Robert J Wilkinson

Robert J Wilkinson

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Robert J Wilkinson

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Neutrophils: Innate Effectors of TB Resistance?

Front Immunol 2018 14;9:2637. Epub 2018 Nov 14.

Program in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2018.02637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246713PMC
October 2019

Key considerations in the pharmacotherapy of tuberculous meningitis.

Expert Opin Pharmacother 2019 Oct 15;20(15):1791-1795. Epub 2019 Jul 15.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa.

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http://dx.doi.org/10.1080/14656566.2019.1638912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763362PMC
October 2019

PD-1 Expression on -Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.

Front Immunol 2018 31;9:1995. Epub 2018 Aug 31.

South African Tuberculosis Vaccine Initiative (SATVI) and School of Child and Adolescent Health, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fimmu.2018.01995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127207PMC
September 2019

Tuberculosis, HIV and the association with transient hyperglycaemia in peri-urban South Africa.

Clin Infect Dis 2019 Sep 26. Epub 2019 Sep 26.

Division of Public Health Medicine, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/cid/ciz928DOI Listing
September 2019

Tuberculosis antigen-specific T cell responses during the first 6 months of antiretroviral treatment.

J Infect Dis 2019 Aug 17. Epub 2019 Aug 17.

Wellcome Center for Infectious Disease Research in Africa.

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http://dx.doi.org/10.1093/infdis/jiz417DOI Listing
August 2019

Differential Effect of Viable Versus Necrotic Neutrophils on Growth and Cytokine Induction in Whole Blood.

Front Immunol 2018 27;9:903. Epub 2018 Apr 27.

Barts and The London School of Medicine, Blizard Institute, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934482PMC
July 2019

Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study.

PLoS Med 2019 Jul 5;16(7):e1002840. Epub 2019 Jul 5.

Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1371/journal.pmed.1002840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611568PMC
July 2019

Invariant Natural Killer T cell dynamics in HIV-associated tuberculosis.

Clin Infect Dis 2019 Jun 12. Epub 2019 Jun 12.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Republic of South Africa.

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http://dx.doi.org/10.1093/cid/ciz501DOI Listing
June 2019

The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis.

PLoS One 2018 27;13(12):e0209516. Epub 2018 Dec 27.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209516PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307796PMC
May 2019

Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting.

AIDS 2019 Mar;33(3):525-536

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://Insights.ovid.com/crossref?an=00002030-900000000-9706
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http://dx.doi.org/10.1097/QAD.0000000000002053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355370PMC
March 2019

Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study.

Lancet Infect Dis 2019 Mar 8;19(3):298-307. Epub 2019 Feb 8.

Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; Centre for Infectious Disease Epidemiology & Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30673-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482382PMC
March 2019

Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

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http://dx.doi.org/10.3390/ijms20061350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471445PMC
March 2019

The pathogenesis of tuberculous meningitis.

J Leukoc Biol 2019 02 15;105(2):267-280. Epub 2019 Jan 15.

The Francis Crick Institute, Midland Road, London, United Kingdom.

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http://doi.wiley.com/10.1002/JLB.MR0318-102R
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http://dx.doi.org/10.1002/JLB.MR0318-102RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355360PMC
February 2019

Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.

J Pediatric Infect Dis Soc 2019 Feb 12. Epub 2019 Feb 12.

Division of Neurosurgery, Department of Surgery.

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http://dx.doi.org/10.1093/jpids/piy141DOI Listing
February 2019

The tuberculosis-associated immune reconstitution inflammatory syndrome: recent advances in clinical and pathogenesis research.

Curr Opin HIV AIDS 2018 11;13(6):512-521

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/COH.0000000000000502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181275PMC
November 2018

Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression.

Nat Microbiol 2018 11 10;3(11):1198-1205. Epub 2018 Sep 10.

T Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41564-018-0231-6
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http://dx.doi.org/10.1038/s41564-018-0231-6DOI Listing
November 2018

Recent progress in understanding immune activation in the pathogenesis in HIV-tuberculosis co-infection.

Curr Opin HIV AIDS 2018 11;13(6):455-461

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine.

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http://dx.doi.org/10.1097/COH.0000000000000501DOI Listing
November 2018

The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis.

Nat Immunol 2018 11 17;19(11):1159-1168. Epub 2018 Oct 17.

Laboratory of Immunoregulation and Infection, The Francis Crick Institute, London, UK.

