Robert G Roeder

Robert G Roeder

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Robert G Roeder

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50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms.

Authors:
Robert G Roeder

Nat Struct Mol Biol 2019 Sep 22;26(9):783-791. Epub 2019 Aug 22.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/s41594-019-0287-xDOI Listing
September 2019

AID-RNA polymerase II transcription-dependent deamination of IgV DNA.

Nucleic Acids Res 2019 Sep 30. Epub 2019 Sep 30.

Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1093/nar/gkz821DOI Listing
September 2019

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Mol Cell 2019 Aug 6;75(4):683-699.e7. Epub 2019 Aug 6.

The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.06.034DOI Listing
August 2019

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.

Leukemia 2019 07 12;33(7):1822-1827. Epub 2019 Feb 12.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/s41375-019-0398-8DOI Listing
July 2019

PML-RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1.

Transcription 2019 06 5;10(3):147-156. Epub 2019 Jun 5.

a Laboratory of Hematology, Division of Medical Biophysics , Kobe University Graduate School of Health Sciences , Kobe , Japan.

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http://dx.doi.org/10.1080/21541264.2019.1624467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619921PMC
June 2019

Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway.

Mol Cell 2019 04 19;74(2):268-283.e5. Epub 2019 Mar 19.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598686PMC
April 2019

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.

Proc Natl Acad Sci U S A 2019 01 28;116(3):890-899. Epub 2018 Dec 28.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;

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http://dx.doi.org/10.1073/pnas.1809327116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338862PMC
January 2019

Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control.

Cell Rep 2019 Jan;26(5):1303-1317.e7

Laboratory of Transcription Biology, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja, S.C. Mullick Road, Kolkata 32, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193002
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http://dx.doi.org/10.1016/j.celrep.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368250PMC
January 2019

Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.

Proc Natl Acad Sci U S A 2018 10 17;115(40):9998-10003. Epub 2018 Sep 17.

Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, 100875 Beijing, China;

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http://dx.doi.org/10.1073/pnas.1812256115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176576PMC
October 2018

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.

Nucleic Acids Res 2018 09;46(15):7716-7730

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.1093/nar/gky568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125638PMC
September 2018

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Nat Struct Mol Biol 2018 09 6;25(9):859-867. Epub 2018 Sep 6.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41594-018-0118-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298426PMC
September 2018

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Mol Cell 2018 05;70(4):663-678.e6

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029451PMC
May 2018

Inhibition of Adhesion Molecule Gene Expression and Cell Adhesion by the Metabolic Regulator PGC-1α.

PLoS One 2016 16;11(12):e0165598. Epub 2016 Dec 16.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165598PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161318PMC
July 2017

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.

Nature 2017 03 15;543(7646):568-572. Epub 2017 Mar 15.

Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, 1230 York Ave, Box 186, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature21690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488729PMC
March 2017

Control of Secreted Protein Gene Expression and the Mammalian Secretome by the Metabolic Regulator PGC-1α.

J Biol Chem 2017 Jan 1;292(1):43-50. Epub 2016 Dec 1.

From the Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065

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http://dx.doi.org/10.1074/jbc.C116.761049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217698PMC
January 2017

Mediator: A Drawbridge across the Enhancer-Promoter Divide.

Mol Cell 2016 11;64(3):433-434

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2016.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114138PMC
November 2016

Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro.

Biochem Biophys Res Commun 2016 09 3;478(4):1706-12. Epub 2016 Sep 3.

Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Research Organization for Nano & Life Innovation, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 159-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808943PMC
September 2016

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.

Mol Cell 2016 04;62(2):181-193

MOE Key Laboratory of Protein Sciences, Department of Basic Medical Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Beijing 100084, PRC; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, PRC; Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841940PMC
April 2016

The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.

EMBO J 2015 Dec 1;34(23):2885-902. Epub 2015 Sep 1.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences, Shanghai, China

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http://dx.doi.org/10.15252/embj.201591279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687689PMC
December 2015

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.

Science 2015 Dec;350(6266):1383-6

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aad2338DOI Listing
December 2015

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α.

Proc Natl Acad Sci U S A 2015 Oct 5;112(42):E5669-78. Epub 2015 Oct 5.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065

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http://dx.doi.org/10.1073/pnas.1516219112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620912PMC
October 2015

JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.

Genes Dev 2015 Oct;29(20):2123-39

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.267278.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617977PMC
October 2015

Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):10365-70. Epub 2015 Aug 3.

Department of Chemistry, Princeton University, Princeton, NJ 08544;

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http://dx.doi.org/10.1073/pnas.1504483112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547310PMC
August 2015

Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.

