Robert H McCusker

Robert H McCusker

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Robert H McCusker

Robert H McCusker

Publications by authors named "Robert H McCusker"

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Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling.

Brain Behav Immun 2019 Aug 17;80:763-776. Epub 2019 May 17.

Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA; Department of Animal Sciences, University of Illinois, Urbana, IL, USA; Department of Pathology, Program in Integrative Immunology and Behavior, University of Illinois, Urbana, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664453PMC
August 2019

Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice.

Epilepsia 2019 Apr 15;60(4):626-635. Epub 2019 Feb 15.

Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences, Urbana, Illinois.

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http://dx.doi.org/10.1111/epi.14675DOI Listing
April 2019

Behavioral response to fiber feedingis cohort-dependent and associated with gut microbiota composition in mice.

Behav Brain Res 2019 02 19;359:731-736. Epub 2018 Sep 19.

Division of Nutritional Sciences, University of Illinois Urbana-Champaign, IL, United States; Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2018.09.012DOI Listing
February 2019

Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone.

Brain Behav Immun 2018 03 11;69:321-335. Epub 2017 Dec 11.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Pathology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08891591173054
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http://dx.doi.org/10.1016/j.bbi.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857427PMC
March 2018

Glial and tissue-specific regulation of dioxygenases by acute stress of mice.

Neurobiol Stress 2017 Dec 12;7:1-15. Epub 2017 Feb 12.

Neuroscience Program, 250 Edward R Madigan Laboratory, 1201 W. Gregory Drive, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.ynstr.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840960PMC
December 2017

Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice.

Exp Gerontol 2017 11 14;98:22-29. Epub 2017 Aug 14.

Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Pathology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2017.08.020DOI Listing
November 2017

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition.

Metabolism 2017 06 9;71:70-82. Epub 2017 Mar 9.

Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA; Department of Animal Sciences, University of Illinois, Urbana, IL, USA; Department of Pathology, Program in Integrative Immunology and Behavior, University of Illinois, Urbana, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439304PMC
June 2017

Dose-dependent decrease in mortality with no cognitive or muscle function improvements due to dietary EGCG supplementation in aged mice.

Appl Physiol Nutr Metab 2017 May 5;42(5):495-502. Epub 2017 Jan 5.

a Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1139/apnm-2016-0530DOI Listing
May 2017

Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma.

Brain Behav Immun 2017 May 4;62:24-29. Epub 2017 Feb 4.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2017.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514839PMC
May 2017

Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases.

Brain Behav Immun 2017 May 16;62:219-229. Epub 2017 Feb 16.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Pathology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382643PMC
May 2017

Immunomodulatory Factors Galectin-9 and Interferon-Gamma Synergize to Induce Expression of Rate-Limiting Enzymes of the in the Mouse Hippocampus.

Front Immunol 2016 17;7:422. Epub 2016 Oct 17.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Department of Pathology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

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http://dx.doi.org/10.3389/fimmu.2016.00422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065983PMC
October 2016

The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy.

J Clin Neurosci 2015 Dec 14;22(12):1964-8. Epub 2015 Aug 14.

Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Tarry Bldg 2-703, 300 East Superior Street, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2015.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548799PMC
December 2015

Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice.

Physiol Behav 2015 Jun 19;145:29-37. Epub 2015 Mar 19.

Beckman Institute, Center for Nutrition, Learning and Memory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Division of Nutritional Sciences, Center for Nutrition, Learning and Memory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Integrative Immunology and Behavior Program, Center for Nutrition, Learning and Memory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Psychology, Center for Nutrition, Learning and Memory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address:

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http://dx.doi.org/10.1016/j.physbeh.2015.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427239PMC
June 2015

Analytical workflow profiling gene expression in murine macrophages.

J Bioinform Comput Biol 2015 Apr 14;13(2):1550010. Epub 2015 Jan 14.

Illinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1142/S0219720015500109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539142PMC
April 2015

Getting nervous about immunity.

Semin Immunol 2014 Oct 18;26(5):389-93. Epub 2014 Feb 18.

Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Pathology, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.

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http://dx.doi.org/10.1016/j.smim.2014.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136993PMC
October 2014

Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety.

Brain Behav Immun 2014 Oct 4;41:218-31. Epub 2014 Jun 4.

Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA; Department of Pathology, Program in Integrative Immunology and Behavior, University of Illinois, Urbana, IL, USA; Department of Animal Sciences, University of Illinois, Urbana, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2014.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167209PMC
October 2014

Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice.

