Publications by authors named "Robert Janowski"

38Publications

Structural basis for the recognition of transiently structured AU-rich elements by Roquin.

Nucleic Acids Res 2020 07;48(13):7385-7403

Institute for Molecular Biosciences, Goethe University Frankfurt and Center for Biomolecular Magnetic Resonance (BMRZ), 60438 Frankfurt, Germany.

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http://dx.doi.org/10.1093/nar/gkaa465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367199PMC
July 2020

The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life.

RNA Biol 2020 09 31;17(9):1228-1238. Epub 2020 May 31.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health , Neuherberg, Germany.

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http://dx.doi.org/10.1080/15476286.2020.1761639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549692PMC
September 2020

Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization.

Biotechnol J 2020 Apr 17:e2000010. Epub 2020 Apr 17.

Technische Universität München, Lehrstuhl für Bioverfahrenstechnik, Boltzmannstraße 15, Garching, 85748, Germany.

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http://dx.doi.org/10.1002/biot.202000010DOI Listing
April 2020

Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.

Mol Pharm 2020 May 13;17(5):1663-1673. Epub 2020 Apr 13.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 300308 Tianjin, China.

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00098DOI Listing
May 2020

Defining and expanding the phenotype of -associated developmental epileptic encephalopathy.

Neurol Genet 2019 Dec 10;5(6):e373. Epub 2019 Dec 10.

Department of Epilepsy Genetics and Precision Medicine (K.J.M., E.G., G.R., R.S.M.), The Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Institute for Regional Health Services (K.J.M., E.G., R.S.M.), University of Southern Denmark, Odense; Institute of Human Genetics (D.M., R. Jamra, A.F., J.R.L.), University of Leipzig Medical Center, Germany; Institute of Structural Biology (R. Janowski, D.N.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Department of Paediatric Radiology (C.R.), University of Leipzig Medical Center, Germany; Department of Epilepsy, Sleep and Pediatric Neurophysiology (J.T.), Lyon University Hospital, France; Neuropediatric Unit (A.-L.P., D.M.V., G.L.), Lyon University Hospital, France; Department of Medical Genetics (N.C., G.L.), Lyon University Hospital, France; GenDev Team (N.C.), CNRS UMR 5292, INSERM U1028, CNRL and University of Lyon, France; Department of Genetics (E.B.), University Medical Center Utrecht, The Netherlands; Department of Child Neurology (K.G.), Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands; Department of Paediatrics (A.P.B.), Copenhagen University Hospital Rigshospitalet, Denmark; Baylor College of Medicine (S.M., K.N.), Children's Hospital of San Antonio; Undiagnosed Diseases Program (G.B., C.P.), Genetic Services of Western Australia, Department of Health, Government of Western Australia, Perth; Western Australian Register of Developmental Anomalies (G.B., D.G.), Australia; Telethon Kids Institute and the School of Paediatrics and Child Health (G.B.), University of Western Australia, Perth; Linear Clinical Research (L.D.), WA, Australia; Center of Human Genetics (S.S), Jena University Hospital, Germany; Department of Neuropediatrics (A.D.), Jena University Hospital, Germany; Division of Neurology (K.L.H.), Children's Hospital of Philadelphia, PA; Division of Neuropediatrics (A.M.), University of Leipzig Medical Center, Germany; Amplexa Genetics (H.H.), Odense, Denmark; Clinic for Children (H.H.), Værløse, Denmark; Center for Integrative Brain Research (G.M.), Seattle Children's Research Institute, WA; Department of Pediatrics (G.M.), University of Washington, Seattle; Medical Genetics Unit (F.B.), Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; Istituto Dermopatico dell'Immacolata (F.B.), IDI-IRCCS, Rome, Italy; Institute of Human Genetics (T.B., M.H.), University Medical Center Hamburg-Eppendorf, Germany; Childrens Hospital (J.D.), University Medical Center Hamburg-Eppendorf, Germany; University of Copenhagen (G.R.), Denmark; Institute for Human Genetics (P.M.), University Hospital Magdeburg, Germany; Children's Hospital A. Meyer (R.G., A.V.), University of Florence, Italy; and Institute of Pharmaceutical Biotechnology (D.N.), Ulm University, Germany.

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http://dx.doi.org/10.1212/NXG.0000000000000373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927360PMC
December 2019

Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.

J Struct Biol 2018 12 1;204(3):519-522. Epub 2018 Oct 1.

Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2018.09.013DOI Listing
December 2018

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.

Oncotarget 2018 Jun 29;9(50):29365-29378. Epub 2018 Jun 29.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.

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http://dx.doi.org/10.18632/oncotarget.25532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047675PMC
June 2018

Evidence for Complex Formation of the Bacillus cereus Haemolysin BL Components in Solution.

Toxins (Basel) 2017 09 16;9(9). Epub 2017 Sep 16.

Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Schönleutnerstr 8, 85764 Oberschleißheim, Germany.

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http://www.mdpi.com/2072-6651/9/9/288
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http://dx.doi.org/10.3390/toxins9090288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618221PMC
September 2017

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.

Sci Rep 2017 04 21;7(1):1051. Epub 2017 Apr 21.

Munich Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Technische Universität München, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41598-017-01031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430869PMC
April 2017

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.

Nat Struct Mol Biol 2017 02 16;24(2):152-161. Epub 2017 Jan 16.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

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http://www.nature.com/articles/nsmb.3351
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http://dx.doi.org/10.1038/nsmb.3351DOI Listing
February 2017

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.

