Robert L Hettich

Robert L Hettich

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Robert L Hettich

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Utilization of a Detergent-Based Method for Direct Microbial Cellular Lysis/Proteome Extraction from Soil Samples for Metaproteomics Studies.

Methods Mol Biol 2018 ;1841:293-302

Chemical Sciences Division, Oak Ridge National Lab, Oak Ridge, TN, USA.

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http://dx.doi.org/10.1007/978-1-4939-8695-8_20DOI Listing
April 2019

Evaluation of an untargeted nano-liquid chromatography-mass spectrometry approach to expand coverage of low molecular weight dissolved organic matter in Arctic soil.

Sci Rep 2019 Apr 9;9(1):5810. Epub 2019 Apr 9.

Bredesen Center for Interdisciplinary Research & Graduate Education, University of Tennessee, Knoxville, TN, 37996, USA.

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http://dx.doi.org/10.1038/s41598-019-42118-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456581PMC
April 2019

Quantifying codon usage in signal peptides: Gene expression and amino acid usage explain apparent selection for inefficient codons.

Biochim Biophys Acta Biomembr 2018 12 19;1860(12):2479-2485. Epub 2018 Sep 19.

Genome Science and Technology, University of Tennessee, Knoxville, United States of America; Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, United States of America; National Institute for Mathematical and Biological Synthesis, Knoxville, TN, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2018.09.010DOI Listing
December 2018

Transcriptomic and proteomic changes from medium supplementation and strain evolution in high-yielding Clostridium thermocellum strains.

J Ind Microbiol Biotechnol 2018 Nov 5;45(11):1007-1015. Epub 2018 Sep 5.

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.

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http://dx.doi.org/10.1007/s10295-018-2073-xDOI Listing
November 2018

Quantitative Proteomic Analysis of Biological Processes and Responses of the Bacterium Desulfovibrio desulfuricans ND132 upon Deletion of Its Mercury Methylation Genes.

Proteomics 2018 09 16;18(17):e1700479. Epub 2018 Aug 16.

Environmental Sciences Division, Oak Ridge National Laboratory, 37831 Oak Ridge, TN, USA.

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http://dx.doi.org/10.1002/pmic.201700479DOI Listing
September 2018

Biogeochemical Cycling by a Low-Diversity Microbial Community in Deep Groundwater.

Front Microbiol 2018 7;9:2129. Epub 2018 Sep 7.

Environmental Microbiology Laboratory, Environmental Engineering Institute, School of Architecture, Civil and Environmental Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02129
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http://dx.doi.org/10.3389/fmicb.2018.02129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137086PMC
September 2018

Phosphorylation of Ribosomal Protein RPS6 Integrates Light Signals and Circadian Clock Signals.

Front Plant Sci 2017 19;8:2210. Epub 2018 Jan 19.

Department of Biochemistry, Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN, United States.

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http://dx.doi.org/10.3389/fpls.2017.02210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780430PMC
January 2018

Phylogenetically conserved resource partitioning in the coastal microbial loop.

ISME J 2017 12 11;11(12):2781-2792. Epub 2017 Aug 11.

Department of Microbiology, Oregon State University, Corvallis, OR, USA.

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http://dx.doi.org/10.1038/ismej.2017.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702734PMC
December 2017

Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in KT2440.

Metab Eng Commun 2017 Dec 31;5:19-25. Epub 2017 May 31.

National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401, United States.

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http://dx.doi.org/10.1016/j.meteno.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699531PMC
December 2017

Mechanisms of subzero growth in the cryophile Planococcus halocryophilus determined through proteomic analysis.

Environ Microbiol 2017 11 13;19(11):4460-4479. Epub 2017 Oct 13.

Macdonald Campus, McGill University, 21,111 Lakeshore Rd, Ste.-Anne-de-Bellevue, QC, H9X 3V9, Canada.

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http://dx.doi.org/10.1111/1462-2920.13893DOI Listing
November 2017

Maternal consumption of fish oil programs reduced adiposity in broiler chicks.

Sci Rep 2017 10 13;7(1):13129. Epub 2017 Oct 13.

Department of Animal Science, University of Tennessee, Knoxville, TN, United States.

