Robert J Morell

Robert J Morell

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Robert J Morell

Robert J Morell

Publications by authors named "Robert J Morell"

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41Publications

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The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.

Front Cell Neurosci 2018 23;12:445. Epub 2018 Nov 23.

Section on Sensory Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.

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https://www.frontiersin.org/article/10.3389/fncel.2018.00445
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http://dx.doi.org/10.3389/fncel.2018.00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265442PMC
November 2018

Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness.

Cell 2018 07 28;174(3):536-548.e21. Epub 2018 Jun 28.

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370011PMC
July 2018

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

J Clin Invest 2018 04 12;128(4):1509-1522. Epub 2018 Mar 12.

Laboratory of Molecular Genetics, Department of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/JCI97350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873844PMC
April 2018

Molecular architecture underlying fluid absorption by the developing inner ear.

Elife 2017 10 10;6. Epub 2017 Oct 10.

Molecular Biology and Genetics Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.

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http://dx.doi.org/10.7554/eLife.26851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634787PMC
October 2017

Genetic causes of moderate to severe hearing loss point to modifiers.

Clin Genet 2017 Apr 6;91(4):589-598. Epub 2016 Oct 6.

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA 20892.

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http://dx.doi.org/10.1111/cge.12856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365349PMC
April 2017

Recessive mutations of TMC1 associated with moderate to severe hearing loss.

Neurogenetics 2016 Apr 16;17(2):115-123. Epub 2016 Feb 16.

School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan.

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http://dx.doi.org/10.1007/s10048-016-0477-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795972PMC
April 2016

Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear.

Nat Commun 2015 Oct 15;6:8557. Epub 2015 Oct 15.

Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms9557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634134PMC
October 2015

A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss.

J Med Genet 2015 Aug 4;52(8):548-52. Epub 2015 May 4.

School of Biological Sciences, University of the Punjab, Lahore, Pakistan.

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http://dx.doi.org/10.1136/jmedgenet-2015-103023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529444PMC
August 2015

Cone responses in Usher syndrome types 1 and 2 by microvolt electroretinography.

Invest Ophthalmol Vis Sci 2014 Nov 25;56(1):107-14. Epub 2014 Nov 25.

National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, United States.

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http://dx.doi.org/10.1167/iovs.14-15355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288141PMC
November 2014

A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.

Hear Res 2013 Jun 22;300:1-9. Epub 2013 Mar 22.

Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Ct, 2A-19, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.heares.2013.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684051PMC
June 2013

Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.

Am J Hum Genet 2010 Mar 18;86(3):378-88. Epub 2010 Feb 18.

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833391PMC
March 2010

Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D.

Mol Vis 2009 Sep 12;15:1843-57. Epub 2009 Sep 12.

Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743805PMC
September 2009

Mutational spectrum of MYO15A: the large N-terminal extension of myosin XVA is required for hearing.

Hum Mutat 2007 Oct;28(10):1014-9

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville 20850, Maryland, USA.

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http://dx.doi.org/10.1002/humu.20556DOI Listing
October 2007

A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait.

Hum Genet 2007 Aug 29;122(1):103-11. Epub 2007 May 29.

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA.

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http://link.springer.com/10.1007/s00439-007-0384-5
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http://dx.doi.org/10.1007/s00439-007-0384-5DOI Listing
August 2007

Signatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear.

Genomics 2007 Feb 17;89(2):197-206. Epub 2006 Oct 17.

Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.ygeno.2006.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847387PMC
February 2007

Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.

Am J Hum Genet 2006 Jan 21;78(1):137-43. Epub 2005 Nov 21.

Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health (NIH), Rockville, MD 20850, USA.

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http://dx.doi.org/10.1086/499164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380211PMC
January 2006

Modification of human hearing loss by plasma-membrane calcium pump PMCA2.

N Engl J Med 2005 Apr;352(15):1557-64

Section on Human Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Md 20850, USA.

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http://depts.washington.edu/audneuro/Griffith.pdf
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http://www.nejm.org/doi/abs/10.1056/NEJMoa043899
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http://dx.doi.org/10.1056/NEJMoa043899DOI Listing
April 2005

Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development.

Dev Biol 2005 Apr;280(2):295-306

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.ydbio.2005.01.015DOI Listing
April 2005

Mutations of MYO6 are associated with recessive deafness, DFNB37.

Am J Hum Genet 2003 May 8;72(5):1315-22. Epub 2003 Apr 8.

Section on Human Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180285PMC
http://dx.doi.org/10.1086/375122DOI Listing
May 2003

Clinical presentation of DFNB12 and Usher syndrome type 1D.

Adv Otorhinolaryngol 2002 ;61:145-52

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Md., USA.

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February 2003

Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.

Hum Mol Genet 2002 Nov;11(23):2877-85

Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1093/hmg/11.23.2877DOI Listing
November 2002

Mutations in a novel gene, TMIE, are associated with hearing loss linked to the DFNB6 locus.

Am J Hum Genet 2002 Sep 24;71(3):632-6. Epub 2002 Jul 24.

Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, 20850, USA.

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http://dx.doi.org/10.1086/342193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379198PMC
September 2002