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http://www.nature.com/articles/s41590-018-0225-9
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http://dx.doi.org/10.1038/s41590-018-0225-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554194PMC
November 2018

Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS.

N Engl J Med 2018 11;379(20):1915-1925

From the Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (G. Meintjes, C. Stek, L.B., F.T., C. Schutz, A.N., A.J., R.J.W.), the Department of Medicine (G. Meintjes, C. Stek, F.T., C. Schutz, R.J.W.), and the Division of Clinical Pharmacology, Department of Medicine (G. Maartens), University of Cape Town, Cape Town, South Africa; the Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium (C. Stek, J.B., R.R., H.L., R.C., L.L.); the Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland (F.T.); and the Department of Medicine, Imperial College London and the Francis Crick Institute, London (R.J.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1800762
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http://dx.doi.org/10.1056/NEJMoa1800762DOI Listing
November 2018

ANIMA: Association network integration for multiscale analysis.

Wellcome Open Res 2018 14;3:27. Epub 2018 Nov 14.

Computational Biology Division, Department Integrative Biomedical Sciences, IDM, University of Cape Town, Cape Town, 7925, South Africa.

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https://wellcomeopenresearch.org/articles/3-27/v2
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http://dx.doi.org/10.12688/wellcomeopenres.14073.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134339.3PMC
November 2018

Corticosteroids as an adjunct to tuberculosis therapy.

Expert Rev Respir Med 2018 10 6;12(10):881-891. Epub 2018 Sep 6.

a Wellcome Centre for Infectious Diseases Research in Africa , Institute of Infectious Disease and Molecular Medicine , Cape Town , South Africa.

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http://dx.doi.org/10.1080/17476348.2018.1515628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293474PMC
October 2018

Phase 2b Controlled Trial of M72/AS01 Vaccine to Prevent Tuberculosis.

N Engl J Med 2018 10 25;379(17):1621-1634. Epub 2018 Sep 25.

From GlaxoSmithKline, Wavre, Belgium (O.V.D.M., M.-A.D., T.S., E.J.A., A.K.A., A.B., P.G.); South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology (M.H., T.J.S., M.T.), and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (R.J.W., F.T.), University of Cape Town, Task Applied Science (E.V.B., A.D.), Stellenbosch University (A.D.), and Aeras Global TB Vaccine Foundation (D.R.T.) Cape Town, Setshaba Research Centre, Pretoria (M. Malahleha), the Aurum Institute, Klerksdorp and Tembisa Research Centres (J.C.I.), and the Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, South African Medical Research Council Collaborating Centre for HIV/AIDS and TB, and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, University of the Witwatersrand (N.M.), Johannesburg, and Be Part Yoluntu Centre, Paarl (E.H.) - all in South Africa; Kenya Medical Research Institute, Nairobi (V.N.); Francis Crick Institute (R.J.W.), the Department of Medicine, Imperial College London (R.J.W.), and the London School of Hygiene and Tropical Medicine (H.M.A.) - all in London; Centre for Infectious Disease Research in Zambia (M. Muyoyeta, G.H.) and Zambart, University of Zambia (H.M.A.) - both in Lusaka, Zambia; the Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland (F.T.); and Aeras, Rockville (G.L.B., A.M.G., T.G.E.), and Johns Hopkins University Center for Tuberculosis Research, Baltimore (N.M.) - both in Maryland.

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http://dx.doi.org/10.1056/NEJMoa1803484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151253PMC
October 2018

The Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed Therapy.

Front Microbiol 2018 30;9:2603. Epub 2018 Oct 30.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02603
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http://dx.doi.org/10.3389/fmicb.2018.02603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218626PMC
October 2018

HIV-Associated Mycobacterium tuberculosis Bloodstream Infection Is Underdiagnosed by Single Blood Culture.

J Clin Microbiol 2018 05 25;56(5). Epub 2018 Apr 25.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/JCM.01914-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925727PMC
May 2018

The prevalence and determinants of active tuberculosis among diabetes patients in Cape Town, South Africa, a high HIV/TB burden setting.

Diabetes Res Clin Pract 2018 Apr 31;138:16-25. Epub 2018 Jan 31.

Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688227173133
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http://dx.doi.org/10.1016/j.diabres.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931785PMC
April 2018

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons.

