Publications by authors named "Robert J Wilkinson"

100Publications

Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.

Mucosal Immunol 2020 Jul 16. Epub 2020 Jul 16.

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, 7925, South Africa.

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http://dx.doi.org/10.1038/s41385-020-0322-6DOI Listing
July 2020

Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies.

Wellcome Open Res 2019 3;4:204. Epub 2020 Jun 3.

Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.12688/wellcomeopenres.15497.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194504.2PMC
June 2020

Tuberculosis and type 2 Diabetes Mellitus: an inflammatory danger signal in the time of COVID-19.

Clin Infect Dis 2020 Jun 13. Epub 2020 Jun 13.

The Francis Crick institute London , United Kingdom.

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http://dx.doi.org/10.1093/cid/ciaa747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314248PMC
June 2020

The -HIV syndemic interaction: why treating infection may be crucial for HIV-1 eradication.

Future Virol 2020 Feb;15(2):101-125

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Observatory 7925, WC, South Africa.

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http://dx.doi.org/10.2217/fvl-2019-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132588PMC
February 2020

The immunopathogenesis of tuberculous pericarditis.

Microbes Infect 2020 May - Jun;22(4-5):172-181. Epub 2020 Feb 21.

Department of Medicine, University of Cape Town, Observatory 7925, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa; Francis Crick Institute, 1 Midland Rd, London NW1 1AT, United Kingdom; Department of Infectious Diseases, Imperial College London, W2 1PG, United Kingdom.

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http://dx.doi.org/10.1016/j.micinf.2020.02.001DOI Listing
February 2020

Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis.

Wellcome Open Res 2019 13;4:178. Epub 2019 Nov 13.

Weill Institute of Neurosciences, Department of Neurology and Division of Infectious Diseases, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.12688/wellcomeopenres.15516.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971841PMC
November 2019

Diagnostic tests for tuberculous meningitis.

Lancet Infect Dis 2020 03 7;20(3):262-263. Epub 2020 Jan 7.

Francis Crick Institute, London, UK; School of Life and Medical Sciences, University College London, London W1T 7NF, UK; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Observatory, South Africa; Department of Infectious Diseases, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/S1473-3099(19)30718-2DOI Listing
March 2020

'SILVAMP TB LAM' rapid urine tuberculosis test predicts mortality in hospitalized HIV patients in South Africa.

Clin Infect Dis 2020 Jan 9. Epub 2020 Jan 9.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Republic of South Africa.

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http://dx.doi.org/10.1093/cid/ciaa024DOI Listing
January 2020

Early antituberculosis drug exposure in hospitalized patients with human immunodeficiency virus-associated tuberculosis.

Br J Clin Pharmacol 2020 May 17;86(5):966-978. Epub 2020 Feb 17.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1111/bcp.14207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163385PMC
May 2020

Safety implications of combined antiretroviral and anti-tuberculosis drugs.

Expert Opin Drug Saf 2020 Jan 6;19(1):23-41. Epub 2019 Dec 6.

Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1080/14740338.2020.1694901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938542PMC
January 2020

Final Analysis of a Trial of M72/AS01 Vaccine to Prevent Tuberculosis.

N Engl J Med 2019 12 29;381(25):2429-2439. Epub 2019 Oct 29.

From the International AIDS Vaccine Initiative (IAVI) (D.R.T.), the South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology (M.H., T.J.S., M.T.), and the Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (F.T., R.J.W.), University of Cape Town, TASK Applied Science (E.V.B., A.D.), and Stellenbosch University (A.D.), Cape Town, the Be Part Yoluntu Centre, Paarl (E.H.), the Aurum Institute, Klerksdorp Research Centre, Klerksdorp (J.C.I.), the Aurum Institute, Tembisa Research Centre, Tembisa (J.C.I.), Setshaba Research Centre, Pretoria (M. Malahleha), and the Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, South African Medical Research Council Collaborating Centre for HIV/AIDS and TB, and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, University of the Witwatersrand, Johannesburg (N.M.) - all in South Africa; GlaxoSmithKline, Wavre, and GlaxoSmithKline, Rixensart - both in Belgium (O.V.D.M., B.S., E.J.A., A.B., M.-A.D., P.G., D.M.V., T.G.P., F.R.); the IAVI, New York (A.M.G., T.G.E., M.L.); Zambart, University of Zambia (H.M.A.), and the Centre for Infectious Disease Research in Zambia (M. Muyoyeta) - both in Lusaka; the London School of Hygiene and Tropical Medicine (H.M.A.) and Francis Crick Institute and the Department of Medicine, Imperial College London (R.J.W.) - all in London; Johns Hopkins University Center for Tuberculosis Research, Baltimore (N.M.); the Kenya Medical Research Institute Centre for Respiratory Diseases Research, Nairobi (V.N.); and the Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland (F.T.).

