Robert G Hart

Robert G Hart

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Stroke Outcomes in the COMPASS Trial.

Circulation 2019 Feb;139(9):1134-1145

McMaster University/Population Health Research Institute, Hamilton, Canada (M.S., R.G.H., S.J.C., J.B., O.S., K.K.H.N., L.C., S.Y., J.W.E.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035864DOI Listing
February 2019

Atrial Fibrillation and Cognitive Function: JACC Review Topic of the Week.

J Am Coll Cardiol 2019 Feb;73(5):612-619

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183934
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http://dx.doi.org/10.1016/j.jacc.2018.10.077DOI Listing
February 2019

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.

N Engl J Med 2018 09;379(10):987

Bayer, Wuppertal, Germany

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http://dx.doi.org/10.1056/NEJMc1809065DOI Listing
September 2018

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.

N Engl J Med 2018 Jun 16;378(23):2191-2201. Epub 2018 May 16.

From the Departments of Medicine-Neurology (R.G.H., M.S., A.S.), Health Research Methods, Evidence, and Impact (S.I.B.), Pathology and Molecular Medicine (G. Pare), and Medicine-Cardiology (S.J.C.), Population Health Research Institute (B.S., P.S., E.T.), and the Thrombosis and Atherosclerosis Research Institute and McMaster University (J.I.W.), Hamilton, ON, the Vancouver Stroke Program, University of British Columbia, Vancouver (O.R.B.), and Sunnybrook Health Sciences Centre, University of Toronto, Toronto (C.J.) - all in Canada; Bayer, Wuppertal (H.M.), Klinik für Neurologie, Charité-Universitätsmedizin Berlin (M.E.), and Bayer (B.K.), Berlin, and Bayer, Leverkusen (C.P.) - all in Germany; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.), and Janssen Research and Development, Spring House (G. Peters) - both in Pennsylvania; Bayer U.S., Pharmaceuticals Clinical Development Thrombosis, Whippany, NJ (S.D.B.); Clínica Alemana de Santiago, Santiago, Chile (P.L.); the Department of Neurology and Stroke Center, Beijing Tiantan Hospital, Beijing (Yongjun Wang, Yilong Wang); Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona (A.D.); Pirogov Russian National Research Medical University, Moscow (N.S.); International Clinical Research Center and Neurology Department, St. Anne's University Hospital, Brno, Czech Republic (R.M.); Centro Hospitalar e Universitário de Coimbra, Hospitais da Universidade de Coimbra, Coimbra, Portugal (L.C.); the Department of Clinical Sciences (Neurology), Lund University, and the Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund (A.L.), and the Department of Clinical Neuroscience-Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg (T.T.) - all in Sweden; Instituto Nacional de Neurología y Neurocirugía, Mexico City (A.A.); Hospital St. John of God, Sigmund Freud Private University, Medical Faculty, Vienna (W.L.); the 2nd Department of Neurology, Institute of Psychiatry and Neurology, and the Department of Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); the Department of Internal Medicine, University Hospital Basel, Basel, Switzerland (J.E.); Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo (R.J.G.); Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris-Diderot, Sorbonne Paris Cité University, Paris (P.A.); Institute for Neurological Research-Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia, Buenos Aires (S.F.A.); the Department of Neurology, Helsinki University Central Hospital, Helsinki (T.T.); Imperial College London, London (R.V.); Medical School, University of Western Australia, and Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); the Department of Human Neurosciences, Sapienza University of Rome, Rome (D.T.); the Department of Neurology, Semmelweis University, Budapest, Hungary (D.B.); International University of Health and Welfare, Sanno Hospital and Sanno Medical Center, Tokyo (S.U.); the Department of Medicine, University of Thessaly, Larissa, Greece (G.N.); Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea (B.-W.Y.); the Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels (R.B.); the Department of Neurology, ZorgSaam Hospital, Terneuzen, the Netherlands (R.B.); Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom (K.W.M.); Shaare Zedek Medical Center, Jerusalem (N.B.); the Department of Neurology, Selcuk University, Konya, Turkey (S.O.); Health Research Board Clinical Research Facility, National University of Ireland, Galway (M.J.O.); Tiervlei Trial Centre and Head of Internal Medicine Karl Bremer Hospital, Bellville, South Africa (M.M.D.V.B.); and Baylor College of Medicine, Houston (W.F.P.).

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http://dx.doi.org/10.1056/NEJMoa1802686DOI Listing
June 2018

Frequency and features of embolic stroke of undetermined source in young adults.