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http://dx.doi.org/10.1038/s41598-017-13519-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640664PMC
October 2017

Multi-omics analysis provides insight to the Ignicoccus hospitalis-Nanoarchaeum equitans association.

Biochim Biophys Acta Gen Subj 2017 Sep 4;1861(9):2218-2227. Epub 2017 Jun 4.

Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States; Thermal Biology Institute, Montana State University, Bozeman, MT 59717, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557295PMC
September 2017

Optimized Extraction Method To Remove Humic Acid Interferences from Soil Samples Prior to Microbial Proteome Measurements.

J Proteome Res 2017 07 5;16(7):2537-2546. Epub 2017 Jun 5.

Chemical Sciences Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00103DOI Listing
July 2017

Genome-Resolved Meta-Omics Ties Microbial Dynamics to Process Performance in Biotechnology for Thiocyanate Degradation.

Environ Sci Technol 2017 03 13;51(5):2944-2953. Epub 2017 Feb 13.

Department of Earth and Planetary Sciences, University of California , Berkeley, California 94720, United States.

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http://pubs.acs.org/doi/10.1021/acs.est.6b04477
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http://dx.doi.org/10.1021/acs.est.6b04477DOI Listing
March 2017

The protein and neutral lipid composition of lipid droplets isolated from the fission yeast, Schizosaccharomyces pombe.

J Microbiol 2017 Feb 26;55(2):112-122. Epub 2017 Jan 26.

Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN, 37996-2200, USA.

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http://dx.doi.org/10.1007/s12275-017-6205-1DOI Listing
February 2017

Improved growth rate in hydrogenase mutant via perturbed sulfur metabolism.

Biotechnol Biofuels 2017 3;10. Epub 2017 Jan 3.

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830 USA ; BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37830 USA ; One Bethel Valley Road, Oak Ridge, TN 37831-6038 USA.

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http://dx.doi.org/10.1186/s13068-016-0684-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209896PMC
January 2017

Proteogenomic analyses indicate bacterial methylotrophy and archaeal heterotrophy are prevalent below the grass root zone.

PeerJ 2016 8;4:e2687. Epub 2016 Nov 8.

Department of Earth and Planetary Sciences, University of California, Berkeley, CA, United States; Lawrence Berkeley National Laboratory, Berkeley, CA, United States.

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http://dx.doi.org/10.7717/peerj.2687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103831PMC
November 2016

Global Proteome Response to Deletion of Genes Related to Mercury Methylation and Dissimilatory Metal Reduction Reveals Changes in Respiratory Metabolism in Geobacter sulfurreducens PCA.

J Proteome Res 2016 10 2;15(10):3540-3549. Epub 2016 Sep 2.

Environmental Sciences Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00263DOI Listing
October 2016

Reconstructing a hydrogen-driven microbial metabolic network in Opalinus Clay rock.

Nat Commun 2016 10 14;7:12770. Epub 2016 Oct 14.

Ecole Polytechnique Fédérale de Lausanne, Environmental Microbiology Laboratory, Station 6, Lausanne CH-1015, Switzerland.

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http://dx.doi.org/10.1038/ncomms12770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067608PMC
October 2016

Characterization of Fatty Acids in Crenarchaeota by GC-MS and NMR.

Archaea 2015 31;2015:472726. Epub 2015 Dec 31.

Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA; Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA.

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http://www.hindawi.com/journals/archaea/2015/472726/
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http://dx.doi.org/10.1155/2015/472726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736080PMC
August 2016

Proteomic Stable Isotope Probing Reveals Biosynthesis Dynamics of Slow Growing Methane Based Microbial Communities.

Front Microbiol 2016 29;7:563. Epub 2016 Apr 29.

Division of Geological and Planetary Sciences, California Institute of Technology Pasadena, CA, USA.

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http://dx.doi.org/10.3389/fmicb.2016.00563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850331PMC
May 2016

Enhancing metaproteomics--The value of models and defined environmental microbial systems.

Proteomics 2016 Mar 21;16(5):783-98. Epub 2016 Jan 21.

Department of Chemistry and Bioscience, Center for Microbial Communities, Aalborg University, Aalborg, Denmark.

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http://dx.doi.org/10.1002/pmic.201500305DOI Listing
March 2016

Fungi Contribute Critical but Spatially Varying Roles in Nitrogen and Carbon Cycling in Acid Mine Drainage.