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http://dx.doi.org/10.1056/NEJMoa1909953DOI Listing
December 2019

Tuberculosis, Human Immunodeficiency Virus, and the Association With Transient Hyperglycemia in Periurban South Africa.

Clin Infect Dis 2020 Aug;71(4):1080-1088

Division of Public Health Medicine, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/cid/ciz928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428387PMC
August 2020

Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment.

J Infect Dis 2020 01;221(1):162-167

Wellcome Center for Infectious Disease Research in Africa, University of Cape Town, South Africa.

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http://dx.doi.org/10.1093/infdis/jiz417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910879PMC
January 2020

Key considerations in the pharmacotherapy of tuberculous meningitis.

Expert Opin Pharmacother 2019 10 15;20(15):1791-1795. Epub 2019 Jul 15.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa.

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http://dx.doi.org/10.1080/14656566.2019.1638912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763362PMC
October 2019

Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study.

PLoS Med 2019 07 5;16(7):e1002840. Epub 2019 Jul 5.

Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1371/journal.pmed.1002840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611568PMC
July 2019

Invariant Natural Killer T-cell Dynamics in Human Immunodeficiency Virus-associated Tuberculosis.

Clin Infect Dis 2020 Apr;70(9):1865-1874

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/ciz501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156773PMC
April 2020

Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

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http://dx.doi.org/10.3390/ijms20061350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471445PMC
March 2019

Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study.

Lancet Infect Dis 2019 03 8;19(3):298-307. Epub 2019 Feb 8.

Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; Centre for Infectious Disease Epidemiology & Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30673-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482382PMC
March 2019

The pathogenesis of tuberculous meningitis.

J Leukoc Biol 2019 02 15;105(2):267-280. Epub 2019 Jan 15.

The Francis Crick Institute, Midland Road, London, United Kingdom.

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http://doi.wiley.com/10.1002/JLB.MR0318-102R
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http://dx.doi.org/10.1002/JLB.MR0318-102RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355360PMC
February 2019

The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis.

PLoS One 2018 27;13(12):e0209516. Epub 2018 Dec 27.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209516PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307796PMC
May 2019

Neutrophils: Innate Effectors of TB Resistance?

Front Immunol 2018 14;9:2637. Epub 2018 Nov 14.

Program in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2018.02637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246713PMC
October 2019

ANIMA: Association network integration for multiscale analysis.

Wellcome Open Res 2018 14;3:27. Epub 2018 Nov 14.

Computational Biology Division, Department Integrative Biomedical Sciences, IDM, University of Cape Town, Cape Town, 7925, South Africa.

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https://wellcomeopenresearch.org/articles/3-27/v2
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http://dx.doi.org/10.12688/wellcomeopenres.14073.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134339PMC
November 2018

Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS.

N Engl J Med 2018 11;379(20):1915-1925

From the Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (G. Meintjes, C. Stek, L.B., F.T., C. Schutz, A.N., A.J., R.J.W.), the Department of Medicine (G. Meintjes, C. Stek, F.T., C. Schutz, R.J.W.), and the Division of Clinical Pharmacology, Department of Medicine (G. Maartens), University of Cape Town, Cape Town, South Africa; the Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium (C. Stek, J.B., R.R., H.L., R.C., L.L.); the Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland (F.T.); and the Department of Medicine, Imperial College London and the Francis Crick Institute, London (R.J.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1800762
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http://dx.doi.org/10.1056/NEJMoa1800762DOI Listing
November 2018

The Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed Therapy.

Front Microbiol 2018 30;9:2603. Epub 2018 Oct 30.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02603
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http://dx.doi.org/10.3389/fmicb.2018.02603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218626PMC
October 2018

The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis.

Nat Immunol 2018 11 17;19(11):1159-1168. Epub 2018 Oct 17.

Laboratory of Immunoregulation and Infection, The Francis Crick Institute, London, UK.

