ainscough David Brough Robert Landsiedel Alexei Verkhratsky Ian Kimber Rebecca J Dearman

Cytokine 2015 Aug 9;74(2):293-304. Epub 2015 Jun 9.

Faculty of Life Sciences, Smith Building, The University of Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2015.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504032PMC
August 2015
24 Reads
5 Citations
2.664 Impact Factor

Oral two-generation reproduction toxicity study with NM-200 synthetic amorphous silica in Wistar rats.

Authors:
André Wolterbeek Thies Oosterwijk Steffen Schneider Robert Landsiedel Didima de Groot Renz van Ee Mariëlle Wouters Han van de Sandt

Reprod Toxicol 2015 Aug 25;56:147-54. Epub 2015 Mar 25.

TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S08906238150004
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http://dx.doi.org/10.1016/j.reprotox.2015.03.006DOI Listing
August 2015
7 Reads
3 Citations
3.230 Impact Factor

The EpiOcular™ Eye Irritation Test is the Method of Choice for the In Vitro Eye Irritation Testing of Agrochemical Formulations: Correlation Analysis of EpiOcular Eye Irritation Test and BCOP Test Data According to the UN GHS, US EPA and Brazil ANVISA Classification Schemes.

Authors:
Susanne N Kolle Maria Cecilia Rey Moreno Winfried Mayer Andrew van Cott Bennard van Ravenzwaay Robert Landsiedel

Altern Lab Anim 2015 Jul;43(3):181-98

BASF SE Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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July 2015
37 Reads
1 Citation
1.592 Impact Factor

Immunophenotyping does not improve predictivity of the local lymph node assay in mice.

Authors:
Volker Strauss Susanne N Kolle Naveed Honarvar Martina Dammann Sibylle Groeters Frank Faulhammer Robert Landsiedel Bennard van Ravenzwaay

J Appl Toxicol 2015 Apr 3;35(4):434-45. Epub 2014 Sep 3.

BASF SE, Experimental Toxicology and Ecology, Z470, 67056, Ludwigshafen, Germany.

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http://dx.doi.org/10.1002/jat.3042DOI Listing
April 2015
21 Reads
2.982 Impact Factor

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping).

Authors:
Josje H E Arts Mackenzie Hadi Muhammad-Adeel Irfan Athena M Keene Reinhard Kreiling Delina Lyon Monika Maier Karin Michel Thomas Petry Ursula G Sauer David Warheit Karin Wiench Wendel Wohlleben Robert Landsiedel

Regul Toxicol Pharmacol 2015 Mar 26;71(2 Suppl):S1-27. Epub 2015 Mar 26.

BASF SE, Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2015.03.007DOI Listing
March 2015
41 Reads
25 Citations
2.031 Impact Factor

A short-term inhalation study protocol: designed for testing of toxicity and fate of nanomaterials.

Authors:
Lan Ma-Hock Thomas Hofmann Robert Landsiedel Bennard van Ravenzwaay

Methods Mol Biol 2014 ;1199:207-12

Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/978-1-4939-1280-3_16DOI Listing
March 2015
22 Reads

Assessing skin sensitization hazard in mice and men using non-animal test methods.

Authors:
Daniel Urbisch Annette Mehling Katharina Guth Tzutzuy Ramirez Naveed Honarvar Susanne Kolle Robert Landsiedel Joanna Jaworska Petra S Kern Frank Gerberick Andreas Natsch Roger Emter Takao Ashikaga Masaaki Miyazawa Hitoshi Sakaguchi

Regul Toxicol Pharmacol 2015 Mar 23;71(2):337-51. Epub 2014 Dec 23.

Safety Science Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-349, Japan.

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http://dx.doi.org/10.1016/j.yrtph.2014.12.008DOI Listing
March 2015
33 Reads
13 Citations
2.031 Impact Factor

Influence of dispersive agent on nanomaterial agglomeration and implications for biological effects in vivo or in vitro.

Authors:
Ursula G Sauer Alexandra Aumann Lan Ma-Hock Robert Landsiedel Wendel Wohlleben

Toxicol In Vitro 2015 Feb;29(1):182-6

Scientific Consultancy – Animal Welfare, Neubiberg, Germany.

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http://dx.doi.org/10.1016/j.tiv.2014.10.011DOI Listing
February 2015
13 Reads
4 Citations
2.903 Impact Factor

Suitability of skin integrity tests for dermal absorption studies in vitro.

Authors:
Katharina Guth Monika Schäfer-Korting Eric Fabian Robert Landsiedel Ben van Ravenzwaay

Toxicol In Vitro 2015 Feb 2;29(1):113-23. Epub 2014 Oct 2.

