Robert J Wechsler-Reya

Robert J Wechsler-Reya

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Robert J Wechsler-Reya

Robert J Wechsler-Reya

Publications by authors named "Robert J Wechsler-Reya"

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61Publications

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Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.

PLoS One 2019 20;14(9):e0214901. Epub 2019 Sep 20.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD), La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214901PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754133PMC
September 2019

Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors.

J Med Chem 2019 Apr 5;62(8):3873-3885. Epub 2019 Apr 5.

Department of Pharmaceutical Sciences , University of Connecticut , 69 North Eagleville Road, Unit 3092 , Storrs , Connecticut 06269 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01283DOI Listing
April 2019

Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.

Eur J Med Chem 2019 Feb 23;163:320-332. Epub 2018 Nov 23.

Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, Unit 3092, Storrs, CT, 06269, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358021PMC
February 2019

Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.

Eur J Med Chem 2019 Jan 10;162:495-506. Epub 2018 Nov 10.

Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT, 06269, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.028DOI Listing
January 2019

Publisher Correction: N-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Nat Neurosci 2018 Aug;21(8):1139

Tumor Initiation and Maintenance Program, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41593-018-0169-2DOI Listing
August 2018

Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies.

Annu Rev Neurosci 2018 07 11;41:207-232. Epub 2018 Apr 11.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA; email:

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http://dx.doi.org/10.1146/annurev-neuro-070815-013838DOI Listing
July 2018

NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.

Cancer Cell 2018 03;33(3):435-449.e6

Institut Curie - Recherche, Laboratoire 110, Centre Universitaire, Orsay Cedex 91405, France; INSERM U1021, Centre Universitaire, Orsay 91405, France; CNRS UMR 3347, Centre Universitaire, Orsay 91405, France; Université Paris Sud-11, 91405 Orsay, France; PSL Research University, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183005
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http://dx.doi.org/10.1016/j.ccell.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368680PMC
March 2018

N-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Nat Neurosci 2018 02 15;21(2):195-206. Epub 2018 Jan 15.

Tumor Initiation and Maintenance Program, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41593-017-0057-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317335PMC
February 2018

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Cell 2018 02;172(5):1050-1062.e14

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346737PMC
February 2018

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.

PLoS One 2014 10;9(12):e114433. Epub 2014 Dec 10.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114433PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262395PMC
October 2017

Brain Tumor Stem Cells Remain in Play.

J Clin Oncol 2017 07 22;35(21):2428-2431. Epub 2017 Jun 22.

Luis F. Parada, Memorial Sloan Kettering Cancer Center, New York, NY; Peter B. Dirks, University of Toronto, Toronto, Ontario, Canada; and Robert J. Wechsler-Reya, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.

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http://dx.doi.org/10.1200/JCO.2017.73.9540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516484PMC
July 2017

Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo.

J Control Release 2017 05 3;253:172-182. Epub 2017 Mar 3.

Barrow Brain Tumor Research Center, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA; School of Biological and Health Systems Engineering, Arizona State University, P.O. Box 879709, Tempe, AZ 85287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.02.033DOI Listing
May 2017

Molecular mechanisms and therapeutic targets in pediatric brain tumors.

Sci Signal 2017 Mar 14;10(470). Epub 2017 Mar 14.

Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scisignal.aaf7593DOI Listing
March 2017

Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.

Nat Cell Biol 2016 Apr 21;18(4):418-30. Epub 2016 Mar 21.

Children's Health Research Center, Sanford Research, 2301 E 60th Street North, Sioux Falls, South Dakota 57104, USA.

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http://dx.doi.org/10.1038/ncb3327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814324PMC
April 2016

Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.

J Med Chem 2016 04 6;59(8):3635-49. Epub 2016 Apr 6.

Department of Pharmaceutical Sciences, University of Connecticut , 69 North Eagleville Road, Unit 3092, Storrs, Connecticut 06269-3092, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061146PMC
http://dx.doi.org/10.1021/acs.jmedchem.5b01718DOI Listing
April 2016

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

SnapShot: Medulloblastoma.

Cancer Cell 2014 Dec;26(6):940-940.e1

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ccell.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324613PMC
December 2014

Cancer. For pediatric glioma, leave no histone unturned.

