Robert H Henning

Robert H Henning

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Robert H Henning

Robert H Henning

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Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation.

Cells 2019 Oct 5;8(10). Epub 2019 Oct 5.

Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/cells8101202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829298PMC
October 2019

Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis.

Antioxid Redox Signal 2019 Jul 23;31(2):134-152. Epub 2019 Jan 23.

1 Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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https://www.liebertpub.com/doi/10.1089/ars.2018.7537
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http://dx.doi.org/10.1089/ars.2018.7537DOI Listing
July 2019

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation.

Drug Des Devel Ther 2019 18;13:345-364. Epub 2019 Jan 18.

Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands,

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http://dx.doi.org/10.2147/DDDT.S176924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342224PMC
June 2019

Gasotransmitters in health and disease: a mitochondria-centered view.

Curr Opin Pharmacol 2019 Apr 17;45:87-93. Epub 2019 Jul 17.

Department of Pathology and Medical Biology, Pathology Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2019.07.001DOI Listing
April 2019

The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats.

Nephrol Dial Transplant 2018 12;33(12):2128-2138

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfy080DOI Listing
December 2018

Reply.

Ann Thorac Surg 2018 12 11;106(6):1891-1892. Epub 2018 Aug 11.

Department of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.athoracsur.2018.07.006DOI Listing
December 2018

Converse role of class I and class IIa HDACs in the progression of atrial fibrillation.

J Mol Cell Cardiol 2018 12 12;125:39-49. Epub 2018 Oct 12.

Department of Physiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, Vrije Universiteit Amsterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828183054
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http://dx.doi.org/10.1016/j.yjmcc.2018.09.010DOI Listing
December 2018

Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling.

Heart Rhythm 2018 11 11;15(11):1708-1716. Epub 2018 Jun 11.

Department of Clinical Pharmacy and Pharmacology, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.06.014DOI Listing
November 2018

Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system.

Comp Biochem Physiol B Biochem Mol Biol 2018 09 9;223:23-28. Epub 2018 Jun 9.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.cbpb.2018.06.001DOI Listing
September 2018

Acute Kidney Injury Classification Underestimates Long-Term Mortality After Cardiac Valve Operations.

Ann Thorac Surg 2018 07 1;106(1):92-98. Epub 2018 Mar 1.

Department of Anesthesiology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.athoracsur.2018.01.066DOI Listing
July 2018

A Hibernation-Like State for Transplantable Organs: Is Hydrogen Sulfide Therapy the Future of Organ Preservation?

Antioxid Redox Signal 2018 06 29;28(16):1503-1515. Epub 2017 Aug 29.

3 Matthew Mailing Center for Translational Transplant Studies, Western University , London, Canada .

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http://www.liebertpub.com/doi/10.1089/ars.2017.7127
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http://dx.doi.org/10.1089/ars.2017.7127DOI Listing
June 2018

Proteostasis in cardiac health and disease.

Nat Rev Cardiol 2017 Nov 29;14(11):637-653. Epub 2017 Jun 29.

Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrcardio.2017.89DOI Listing
November 2017

Differences in mitochondrial function and morphology during cooling and rewarming between hibernator and non-hibernator derived kidney epithelial cells.

Sci Rep 2017 11 14;7(1):15482. Epub 2017 Nov 14.

Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-15606-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686174PMC
November 2017

Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation.

BMC Gastroenterol 2017 Nov 28;17(1):131. Epub 2017 Nov 28.

University Hospital Bratislava, Nemocnica Ruzinov, ICU, KAIM, Clinic of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.

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http://dx.doi.org/10.1186/s12876-017-0695-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704353PMC
November 2017

Renal Mitochondrial Response to Low Temperature in Non-Hibernating and Hibernating Species.

Antioxid Redox Signal 2017 Sep 26;27(9):599-617. Epub 2017 Apr 26.

1 Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen , Groningen, the Netherlands .

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http://dx.doi.org/10.1089/ars.2016.6705DOI Listing
September 2017

Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin.

