Publications by authors named "Robert J Lipinski"

37Publications

Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development.

Front Cell Dev Biol 2020 7;8:590539. Epub 2020 Oct 7.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.

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October 2020

Identifying environmental risk factors and gene-environment interactions in holoprosencephaly.

Birth Defects Res 2021 Jan 28;113(1):63-76. Epub 2020 Oct 28.

Medical Genetics Branch, National Human Genome Research Institute, The National Institutes of Health, Bethesda, Maryland, USA.

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January 2021

Examining the developmental toxicity of piperonyl butoxide as a Sonic hedgehog pathway inhibitor.

Chemosphere 2021 Feb 23;264(Pt 1):128414. Epub 2020 Sep 23.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53706, USA; Molecular and Environmental Toxicology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, 53706, USA. Electronic address:

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February 2021

Gene-environment interactions: aligning birth defects research with complex etiology.

Development 2020 07 17;147(21). Epub 2020 Jul 17.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA

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July 2020

Prenatal exposure to pesticides and risk for holoprosencephaly: a case-control study.

Environ Health 2020 06 8;19(1):65. Epub 2020 Jun 8.

Medical Genetics Branch, National Human Genome Research Institute, The National Institutes of Health, Bethesda, MD, USA.

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June 2020

40th Annual David W Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2019 Annual Meeting.

Am J Med Genet A 2020 Apr;182(4):877-942

Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

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April 2020

Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.

Am J Hum Genet 2020 01 26;106(1):121-128. Epub 2019 Dec 26.

The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 1X8, Canada.

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January 2020

A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly.

Am J Hum Genet 2019 05 18;104(5):990-993. Epub 2019 Apr 18.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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May 2019

A forebrain undivided: Unleashing model organisms to solve the mysteries of holoprosencephaly.

Dev Dyn 2019 08 1;248(8):626-633. Epub 2019 May 1.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.

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August 2019

Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics.

BMC Genomics 2018 Jun 27;19(1):497. Epub 2018 Jun 27.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr., Madison, WI, 53706, USA.

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June 2018

Common basis for orofacial clefting and cortical interneuronopathy.

Transl Psychiatry 2018 01 10;8(1). Epub 2018 Jan 10.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA.

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January 2018

Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway.

Cell Signal 2018 04 26;44:1-9. Epub 2017 Dec 26.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States; Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States. Electronic address:

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April 2018

Human germline hedgehog pathway mutations predispose to fatty liver.

J Hepatol 2017 10 21;67(4):809-817. Epub 2017 Jun 21.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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October 2017

Sonic hedgehog regulation of promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis.

Development 2017 06 15;144(11):2082-2091. Epub 2017 May 15.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA

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June 2017

Gene-environment interactions in cortical interneuron development and dysfunction: A review of preclinical studies.

Neurotoxicology 2017 01 5;58:120-129. Epub 2016 Dec 5.

Department of Comparative Biosciences School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA; Comparative Biomedical Sciences Graduate Program, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA; Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, 1010B McArdle Building, 1400 University Avenue, Madison, WI, 53706, USA. Electronic address:

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January 2017

Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model.

Dis Model Mech 2016 11 1;9(11):1307-1315. Epub 2016 Sep 1.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA

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November 2016

A Simple and Reliable Method for Early Pregnancy Detection in Inbred Mice.

J Am Assoc Lab Anim Sci 2015 Jul;54(4):368-71

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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July 2015

35(th) Annual David W Smith Workshop on Malformations and Morphogenesis: abstracts of the 2014 annual meeting.

Am J Med Genet A 2015 Aug 22;167A(8):1685-740. Epub 2015 May 22.

Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

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August 2015

Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate.

PLoS One 2015 20;10(3):e0120517. Epub 2015 Mar 20.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America; Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States of America.

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February 2016

Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling.

Mol Endocrinol 2014 Nov 5;28(11):1866-74. Epub 2014 Sep 5.

Departments of Dairy Science (J.L., S.R.W., C.M.C., A.P.P., L.L.H.), Comparative Biosciences (K.P.K., G.W.H., C.M.V., R.J.L.), and Animal Science (T.D.C.), University of Wisconsin-Madison, Madison, Wisconsin 53706.

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November 2014

Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate.

PLoS One 2014 21;9(7):e102603. Epub 2014 Jul 21.

The Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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April 2015

The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse.

PLoS One 2014 19;9(2):e89448. Epub 2014 Feb 19.

The Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America ; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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October 2014

Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder.

Neuropsychol Rev 2011 Jun 29;21(2):167-85. Epub 2011 Mar 29.

Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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June 2011

Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.

Toxicol In Vitro 2010 Aug 29;24(5):1404-9. Epub 2010 Apr 29.

Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 27599, USA.

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August 2010

Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications.

Birth Defects Res A Clin Mol Teratol 2010 Apr;88(4):232-40

Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

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April 2010

Genesis of teratogen-induced holoprosencephaly in mice.

Am J Med Genet C Semin Med Genet 2010 Feb;154C(1):29-42

University of North Carolina at Chapel Hill, 27599, USA.

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February 2010

Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells.

BMC Dev Biol 2009 Oct 7;9:50. Epub 2009 Oct 7.

Department of Urology, University of Wisconsin-Madison, Madison, WI, USA.

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October 2009

Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines.

BMC Cell Biol 2008 Sep 13;9:49. Epub 2008 Sep 13.

Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

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September 2008

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

Toxicol Sci 2008 Jul 14;104(1):189-97. Epub 2008 Apr 14.

Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison WI 53703, USA.

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July 2008

Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

Toxicol Sci 2007 Dec 28;100(2):456-63. Epub 2007 Aug 28.

Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI 53703, USA.

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December 2007

Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.

Exp Cell Res 2006 Jul 29;312(11):1925-38. Epub 2006 Mar 29.

Molecular and Environmental Toxicology Center, Madison, WI 53705-222, USA.

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July 2006