BASF SE, Experimental Toxicology and Ecology, Carl-Bosch-Str. 38, 67056 Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2014.09.007DOI Listing
February 2015
6 Reads
4 Citations
2.903 Impact Factor

LuSens: a keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification.

Authors:
Tzutzuy Ramirez Annette Mehling Susanne N Kolle Christoph J Wruck Wera Teubner Tobias Eltze Alexandra Aumann Daniel Urbisch Ben van Ravenzwaay Robert Landsiedel

Toxicol In Vitro 2014 Dec 27;28(8):1482-97. Epub 2014 Aug 27.

BASF SE, Experimental Toxicology and Ecology, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2014.08.002DOI Listing
December 2014
101 Reads
6 Citations
2.903 Impact Factor

Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties.

Authors:
Viviana Marzaioli Juan Antonio Aguilar-Pimentel Ingrid Weichenmeier Georg Luxenhofer Martin Wiemann Robert Landsiedel Wendel Wohlleben Stefanie Eiden Martin Mempel Heidrun Behrendt Carsten Schmidt-Weber Jan Gutermuth Francesca Alessandrini

Int J Nanomedicine 2014 5;9:2815-32. Epub 2014 Jun 5.

Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://dx.doi.org/10.2147/IJN.S57396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051720PMC
December 2014
18 Reads
14 Citations

A critical appraisal of existing concepts for the grouping of nanomaterials.

Authors:
Josje H E Arts Mackenzie Hadi Athena M Keene Reinhard Kreiling Delina Lyon Monika Maier Karin Michel Thomas Petry Ursula G Sauer David Warheit Karin Wiench Robert Landsiedel

Regul Toxicol Pharmacol 2014 Nov 7;70(2):492-506. Epub 2014 Aug 7.

BASF SE, Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2014.07.025DOI Listing
November 2014
45 Reads
17 Citations
2.031 Impact Factor

Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria.

Authors:
Jana Keller Wendel Wohlleben Lan Ma-Hock Volker Strauss Sibylle Gröters Karin Küttler Karin Wiench Christiane Herden Günter Oberdörster Bennard van Ravenzwaay Robert Landsiedel

Arch Toxicol 2014 Nov 2;88(11):2033-59. Epub 2014 Oct 2.

Experimental Toxicology and Ecology, BASF SE, 67056, Ludwigshafen am Rhein, Germany.

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http://dx.doi.org/10.1007/s00204-014-1349-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555363PMC
November 2014
30 Reads
17 Citations
5.980 Impact Factor

Pulmonary toxicity of nanomaterials: a critical comparison of published in vitro assays and in vivo inhalation or instillation studies.

Authors:
Robert Landsiedel Ursula G Sauer Lan Ma-Hock Jürgen Schnekenburger Martin Wiemann

Nanomedicine (Lond) 2014 Nov;9(16):2557-85

BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.2217/nnm.14.149DOI Listing
November 2014
34 Reads
15 Citations
5.413 Impact Factor

Effects of SiO₂, ZrO₂, and BaSO₄ nanomaterials with or without surface functionalization upon 28-day oral exposure to rats.

Authors:
Roland Buesen Robert Landsiedel Ursula G Sauer Wendel Wohlleben Sibylle Groeters Volker Strauss Hennicke Kamp Bennard van Ravenzwaay

Arch Toxicol 2014 Oct 28;88(10):1881-906. Epub 2014 Aug 28.

Experimental Toxicology and Ecology, BASF SE, 67056, Ludwigshafen am Rhein, Germany.

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http://dx.doi.org/10.1007/s00204-014-1337-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161931PMC
October 2014
17 Reads
6 Citations
5.980 Impact Factor

Biokinetics and effects of barium sulfate nanoparticles.

Authors:
Nagarjun Konduru Jana Keller Lan Ma-Hock Sibylle Gröters Robert Landsiedel Thomas C Donaghey Joseph D Brain Wendel Wohlleben Ramon M Molina

Part Fibre Toxicol 2014 Oct 21;11:55. Epub 2014 Oct 21.

Department of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12989-014-0055-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219084PMC
October 2014
12 Reads
13 Citations
7.113 Impact Factor

Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R.

Authors:
Ursula G Sauer Thomas Wächter Lars Hareng Britta Wareing Angelika Langsch Matthias Zschunke Michael R Alvers Robert Landsiedel

Toxicol In Vitro 2014 Jun 2;28(4):571-87. Epub 2014 Jan 2.

BASF SE, Product Safety - Experimental Toxicology and Ecology, Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2013.12.011DOI Listing
June 2014
23 Reads
4 Citations
2.903 Impact Factor

Concern-driven integrated approaches to nanomaterial testing and assessment--report of the NanoSafety Cluster Working Group 10.