Front Microbiol 2016 3;7:238. Epub 2016 Mar 3.

Department of Earth and Planetary Science, University of California, BerkeleyBerkeley, CA, USA; Department of Environmental Science, Policy, and Management, University of California, BerkeleyBerkeley, CA, USA.

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http://dx.doi.org/10.3389/fmicb.2016.00238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776211PMC
March 2016

Integrating mRNA and Protein Sequencing Enables the Detection and Quantitative Profiling of Natural Protein Sequence Variants of Populus trichocarpa.

J Proteome Res 2015 Dec 30;14(12):5318-26. Epub 2015 Oct 30.

Chemical Sciences Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00823DOI Listing
December 2015

Microbial metaproteomics for characterizing the range of metabolic functions and activities of human gut microbiota.

Proteomics 2015 Oct 28;15(20):3424-38. Epub 2015 May 28.

Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.

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http://doi.wiley.com/10.1002/pmic.201400571
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http://dx.doi.org/10.1002/pmic.201400571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607593PMC
October 2015

Rescuing Those Left Behind: Recovering and Characterizing Underdigested Membrane and Hydrophobic Proteins To Enhance Proteome Measurement Depth.

Anal Chem 2015 Aug 21;87(15):7720-8. Epub 2015 Jul 21.

†Chemical Sciences Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b01187DOI Listing
August 2015

Untargeted metabolomics studies employing NMR and LC-MS reveal metabolic coupling between and its archaeal host .

Metabolomics 2015 Aug;11(4):895-907

Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717 ; Thermal Biology Institute, Montana State University, Bozeman, MT 59717.

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http://dx.doi.org/10.1007/s11306-014-0747-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529127PMC
August 2015

Metagenome sequencing of a coastal marine microbial community from monterey bay, california.

Genome Announc 2015 Apr 30;3(2). Epub 2015 Apr 30.

Physical and Life Science Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA.

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http://dx.doi.org/10.1128/genomeA.00341-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417694PMC
April 2015

Life on the edge: functional genomic response of Ignicoccus hospitalis to the presence of Nanoarchaeum equitans.

ISME J 2015 Jan 11;9(1):101-14. Epub 2014 Jul 11.

1] Oak Ridge National Laboratory, Oak Ridge, TN, USA [2] Department of Microbiology, University of Tennessee, Knoxville, TN, USA.

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http://dx.doi.org/10.1038/ismej.2014.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274422PMC
January 2015

Elevated temperature alters proteomic responses of individual organisms within a biofilm community.

ISME J 2015 Jan 22;9(1):180-94. Epub 2014 Jul 22.

1] Department of Earth and Planetary Science, University of California, Berkeley, CA, USA [2] Department of Environmental Science, Policy, and Management, University of California, Berkeley, Berkeley, CA, USA.

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http://dx.doi.org/10.1038/ismej.2014.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274423PMC
January 2015

Development of an enhanced metaproteomic approach for deepening the microbiome characterization of the human infant gut.

J Proteome Res 2015 Jan 12;14(1):133-41. Epub 2014 Nov 12.

Chemical Sciences Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.

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http://dx.doi.org/10.1021/pr500936pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286196PMC
January 2015

A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde detoxification in Thermoanaerobacter pseudethanolicus 39E.

Biotechnol Biofuels 2014 3;7(1):165. Epub 2014 Dec 3.

BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6341 USA ; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6341 USA.

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http://biotechnologyforbiofuels.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13068-014-0165-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265447PMC
December 2014

(15)N- and (2)H proteomic stable isotope probing links nitrogen flow to archaeal heterotrophic activity.

Environ Microbiol 2014 Oct 20;16(10):3224-37. Epub 2014 May 20.

Department of Earth and Planetary Science, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1111/1462-2920.12488DOI Listing
October 2014

Nitrogen cycling. The environmental controls that govern the end product of bacterial nitrate respiration.

Science 2014 Aug;345(6197):676-9

Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany. Institute for Genome Research and Systems Biology, Center for Biotechnology, University of Bielefeld, 33615 Bielefeld, Germany. Department of Geoscience, University of Calgary, Calgary, Alberta T2N 1N4, Canada.