Sci Rep 2017 09 8;7(1):10975. Epub 2017 Sep 8.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-11430-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591199PMC
September 2017

Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries.

PLoS One 2016 1;11(9):e0162029. Epub 2016 Sep 1.

Department of Clinical Pharmacy and Pharmacology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162029PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008781PMC
July 2017

The influence of sex and diet on the characteristics of hibernation in Syrian hamsters.

J Comp Physiol B 2017 Jul 21;187(5-6):725-734. Epub 2017 Mar 21.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00360-017-1072-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486544PMC
July 2017

Predictive Properties of Biomarkers GDF-15, NTproBNP, and hs-TnT for Morbidity and Mortality in Patients With Type 2 Diabetes With Nephropathy.

Diabetes Care 2017 06 24;40(6):784-792. Epub 2017 Mar 24.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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http://dx.doi.org/10.2337/dc16-2175DOI Listing
June 2017

The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells.

Biomaterials 2017 03 9;119:43-52. Epub 2016 Dec 9.

Cardiovascular Regenerative Medicine, Dept. Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713GZ, Groningen, The Netherlands; Sulfateq B.V., Admiraal de Ruyterlaan 5, 9726GN, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.12.008DOI Listing
March 2017

Derailed Proteostasis as a Determinant of Cardiac Aging.

Can J Cardiol 2016 09 19;32(9):1166.e11-20. Epub 2016 Mar 19.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2016.03.005DOI Listing
September 2016

Long-term survival in permanent middle cerebral artery occlusion: a model of malignant stroke in rats.

Sci Rep 2016 06 22;6:28401. Epub 2016 Jun 22.

Division of Neurosurgical Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, D-68167, Germany.

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http://dx.doi.org/10.1038/srep28401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916503PMC
June 2016

How hibernation and hypothermia help to improve anticoagulant control.

Temperature (Austin) 2015 Jan-Mar;2(1):44-6. Epub 2014 Sep 25.

Department of Clinical Pharmacy and Pharmacology; University Medical Center Groningen ; University of Groningen ; Groningen, The Netherlands.

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http://dx.doi.org/10.4161/23328940.2014.967595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843874PMC
May 2016

Induction of a Torpor-Like State by 5'-AMP Does Not Depend on H2S Production.

PLoS One 2015 21;10(8):e0136113. Epub 2015 Aug 21.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136113PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546583PMC
May 2016

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.

PLoS One 2015 20;10(7):e0133553. Epub 2015 Jul 20.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508109PMC
April 2016

Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation.

Cardiovasc Res 2016 Apr 8;109(4):519-26. Epub 2015 Dec 8.

Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700RB Groningen, The Netherlands Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

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http://dx.doi.org/10.1093/cvr/cvv265DOI Listing
April 2016

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming - The role of renal H2S-producing enzymes.

Eur J Pharmacol 2015 Dec 21;769:225-33. Epub 2015 Nov 21.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.11.022DOI Listing
December 2015

Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in zucker diabetic fatty rat.

Curr Vasc Pharmacol 2014 ;12(6):836-44

Department of Pharmacology and Toxicology Comenius University in Bratislava, Faculty of Pharmacy, Odbojarov 10, 83232, Bratislava, Slovak Republic.

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http://dx.doi.org/10.2174/15701611113116660151DOI Listing
August 2015

Reviving the protein quality control system: therapeutic target for cardiac disease in the elderly.

Trends Cardiovasc Med 2015 Apr 28;25(3):243-7. Epub 2014 Oct 28.

Department of Clinical Pharmacy and Pharmacology, EB71, University Institute for Drug Exploration (GUIDE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2014.10.013DOI Listing
April 2015

Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia.

PLoS One 2014 10;9(4):e93218. Epub 2014 Apr 10.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093218PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982955PMC
January 2015

Reviving the protein quality control system: therapeutic target for cardiac disease in the elderly.

Trends Cardiovasc Med 2015 Apr 28;25(3):243-7. Epub 2014 Oct 28.