Authors:
Agnes G Oomen Peter M J Bos Teresa F Fernandes Kerstin Hund-Rinke Diana Boraschi Hugh J Byrne Karin Aschberger Stefania Gottardo Frank von der Kammer Dana Kühnel Danail Hristozov Antonio Marcomini Lucia Migliore Janeck Scott-Fordsmand Peter Wick Robert Landsiedel

Nanotoxicology 2014 May 28;8(3):334-48. Epub 2013 May 28.

IVM, National Institute for Public Health and the Environment , Bilthoven , The Netherlands.

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http://dx.doi.org/10.3109/17435390.2013.802387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002633PMC
May 2014
62 Reads
24 Citations
6.411 Impact Factor

Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation.

Authors:
Ursula G Sauer Sandra Vogel Alexandra Aumann Annemarie Hess Susanne N Kolle Lan Ma-Hock Wendel Wohlleben Martina Dammann Volker Strauss Silke Treumann Sibylle Gröters Karin Wiench Bennard van Ravenzwaay Robert Landsiedel

Toxicol Appl Pharmacol 2014 Apr 29;276(1):1-20. Epub 2013 Dec 29.

Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2013.12.017DOI Listing
April 2014
51 Reads
9 Citations
3.705 Impact Factor

Skin sensitisation--moving forward with non-animal testing strategies for regulatory purposes in the EU.

Authors:
David Basketter Nathalie Alépée Silvia Casati Jonathan Crozier Dorothea Eigler Peter Griem Bruno Hubesch Joop de Knecht Robert Landsiedel Kimmo Louekari Irene Manou Gavin Maxwell Annette Mehling Tatiana Netzeva Thomas Petry Laura H Rossi

Regul Toxicol Pharmacol 2013 Dec 16;67(3):531-5. Epub 2013 Oct 16.

DABMEB Consultancy Ltd., Sharnbrook MK44 1PR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2013.10.002DOI Listing
December 2013
20 Reads
2 Citations
2.031 Impact Factor

Computer models versus reality: how well do in silico models currently predict the sensitization potential of a substance.

Authors:
Wera Teubner Anette Mehling Paul Xaver Schuster Katharina Guth Andrew Worth Julien Burton Bennard van Ravenzwaay Robert Landsiedel

Regul Toxicol Pharmacol 2013 Dec 30;67(3):468-85. Epub 2013 Sep 30.

BASF Schweiz AG, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2013.09.007DOI Listing
December 2013
21 Reads
5 Citations
2.031 Impact Factor

A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment.

Authors:
Andre E Nel Elina Nasser Hilary Godwin David Avery Tina Bahadori Lynn Bergeson Elizabeth Beryt James C Bonner Darrell Boverhof Janet Carter Vince Castranova J R Deshazo Saber M Hussain Agnes B Kane Frederick Klaessig Eileen Kuempel Mark Lafranconi Robert Landsiedel Timothy Malloy Mary Beth Miller Jeffery Morris Kenneth Moss Gunter Oberdorster Kent Pinkerton Richard C Pleus Jo Anne Shatkin Russell Thomas Thabet Tolaymat Amy Wang Jeffrey Wong

ACS Nano 2013 Aug 7;7(8):6422-33. Epub 2013 Aug 7.

Department of Medicine, Division of NanoMedicine, University of California Center for Environmental Implications of Nanotechnology, University of California, Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/nn4037927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004078PMC
August 2013
39 Reads
17 Citations
12.881 Impact Factor

Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data.

Authors:
Limor Horev-Azaria Giovanni Baldi Delila Beno Daniel Bonacchi Ute Golla-Schindler James C Kirkpatrick Susanne Kolle Robert Landsiedel Oded Maimon Patrice N Marche Jessica Ponti Roni Romano François Rossi Dieter Sommer Chiara Uboldi Ronald E Unger Christian Villiers Rafi Korenstein

Part Fibre Toxicol 2013 Jul 29;10:32. Epub 2013 Jul 29.

Department of Physiology and Pharmacology, Faculty of Medicine and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel-Aviv 69978, Israel.

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http://dx.doi.org/10.1186/1743-8977-10-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734223PMC
July 2013
26 Reads
12 Citations
7.113 Impact Factor

Additional histopathologic examination of the lungs from a 3-month inhalation toxicity study with multiwall carbon nanotubes in rats.

Authors:
Silke Treumann Lan Ma-Hock Sibylle Gröters Robert Landsiedel Bennard van Ravenzwaay

Toxicol Sci 2013 Jul 9;134(1):103-10. Epub 2013 Apr 9.

Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.1093/toxsci/kft089DOI Listing
July 2013
10 Reads
8 Citations

Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate.

Authors:
Franzisca Marie Bätz Wiebke Klipper Hans Christian Korting Frank Henkler Robert Landsiedel Andreas Luch Uwe von Fritschen Günther Weindl Monika Schäfer-Korting

Eur J Pharm Biopharm 2013 Jun 29;84(2):374-85. Epub 2012 Nov 29.

Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin (FU), Berlin, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2012.11.008DOI Listing
June 2013
102 Reads
5 Citations
3.383 Impact Factor

Genotoxicity of nanomaterials: refining strategies and tests for hazard identification.

Authors:
Stefan Pfuhler Rosalie Elespuru Marilyn J Aardema Shareen H Doak E Maria Donner Masamitsu Honma Micheline Kirsch-Volders Robert Landsiedel Mugimane Manjanatha Tim Singer James H Kim

Environ Mol Mutagen 2013 May 21;54(4):229-39. Epub 2013 Mar 21.

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http://dx.doi.org/10.1002/em.21770DOI Listing
May 2013
16 Reads
1 Citation
2.630 Impact Factor

Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers.

Authors:
Christine Jäckh Eric Fabian Bennard van Ravenzwaay Robert Landsiedel

J Immunotoxicol 2012 Oct-Dec;9(4):426-38. Epub 2012 Apr 3.

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.3109/1547691X.2012.664578DOI Listing
May 2013
5 Reads
3 Citations
1.910 Impact Factor

Erratum to "Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: substantiating test strategies with data from routine studies" [Regul. Toxicol. Pharmacol. (2012) 402-414].

Authors:
Susanne N Kolle Kristie M Sullivan Annette Mehling Bennard van Ravenzwaay Robert Landsiedel

Regul Toxicol Pharmacol 2013 Apr;65(3):366-78

BASF SE, Experimental Toxicology and Ecology, Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany.

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April 2013
15 Reads
1 Citation
2.031 Impact Factor

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency.

Authors:
Marc Teunis Emanuela Corsini Mieke Smits Charlotte Bernhard Madsen Tobias Eltze Janine Ezendam Valentina Galbiati Eric Gremmer Cyrille Krul Annette Landin Robert Landsiedel Raymond Pieters Tina Frid Rasmussen Judith Reinders Erwin Roggen Sander Spiekstra Susan Gibbs

Toxicol In Vitro 2013 Apr 19;27(3):1135-50. Epub 2012 Jun 19.

University of Applied Sciences, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.tiv.2012.06.004DOI Listing
April 2013
37 Reads
3 Citations
2.903 Impact Factor

Performance standards and alternative assays: practical insights from skin sensitization.

Authors:
Susanne N Kolle David A Basketter Silvia Casati William S Stokes Judy Strickland Bennard van Ravenzwaay Hans-Werner Vohr Robert Landsiedel

Regul Toxicol Pharmacol 2013 Mar 29;65(2):278-85. Epub 2012 Dec 29.

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.yrtph.2012.12.006DOI Listing
March 2013
6 Reads
3 Citations
2.031 Impact Factor

In vivo-in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems.

Authors:
Ursula G Sauer Sandra Vogel Annemarie Hess Susanne N Kolle Lan Ma-Hock Bennard van Ravenzwaay Robert Landsiedel

Toxicol In Vitro 2013 Feb 22;27(1):174-90. Epub 2012 Oct 22.

Scientific Consultancy - Animal Welfare, Neubiberg, Germany.

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http://dx.doi.org/10.1016/j.tiv.2012.10.007DOI Listing
February 2013
13 Reads
10 Citations
2.903 Impact Factor

Elastic CNT-polyurethane nanocomposite: synthesis, performance and assessment of fragments released during use.

Authors:
Wendel Wohlleben Matthias W Meier Sandra Vogel Robert Landsiedel Gerhard Cox Sabine Hirth Željko Tomović

Nanoscale 2013 Jan 21;5(1):369-80. Epub 2012 Nov 21.

BASF SE, Material Physics, GMC, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1039/c2nr32711bDOI Listing
January 2013
25 Reads
14 Citations
7.394 Impact Factor

Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward.

Authors:
Robert Landsiedel Lan Ma-Hock Hans-Juergen Haussmann Ben van Ravenzwaay Martin Kayser Karin Wiench

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2012 Jul-Aug;4(4):399-413. Epub 2012 May 25.

BASF Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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http://dx.doi.org/10.1002/wnan.1173DOI Listing
January 2013
9 Reads
6 Citations

Deposition behavior of inhaled nanostructured TiO2 in rats: fractions of particle diameter below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy.

