Publications by authors named "Robert H Brown"

100Publications

Association of Lung Function With HIV-Related Quality of Life and Health Care Utilization in a High-Risk Cohort.

J Acquir Immune Defic Syndr 2020 Oct;85(2):219-226

aDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD; bDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and cDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1097/QAI.0000000000002431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494951PMC
October 2020

CT, MRI, COPD, and Worsening FEV; "Once You Do Know What the Question Actually Is, You'll Know What the Answer Means".

Authors:
Robert H Brown

Acad Radiol 2020 Aug 24. Epub 2020 Aug 24.

Johns Hopkins Medical Institutions, Departments of Anesthesiology and Critical Care Medicine, Environmental Health and Engineering, Medicine, Division of Pulmonary Medicine, and Radiology, 615 N. Wolfe St, Baltimore, MD 21287. Electronic address:

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http://dx.doi.org/10.1016/j.acra.2020.07.036DOI Listing
August 2020

Amyotrophic Lateral Sclerosis: Fuel for the Corticofugal Feud.

Ann Neurol 2020 Oct 22;88(4):682-684. Epub 2020 Aug 22.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1002/ana.25861DOI Listing
October 2020

Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS.

N Engl J Med 2020 07;383(2):151-158

From the Horae Gene Therapy Center, Department of Pediatrics, University of Massachusetts Medical School (UMMS) (C.M., G.G., M.B., T.R.F.), and the Department of Neurology, UMMS and UMass Memorial Medical Center (D.M.M.-Y., M.A.O., C.L.D., N.S.W., R.H.B.), Worcester, and the Healey Center for ALS, Department of Neurology (J.D.B., L.M.P., D.G., S.D.L., M.P.F., M.E.C.), and the C.S. Kubik Laboratory for Neuropathology (D.H.O., M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMoa2005056DOI Listing
July 2020

Correction to: Low-moderate arsenic exposure and respiratory health in American Indian communities in the Strong Heart Study.

Environ Health 2020 Feb 26;19(1):24. Epub 2020 Feb 26.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/s12940-020-00576-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043028PMC
February 2020

Intralingual and Intrapleural AAV Gene Therapy Prolongs Survival in a SOD1 ALS Mouse Model.

Mol Ther Methods Clin Dev 2020 Jun 24;17:246-257. Epub 2019 Dec 24.

Division of Pulmonary Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1016/j.omtm.2019.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962641PMC
June 2020

Low-moderate arsenic exposure and respiratory in American Indian communities in the Strong Heart Study.

Environ Health 2019 11 28;18(1):104. Epub 2019 Nov 28.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/s12940-019-0539-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883619PMC
November 2019

NurOwn, phase 2, randomized, clinical trial in patients with ALS: Safety, clinical, and biomarker results.

Neurology 2019 12 18;93(24):e2294-e2305. Epub 2019 Nov 18.

From Massachusetts General Hospital Neurological Clinical Research Institute and Harvard Medical School (J.D.B., M.E.C., K.N.), Boston; Mayo Clinic (A.J.W., N.P.S.), Rochester, MN; University of Massachusetts (M.O., D.M.-Y., R.H.B.), Worcester; Brainstorm Cell Therapeutics (Y.S.L., N.A., H.K., R.A., Y.G.), Petach Tikva, Israel; and Tigermed USA (M.M.), Somerset, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000008620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937497PMC
December 2019

Mobilization of Environmental Toxicants Following Bariatric Surgery.

Obesity (Silver Spring) 2019 11;27(11):1865-1873

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/oby.22618DOI Listing
November 2019

Effects of Obstructive Sleep Apnea and Obesity on Morphine Pharmacokinetics in Children.

Anesth Analg 2020 09;131(3):876-884

From the *Division of Pediatric Anesthesiology and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland †Department of Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland ‡Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland §Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland ‖Division of Pediatric Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland ¶Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado #Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1213/ANE.0000000000004509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301293PMC
September 2020

Prospective natural history study of ALS clinical characteristics and biomarkers.

Neurology 2019 10 2;93(17):e1605-e1617. Epub 2019 Oct 2.