Science 2014 Dec;346(6216):1458-9

Tumor Initiation & Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1126/science.aaa3814DOI Listing
December 2014

The role of stem cells and progenitors in the genesis of medulloblastoma.

Exp Neurol 2014 Oct 22;260:69-73. Epub 2012 Nov 22.

Tumor Development Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2012.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718859PMC
October 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1.

Development 2014 Jan;141(2):389-98

MRC Centre for Developmental Neurobiology, King's College London, 4th floor New Hunt's House, London SE1 1UL, UK.

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http://dx.doi.org/10.1242/dev.099119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879817PMC
January 2014

A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity.

Nat Neurosci 2013 Dec 20;16(12):1737-44. Epub 2013 Oct 20.

1] Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, USA. [2] Department of Clinical Biochemistry, Southwest Hospital, Third Military Medical University, Chongqing, China.

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http://dx.doi.org/10.1038/nn.3553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845444PMC
December 2013

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.

Cancer Res 2013 Oct 25;73(20):6310-22. Epub 2013 Sep 25.

Authors' Affiliations: Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)-Designated Cancer Center, Sanford-Burnham Medical Research Institute; Sanford Consortium for Regenerative Medicine; Departments of Pediatrics, Neurosciences, and Neurosurgery, University of California San Diego, La Jolla; Rady Children's Hospital, San Diego, California; Departments of Pharmacology and Cancer Biology, Medicine, Division of Pulmonary, Allergy, and Critical Care, Pediatrics, Division of Pediatric Hematology/Oncology, and Surgery, Duke University Medical Center, Durham, North Carolina; German Cancer Research Center (DKFZ), Heidelberg, Germany; and Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800039PMC
October 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://is.muni.cz/repo/990835/nature11327.pdf
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http://www.nature.com/doifinder/10.1038/nature11327
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http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma.

Cancer Res 2012 Jan 3;72(1):122-32. Epub 2011 Nov 3.

Department of Pediatrics, Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520097PMC
January 2012

Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma.

Cancer Cell 2012 Jan;21(1):1-3

Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.12.011DOI Listing
January 2012

A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas.

Cancer Cell 2010 Dec;18(6):546-7

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012268PMC
December 2010

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

Genes Dev 2009 Jan;23(2):157-70

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1101/gad.1759909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648542PMC
January 2009

Stem cells and the origin and propagation of brain tumors.

J Child Neurol 2008 Oct;23(10):1172-8

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1177/0883073808321062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674560PMC
October 2008

Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.

Proc Natl Acad Sci U S A 2007 Feb 13;104(8):2973-8. Epub 2007 Feb 13.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0605770104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815291PMC
February 2007

Hit 'em where they live: targeting the cancer stem cell niche.

Cancer Cell 2007 Jan;11(1):3-5

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.12.007DOI Listing
January 2007

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Mol Cell Biol 2006 Oct 14;26(20):7550-60. Epub 2006 Aug 14.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/MCB.00546-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636865PMC
October 2006

Morphing into cancer: the role of developmental signaling pathways in brain tumor formation.

J Neurobiol 2005 Sep;64(4):458-75

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1002/neu.20166DOI Listing
September 2005

Isolation of neural stem cells from the postnatal cerebellum.

Nat Neurosci 2005 Jun 22;8(6):723-9. Epub 2005 May 22.

Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nn1473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377345PMC
June 2005

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

Development 2005 May 20;132(10):2425-39. Epub 2005 Apr 20.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01793
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http://dx.doi.org/10.1242/dev.01793DOI Listing
May 2005

Getting at the root and stem of brain tumors.

Neuron 2004 Jun;42(6):885-8

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.neuron.2004.06.011DOI Listing
June 2004

Analysis of gene expression in the normal and malignant cerebellum.

Recent Prog Horm Res 2003 ;58:227-48

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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July 2003

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.

Proc Natl Acad Sci U S A 2003 Jun 30;100(12):7331-6. Epub 2003 May 30.

Department of Pharmacology and Cancer Biology and Bioinformatics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0832317100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165875PMC
June 2003