Robert Kralovics

Robert Kralovics

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Robert Kralovics

Publications by authors named "Robert Kralovics"

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Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions.

Int J Hematol 2019 Nov 18. Epub 2019 Nov 18.

Department of Laboratory Medicine, Medical University of Vienna, 18-20 Währinger Gürtel, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s12185-019-02778-9DOI Listing
November 2019

Mutations in myeloproliferative neoplasms - their significance and clinical use.

Expert Rev Hematol 2017 11 25;10(11):961-973. Epub 2017 Sep 25.

a CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , Vienna , Austria.

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http://dx.doi.org/10.1080/17474086.2017.1380515DOI Listing
November 2017

Impact of white blood cell counts at diagnosis and during follow-up in patients with essential thrombocythaemia and prefibrotic primary myelofibrosis.

Br J Haematol 2017 10 19;179(1):166-169. Epub 2016 Jul 19.

Division of Haematology and Blood Coagulation, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/bjh.14202DOI Listing
October 2017

Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms.

Blood 2017 02 27;129(6):667-679. Epub 2016 Dec 27.

Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1182/blood-2016-10-695940DOI Listing
February 2017

8p11 myeloproliferative syndrome: diagnostic challenges and pitfalls.

J BUON 2016 May-Jun;21(3):745-9

Clinic for Hematology, Clinical Center Serbia, Belgrade, Serbia.

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December 2016

LNK mutations in familial myeloproliferative neoplasms.

Blood 2016 07 23;128(1):144-5. Epub 2016 May 23.

Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy; and.

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http://dx.doi.org/10.1182/blood-2016-04-711150DOI Listing
July 2016

Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans.

Genome Biol 2016 Jan 29;17:14. Epub 2016 Jan 29.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s13059-016-0873-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731934PMC
January 2016

Efficacy of ruxolitinib in myeloid neoplasms with PCM1-JAK2 fusion gene.

Ann Hematol 2015 Nov 23;94(11):1927-8. Epub 2015 Jul 23.

Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100, Pavia, Italy.

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http://dx.doi.org/10.1007/s00277-015-2451-7DOI Listing
November 2015

Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera.

Blood 2015 Oct 10;126(15):1762-9. Epub 2015 Aug 10.

Laboratory for Immunological and Molecular Cancer Research, Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases, Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria; and.

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http://dx.doi.org/10.1182/blood-2015-04-637280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608390PMC
October 2015

Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms.

Am J Hematol 2014 Dec 26;89(12):1107-10. Epub 2014 Sep 26.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1002/ajh.23842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657470PMC
December 2014

Decanucleotide insertion polymorphism of F7 significantly influences the risk of thrombosis in patients with essential thrombocythemia.

Eur J Haematol 2014 Aug 23;93(2):103-11. Epub 2014 Apr 23.

Division of Hematology and Blood Coagulation, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/ejh.12307DOI Listing
August 2014

From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms.

Blood 2014 Jun 30;123(24):3714-9. Epub 2014 Apr 30.

Center for Molecular Medicine of the Austrian Academy of Sciences and Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1182/blood-2014-03-530865DOI Listing
June 2014

Restoration of response to ruxolitinib upon brief withdrawal in two patients with myelofibrosis.

Am J Hematol 2014 Mar;89(3):344-6

Department of Hematology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ajh.23637DOI Listing
March 2014

JAK inhibitor in CALR-mutant myelofibrosis.

N Engl J Med 2014 03;370(12):1169

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http://dx.doi.org/10.1056/NEJMc1400499DOI Listing
March 2014

A novel germline JAK2 mutation in familial myeloproliferative neoplasms.

Am J Hematol 2014 Jan;89(1):117-8

Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1002/ajh.23614DOI Listing
January 2014

Genetic basis of MPN: Beyond JAK2-V617F.

Curr Hematol Malig Rep 2013 Dec;8(4):299-306

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT25.3, 1090, Vienna, Austria,

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http://dx.doi.org/10.1007/s11899-013-0184-zDOI Listing
December 2013

Somatic mutations of calreticulin in myeloproliferative neoplasms.

N Engl J Med 2013 Dec 10;369(25):2379-90. Epub 2013 Dec 10.

From CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (T.K., A.S.H., H.N., J.D.M., N.C.C.T., T.B., D.C., G.I.V., K.B., F.S., C.C., M. Six, A.S., C.B., G.S.-F., R.K.) and the Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna (H.G., B.G., M. Schalling, R.K.) - both in Vienna; and the Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo (E.R., D.P., C.M., I.C.C., E.S., V.F., C.E., L.M., C.P., M.C.), and the Department of Molecular Medicine, University of Pavia (L.M., M.C.) - both in Pavia, Italy.

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http://dx.doi.org/10.1056/NEJMoa1311347DOI Listing
December 2013

Molecular basis and clonal evolution of myeloproliferative neoplasms.