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http://dx.doi.org/10.1126/science.1254070DOI Listing
August 2014

Diverse and divergent protein post-translational modifications in two growth stages of a natural microbial community.

Nat Commun 2014 Jul 25;5:4405. Epub 2014 Jul 25.

1] Computer Science and Mathematics Division and Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA [2] Graduate School of Genome Science and Technology, University of Tennessee-Oak Ridge National Laboratory, Knoxville, Tennessee 37996, USA.

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http://dx.doi.org/10.1038/ncomms5405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279252PMC
July 2014

Geochemical, metagenomic and metaproteomic insights into trace metal utilization by methane-oxidizing microbial consortia in sulphidic marine sediments.

Environ Microbiol 2014 Jun 14;16(6):1592-611. Epub 2013 Nov 14.

Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.

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http://dx.doi.org/10.1111/1462-2920.12314DOI Listing
June 2014

Recoding of the stop codon UGA to glycine by a BD1-5/SN-2 bacterium and niche partitioning between Alpha- and Gammaproteobacteria in a tidal sediment microbial community naturally selected in a laboratory chemostat.

Front Microbiol 2014 16;5:231. Epub 2014 May 16.

Microbial Fitness Group, Max Planck Institute for Marine Microbiology Bremen, Germany ; Center for Biotechnology, University of Bielefeld Bielefeld, Germany ; Department of Geoscience, University of Calgary Calgary, AB, Canada.

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http://dx.doi.org/10.3389/fmicb.2014.00231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032931PMC
June 2014

Metaproteomics: extracting and mining proteome information to characterize metabolic activities in microbial communities.

Curr Protoc Bioinformatics 2014 Jun 17;46:13.26.1-14. Epub 2014 Jun 17.

Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee.

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http://dx.doi.org/10.1002/0471250953.bi1326s46DOI Listing
June 2014

Isolation and chemical analysis of nanoparticles from English ivy (Hedera helix L.).

J R Soc Interface 2013 Oct 24;10(87):20130392. Epub 2013 Jul 24.

Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.1098/rsif.2013.0392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757999PMC
October 2013

Environmental proteomics reveals early microbial community responses to biostimulation at a uranium- and nitrate-contaminated site.

Proteomics 2013 Oct 22;13(18-19):2921-30. Epub 2013 Aug 22.

Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.

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http://dx.doi.org/10.1002/pmic.201300155DOI Listing
October 2013

Moving away from the reference genome: evaluating a peptide sequencing tagging approach for single amino acid polymorphism identifications in the genus Populus.

J Proteome Res 2013 Aug 23;12(8):3642-51. Epub 2013 Jul 23.

Graduate School of Genome Science and Technology, University of Tennessee , Knoxville, Tennessee 37830, USA.

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http://dx.doi.org/10.1021/pr400192rDOI Listing
August 2013

Comparative informatics analysis to evaluate site-specific protein oxidation in multidimensional LC-MS/MS data.

J Proteome Res 2013 Jul 19;12(7):3307-16. Epub 2013 Jun 19.

Graduate School of Genome Science and Technology, University of Tennessee-Oak Ridge National Laboratory, 1060 Commerce Park, Oak Ridge, Tennessee 37830, USA.

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http://dx.doi.org/10.1021/pr400141pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747030PMC
July 2013

Experimental approach to controllably vary protein oxidation while minimizing electrode adsorption for boron-doped diamond electrochemical surface mapping applications.

Anal Chem 2013 Jan 17;85(1):213-9. Epub 2012 Dec 17.

Graduate School of Genome Science and Technology, University of Tennessee-Oak Ridge National Laboratory, 37830, United States.

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http://dx.doi.org/10.1021/ac302418tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549720PMC
January 2013

Coupling a detergent lysis/cleanup methodology with intact protein fractionation for enhanced proteome characterization.

J Proteome Res 2012 Dec 19;11(12):6008-18. Epub 2012 Nov 19.

UT-ORNL Graduate School of Genome Science and Technology, University of Tennessee, Knoxville-Tennessee 37996, United States.

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http://pubs.acs.org/doi/10.1021/pr300709k
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http://dx.doi.org/10.1021/pr300709kDOI Listing
December 2012