Mol Cell 2015 04 26;58(2):203-15. Epub 2015 Mar 26.

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501262PMC
April 2015

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.

Genes Dev 2015 Feb;29(3):308-21

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.252809.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318147PMC
February 2015

Chromatin and transcriptional tango on the immune dance floor.

Front Immunol 2014 15;5:631. Epub 2014 Dec 15.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University , New York, NY , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266087PMC
January 2015

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.

Nat Struct Mol Biol 2014 Dec 10;21(12):1028-34. Epub 2014 Nov 10.

Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259101PMC
December 2014

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

Cancer Cell 2014 Dec 20;26(6):896-908. Epub 2014 Nov 20.

Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA; Department of Pediatrics and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291116PMC
December 2014

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

Proc Natl Acad Sci U S A 2014 Jul 9;111(29):10684-9. Epub 2014 Jul 9.

Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;Center for Life Sciences, Peking-Tsinghua University, Beijing 100871, China

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http://www.pnas.org/cgi/doi/10.1073/pnas.1411026111
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http://dx.doi.org/10.1073/pnas.1411026111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115576PMC
July 2014

CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function.

Genes Cells 2014 Jan 19;19(1):28-51. Epub 2013 Nov 19.

Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Kobe, 654-0142, Japan.

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http://dx.doi.org/10.1111/gtc.12104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388278PMC
January 2014

Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.

Cell Rep 2013 Dec 19;5(6):1690-703. Epub 2013 Dec 19.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA. Electronic address:

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http://www.cell.com/cms/attachment/2035054537/2050361449/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471300722
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http://dx.doi.org/10.1016/j.celrep.2013.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901356PMC
December 2013

Biochemistry. Have your PIC!

Science 2013 Nov;342(6159):706-7

Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1246170DOI Listing
November 2013

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.

Nat Struct Mol Biol 2013 Oct 1;20(10):1156-63. Epub 2013 Sep 1.

1] Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York, USA. [2] Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA. [3] UAB Stem Cell Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA. [4].

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http://dx.doi.org/10.1038/nsmb.2656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813012PMC
October 2013

FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro.

Biochem Biophys Res Commun 2013 Oct 16;440(1):125-31. Epub 2013 Sep 16.

Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.09.044DOI Listing
October 2013

Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.

Biochem Biophys Res Commun 2013 Oct 18;440(1):184-9. Epub 2013 Sep 18.

Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.09.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388257PMC
October 2013

H3R42me2a is a histone modification with positive transcriptional effects.

Proc Natl Acad Sci U S A 2013 Sep 26;110(37):14894-9. Epub 2013 Aug 26.

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1312925110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773778PMC
September 2013

A TAF4 coactivator function for E proteins that involves enhanced TFIID binding.

Genes Dev 2013 Jul;27(14):1596-609

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.216192.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731548PMC
July 2013

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.

Proc Natl Acad Sci U S A 2013 Mar 14;110(10):3901-6. Epub 2013 Feb 14.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.1301045110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593849PMC
March 2013

The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation.

Mol Cell 2013 Mar 28;49(6):1121-33. Epub 2013 Feb 28.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615140PMC
March 2013

H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation.

Cell 2013 Feb;152(5):1021-36

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2013.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588593PMC
February 2013

Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.

Proc Natl Acad Sci U S A 2012 Dec 10;109(52):21319-24. Epub 2012 Dec 10.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1073/pnas.1218331110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535616PMC
December 2012

A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes.

Transcription 2012 Mar-Apr;3(2):92-104. Epub 2012 Mar 1.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.4161/trns.19783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337830PMC
June 2012

Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.

Mol Cell Biol 2012 Apr 13;32(8):1483-95. Epub 2012 Feb 13.

Laboratory of Hematology, Kobe University Graduate School of Health Sciences, Division of Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://mcb.asm.org/content/early/2012/02/06/MCB.05245-11.ful
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http://mcb.asm.org/cgi/doi/10.1128/MCB.05245-11
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http://dx.doi.org/10.1128/MCB.05245-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318591PMC
April 2012

Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.

Mol Cell Endocrinol 2012 Mar 2;350(1):87-98. Epub 2011 Dec 2.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.mce.2011.11.025DOI Listing
March 2012

Suppression of the antiviral response by an influenza histone mimic.

Nature 2012 Mar 14;483(7390):428-33. Epub 2012 Mar 14.

Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature10892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598589PMC
March 2012

p53 requires an intact C-terminal domain for DNA binding and transactivation.

J Mol Biol 2012 Feb 9;415(5):843-54. Epub 2011 Dec 9.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267882PMC
February 2012

Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription.