Annu Rev Immunol 2018 04 28;36:603-638. Epub 2018 Feb 28.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, University of Cape Town, Cape Town 7925, Republic of South Africa; email:

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http://dx.doi.org/10.1146/annurev-immunol-042617-053420DOI Listing
April 2018

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study.

Int J Cardiol Heart Vasc 2018 Mar 3;18:104-108. Epub 2017 Nov 3.

The Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory 7925, South Africa.

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http://dx.doi.org/10.1016/j.ijcha.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941241PMC
March 2018

Neutrophil Activation and Enhanced Release of Granule Products in HIV-TB Immune Reconstitution Inflammatory Syndrome.

J Acquir Immune Defic Syndr 2018 02;77(2):221-229

Department of Medicine, Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1097/QAI.0000000000001582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765966PMC
February 2018

Treatment of Tuberculous Meningitis and Its Complications in Adults.

Curr Treat Options Neurol 2018 Feb 28;20(3). Epub 2018 Feb 28.

University College London, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1007/s11940-018-0490-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830467PMC
February 2018

Biomarkers of Cerebral Injury and Inflammation in Pediatric Tuberculous Meningitis.

Clin Infect Dis 2017 10;65(8):1298-1307

Division of Neurosurgery and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/cid/cix540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815568PMC
October 2017

Tuberculous meningitis.

Nat Rev Neurol 2017 Oct 8;13(10):581-598. Epub 2017 Sep 8.

Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1038/nrneurol.2017.120DOI Listing
October 2017

Analysis of the Phenotype of -Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals.

Front Immunol 2017 10;8:968. Epub 2017 Aug 10.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fimmu.2017.00968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554366PMC
August 2017

The CSF Immune Response in HIV-1-Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2017 07;75(3):299-307

*Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa; †Liverpool School of Tropical Medicine, Liverpool, United Kingdom; ‡Wellcome Trust Liverpool Glasgow Centre for Global Health Research, Liverpool, United Kingdom; §Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa; ‖South African TB Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; ¶The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, London, United Kingdom; #Department of Medicine, Imperial College, London, United Kingdom; and **Department of Medicine, University of Minnesota, MN.

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http://dx.doi.org/10.1097/QAI.0000000000001382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469563PMC
July 2017

The Influence of HIV on the Evolution of Mycobacterium tuberculosis.

Mol Biol Evol 2017 07;34(7):1654-1668

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, University of Cape Town, Cape Town, South Africa.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/msx107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455964PMC
July 2017

Trilateral overlap of tuberculosis, diabetes and HIV-1 in a high-burden African setting: implications for TB control.

Eur Respir J 2017 07 20;50(1). Epub 2017 Jul 20.

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00004
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http://dx.doi.org/10.1183/13993003.00004-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538899PMC
July 2017

Minimizing Tuberculosis Risk in Patients Receiving Anti-TNF Therapy.

Ann Am Thorac Soc 2017 05;14(5):621-623

1 Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1513/AnnalsATS.201701-055EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427745PMC
May 2017

A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.

Cell Host Microbe 2017 May;21(5):619-628.e5

Host-Pathogen Interactions In Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432432PMC
May 2017

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition.

Microbes Infect 2017 Mar 22;19(3):177-192. Epub 2016 Oct 22.

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa; The Francis Crick Institute, London, NW1 2AT, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S12864579163014
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http://dx.doi.org/10.1016/j.micinf.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335906PMC
March 2017

Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis.

J Infect Dis 2017 03;215(5):677-686

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.

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http://dx.doi.org/10.1093/infdis/jiw561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388298PMC
March 2017

Immunological consequences of strain variation within the Mycobacterium tuberculosis complex.

Eur J Immunol 2017 03 24;47(3):432-445. Epub 2017 Feb 24.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Observatory, Republic of South Africa.

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http://dx.doi.org/10.1002/eji.201646562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363233PMC
March 2017

Antibodies and tuberculosis.

Tuberculosis (Edinb) 2016 12 26;101:102-113. Epub 2016 Aug 26.

Department of Medicine, Imperial College London, W2 1PG, United Kingdom; Clinical Infectious Diseases Research Initiative and Department of Medicine, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa; The Francis Crick Institute, London NW1 2AT, United Kingdom.

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http://dx.doi.org/10.1016/j.tube.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120988PMC
December 2016

Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.

Tuberculosis (Edinb) 2016 12 9;101:25-30. Epub 2016 Aug 9.

Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14729792163020
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http://dx.doi.org/10.1016/j.tube.2016.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119638PMC
December 2016

Brief Report: HIV-1 Infection Impairs CD16 and CD35 Mediated Opsonophagocytosis of Mycobacterium tuberculosis by Human Neutrophils.

J Acquir Immune Defic Syndr 2016 11;73(3):263-267

*Clinical Infectious Diseases Research Initiative, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; †Institute of Tropical Medicine, Antwerp, Belgium; ‡Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda; §Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom; ‖Department of Medicine, Imperial College London, London, United Kingdom; ¶Mill Hill Laboratory, The Francis Crick Institute, London, United Kingdom; and #Institute of Immunity and Transplantation, University College London, London, United Kingdom.

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https://insights.ovid.com/crossref?an=00126334-201611010-000
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http://dx.doi.org/10.1097/QAI.0000000000001103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018214PMC
November 2016

HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients.

Antimicrob Agents Chemother 2016 10 23;60(10):6050-9. Epub 2016 Sep 23.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.00480-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038257PMC
October 2016

QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response.

BMC Infect Dis 2016 Oct 7;16(1):545. Epub 2016 Oct 7.

Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s12879-016-1875-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055657PMC
October 2016

Vitamin D Status and Its Consequences for Health in South Africa.

Int J Environ Res Public Health 2016 10 18;13(10). Epub 2016 Oct 18.

South African Medical Research Council, Environment and Health Research Unit and University of Pretoria, Department of Geography, Geoinformatics and Meteorology, Pretoria 0001, South Africa.

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http://dx.doi.org/10.3390/ijerph13101019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086758PMC
October 2016

Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors.

BMC Infect Dis 2016 Sep 27;16(1):518. Epub 2016 Sep 27.

Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039896PMC
http://dx.doi.org/10.1186/s12879-016-1850-2DOI Listing
September 2016

Risk Factors for Acquired Rifamycin and Isoniazid Resistance: A Systematic Review and Meta-Analysis.

PLoS One 2015 25;10(9):e0139017. Epub 2015 Sep 25.

Department of Medicine, Imperial College, London W2 1PG, United Kingdom; Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583446PMC
June 2016

A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis.

J Infect Dis 2016 06 14;213(11):1725-34. Epub 2016 Jan 14.

Department of Medicine, Imperial College London Clinical Infectious Diseases Research Initiative Department of Medicine, University of Cape Town and Groote Schuur Hospital, South Africa.

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http://dx.doi.org/10.1093/infdis/jiw007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857465PMC
June 2016

Assessment of treatment response in tuberculosis.

Expert Rev Respir Med 2016 06 31;10(6):643-54. Epub 2016 Mar 31.

a Department of Medicine , Imperial College London , London , UK.

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http://www.tandfonline.com/doi/full/10.1586/17476348.2016.11
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http://dx.doi.org/10.1586/17476348.2016.1166960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949330PMC
June 2016

Post-treatment effect of isoniazid preventive therapy on tuberculosis incidence in HIV-infected individuals on antiretroviral therapy.

AIDS 2016 05;30(8):1279-86

aDepartment of Infectious Disease Epidemiology, TB Modelling Group, TB Centre, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine bDepartment of Infection and Population Health, Centre for Infectious Disease Epidemiology, University College London, London, UK cDepartment of Medicine, Institute of Infectious Disease and Molecular Medicine, University of Cape Town dDivision of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa eTuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA fCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa gDepartment of Medicine, Imperial College London hThe Francis Crick Institute Mill Hill Laboratory, London, UK iInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000001078DOI Listing
May 2016

HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells.

J Immunol 2016 Apr 29;196(7):3006-18. Epub 2016 Feb 29.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, 7925, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7925, Cape Town, South Africa;

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http://dx.doi.org/10.4049/jimmunol.1502094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799776PMC
April 2016

HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome.

Semin Immunopathol 2016 Mar 30;38(2):185-98. Epub 2015 Sep 30.

The Francis Crick Institute, Mill Hill Laboratory, London, NW7 1AA, UK.

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http://dx.doi.org/10.1007/s00281-015-0532-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779131PMC
March 2016

Paradoxical TB-IRIS in HIV-infected adults: a systematic review and meta-analysis.

Future Microbiol 2015 ;10(6):1077-99

Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.2217/fmb.15.9DOI Listing
February 2016

Population tailored modification of tuberculosis specific interferon-gamma release assay.

J Infect 2016 Feb 26;72(2):179-88. Epub 2015 Nov 26.

Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; The Francis Crick Institute Mill Hill Laboratory, London NW7 1AA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2015.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747975PMC
February 2016

Interleukin-17 mediated differences in the pathogenesis of HIV-1-associated tuberculous and cryptococcal meningitis.

AIDS 2016 Jan;30(3):395-404

aClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular MedicinebDivision of Neurology, Department of Medicine, University of Cape TowncDepartment of Medicine, University of Cape Town, Cape Town, South AfricadDepartment of Medicine, Imperial CollegeeThe Francis Crick Institute, Mill Hill Laboratory, London, UK.

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http://dx.doi.org/10.1097/QAD.0000000000000904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711381PMC
January 2016

Raised Venous Lactate and Markers of Intestinal Translocation Are Associated With Mortality Among In-Patients With HIV-Associated TB in Rural South Africa.

J Acquir Immune Defic Syndr 2015 Dec;70(4):406-13

*Madwaleni Hospital, Elliotdale, South Africa; †Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; ‡Department of Medicine, University of Cape Town, Cape Town, South Africa; §MRC National Institute for Medical Research, London, United Kingdom; ‖Monsall Unit, Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom; ¶Department of Statistics, Texas A&M University, College Station, TX; #National Science Foundation, Arlington, VA; **Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX; and ††Department of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000000763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625603PMC
December 2015

Are the Present Doses of Anti Tubercular Drugs Adequate for Severe Disease?

EBioMedicine 2015 Nov 9;2(11):1572-3. Epub 2015 Oct 9.

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Medicine, University of Cape Town, South Africa; Department of Medicine, Imperial College London, London W2 1PG, UK,; The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740294PMC
November 2015

Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study.

AIDS Res Ther 2015 6;12:35. Epub 2015 Oct 6.

Department of Medicine, University of Cape Town, Anzio Road, Cape Town, 7925 South Africa ; Division of Pharmacology, Groote Schuur Hospital, Anzio Road, Cape Town, 7925 South Africa.

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http://dx.doi.org/10.1186/s12981-015-0076-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596495PMC
October 2015

Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.

J Immunol 2015 Aug 19;195(3):882-91. Epub 2015 Jun 19.

Infectious Diseases and Immunity, Imperial College London, London W12 0NN, United Kingdom; National Institute for Health Research Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom

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http://dx.doi.org/10.4049/jimmunol.1403110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505956PMC
August 2015

Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis.

Tuberculosis (Edinb) 2015 Jul 28;95(4):463-9. Epub 2015 May 28.

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, P.O. Box 30096, Chichiri, Blantyre 3, Malawi; Department of Medicine, College of Medicine, Private Bag 360, Chichiri, Blantyre 3, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503815PMC
July 2015

Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3.

PLoS Pathog 2015 Jul 2;11(7):e1005007. Epub 2015 Jul 2.

Division of Mycobacterial Research, MRC National Institute of Medical Research, London, United Kingdom; Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.ppat.1005007
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http://dx.doi.org/10.1371/journal.ppat.1005007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489717PMC
July 2015

High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.

Proc Natl Acad Sci U S A 2015 Jun 15;112(26):8052-7. Epub 2015 Jun 15.

Department of Anthropology, The Pennsylvania State University, University Park, PA 16802; Stellenbosch Institute for Advanced Studies, Stellenbosch 7600, South Africa;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1500909112
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http://dx.doi.org/10.1073/pnas.1500909112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491791PMC
June 2015

ART and prevention of HIV-associated tuberculosis.

Lancet HIV 2015 Jun 17;2(6):e221-2. Epub 2015 May 17.

The Desmond Tutu HIV Centre, and Clinical Infectious Diseases Research Initiative; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Republic of South Africa; The Francis Crick Institute Mill Hill Laboratory, London, UK; Department of Medicine, Imperial College, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S23523018150008
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http://dx.doi.org/10.1016/S2352-3018(15)00081-8DOI Listing
June 2015

Tricks to translating TB transcriptomics.

Ann Transl Med 2015 May;3(Suppl 1):S43

1 Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, 2 Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Observatory, 7925, South Africa ; 3 The Francis Crick Institute, Mill Hill Laboratory, London, NW7 1AA, UK ; 4 Department of Medicine, Imperial College London, W2 1PG, UK.

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http://www.atmjournal.org/article/view/6419/7249
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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.04.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437947PMC
May 2015