From the Department of Neurology (A.J.C., T.H., C.D., J.J.-B., A.M., S.B., A.S., T.J.E., C.C., T.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (N.A., H.Y., A.V.S., M.C.), Neurological Clinical Research Institute, Massachusetts General Hospital, Boston; Department of Neurology (L.H.v.d.B., M.A.v.E., J.H.V., B.S.d.V.), Brain Center Rudolf Magnus, University Medical Center Utrecht, University Utrecht, the Netherlands; Department of Neurology (M.H.), Columbia University, New York, NY; Department of Neurology (R.H. Baloh), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (R.H. Brown, N.W., D.M.-Y., M.A.O., C.D.), University of Massachusetts, Worcester; Department of Neurology (J.D.R.), Johns Hopkins University, Baltimore, MD; and Biogen Inc. (A.M., T.F.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946465PMC
October 2019

Longitudinal assessment of interstitial lung disease in single lung transplant recipients with scleroderma.

Rheumatology (Oxford) 2020 04;59(4):790-798

Department of Medicine, Division of Clinical and Molecular Rheumatology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/rheumatology/kez341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188227PMC
April 2020

Breathing Life into Pulmonary Physiology: How Age and Body Weight Impair Oxygenation.

Anesthesiology 2019 Jul;131(1):7-9

From the Department of Medicine (J.T., R.H.B.) Department of Anesthesiology and Critical Care Medicine (R.H.B.) Department of Environmental Health and Engineering (R.H.B.) Department of Radiology (R.H.B.), Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1097/ALN.0000000000002710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586501PMC
July 2019

Nucleic Acid Therapeutics for Neurological Diseases.

Neurotherapeutics 2019 04;16(2):245-247

RNA Therapeutics Institute, UMass Medical School, Worcester, Massachusetts, 01605, USA.

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http://link.springer.com/10.1007/s13311-019-00736-1
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http://dx.doi.org/10.1007/s13311-019-00736-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554381PMC
April 2019

Safe and effective superoxide dismutase 1 silencing using artificial microRNA in macaques.

Sci Transl Med 2018 10;10(465)

Horae Gene Therapy Center, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aau6414DOI Listing
October 2018

Current Advances in COPD Imaging.

Acad Radiol 2019 03 6;26(3):335-343. Epub 2018 Aug 6.

Johns Hopkins University, Department of Anesthesiology and Critical Care Medicine, Medicine, Department of Medicine, Division of Pulmonary Medicine, Department of Environmental Health and Engineering, and Department of Radiology, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.acra.2018.05.023DOI Listing
March 2019

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A 2018 08 23;115(32):8209-8214. Epub 2018 Jul 23.

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile 8380453;

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http://dx.doi.org/10.1073/pnas.1801109115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094144PMC
August 2018

Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis.

Exp Neurol 2019 01 18;311:305-312. Epub 2018 Jul 18.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263852PMC
January 2019

Cortical Spreading Depression Denotes Concussion Injury.

J Neurotrauma 2019 04 24;36(7):1008-1017. Epub 2018 Aug 24.

1 Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts.

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https://www.liebertpub.com/doi/10.1089/neu.2018.5844
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http://dx.doi.org/10.1089/neu.2018.5844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444888PMC
April 2019

Finding a Treatment for ALS - Will Gene Editing Cut It?

N Engl J Med 2018 Apr;378(15):1454-1456

From King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology, and Neuroscience, De Crespigny Park, and King's College Hospital, Denmark Hill - both in London (A.A.-C.); and the Department of Neurology, University of Massachusetts Medical School, Worcester (R.H.B.).

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http://dx.doi.org/10.1056/NEJMcibr1716741DOI Listing
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Admission Criteria for Children With Obstructive Sleep Apnea After Adenotonsillectomy: Considerations for Cost.

J Clin Sleep Med 2017 12 15;13(12):1463-1472. Epub 2017 Dec 15.