Authors:
Peter Morfeld Silke Treumann Lan Ma-Hock Joachim Bruch Robert Landsiedel

Inhal Toxicol 2012 Dec;24(14):939-51

Institute and Policlinic for Occupational Medicine, Environmental Medicine and Preventive Research, School of Medicine and Dentistry, University of Cologne, Germany.

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http://dx.doi.org/10.3109/08958378.2012.738256DOI Listing
December 2012
12 Reads
7 Citations
2.260 Impact Factor

Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: substantiating test strategies with data from routine studies.

Authors:
Susanne N Kolle Kristie M Sullivan Annette Mehling Bennard van Ravenzwaay Robert Landsiedel

Regul Toxicol Pharmacol 2012 Dec 30;64(3):402-14. Epub 2012 Aug 30.

BASF SE, Experimental Toxicology and Ecology, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.yrtph.2012.08.015DOI Listing
December 2012
12 Reads
2.031 Impact Factor

Non-animal test methods for predicting skin sensitization potentials.

Authors:
Annette Mehling Tove Eriksson Tobias Eltze Susanne Kolle Tzutzuy Ramirez Wera Teubner Bennard van Ravenzwaay Robert Landsiedel

Arch Toxicol 2012 Aug 16;86(8):1273-95. Epub 2012 Jun 16.

BASF Personal Care and Nutrition GmbH, Düsseldorf, Germany.

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http://dx.doi.org/10.1007/s00204-012-0867-6DOI Listing
August 2012
33 Reads
13 Citations
5.980 Impact Factor

Experience with local lymph node assay performance standards using standard radioactivity and nonradioactive cell count measurements.

Authors:
David Basketter Susanne N Kolle Arnhild Schrage Naveed Honarvar Armin O Gamer Bennard van Ravenzwaay Robert Landsiedel

J Appl Toxicol 2012 Aug 25;32(8):590-6. Epub 2011 May 25.

DABMEB Consultancy Ltd, Sharnbrook, UK.

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http://dx.doi.org/10.1002/jat.1684DOI Listing
August 2012
33 Reads
2.982 Impact Factor

Further experience with the local lymph node assay using standard radioactive and nonradioactive cell count measurements.

Authors:
Susanne N Kolle David Basketter Arnhild Schrage Armin O Gamer Bennard van Ravenzwaay Robert Landsiedel

J Appl Toxicol 2012 Aug 25;32(8):597-607. Epub 2012 May 25.

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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http://dx.doi.org/10.1002/jat.2754DOI Listing
August 2012
20 Reads
2.982 Impact Factor

Putting the parts together: combining in vitro methods to test for skin sensitizing potentials.

Authors:
Caroline Bauch Susanne N Kolle Tzutzuy Ramirez Tobias Eltze Eric Fabian Annette Mehling Wera Teubner Bennard van Ravenzwaay Robert Landsiedel

Regul Toxicol Pharmacol 2012 Aug 1;63(3):489-504. Epub 2012 Jun 1.

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.yrtph.2012.05.013DOI Listing
August 2012
44 Reads
14 Citations
2.031 Impact Factor

Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies.

Authors:
Christoph L Klein Karin Wiench Martin Wiemann Lan Ma-Hock Ben van Ravenzwaay Robert Landsiedel

Arch Toxicol 2012 Jul 25;86(7):1137-51. Epub 2012 Apr 25.

European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Italy.

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http://dx.doi.org/10.1007/s00204-012-0834-2DOI Listing
July 2012
29 Reads
15 Citations
5.980 Impact Factor

Genotoxicity investigations on nanomaterials.

Authors:
Franz Oesch Robert Landsiedel

Arch Toxicol 2012 Jul 29;86(7):985-94. Epub 2012 Mar 29.

Institute of Toxicology, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s00204-012-0838-yDOI Listing
July 2012
4 Reads
6 Citations
5.980 Impact Factor

Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks.

Authors:
Michael Bräu Lan Ma-Hock Christoph Hesse Luc Nicoleau Volker Strauss Silke Treumann Karin Wiench Robert Landsiedel Wendel Wohlleben

Arch Toxicol 2012 Jul 31;86(7):1077-87. Epub 2012 Mar 31.

BASF Construction Chemicals GmbH, Polymer Research, Mineralogy, Trostberg, Germany.

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http://dx.doi.org/10.1007/s00204-012-0839-xDOI Listing
July 2012
13 Reads
2 Citations
5.980 Impact Factor

Toxico-/biokinetics of nanomaterials.

Authors:
Robert Landsiedel Eric Fabian Lan Ma-Hock Ben van Ravenzwaay Wendel Wohlleben Karin Wiench Franz Oesch

Arch Toxicol 2012 Jul 11;86(7):1021-60. Epub 2012 May 11.

Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/s00204-012-0858-7DOI Listing
July 2012
17 Reads
24 Citations
5.980 Impact Factor

Short-term rat inhalation study with aerosols of acrylic ester-based polymer dispersions containing a fraction of nanoparticles.

Authors:
Lan Ma-Hock Robert Landsiedel Karin Wiench Dominik Geiger Volker Strauss Sibylle Gröters Bennard van Ravenzwaay Matthias Gerst Wendel Wohlleben Gertrud Scherer

Int J Toxicol 2012 Jan-Feb;31(1):46-57. Epub 2012 Jan 19.

Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.1177/1091581811424778DOI Listing
June 2012
7 Reads
3 Citations
1.233 Impact Factor

Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats.

Authors:
Markus Schulz Lan Ma-Hock Sandra Brill Volker Strauss Silke Treumann Sibylle Gröters Bennard van Ravenzwaay Robert Landsiedel

Mutat Res 2012 Jun 7;745(1-2):51-7. Epub 2011 Dec 7.

Experimental Toxicology and Ecology, BASF SE, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.mrgentox.2011.11.016DOI Listing
June 2012
11 Reads
8 Citations
3.680 Impact Factor

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.

Authors:
David A Basketter Harvey Clewell Ian Kimber Annamaria Rossi Bas Blaauboer Robert Burrier Mardas Daneshian Chantra Eskes Alan Goldberg Nina Hasiwa Sebastian Hoffmann Joanna Jaworska Thomas B Knudsen Robert Landsiedel Marcel Leist Paul Locke Gavin Maxwell James McKim Emily A McVey Gladys Ouédraogo Grace Patlewicz Olavi Pelkonen Erwin Roggen Costanza Rovida Irmela Ruhdel Michael Schwarz Andreas Schepky Greet Schoeters Nigel Skinner Kerstin Trentz Marian Turner Philippe Vanparys James Yager Joanne Zurlo Thomas Hartung

ALTEX 2012 ;29(1):3-91

DABMEB Consultancy, Sharnbrook, UK.

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http://dx.doi.org/10.14573/altex.2012.1.003DOI Listing
June 2012
62 Reads
34 Citations
5.470 Impact Factor

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I).

Authors:
Christine Götz Roland Pfeiffer Julia Tigges Veronika Blatz Christine Jäckh Eva-Maria Freytag Eric Fabian Robert Landsiedel Hans F Merk Jean Krutmann Robert J Edwards Camilla Pease Carsten Goebel Nicola Hewitt Ellen Fritsche

Exp Dermatol 2012 May;21(5):358-63

Leibniz-Institut für Umweltmedizinische Forschung (IUF), Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1111/j.1600-0625.2012.01486.xDOI Listing
May 2012
54 Reads
11 Citations
3.762 Impact Factor

t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.

Authors:
Ellen K Silbergeld Elizabeth Q Contreras Thomas Hartung Cordula Hirsch Helena Hogberg Ashish C Jachak William Jordan Robert Landsiedel Jeffery Morris Anil Patri Joel G Pounds Andrea de Vizcaya Ruiz Anna Shvedova Robert Tanguay Norihasa Tatarazako Erwin van Vliet Nigel J Walker Mark Wiesner Neil Wilcox Joanne Zurlo

ALTEX 2011 ;28(3):236-41

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038011PMC
February 2012
22 Reads
4 Citations
5.470 Impact Factor

Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models.

Authors:
Christine Jäckh Veronika Blatz Eric Fabian Katharina Guth Ben van Ravenzwaay Kerstin Reisinger Robert Landsiedel

Toxicol In Vitro 2011 Sep 22;25(6):1209-14. Epub 2011 Mar 22.

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.tiv.2011.03.012DOI Listing
September 2011
42 Reads
3 Citations
2.903 Impact Factor

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals.

Authors:
Caroline Bauch Susanne N Kolle Eric Fabian Christina Pachel Tzutzuy Ramirez Benjamin Wiench Christoph J Wruck Bennard van Ravenzwaay Robert Landsiedel

Toxicol In Vitro 2011 Sep 7;25(6):1162-8. Epub 2011 Jun 7.

BASF SE, Experimental Toxicology and Ecology, Germany.

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http://dx.doi.org/10.1016/j.tiv.2011.05.030DOI Listing
September 2011
28 Reads
7 Citations
2.903 Impact Factor

In-house validation of the EpiOcular(TM) eye irritation test and its combination with the bovine corneal opacity and permeability test for the assessment of ocular irritation.