Behav Brain Res 2014 Oct 5;272:131-40. Epub 2014 Jul 5.

Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2014.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428596PMC
October 2014

Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.

Brain Behav Immun 2013 Aug 26;32:63-9. Epub 2013 Feb 26.

Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.bbi.2013.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686980PMC
August 2013

Immune-neural connections: how the immune system's response to infectious agents influences behavior.

J Exp Biol 2013 Jan;216(Pt 1):84-98

Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801-3873, USA.

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http://dx.doi.org/10.1242/jeb.073411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515033PMC
January 2013

Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide.

J Neuroinflammation 2011 Dec 21;8:179. Epub 2011 Dec 21.

Integrated Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Illinois 61801-3873, USA.

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http://dx.doi.org/10.1186/1742-2094-8-179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264674PMC
December 2011

Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice.

J Neuroinflammation 2011 Feb 9;8:12. Epub 2011 Feb 9.

Integrated Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801-3873, USA.

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http://dx.doi.org/10.1186/1742-2094-8-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045937PMC
February 2011

The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior.

Psychopharmacology (Berl) 2009 Jan 30;201(4):549-56. Epub 2008 Sep 30.

Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana-Champaign, 227 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801-3873, USA.

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http://link.springer.com/10.1007/s00213-008-1331-4
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http://dx.doi.org/10.1007/s00213-008-1331-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711641PMC
January 2009

Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology.

Cell Immunol 2008 Mar-Apr;252(1-2):91-110. Epub 2008 Mar 5.

Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000887490700264
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http://dx.doi.org/10.1016/j.cellimm.2007.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615236PMC
August 2008

Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10.

J Neuroimmunol 2008 Aug 18;199(1-2):56-62. Epub 2008 Jun 18.

Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2008.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578822PMC
August 2008

Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta.

Am J Physiol Endocrinol Metab 2008 Apr 12;294(4):E709-18. Epub 2008 Feb 12.

Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00662.2007
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http://dx.doi.org/10.1152/ajpendo.00662.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951888PMC
April 2008

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

J Neuroimmunol 2007 Aug 18;188(1-2):48-55. Epub 2007 Jun 18.

Laboratories of Integrative Immunophysiology, College of Medicine, University of Illinois, Urbana, IL 61801, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280700169
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http://dx.doi.org/10.1016/j.jneuroim.2007.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2078530PMC
August 2007

TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I.

J Neuroimmunol 2007 Jul 18;187(1-2):55-60. Epub 2007 May 18.

Department of Animal Sciences, Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, University of Illinois at Urbana--Champaign, IL, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280700130
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http://dx.doi.org/10.1016/j.jneuroim.2007.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915825PMC
July 2007

C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.

Endocrinology 2006 Sep 15;147(9):4363-73. Epub 2006 Jun 15.

Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1210/en.2005-1541DOI Listing
September 2006

Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide.

Endocrinology 2004 Oct 15;145(10):4592-602. Epub 2004 Jul 15.

University of Illinois, Laboratory of Immunophysiology, 207 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1210/en.2003-1749DOI Listing
October 2004

IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts.

J Immunol 2004 Jun;172(12):7713-20

Laboratories of Immunophysiology,207 Edward R. Madigan Laboratory, University of Illinois at Urbana-Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA.

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http://dx.doi.org/10.4049/jimmunol.172.12.7713DOI Listing
June 2004

Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis.

J Biol Chem 2004 Feb 16;279(9):7438-46. Epub 2003 Dec 16.

Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1074/jbc.M310264200DOI Listing
February 2004

Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells.

J Cell Physiol 2003 Dec;197(3):388-99

Department of Animal Sciences, Laboratory for Developmental Endocrinology, The University of Illinois, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1002/jcp.10360DOI Listing
December 2003

Zinc alters the kinetics of IGF-II binding to cell surface receptors and binding proteins.

Endocrine 2003 Aug;21(3):279-88

Laboratory for Developmental Endocrinology, The Department of Animal Sciences, The University of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1385/ENDO:21:3:279DOI Listing
August 2003

Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts.

Endocrinology 2003 Jul;144(7):2988-96

Laboratory of Immunophysiology, Department of Animal Sciences and Pathology, College of Medicine, University of Illinois at Urbana-Champaign, 207 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1210/en.2003-0087DOI Listing
July 2003