Department of Clinical Pharmacy and Pharmacology, EB71, University Institute for Drug Exploration (GUIDE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2014.10.013DOI Listing
April 2015

Endothelium-dependent relaxation and angiotensin II sensitivity in experimental preeclampsia.

PLoS One 2013 6;8(11):e79884. Epub 2013 Nov 6.

Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands ; Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079884PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819278PMC
June 2014

Ultrasound and microbubble-targeted delivery of small interfering RNA into primary endothelial cells is more effective than delivery of plasmid DNA.

Ultrasound Med Biol 2014 Mar 19;40(3):532-40. Epub 2013 Dec 19.

Department of Clinical Pharmacology, Groningen Institute for Drug Exploration (GUIDE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2013.09.031DOI Listing
March 2014

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.

Circulation 2014 Jan 21;129(3):346-58. Epub 2013 Oct 21.

Departments of Clinical Pharmacology (D.Z., R.A.M.M., F.H.-B., R.H.H., B.J.J.M.B.) and Cell Biology (O.C.M.S.), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Research Center and Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, QB, Canada (C.T.W., X.Y.Q., A.T., S.N.); Chang-Gung Memorial Hospital and Chang-Gung University, Taoyuan, Taiwan, Republic of China (C.T.W.); Nyken BV, Groningen, The Netherlands (F.-H.B.); Ankara University Biotechnology Institute, Ankara, Turkey (G.C.D., S.D.); Ankara University Stem Cell Institute, Ankara, Turkey (G.C.D., S.D., A.R.A.); Department of Cardiovascular Surgery, Ankara University School of Medicine, Ankara, Turkey (S.D., A.R.A.); and Department of Pharmacology, McGill University, Montreal, QB, Canada (S.N.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.005300DOI Listing
January 2014

Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide.

BMC Cell Biol 2014 Jan 6;15. Epub 2014 Jan 6.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 AD Groningen, The Netherlands.

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http://dx.doi.org/10.1186/1471-2121-15-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998068PMC
January 2014

Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes.

Am J Physiol Renal Physiol 2013 Nov 28;305(9):F1249-64. Epub 2013 Aug 28.

Dept. Clinical Pharmacology, UMCG, A. Deusinglaan 1, 9713AV Groningen, The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00387.2013DOI Listing
November 2013

Intracellular transactivation of epidermal growth factor receptor by α1A-adrenoceptor is mediated by phosphatidylinositol 3-kinase independently of activation of extracellular signal regulated kinases 1/2 and serine-threonine kinases in Chinese hamster ovary cells.

J Pharmacol Exp Ther 2013 Oct 31;347(1):47-56. Epub 2013 Jul 31.

Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands (N.U., R.H.H., M.D.); Department of Medical Pharmacology, Faculty of Medicine, University of Ufuk, Ankara, Turkey (S.G.); and Department of Medical Pharmacology, Faculty of Medicine, University of Ankara, Ankara, Turkey (T.Z., B.D., H.G.).

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.113.20624
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http://dx.doi.org/10.1124/jpet.113.206243DOI Listing
October 2013

Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination.

J Leukoc Biol 2013 Sep 13;94(3):431-7. Epub 2013 Jun 13.

Department of Clinical Pharmacology, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1189/jlb.0611298DOI Listing
September 2013

Troubleshooting methods for microarray gene expression analysis in the onset of diabetic kidney disease.

J Pharmacol Toxicol Methods 2013 Mar-Apr;67(2):61-8. Epub 2013 Jan 30.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.vascn.2013.01.012DOI Listing
August 2013

Renal myogenic constriction protects the kidney from age-related hypertensive renal damage in the Fawn-Hooded rat.

J Hypertens 2013 Aug;31(8):1637-45

Department of Clinical Pharmacology, University of Groningen, Groningen University Institute for Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/HJH.0b013e328361d506DOI Listing
August 2013

5'-AMP impacts lymphocyte recirculation through activation of A2B receptors.

J Leukoc Biol 2013 Jul 16;94(1):89-98. Epub 2013 May 16.

University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1189/jlb.1212613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685012PMC
July 2013

Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.