Authors:
Susanne N Kolle Helena Kandárová Britta Wareing Bennard van Ravenzwaay Robert Landsiedel

Altern Lab Anim 2011 Sep;39(4):365-87

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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September 2011
9 Reads
7 Citations
1.592 Impact Factor

Assessment of combinations of antiandrogenic compounds vinclozolin and flutamide in a yeast based reporter assay.

Authors:
Susanne N Kolle Stephanie Melching-Kollmuss Gerhard Krennrich Robert Landsiedel Bennard van Ravenzwaay

Regul Toxicol Pharmacol 2011 Aug 18;60(3):373-80. Epub 2011 May 18.

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.yrtph.2011.05.005DOI Listing
August 2011
12 Reads
2.031 Impact Factor

On the lifecycle of nanocomposites: comparing released fragments and their in-vivo hazards from three release mechanisms and four nanocomposites.

Authors:
Wendel Wohlleben Sandra Brill Matthias W Meier Michael Mertler Gerhard Cox Sabine Hirth Bernhard von Vacano Volker Strauss Silke Treumann Karin Wiench Lan Ma-Hock Robert Landsiedel

Small 2011 Aug 14;7(16):2384-95. Epub 2011 Jun 14.

Experimental Toxicology GV/T, BASF SE 67056 Ludwigshafen, Germany; Polymer Physics GKC, BASF SE 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1002/smll.201002054DOI Listing
August 2011
36 Reads
20 Citations
8.370 Impact Factor

Feasibility Assessment of Micro-Electrode Chip Assay as a Method of Detecting Neurotoxicity in vitro.

Authors:
Enrico Defranchi Antonio Novellino Maurice Whelan Sandra Vogel Tzutzuy Ramirez Ben van Ravenzwaay Robert Landsiedel

Front Neuroeng 2011 28;4. Epub 2011 Apr 28.

ETT s.r.l. Genova, Italy.

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http://dx.doi.org/10.3389/fneng.2011.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088865PMC
July 2011
14 Reads
10 Citations

Refinement and reduction of acute oral toxicity testing: a critical review of the use of cytotoxicity data.

Authors:
Arnhild Schrage Katja Hempel Markus Schulz Susanne N Kolle Bennard van Ravenzwaay Robert Landsiedel

Altern Lab Anim 2011 Jul;39(3):273-95

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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July 2011
31 Reads
2 Citations
1.592 Impact Factor

Linking energy metabolism to dysfunctions in mitochondrial respiration--a metabolomics in vitro approach.

Authors:
G U Balcke S N Kolle H Kamp B Bethan R Looser S Wagner Robert Landsiedel B van Ravenzwaay

Toxicol Lett 2011 Jun 23;203(3):200-9. Epub 2011 Mar 23.

Metanomics GmbH, Berlin, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2011.03.013DOI Listing
June 2011
2 Reads
12 Citations
3.262 Impact Factor

Chemical toxicity testing in vitro using cytochrome P450-expressing cell lines, such as human CYP1B1.

Authors:
Robert Landsiedel Eric Fabian Tewes Tralau Andreas Luch

Nat Protoc 2011 May 28;6(5):677-87. Epub 2011 Apr 28.

Department of Nutritional Toxicology, German Institute of Human Nutrition (DIfE), Nuthetal, Germany.

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http://dx.doi.org/10.1038/nprot.2011.316DOI Listing
May 2011
7 Reads
1 Citation

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: results of a ring-study in five laboratories.

Authors:
Natsch Andreas Bauch Caroline Foertsch Leslie Gerberick Frank Norman Kimberly Hilberer Allison Inglis Heather Landsiedel Robert Onken Stefan Reuter Hendrik Schepky Andreas Emter Roger

Toxicol In Vitro 2011 Apr 30;25(3):733-44. Epub 2010 Dec 30.

Givaudan Schweiz AG, Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland.

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http://dx.doi.org/10.1016/j.tiv.2010.12.014DOI Listing
April 2011
32 Reads
5 Citations
2.903 Impact Factor

The bovine corneal opacity and permeability test in routine ocular irritation testing and its improvement within the limits of OECD test guideline 437.

Authors:
Arnhild Schrage Susanne N Kolle Maria C R Moreno Kimberly Norman Hans Raabe Rodger Curren Bennard van Ravenzwaay Robert Landsiedel

Altern Lab Anim 2011 Mar;39(1):37-53

BASF SE, Product Safety, Ludwigshafen, Germany.

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March 2011
8 Reads
1 Citation
1.592 Impact Factor

Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations.