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http://www.nature.com/articles/s41590-018-0225-9
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http://dx.doi.org/10.1038/s41590-018-0225-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554194PMC
November 2018

Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting.

AIDS 2019 03;33(3):525-536

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://Insights.ovid.com/crossref?an=00002030-900000000-9706
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http://dx.doi.org/10.1097/QAD.0000000000002053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355370PMC
March 2019

Recent progress in understanding immune activation in the pathogenesis in HIV-tuberculosis co-infection.

Curr Opin HIV AIDS 2018 11;13(6):455-461

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine.

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http://dx.doi.org/10.1097/COH.0000000000000501DOI Listing
November 2018

Phase 2b Controlled Trial of M72/AS01 Vaccine to Prevent Tuberculosis.

N Engl J Med 2018 10 25;379(17):1621-1634. Epub 2018 Sep 25.

From GlaxoSmithKline, Wavre, Belgium (O.V.D.M., M.-A.D., T.S., E.J.A., A.K.A., A.B., P.G.); South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology (M.H., T.J.S., M.T.), and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (R.J.W., F.T.), University of Cape Town, Task Applied Science (E.V.B., A.D.), Stellenbosch University (A.D.), and Aeras Global TB Vaccine Foundation (D.R.T.) Cape Town, Setshaba Research Centre, Pretoria (M. Malahleha), the Aurum Institute, Klerksdorp and Tembisa Research Centres (J.C.I.), and the Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, South African Medical Research Council Collaborating Centre for HIV/AIDS and TB, and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, University of the Witwatersrand (N.M.), Johannesburg, and Be Part Yoluntu Centre, Paarl (E.H.) - all in South Africa; Kenya Medical Research Institute, Nairobi (V.N.); Francis Crick Institute (R.J.W.), the Department of Medicine, Imperial College London (R.J.W.), and the London School of Hygiene and Tropical Medicine (H.M.A.) - all in London; Centre for Infectious Disease Research in Zambia (M. Muyoyeta, G.H.) and Zambart, University of Zambia (H.M.A.) - both in Lusaka, Zambia; the Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland (F.T.); and Aeras, Rockville (G.L.B., A.M.G., T.G.E.), and Johns Hopkins University Center for Tuberculosis Research, Baltimore (N.M.) - both in Maryland.

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http://dx.doi.org/10.1056/NEJMoa1803484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151253PMC
October 2018

PD-1 Expression on -Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.

Front Immunol 2018 31;9:1995. Epub 2018 Aug 31.

South African Tuberculosis Vaccine Initiative (SATVI) and School of Child and Adolescent Health, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fimmu.2018.01995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127207PMC
September 2019

Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression.

Nat Microbiol 2018 11 10;3(11):1198-1205. Epub 2018 Sep 10.

T Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41564-018-0231-6
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http://dx.doi.org/10.1038/s41564-018-0231-6DOI Listing
November 2018

Corticosteroids as an adjunct to tuberculosis therapy.

Expert Rev Respir Med 2018 10 6;12(10):881-891. Epub 2018 Sep 6.

a Wellcome Centre for Infectious Diseases Research in Africa , Institute of Infectious Disease and Molecular Medicine , Cape Town , South Africa.

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http://dx.doi.org/10.1080/17476348.2018.1515628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293474PMC
October 2018

The tuberculosis-associated immune reconstitution inflammatory syndrome: recent advances in clinical and pathogenesis research.

Curr Opin HIV AIDS 2018 11;13(6):512-521

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/COH.0000000000000502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181275PMC
November 2018

Differential Effect of Viable Versus Necrotic Neutrophils on Growth and Cytokine Induction in Whole Blood.

Front Immunol 2018 27;9:903. Epub 2018 Apr 27.

Barts and The London School of Medicine, Blizard Institute, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934482PMC
July 2019

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study.

Int J Cardiol Heart Vasc 2018 Mar 3;18:104-108. Epub 2017 Nov 3.

The Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.

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http://dx.doi.org/10.1016/j.ijcha.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941241PMC
March 2018

Treatment of Tuberculous Meningitis and Its Complications in Adults.

Curr Treat Options Neurol 2018 Feb 28;20(3). Epub 2018 Feb 28.

University College London, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1007/s11940-018-0490-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830467PMC
February 2018

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons.