Clin Chem Lab Med 2013 Oct;51(10):1889-96

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http://dx.doi.org/10.1515/cclm-2013-0135DOI Listing
October 2013

Efficacy of ruxolitinib in chronic eosinophilic leukemia associated with a PCM1-JAK2 fusion gene.

J Clin Oncol 2013 Jun 29;31(17):e269-71. Epub 2013 Apr 29.

Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.

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http://dx.doi.org/10.1200/JCO.2012.46.4370DOI Listing
June 2013

Anagrelide compared with hydroxyurea in WHO-classified essential thrombocythemia: the ANAHYDRET Study, a randomized controlled trial.

Blood 2013 Mar 11;121(10):1720-8. Epub 2013 Jan 11.

Medical University of Vienna, Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Vienna, Austria.

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http://dx.doi.org/10.1182/blood-2012-07-443770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591796PMC
March 2013

Genetic and epigenetic alterations of myeloproliferative disorders.

Int J Hematol 2013 Feb 12;97(2):183-97. Epub 2012 Dec 12.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT25.3, 1090 Vienna, Austria.

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http://dx.doi.org/10.1007/s12185-012-1235-2DOI Listing
February 2013

β Thalassemia major due to acquired uniparental disomy in a previously healthy adolescent.

Haematologica 2013 Jan 8;98(1):e4-6. Epub 2012 Aug 8.

Serviço de Hematologia, CHC. Centro Hospitalar e Universitário de Coimbra, Portugal. .

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http://dx.doi.org/10.3324/haematol.2012.064097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533667PMC
January 2013

Role of germline genetic factors in MPN pathogenesis.

Hematol Oncol Clin North Am 2012 Oct 21;26(5):1037-51. Epub 2012 Aug 21.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, BT25.3, Vienna 1090, Austria.

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http://dx.doi.org/10.1016/j.hoc.2012.07.005DOI Listing
October 2012

The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms.

Haematologica 2011 Mar 20;96(3):367-74. Epub 2010 Dec 20.

Center for Molecular Medicine, Austrian Academy of Sciences, Lazarettgasse 14, AKH BT25.3, 1090 Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.2010.034488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046267PMC
March 2011

p53 lesions in leukemic transformation.

N Engl J Med 2011 Feb;364(5):488-90

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http://dx.doi.org/10.1056/NEJMc1012718DOI Listing
February 2011

Molecular pathogenesis of Philadelphia chromosome negative chronic myeloproliferative neoplasms.

Curr Cancer Drug Targets 2011 Jan;11(1):20-30

Center for Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.2174/156800911793743628DOI Listing
January 2011

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.

Nat Genet 2009 Apr 15;41(4):450-4. Epub 2009 Mar 15.

Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/ng.341DOI Listing
April 2009

A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family.

Haematologica 2008 May 26;93(5):706-14. Epub 2008 Mar 26.

Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.3324/haematol.11801DOI Listing
May 2008

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations.

Blood 2008 Apr 14;111(7):3863-6. Epub 2008 Jan 14.

Department of Research, Experimental Hematology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2007-09-111971DOI Listing
April 2008

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders.

Blood 2008 Feb 5;111(3):1686-9. Epub 2007 Nov 5.

Department of Hematology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo and University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2007-07-101576DOI Listing
February 2008

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders.

Blood 2006 Aug 4;108(4):1377-80. Epub 2006 May 4.

Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2005-11-009605DOI Listing
August 2006

Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.

Blood 2005 Nov 4;106(10):3374-6. Epub 2005 Aug 4.

Experimental Hematology, Department of Research, Division of Clinical Hematology, Division of Pneumology, Basel University Hospital, Switzerland.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-05-18
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http://dx.doi.org/10.1182/blood-2005-05-1889DOI Listing
November 2005

A gain-of-function mutation of JAK2 in myeloproliferative disorders.

N Engl J Med 2005 Apr;352(17):1779-90

Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1056/NEJMoa051113DOI Listing
April 2005

Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.

Blood Rev 2005 Jan;19(1):1-13

Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S0268960X0400014
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http://dx.doi.org/10.1016/j.blre.2004.02.002DOI Listing
January 2005

Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the disease.

Blood 2003 Nov 26;102(10):3793-6. Epub 2003 Jun 26.

Department of Research, Experimental Hematology, Basel University Hospital, Switzerland.

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http://dx.doi.org/10.1182/blood-2003-03-0885DOI Listing
November 2003

Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders.

Blood 2003 Sep 1;102(5):1869-71. Epub 2003 May 1.

Department of Research, Experimental Hematology, Basel University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2003-03-0744DOI Listing
September 2003

Endemic polycythemia in Russia: mutation in the VHL gene.

Blood Cells Mol Dis 2002 Jan-Feb;28(1):57-62

Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1006/bcmd.2002.0488DOI Listing
June 2003

Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera.

Exp Hematol 2002 Mar;30(3):229-36

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s0301-472x(01)00789-5DOI Listing
March 2002