Authors:
Robert Landsiedel Lan Ma-Hock Ben Van Ravenzwaay Markus Schulz Karin Wiench Samantha Champ Stefan Schulte Wendel Wohlleben Franz Oesch

Nanotoxicology 2010 Dec;4:364-81

Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.3109/17435390.2010.506694DOI Listing
December 2010
26 Reads
10 Citations
6.411 Impact Factor

Testing metal-oxide nanomaterials for human safety.

Authors:
Robert Landsiedel Lan Ma-Hock Alexandra Kroll Daniela Hahn Jürgen Schnekenburger Karin Wiench Wendel Wohlleben

Adv Mater 2010 Jun;22(24):2601-27

BASF SE 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1002/adma.200902658DOI Listing
June 2010
7 Reads
48 Citations
17.493 Impact Factor

Experience with the HET-CAM method in the routine testing of a broad variety of chemicals and formulations.

Authors:
Arnhild Schrage Armin O Gamer Ben van Ravenzwaay Robert Landsiedel

Altern Lab Anim 2010 Mar;38(1):39-52

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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March 2010
9 Reads
1.592 Impact Factor

Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months.

Authors:
Lan Ma-Hock Silke Treumann Volker Strauss Sandra Brill Frederic Luizi Michael Mertler Karin Wiench Armin O Gamer Bennard van Ravenzwaay Robert Landsiedel

Toxicol Sci 2009 Dec 7;112(2):468-81. Epub 2009 Jul 7.

Product Safety, BASF SE, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1093/toxsci/kfp146DOI Listing
December 2009
12 Reads
88 Citations

Acute and chronic effects of nano- and non-nano-scale TiO(2) and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna.

Authors:
Karin Wiench Wendel Wohlleben Volker Hisgen Kristin Radke Edward Salinas Sabine Zok Robert Landsiedel

Chemosphere 2009 Sep 5;76(10):1356-65. Epub 2009 Jul 5.

BASF, Product Safety--Regulations, Toxicology and Ecology, GUP/CB-Z470, Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.chemosphere.2009.06.025DOI Listing
September 2009
25 Reads
20 Citations
3.340 Impact Factor

Comparing fate and effects of three particles of different surface properties: nano-TiO(2), pigmentary TiO(2) and quartz.

Authors:
Ben van Ravenzwaay Robert Landsiedel Eric Fabian Silke Burkhardt Volker Strauss Lan Ma-Hock

Toxicol Lett 2009 May 7;186(3):152-9. Epub 2008 Dec 7.

BASF Product Safety, BASF SE, GV/T - Z470, D-67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2008.11.020DOI Listing
May 2009
13 Reads
22 Citations
3.262 Impact Factor

Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers.

Authors:
Robert Landsiedel Maike Diana Kapp Markus Schulz Karin Wiench Franz Oesch

Mutat Res 2009 Mar-Jun;681(2-3):241-58. Epub 2008 Nov 11.

Department of Product Safety, BASF SE, 67056 Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.mrrev.2008.10.002DOI Listing
April 2009
8 Reads
34 Citations
3.680 Impact Factor

Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance.

Authors:
Lan Ma-Hock Silke Burkhardt Volker Strauss Armin O Gamer Karin Wiench Bennard van Ravenzwaay Robert Landsiedel

Inhal Toxicol 2009 Feb;21(2):102-18

Department of Product Safety, BASF SE, Ludwigshafen, Germany.

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http://dx.doi.org/10.1080/08958370802361057 DOI Listing
February 2009
17 Reads
31 Citations
2.260 Impact Factor

Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats.

Authors:
Eric Fabian Robert Landsiedel Lan Ma-Hock Karin Wiench Wendel Wohlleben Ben van Ravenzwaay

Arch Toxicol 2008 Mar 14;82(3):151-7. Epub 2007 Nov 14.

BASF Product Safety, BASF Aktiengesellschaft, Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/s00204-007-0253-yDOI Listing
March 2008
10 Reads
38 Citations
5.980 Impact Factor

Drug-metabolizing enzymes in the skin of man, rat, and pig.

Authors:
Franz Oesch Eric Fabian Barbara Oesch-Bartlomowicz Christoph Werner Robert Landsiedel

Drug Metab Rev 2007 ;39(4):659-98

Institute of Toxicology, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1080/03602530701690366 DOI Listing
December 2007
27 Reads
15 Citations
5.360 Impact Factor

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Bennard van Ravenzwaay
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Lan Ma-Hock
Lan Ma-Hock

Universität Ulm

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Wendel Wohlleben
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Institute of Advanced Materials and Processes (ZMP)

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Karin Wiench
Karin Wiench

Institute for Health and Consumer Protection

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Susanne N Kolle
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Ursula G Sauer
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Volker Strauss
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Annette Mehling
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Silke Treumann
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