PLoS One 2012 26;7(12):e52647. Epub 2012 Dec 26.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052647PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530435PMC
June 2013

Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats.

J Pharmacol Exp Ther 2013 Jun 25;345(3):393-403. Epub 2013 Mar 25.

Department of Clinical Pharmacology, University of Groningen, University Medical Centre Groningen, A. Deusinglaan 1, Building 3211, Floor 6, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1124/jpet.113.203497DOI Listing
June 2013

Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel.

Dev Comp Immunol 2013 Mar 24;39(3):154-60. Epub 2012 Nov 24.

Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.dci.2012.11.004DOI Listing
March 2013

Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium.

Am J Physiol Heart Circ Physiol 2013 Mar 21;304(5):H709-18. Epub 2012 Dec 21.

Department of Clinical Pharmacology, University of Groningen, and University Medical Center Groningen, Groningen, The Netherlands.

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http://www.physiology.org/doi/10.1152/ajpheart.00543.2012
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http://dx.doi.org/10.1152/ajpheart.00543.2012DOI Listing
March 2013

Structure and function of cerebral and mesenteric resistance arteries in low-dose endotoxin-infused pregnant rats.

Pregnancy Hypertens 2013 Jan 3;3(1):48-56. Epub 2012 Dec 3.

Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S22107789120036
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http://dx.doi.org/10.1016/j.preghy.2012.11.002DOI Listing
January 2013

Growth-differentiation factor 15 predicts worsening of albuminuria in patients with type 2 diabetes.

Diabetes Care 2012 Nov 18;35(11):2340-6. Epub 2012 Jul 18.

Department of Clinical Pharmacology, Division of Nephrology, University of Groningen, University Medical Center of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.2337/dc12-0180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476892PMC
November 2012

Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins.

Front Physiol 2012 23;3:36. Epub 2012 Feb 23.

Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen Groningen, Netherlands.

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http://dx.doi.org/10.3389/fphys.2012.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284689PMC
October 2012

Vascular smooth muscle function of renal glomerular and interlobar arteries predicts renal damage in rats.

Am J Physiol Renal Physiol 2012 Oct 11;303(8):F1187-95. Epub 2012 Jul 11.

Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University Medical Center Groningen, A. Deusinglaan 1, Groningen, The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00653.2011DOI Listing
October 2012

Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury.

PLoS One 2012 12;7(1):e30400. Epub 2012 Jan 12.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030400PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257274PMC
May 2012

Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation.

Trends Cardiovasc Med 2012 Apr 3;22(3):62-8. Epub 2012 Aug 3.

Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.tcm.2012.06.013DOI Listing
April 2012

Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway.

PLoS One 2011 27;6(7):e22568. Epub 2011 Jul 27.

Department of Clinical Pharmacology (FB20), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144905PMC
December 2011

HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.

PLoS One 2011 24;6(6):e20395. Epub 2011 Jun 24.

Department of Radiation and Stress Cell Biology, University Institute for Drug Exploration (GUIDE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020395PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123278PMC
November 2011

Losartan protects mesenteric arteries from ROS-associated decrease in myogenic constriction following 5/6 nephrectomy.

J Renin Angiotensin Aldosterone Syst 2011 Sep 10;12(3):184-94. Epub 2011 Mar 10.

Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration (GUIDE), University Medical Center Groningen, Groningen, The Netherlands.

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http://journals.sagepub.com/doi/10.1177/1470320310391328
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September 2011

Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation.

J Mol Cell Cardiol 2011 Sep 13;51(3):381-9. Epub 2011 Jul 13.

Department of Clinical Pharmacology, University Institute for Drug Exploration, University of Groningen, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2011.06.008DOI Listing
September 2011

Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate.

Proc Natl Acad Sci U S A 2011 Feb 18;108(5):2052-7. Epub 2011 Jan 18.

Department of Clinical Pharmacology, Sections of Immunology and Membrane Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1073/pnas.1008823108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033260PMC
February 2011

Towards graft-specific immune suppression: Gene therapy of the transplanted kidney.