Department of Anesthesiology, Division of Pediatric Anesthesia and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://jcsm.aasm.org/ViewAbstract.aspx?pid=31143
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http://dx.doi.org/10.5664/jcsm.6850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695994PMC
December 2017

Amyotrophic Lateral Sclerosis.

N Engl J Med 2017 10;377(16):1602

King’s College London, London, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1710379DOI Listing
October 2017

Reproducibility of airway luminal size in asthma measured by HRCT.

J Appl Physiol (1985) 2017 Oct 13;123(4):876-883. Epub 2017 Jul 13.

Division of Pulmonary Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1152/japplphysiol.00307.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668456PMC
October 2017

Amyotrophic Lateral Sclerosis.

N Engl J Med 2017 07;377(2):162-172

From the Department of Neurology, University of Massachusetts Medical School, Worcester (R.H.B.); and the Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London (A.A.-C.).

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http://dx.doi.org/10.1056/NEJMra1603471DOI Listing
July 2017

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.

Mol Neurodegener 2017 06 12;12(1):46. Epub 2017 Jun 12.

Department of Psychiatry & Behavioral Sciences, Center for Therapeutic Innovation, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB-413, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1186/s13024-017-0185-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468954PMC
June 2017

Poly(GP) proteins are a useful pharmacodynamic marker for -associated amyotrophic lateral sclerosis.

Sci Transl Med 2017 03;9(383)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1126/scitranslmed.aai7866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576451PMC
March 2017

Genetics of Amyotrophic Lateral Sclerosis.

Cold Spring Harb Perspect Med 2018 05 1;8(5). Epub 2018 May 1.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a024125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932579PMC
May 2018

David A. Drachman, MD (1932-2016).

Neurology 2017 03;88(10):928-929

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http://dx.doi.org/10.1212/WNL.0000000000003757DOI Listing
March 2017

A Handoffs Software Led to Fewer Errors of Omission and Better Provider Satisfaction: A Randomized Control Trial.

J Patient Saf 2020 Sep;16(3):194-198

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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http://dx.doi.org/10.1097/PTS.0000000000000340DOI Listing
September 2020

Further analysis of KIFAP3 gene in ALS patients from Switzerland and Sweden.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 31;18(3-4):302-304. Epub 2017 Jan 31.

b Department of Neurology , University of Massachusetts Medical School , Worcester , MA , USA.

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http://dx.doi.org/10.1080/21678421.2017.1280509DOI Listing
May 2017

HIV Infection Is Independently Associated with Increased CT Scan Lung Density.

Acad Radiol 2017 02 18;24(2):137-145. Epub 2016 Nov 18.

Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Department of Radiology, Johns Hopkins University, Baltimore, Maryland; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.acra.2016.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237394PMC
February 2017

Decoding ALS: from genes to mechanism.

Nature 2016 Nov;539(7628):197-206

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature20413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585017PMC
November 2016

Effects of Obesity and Leptin Deficiency on Morphine Pharmacokinetics in a Mouse Model.

Anesth Analg 2016 12;123(6):1611-1617

From the *Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland; †Department of Otolaryngology/ Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland; ‡Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland; §Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; ‖Department of Pharmacy, and Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland ¶Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland; and #Department of Anesthesiology, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1213/ANE.0000000000001578DOI Listing
December 2016

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.

Proc Natl Acad Sci U S A 2016 10 28;113(41):E6209-E6218. Epub 2016 Sep 28.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605; Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605; Neuroscience Program, University of Massachusetts Medical School, Worcester, MA 01605

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http://dx.doi.org/10.1073/pnas.1605964113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068285PMC
October 2016

Bronchial Artery Angiogenesis Drives Lung Tumor Growth.

Cancer Res 2016 10 28;76(20):5962-5969. Epub 2016 Aug 28.

Departments of Medicine and Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065771PMC
http://dx.doi.org/10.1158/0008-5472.CAN-16-1131DOI Listing
October 2016

Silencing strategies for therapy of SOD1-mediated ALS.

Neurosci Lett 2017 01 6;636:32-39. Epub 2016 Aug 6.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2016.07.059DOI Listing
January 2017

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Pulmonary Hypertension and the Quantification of Lung Density on Chest CT: "I Know It When I See It.".