Annu Rev Immunol 2018 04 28;36:603-638. Epub 2018 Feb 28.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, University of Cape Town, Cape Town 7925, Republic of South Africa; email:

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http://dx.doi.org/10.1146/annurev-immunol-042617-053420DOI Listing
April 2018

HIV-Associated Mycobacterium tuberculosis Bloodstream Infection Is Underdiagnosed by Single Blood Culture.

J Clin Microbiol 2018 05 25;56(5). Epub 2018 Apr 25.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/JCM.01914-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925727PMC
May 2018

The prevalence and determinants of active tuberculosis among diabetes patients in Cape Town, South Africa, a high HIV/TB burden setting.

Diabetes Res Clin Pract 2018 Apr 31;138:16-25. Epub 2018 Jan 31.

Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688227173133
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http://dx.doi.org/10.1016/j.diabres.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931785PMC
April 2018

Neutrophil Activation and Enhanced Release of Granule Products in HIV-TB Immune Reconstitution Inflammatory Syndrome.

J Acquir Immune Defic Syndr 2018 02;77(2):221-229

Department of Medicine, Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1097/QAI.0000000000001582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765966PMC
February 2018

Tuberculous meningitis.

Nat Rev Neurol 2017 Oct 8;13(10):581-598. Epub 2017 Sep 8.

Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1038/nrneurol.2017.120DOI Listing
October 2017

Analysis of the Phenotype of -Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals.

Front Immunol 2017 10;8:968. Epub 2017 Aug 10.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fimmu.2017.00968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554366PMC
August 2017

Trilateral overlap of tuberculosis, diabetes and HIV-1 in a high-burden African setting: implications for TB control.

Eur Respir J 2017 07 20;50(1). Epub 2017 Jul 20.

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00004
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http://dx.doi.org/10.1183/13993003.00004-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538899PMC
July 2017

Biomarkers of Cerebral Injury and Inflammation in Pediatric Tuberculous Meningitis.

Clin Infect Dis 2017 10;65(8):1298-1307

Division of Neurosurgery and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/cid/cix540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815568PMC
October 2017

A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.

Cell Host Microbe 2017 May;21(5):619-628.e5

Host-Pathogen Interactions In Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432432PMC
May 2017

Minimizing Tuberculosis Risk in Patients Receiving Anti-TNF Therapy.

Ann Am Thorac Soc 2017 05;14(5):621-623

1 Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1513/AnnalsATS.201701-055EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427745PMC
May 2017

The Influence of HIV on the Evolution of Mycobacterium tuberculosis.

Mol Biol Evol 2017 07;34(7):1654-1668

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, University of Cape Town, Cape Town, South Africa.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/msx107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455964PMC
July 2017

The CSF Immune Response in HIV-1-Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2017 07;75(3):299-307

*Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa; †Liverpool School of Tropical Medicine, Liverpool, United Kingdom; ‡Wellcome Trust Liverpool Glasgow Centre for Global Health Research, Liverpool, United Kingdom; §Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa; ‖South African TB Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; ¶The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, London, United Kingdom; #Department of Medicine, Imperial College, London, United Kingdom; and **Department of Medicine, University of Minnesota, MN.

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http://dx.doi.org/10.1097/QAI.0000000000001382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469563PMC
July 2017

Immunological consequences of strain variation within the Mycobacterium tuberculosis complex.

Eur J Immunol 2017 03 24;47(3):432-445. Epub 2017 Feb 24.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Observatory, Republic of South Africa.

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http://dx.doi.org/10.1002/eji.201646562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363233PMC
March 2017

Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis.

J Infect Dis 2017 03;215(5):677-686

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.

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http://dx.doi.org/10.1093/infdis/jiw561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388298PMC
March 2017

Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.

Tuberculosis (Edinb) 2016 12 9;101:25-30. Epub 2016 Aug 9.

Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2016.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119638PMC
December 2016

Antibodies and tuberculosis.

Tuberculosis (Edinb) 2016 12 26;101:102-113. Epub 2016 Aug 26.

Department of Medicine, Imperial College London, W2 1PG, United Kingdom; Clinical Infectious Diseases Research Initiative and Department of Medicine, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa; The Francis Crick Institute, London NW1 2AT, United Kingdom.

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http://dx.doi.org/10.1016/j.tube.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120988PMC
December 2016

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition.

Microbes Infect 2017 Mar 22;19(3):177-192. Epub 2016 Oct 22.