Adv Drug Deliv Rev 2010 Nov 3;62(14):1358-68. Epub 2010 Aug 3.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.addr.2010.07.010DOI Listing
November 2010

Drug targeting to the kidney.

Adv Drug Deliv Rev 2010 Nov 16;62(14):1323-4. Epub 2010 Oct 16.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University Sorbonnelaan, The Netherlands.

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http://dx.doi.org/10.1016/j.addr.2010.10.007DOI Listing
November 2010

Collaboration on progress testing in medical schools in the Netherlands.

Med Teach 2010 ;32(6):476-9

Department of Educational Development and Research, University of Maastricht, The Netherlands.

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http://www.tandfonline.com/doi/full/10.3109/0142159X.2010.48
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September 2010

AMP-activated protein kinase as a target for preconditioning in transplantation medicine.

Transplantation 2010 Aug;90(4):353-8

Department of Clinical Pharmacology, Groningen University Institute of Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/TP.0b013e3181e7a3aaDOI Listing
August 2010

Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat.

Am J Physiol Renal Physiol 2010 Mar 9;298(3):F625-33. Epub 2009 Dec 9.

Faculty of Pharmacy, Department of Pharmacology and Toxicology, Comenius University Bratislava, Bratislava, Slovakia.

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http://www.physiology.org/doi/10.1152/ajprenal.00289.2009
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March 2010

Proteinuria-associated endothelial dysfunction is strain dependent.

Am J Nephrol 2009 5;30(3):209-17. Epub 2009 May 5.

Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1159/000218062DOI Listing
February 2010

TGF-beta inhibits Ang II-induced MAPK p44/42 signaling in vascular smooth muscle cells by Ang II type 1 receptor downregulation.

J Vasc Res 2009 10;46(5):459-68. Epub 2009 Feb 10.

Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration (GUIDE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1159/000200961DOI Listing
September 2009

Adjunct nitrous oxide normalizes vascular reactivity changes after hemorrhagic shock in mice under isoflurane anesthesia.

Anesthesiology 2009 Sep;111(3):600-8

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1097/ALN.0b013e3181b31c8eDOI Listing
September 2009

Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage.

Nephrol Dial Transplant 2009 Feb 26;24(2):413-20. Epub 2008 Aug 26.

Department of Clinical Pharmacology, University Medical Center Groningen (UMCG) and Graduate School for Drug Exploration (GUIDE), University of Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfn483DOI Listing
February 2009

Bradykinin protects against oxidative stress-induced endothelial cell senescence.

Hypertension 2009 Feb 15;53(2):417-22. Epub 2008 Dec 15.

Department of Experimental Cardiology, AB 43, University Medical Center Groningen, Antonius Deusinglaan 1, Building 3211, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.123729DOI Listing
February 2009

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation.

J Mol Cell Cardiol 2008 Nov 11;45(5):685-93. Epub 2008 Sep 11.

Department of Radiation and Stress Cell Biology, University Institute for Drug Exploration (GUIDE), University of Groningen, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2008.08.012DOI Listing
November 2008

Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats.

Nephrol Dial Transplant 2008 Oct 25;23(10):3103-10. Epub 2008 May 25.

Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, NL-9700 AD, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfn233DOI Listing
October 2008

Heat shock proteins as molecular targets for intervention in atrial fibrillation.

Cardiovasc Res 2008 Jun 7;78(3):422-8. Epub 2008 Mar 7.

Department of Radiation and Stress Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvn060DOI Listing
June 2008

Immune modulation and graft protection by gene therapy in kidney transplantation.

Eur J Pharmacol 2008 May 15;585(2-3):261-9. Epub 2008 Mar 15.

Department of Clinical Pharmacology, Faculty of Medical Sciences, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2008.02.087DOI Listing
May 2008

Angiotensin-(1-7): pharmacological properties and pharmacotherapeutic perspectives.

Eur J Pharmacol 2008 May 15;585(2-3):303-12. Epub 2008 Mar 15.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S001429990800285
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May 2008

Therapeutic resistance to angiotensin converting enzyme (ACE) inhibition is related to pharmacodynamic and -kinetic factors in 5/6 nephrectomized rats.