Authors:
Robert H Brown

Acad Radiol 2016 08 11;23(8):933-4. Epub 2016 Jun 11.

Departments of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 615 N Wolfe St, Baltimore, MD; Department of Radiology, The Johns Hopkins Medical Institutions, 615 N Wolfe St, Baltimore, MD; Department of Medicine, Division of Pulmonary Medicine, The Johns Hopkins Medical Institutions, 615 N Wolfe St, Baltimore, MD; Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Room E7614, 615 N Wolfe St, Baltimore, MD 21205. Electronic address:

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http://dx.doi.org/10.1016/j.acra.2016.05.006DOI Listing
August 2016

Erratum to: Mutant SOD1 protein increases Na1.3 channel excitability.

J Biol Phys 2016 06;42(3):371

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1007/s10867-016-9421-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942426PMC
June 2016

Measurement of intraindividual airway tone heterogeneity and its importance in asthma.

J Appl Physiol (1985) 2016 07 21;121(1):223-32. Epub 2016 Apr 21.

Department of Medicine, Divisions of Allergy and Clinical Immunology and Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1152/japplphysiol.00545.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967252PMC
July 2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Nat Commun 2016 Apr 15;7:11253. Epub 2016 Apr 15.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1038/ncomms11253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835537PMC
April 2016

Mutant SOD1 protein increases Nav1.3 channel excitability.

J Biol Phys 2016 06 12;42(3):351-70. Epub 2016 Apr 12.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1007/s10867-016-9411-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942418PMC
June 2016

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.

Brain 2016 Apr 11;139(Pt 4):1094-105. Epub 2016 Feb 11.

1 Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1093/brain/aww001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006226PMC
April 2016

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.

Neurology 2016 Apr 24;86(16):1474-81. Epub 2016 Feb 24.

From the Department of Neurology (M.D.W., J.B.D.), University of Washington Medical Center, Seattle; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Neurology (Z.S.), Penn State Hershey Medical Center, Hershey, PA; Department of Neurology (A.S.K., N.A., M.E.C.), Neurological Clinical Research Institute, Massachusetts General Hospital, Boston; Program in Pharmacology and Experimental Therapeutics (D.J.G.), Tufts University School of Medicine, Boston, MA; Department of Neurology (M.G., N.P.), UCLA Medical Center, Los Angeles, CA; Department of Neurology (J.S.S., C.Q., R.H.B.), University of Massachusetts Memorial Medical Center, Worcester; Department of Neurology (J.T.), University of Texas Southwestern Medical Center, Dallas; Department of Neurology (J.M.S.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (R.J.B.), University of Kansas Medical Center, Kansas City; Department of Neurology (A.P.), Washington University Medical Center, St. Louis, MO; and Department of Neurology (A.S.), University of Iowa Hospitals and Clinics, Iowa City.

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http://dx.doi.org/10.1212/WNL.0000000000002507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836879PMC
April 2016

ALS-linked protein disulfide isomerase variants cause motor dysfunction.

EMBO J 2016 Apr 11;35(8):845-65. Epub 2016 Feb 11.

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile Center for Geroscience, Brain Health and Metabolism, Santiago, Chile Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA

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http://dx.doi.org/10.15252/embj.201592224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972141PMC
April 2016

Lung Density in Extremely Large Healthy Lungs.

Chest 2016 Jan 6;149(1):291-2. Epub 2016 Jan 6.

Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1016/j.chest.2015.10.060DOI Listing
January 2016

Amyotrophic Lateral Sclerosis: Review.

Semin Neurol 2015 Aug 6;35(4):469-76. Epub 2015 Oct 6.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0035-1558984DOI Listing
August 2015

Endogenous retroviruses in ALS: A reawakening?

Sci Transl Med 2015 Sep;7(307):307fs40

Wohl Clinical Neuroscience Institute, King's College London and NIHR Dementia Biomedical Research Unit, London SE5 9RX, UK.

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http://stm.sciencemag.org/content/scitransmed/7/307/307fs40.
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.aad35
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http://dx.doi.org/10.1126/scitranslmed.aad3533DOI Listing
September 2015

Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.