Acta Crystallogr F Struct Biol Commun 2016 10 22;72(Pt 10):743-749. Epub 2016 Sep 22.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1107/S2053230X16013686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053159PMC
October 2016

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.

Nat Commun 2016 Mar 24;7:11032. Epub 2016 Mar 24.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg DE-85764, Germany.

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http://dx.doi.org/10.1038/ncomms11032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603727PMC
March 2016

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.

Elife 2016 Jan 8;5. Epub 2016 Jan 8.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.7554/eLife.11297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764581PMC
January 2016

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.

ACS Chem Biol 2016 Apr 19;11(4):1001-11. Epub 2016 Jan 19.

Cancer Drug Development Group, German Cancer Research Center (DKFZ) , Im Neunheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acschembio.5b00755DOI Listing
April 2016

The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.

J Cell Sci 2015 May 23;128(9):1824-34. Epub 2015 Apr 23.

Departamento de Estructura de Macromoléculas, Centro Nacional de Biotecnología (CNB-CSIC), Madrid 28049, Spain

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.167387
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http://dx.doi.org/10.1242/jcs.167387DOI Listing
May 2015

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.

Nat Struct Mol Biol 2014 Aug 13;21(8):671-8. Epub 2014 Jul 13.

1] Biomolecular NMR Spectroscopy, Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. [2] Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1038/nsmb.2855DOI Listing
August 2014

The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms.

Acta Crystallogr D Biol Crystallogr 2010 Jan 21;66(Pt 1):61-72. Epub 2009 Dec 21.

EMBL Hamburg Outstation, c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany.

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http://dx.doi.org/10.1107/S0907444909043960DOI Listing
January 2010

Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis.

J Struct Funct Genomics 2009 Apr 31;10(2):137-50. Epub 2009 Jan 31.

EMBL Hamburg Outstation, c/o DESY, Notkestrasse 85, 22603, Hamburg, Germany.

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http://dx.doi.org/10.1007/s10969-009-9060-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758359PMC
April 2009

Bacterioferritin from Mycobacterium smegmatis contains zinc in its di-nuclear site.

Protein Sci 2008 Jul 29;17(7):1138-50. Epub 2008 Apr 29.

EMBL Hamburg Outstation, D-22603 Hamburg, Germany.

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http://dx.doi.org/10.1110/ps.034819.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442004PMC
July 2008

Reductive methylation to improve crystallization of the putative oxidoreductase Rv0765c from Mycobacterium tuberculosis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Jun 12;63(Pt 6):507-11. Epub 2007 May 12.

EMBL Hamburg Outstation, DESY, Hamburg, Germany.

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http://dx.doi.org/10.1107/S1744309107022506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335070PMC
June 2007

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of Rv2827c from Mycobacterium tuberculosis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Aug 24;62(Pt 8):753-6. Epub 2006 Jul 24.

EMBL Hamburg Outstation, c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany.

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http://dx.doi.org/10.1107/S1744309106024213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242928PMC
August 2006

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapB (Rv2773c) from Mycobacterium tuberculosis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jul 30;61(Pt 7):718-21. Epub 2005 Jun 30.

EMBL Hamburg Outstation, c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany.

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http://dx.doi.org/10.1107/S174430910501938XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952461PMC
July 2005

Checking the conformational stability of cystatin C and its L68Q variant by molecular dynamics studies: why is the L68Q variant amyloidogenic?

J Struct Biol 2006 Apr 18;154(1):68-78. Epub 2006 Jan 18.

Faculty of Chemistry, University of Gdańsk, J. Sobieskiego 18, 80-952 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.jsb.2005.11.015DOI Listing
April 2006

3D domain-swapped human cystatin C with amyloidlike intermolecular beta-sheets.

Proteins 2005 Nov;61(3):570-8

Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland.

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http://dx.doi.org/10.1002/prot.20633DOI Listing
November 2005

The high-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis.

J Mol Biol 2005 Feb 23;346(1):1-11. Epub 2004 Dec 23.

EMBL Hamburg Outstation, c/o DESY, Notkestr. 85, D-22603 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jmb.2004.11.059DOI Listing
February 2005

Domain swapping in N-truncated human cystatin C.

J Mol Biol 2004 Jul;341(1):151-60

Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland.

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https://linkinghub.elsevier.com/retrieve/pii/S00222836040067
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http://dx.doi.org/10.1016/j.jmb.2004.06.013DOI Listing
July 2004

Modeling beta-cell insulin secretion--implications for closed-loop glucose homeostasis.

Diabetes Technol Ther 2003 ;5(6):953-64

Medtronic MiniMed, Inc, Northridge, California 91325, USA.

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http://dx.doi.org/10.1089/152091503322640999DOI Listing
August 2004

Crystallization and preliminary crystallographic studies of Streptococcus pyogenes cysteine protease precursor.

Acta Crystallogr D Biol Crystallogr 2002 Apr 22;58(Pt 4):723-6. Epub 2002 Mar 22.

Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland.

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http://dx.doi.org/10.1107/s0907444902003013DOI Listing
April 2002

Crystallization and preliminary crystallographic studies of five crystal forms of Escherichia coli L-asparaginase II (Asp90Glu mutant).

Acta Crystallogr D Biol Crystallogr 2002 Jan 21;58(Pt 1):130-2. Epub 2001 Dec 21.

Department of Macromolecular Physics, Faculty of Physics, A. Mickiewicz University, Poznañ, Poland.

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http://journals.iucr.org/d/issues/2002/01/00/za0022/za0022.p
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http://dx.doi.org/10.1107/s0907444901016663DOI Listing
January 2002