Eur J Pharmacol 2008 Feb 30;580(1-2):231-40. Epub 2007 Oct 30.

Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation, University Medical Center Groningen, University of Groningen, The Netherlands.

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February 2008

Adenovirus-mediated interleukin-13 gene therapy attenuates acute kidney allograft injury.

J Gene Med 2007 Dec;9(12):1024-32

Department of Clinical Pharmacology, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1002/jgm.1106DOI Listing
December 2007

Optimization of ultrasound and microbubbles targeted gene delivery to cultured primary endothelial cells.

J Drug Target 2007 Dec;15(10):664-71

Department of Clinical Pharmacology, Groningen Institute for Drug Exploration (GUIDE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1080/10611860701605088DOI Listing
December 2007

Beat shock proteins and atrial fibrillation.

Cell Stress Chaperones 2007 ;12(2):97-100

Department of Cell Biology, Clinical Pharmacology, and Cardiology, University Medical Center Groningen and University of Groningen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949326PMC
http://dx.doi.org/10.1379/csc-285.1DOI Listing
August 2007

Induction of heat shock response protects the heart against atrial fibrillation.

Circ Res 2006 Dec 16;99(12):1394-402. Epub 2006 Nov 16.

Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1161/01.RES.0000252323.83137.feDOI Listing
December 2006

Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy.

J Renin Angiotensin Aldosterone Syst 2006 Dec;7(4):217-24

Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation (GUIDE), University Medical Center Groningen, Antonius Deusinglaan 1. NL-9713 AV Groningen NL-9713, The Netherlands.

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http://journals.sagepub.com/doi/10.3317/jraas.2006.041
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December 2006

Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage.

J Cardiovasc Pharmacol 2006 ;47 Suppl 2:S151-62; discussion S172-6

Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration (GUIDE), University of Groningen, the Netherlands.

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http://dx.doi.org/10.1097/00005344-200606001-00009DOI Listing
November 2006

Renal damage after myocardial infarction is prevented by renin-angiotensin-aldosterone-system intervention.

J Am Soc Nephrol 2006 Nov 27;17(11):3059-66. Epub 2006 Sep 27.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2006030209DOI Listing
November 2006

The role of angiotensin(1-7) in renal vasculature of the rat.

J Hypertens 2006 Oct;24(10):1971-8

Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/01.hjh.0000244945.42169.c0DOI Listing
October 2006

Endothelial dysfunction in chronic kidney disease: determinant of susceptibility to end-organ damage and therapeutic response.

J Nephrol 2006 May-Jun;19(3):246-58

Department of Clinical Pharmacology, University Medical Center Groningen (UMCG) and Groningen Institute for Drug Exploration (GUIDE), University of Groningen, Groningen, The Netherlands.

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September 2006

Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.

J Mol Cell Cardiol 2006 Sep 31;41(3):555-62. Epub 2006 Jul 31.

Department of Radiation and Stress Cell Biology, Groningen University Institute for Drug Exploration (GUIDE), University Medical Center of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2006.06.068DOI Listing
September 2006

Microalbuminuria as an early marker for cardiovascular disease.

J Am Soc Nephrol 2006 Aug 6;17(8):2100-5. Epub 2006 Jul 6.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2006050517
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August 2006

Endothelial function predicts the development of renal damage after combined nephrectomy and myocardial infarction.

J Am Soc Nephrol 2006 Apr;17(4 Suppl 2):S49-52

Department of Clinical Pharmacology, University Medical Centre Groningen, The Netherlands.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2005121322
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http://dx.doi.org/10.1681/ASN.2005121322DOI Listing
April 2006

Does angiotensin (1-7) contribute to the anti-proteinuric effect of ACE-inhibitors.

J Renin Angiotensin Aldosterone Syst 2005 Sep;6(2):96-101

Department of Clinical Pharmocology, Division of Nephrology, Groningen University Institute for Drug Exploration (GUIDE), University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.3317/jraas.2005.016DOI Listing
September 2005