Respir Res 2015 Sep 15;16:106. Epub 2015 Sep 15.

Lewis B. and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/s12931-015-0253-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570035PMC
September 2015

A phase 3, multicenter, randomized, double-blind, placebo-controlled, safety, tolerability, and efficacy study of Xtampza ER in patients with moderate-to-severe chronic low back pain.

Pain 2015 Dec;156(12):2458-67

aAnalgesic Solutions, Natick, MA, USA bTufts University School of Medicine, Department of Anesthesiology, Boston, MA, USA cCollegium Pharmaceutical, Inc, Department of Clinical Development - Neuroscience, Canton, MA, USA dINC Research, LLC, Biostatistics, Hendersonville, NC, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/j.pain.0000000000000315DOI Listing
December 2015

Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.

Curr Biol 2015 Aug 30;25(16):2130-6. Epub 2015 Jul 30.

Howard Hughes Medical Institute and Department of Neurobiology, LRB-740A1, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01655, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546534PMC
August 2015

Lung density changes with growth and inflation.

Chest 2015 Oct;148(4):995-1002

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD; Environmental Health Sciences, Division of Physiology, Johns Hopkins University, Baltimore, MD.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692155028
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http://dx.doi.org/10.1378/chest.15-0264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594629PMC
October 2015

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS.

Neurobiol Aging 2015 Mar 31;36(3):1602.e17-27. Epub 2014 Oct 31.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357530PMC
March 2015

A novel dysferlin mutant pseudoexon bypassed with antisense oligonucleotides.

Ann Clin Transl Neurol 2014 Sep 27;1(9):703-20. Epub 2014 Sep 27.

Neurology Department, University of Massachusetts Medical School Worcester, Massachusetts, 01605.

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http://dx.doi.org/10.1002/acn3.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241797PMC
September 2014

Groundhog day: airway narrowing, deep inspirations, and asthma.

Authors:
Robert H Brown

Am J Respir Crit Care Med 2014 Oct;190(8):847-8

1 Department of Anesthesiology and Critical Care Medicine Department of Environmental Health Sciences Department of Medicine, Division of Pulmonary and Critical Care Medicine and Department of Radiology Johns Hopkins Medical Institutions Baltimore, Maryland.

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http://dx.doi.org/10.1164/rccm.201409-1651EDDOI Listing
October 2014

Natural history and biomarkers in hereditary sensory neuropathy type 1.

Muscle Nerve 2015 Apr 11;51(4):489-95. Epub 2015 Feb 11.

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, USA.

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http://doi.wiley.com/10.1002/mus.24336
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http://dx.doi.org/10.1002/mus.24336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484799PMC
April 2015

Obesity and asthma: "What we've got here is failure to communicate".

Authors:
Robert H Brown

Am J Respir Crit Care Med 2014 Jun;189(12):i-ii

1 Departments of Anesthesiology, Medicine, Environmental Health Sciences, and Radiology The Johns Hopkins University Baltimore, Maryland.

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http://dx.doi.org/10.1164/rccm.201405-0989EDDOI Listing
June 2014

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Cell Stem Cell 2014 Jun 3;14(6):781-95. Epub 2014 Apr 3.

The Howard Hughes Medical Institute, USA; Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653065PMC
June 2014

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Cell Rep 2014 Apr 3;7(1):1-11. Epub 2014 Apr 3.

FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023477PMC
April 2014

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):E1121-9. Epub 2014 Mar 10.

Departments of Biochemistry and Molecular Pharmacology, Neurology, Pathology, and Cell Biology, RNA Therapeutic Institute, Howard Hughes Medical Institute, and Neuroscience Program, University of Massachusetts Medical School, Worcester, MA 01605.

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http://dx.doi.org/10.1073/pnas.1322641111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970502PMC
March 2014

Introduction to a special edition of Annals: Therapeutic prospects.

Ann Neurol 2013 Sep;74(3):A15

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http://dx.doi.org/10.1002/ana.24021DOI Listing
September 2013