Genes Dev 2011 Dec;25(23):2513-24

Department of Biochemistry, University of California at Riverside, Riverside, California 92521, USA.

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http://dx.doi.org/10.1101/gad.177360.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243061PMC
December 2011

Enhancer-promoter communication and transcriptional regulation of Igh.

Trends Immunol 2011 Nov 19;32(11):532-9. Epub 2011 Aug 19.

Program in Immunology, Department of Pathology, Tufts University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.it.2011.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200469PMC
November 2011

GlcNAcylation of histone H2B facilitates its monoubiquitination.

Nature 2011 Nov 27;480(7378):557-60. Epub 2011 Nov 27.

Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1038/nature10656DOI Listing
November 2011

Mediator-dependent nuclear receptor function.

Semin Cell Dev Biol 2011 Sep 10;22(7):749-58. Epub 2011 Aug 10.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10849521110011
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http://dx.doi.org/10.1016/j.semcdb.2011.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207035PMC
September 2011

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.

Proc Natl Acad Sci U S A 2011 Sep 6;108(38):15751-6. Epub 2011 Sep 6.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1111498108
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http://dx.doi.org/10.1073/pnas.1111498108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179097PMC
September 2011

Nucleosomal H2B ubiquitylation with purified factors.

Methods 2011 Jul 3;54(3):331-8. Epub 2011 Apr 3.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ymeth.2011.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118980PMC
July 2011

Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.

Mol Cell 2011 May;42(3):342-55

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105350PMC
May 2011

RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.

Mol Cell 2011 May;42(4):477-88

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.molcel.2011.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099049PMC
May 2011

The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.

J Biol Chem 2011 Apr 11;286(13):10911-7. Epub 2011 Feb 11.

Institute of Molecular Biosciences, Massey University, Palmerston North 4442, New Zealand.

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http://dx.doi.org/10.1074/jbc.C110.210211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064146PMC
April 2011

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

Proc Natl Acad Sci U S A 2011 Feb 18;108(5):1925-30. Epub 2011 Jan 18.

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China.

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http://dx.doi.org/10.1073/pnas.1019619108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033317PMC
February 2011

Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.

Cell 2011 Feb;144(4):513-25

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2011.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572774PMC
February 2011

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation.

Nat Rev Genet 2010 Nov 13;11(11):761-72. Epub 2010 Oct 13.

Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrg2901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217725PMC
November 2010

Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.

Cell Cycle 2010 Sep 1;9(18):3687-99. Epub 2010 Sep 1.

Institut Européen de Chimie et Biologie (I.E.C.B.), Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM) U869, Pessac, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047797PMC
http://dx.doi.org/10.4161/cc.9.18.13203DOI Listing
September 2010

The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression.

Mol Cell Biol 2010 Jun 29;30(11):2750-61. Epub 2010 Mar 29.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1128/MCB.00804-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876518PMC
June 2010

A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism.

Proc Natl Acad Sci U S A 2010 Jun 17;107(22):10196-201. Epub 2010 May 17.

Laboratories of Biochemistry and Molecular Biology and Molecular Genetics, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1005626107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890439PMC
June 2010

MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.

Mol Cell Biol 2010 May 1;30(9):2155-69. Epub 2010 Mar 1.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.

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http://dx.doi.org/10.1128/MCB.01238-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863581PMC
May 2010

Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation.

Proc Natl Acad Sci U S A 2010 Apr 29;107(15):6765-70. Epub 2010 Mar 29.

Department of Cancer and Cell Biology, College of Medicine, University of Cincinnati, 3125 Eden Avenue, OH 45267, USA.

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http://dx.doi.org/10.1073/pnas.1001814107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872411PMC
April 2010

Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.

Proc Natl Acad Sci U S A 2010 Mar 12;107(9):4176-81. Epub 2010 Feb 12.

Institut Européen de Chimie et Biologie/ Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale U869, 33607 Pessac, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0914980107
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http://dx.doi.org/10.1073/pnas.0914980107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840155PMC
March 2010

Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene.

Mol Cell 2009 Sep;35(6):755-68

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217464PMC
September 2009

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast.

J Biol Chem 2009 Jul 15;284(31):20582-92. Epub 2009 Jun 15.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M109.017442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742823PMC
July 2009

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

Nature 2009 May 19;459(7245):455-9. Epub 2009 Apr 19.

Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1038/nature07954DOI Listing
May 2009

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

Proc Natl Acad Sci U S A 2009 May 11;106(21):8513-8. Epub 2009 May 11.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0902873106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689008PMC
May 2009