Publications by authors named "Robert J Weatheritt"

30Publications

Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity.

Nat Commun 2021 01 12;12(1):335. Epub 2021 Jan 12.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.

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January 2021

A reference map of the human binary protein interactome.

Nature 2020 04 8;580(7803):402-408. Epub 2020 Apr 8.

Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.

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April 2020

Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.

Cell Rep 2020 03;30(12):4179-4196.e11

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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March 2020

Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control.

Genome Biol 2019 07 17;20(1):141. Epub 2019 Jul 17.

EMBL Australia, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.

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July 2019

Autism spectrum disorder: insights into convergent mechanisms from transcriptomics.

Nat Rev Genet 2019 01;20(1):51-63

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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January 2019

Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop.

Mol Cell 2018 10 13;72(1):187-200.e6. Epub 2018 Sep 13.

Donnelly Centre, University of Toronto, Toronto M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5S 3E1, Canada. Electronic address:

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October 2018

Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing.

Cell 2017 Jul;170(2):324-339.e23

Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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July 2017

The ribosome-engaged landscape of alternative splicing.

Nat Struct Mol Biol 2016 Dec 7;23(12):1117-1123. Epub 2016 Nov 7.

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

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December 2016

Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer.

Mol Cell 2016 08;63(4):579-592

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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August 2016

How do disordered regions achieve comparable functions to structured domains?

Protein Sci 2015 Jun 15;24(6):909-22. Epub 2015 May 15.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.

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June 2015

A highly conserved program of neuronal microexons is misregulated in autistic brains.

Cell 2014 Dec;159(7):1511-23

Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

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December 2014

Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems.

Nat Struct Mol Biol 2014 Sep 24;21(9):833-9. Epub 2014 Aug 24.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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September 2014

Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?

Mol Biosyst 2014 Oct;10(10):2626-42

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany.

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October 2014

Controlling entropy to tune the functions of intrinsically disordered regions.

Curr Opin Struct Biol 2014 Jun 12;26:62-72. Epub 2014 Jun 12.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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June 2014

Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation.

Chem Rev 2014 Jul 13;114(13):6733-78. Epub 2014 Jun 13.

Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL) , Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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July 2014

Evolution. The hidden codes that shape protein evolution.

Science 2013 Dec;342(6164):1325-6

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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December 2013