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa; The Francis Crick Institute, London, NW1 2AT, United Kingdom.

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http://dx.doi.org/10.1016/j.micinf.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335906PMC
March 2017

Vitamin D Status and Its Consequences for Health in South Africa.

Int J Environ Res Public Health 2016 10 18;13(10). Epub 2016 Oct 18.

South African Medical Research Council, Environment and Health Research Unit and University of Pretoria, Department of Geography, Geoinformatics and Meteorology, Pretoria 0001, South Africa.

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http://dx.doi.org/10.3390/ijerph13101019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086758PMC
October 2016

QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response.

BMC Infect Dis 2016 Oct 7;16(1):545. Epub 2016 Oct 7.

Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s12879-016-1875-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055657PMC
October 2016

Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors.

BMC Infect Dis 2016 Sep 27;16(1):518. Epub 2016 Sep 27.

Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039896PMC
http://dx.doi.org/10.1186/s12879-016-1850-2DOI Listing
September 2016

HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients.

Antimicrob Agents Chemother 2016 10 23;60(10):6050-9. Epub 2016 Sep 23.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.00480-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038257PMC
October 2016

Brief Report: HIV-1 Infection Impairs CD16 and CD35 Mediated Opsonophagocytosis of Mycobacterium tuberculosis by Human Neutrophils.

J Acquir Immune Defic Syndr 2016 11;73(3):263-267

*Clinical Infectious Diseases Research Initiative, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; †Institute of Tropical Medicine, Antwerp, Belgium; ‡Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda; §Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom; ‖Department of Medicine, Imperial College London, London, United Kingdom; ¶Mill Hill Laboratory, The Francis Crick Institute, London, United Kingdom; and #Institute of Immunity and Transplantation, University College London, London, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000001103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018214PMC
November 2016

Assessment of treatment response in tuberculosis.

Expert Rev Respir Med 2016 06 31;10(6):643-54. Epub 2016 Mar 31.

a Department of Medicine , Imperial College London , London , UK.

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http://www.tandfonline.com/doi/full/10.1586/17476348.2016.11
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http://dx.doi.org/10.1586/17476348.2016.1166960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949330PMC
June 2016

Post-treatment effect of isoniazid preventive therapy on tuberculosis incidence in HIV-infected individuals on antiretroviral therapy.

AIDS 2016 05;30(8):1279-86

aDepartment of Infectious Disease Epidemiology, TB Modelling Group, TB Centre, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine bDepartment of Infection and Population Health, Centre for Infectious Disease Epidemiology, University College London, London, UK cDepartment of Medicine, Institute of Infectious Disease and Molecular Medicine, University of Cape Town dDivision of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa eTuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA fCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa gDepartment of Medicine, Imperial College London hThe Francis Crick Institute Mill Hill Laboratory, London, UK iInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000001078DOI Listing
May 2016

HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells.

J Immunol 2016 Apr 29;196(7):3006-18. Epub 2016 Feb 29.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, 7925, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7925, Cape Town, South Africa;

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http://dx.doi.org/10.4049/jimmunol.1502094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799776PMC
April 2016

Are the Present Doses of Anti Tubercular Drugs Adequate for Severe Disease?

EBioMedicine 2015 Nov 9;2(11):1572-3. Epub 2015 Oct 9.

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Medicine, University of Cape Town, South Africa; Department of Medicine, Imperial College London, London W2 1PG, UK,; The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740294PMC
November 2015

A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis.

J Infect Dis 2016 06 14;213(11):1725-34. Epub 2016 Jan 14.

Department of Medicine, Imperial College London Clinical Infectious Diseases Research Initiative Department of Medicine, University of Cape Town and Groote Schuur Hospital, South Africa.

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http://dx.doi.org/10.1093/infdis/jiw007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857465PMC
June 2016

Interleukin-17 mediated differences in the pathogenesis of HIV-1-associated tuberculous and cryptococcal meningitis.

AIDS 2016 Jan;30(3):395-404

aClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular MedicinebDivision of Neurology, Department of Medicine, University of Cape TowncDepartment of Medicine, University of Cape Town, Cape Town, South AfricadDepartment of Medicine, Imperial CollegeeThe Francis Crick Institute, Mill Hill Laboratory, London, UK.

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http://dx.doi.org/10.1097/QAD.0000000000000904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711381PMC
January 2016