Eur Stroke J 2018 Jun 24;3(2):110-116. Epub 2018 Jan 24.

1Department of Medicine (Neurology), Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1177/2396987318755585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460410PMC
June 2018

Predictors of Mortality in Patients With Atrial Fibrillation (from the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE A]).

Am J Cardiol 2018 03 11;121(5):584-589. Epub 2017 Dec 11.

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2017.11.028DOI Listing
March 2018

Should Patients With Ischemic Stroke or Transient Ischemic Attack With Atrial Fibrillation and Microbleeds Be Anticoagulated?

Stroke 2017 12 7;48(12):3408-3412. Epub 2017 Nov 7.

From the Department of Medicine, Division of Neurology, McMaster University, Hamilton, Ontario, Canada (A.S., M.S., R.G.H.); Stroke and Cognition Program, Population Health Research Institute, Hamilton, Ontario, Canada (A.S., M.S., R.G.H.); and Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston (A.C.).

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http://dx.doi.org/10.1161/STROKEAHA.117.018467DOI Listing
December 2017

Embolic Stroke.

Circulation 2017 12;136(25):2403-2405

Department of Medicine (Neurology), Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (R.G.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030509DOI Listing
December 2017

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.

N Engl J Med 2017 10 27;377(14):1319-1330. Epub 2017 Aug 27.

From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON (J.W.E., S.J.C., J.B., R.G.H., O.S., E.M.L., S.S.A., D.L., S.Y.), and Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC (G.R.D.) - both in Canada; Estudios Clínicos Latino América and Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.); Amphia Ziekenhuis and Werkgroep Cardiologische Centra Nederland (WCN), Utrecht, the Netherlands (M.A.); Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W.); Osaka International Cancer Institute, Osaka, Japan (M.H.); Instituto Dante Pazzanese de Cardiologia (A.A.), and Hospital do Coração (L.S.P.), São Paulo; University of Washington Medical Center (K.R.H.B.) and University of Washington (J.P.), Seattle; Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston (D.L.B.); FuWai Hospital, Beijing (J.Z., Y.L.); National Association of Hospital Cardiologists Research Center (ANMCO), Florence, Italy (A.P.M.); Research Institute, Fundación Oftalmológica de Santander (FOSCAL)-Bucaramanga, Bucaramanga, Colombia (P.L.-J.); National University of Ireland, Galway (M.O.); Thrombosis Research Institute and University College London, London (A.K.K.), Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.), and University of Glasgow, Glasgow (T.J.G.) - all in the United Kingdom; Collegium Medicum Jagiellonian University, Krakow, Poland (T.J.G); Institute of Cardiology, Kiev, Ukraine (A.N.P.); University of Würzburg and University Hospital, Würzburg (G.E., S.S.), and Bayer, Leverkusen (N.C.B., F.M., E.C.) - all in Germany; Semmelweis University, Budapest, Hungary (M.K.); Karolinska Institutet, Stockholm (L.R.); National Research Center for Preventative Medicine, Moscow (N.P.); University of Philippines, Manila (A.L.D.); Universidad de La Frontera, Temuco, Chile (F.L.); University of Cape Town, Cape Town, South Africa (P.J.C.); University of Aalborg, Copenhagen (C.T.-P.); University of Leuven, Leuven, Belgium (P.B.V.); University of Medicine and Pharmacology, Carol Davila University and Emergency Hospital, Bucharest, Romania (D.V.); Catholic University of Korea, Seoul, South Korea (J.-H.K.); Monash University, Melbourne, VIC, Australia (A.M.T.); Lady Davis Carmel Medical Center, Haifa, Israel (B.S.L.); Facultad de Ciencias de la Salud Eugenio Espejo-Universidad Tecnológica Equinoccial, Quito, Ecuador (C.F.); Universiti Teknologi Mara, Selangor, Malaysia (K.Y.); Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris (P.G.S.); and Turku University Central Hospital and Turku University, Turku, Finland (K.P.M.).

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http://dx.doi.org/10.1056/NEJMoa1709118DOI Listing
October 2017

Embolic Stroke of Undetermined Source: A Systematic Review and Clinical Update.

Stroke 2017 04 6;48(4):867-872. Epub 2017 Mar 6.

From the Department of Medicine (Neurology) (R.G.H., L.C., K.S.P.), Population Health Research Institute and Department of Medicine (Cardiology) (S.J.C.), McMaster University, Hamilton Health Sciences, Ontario, Canada; Department of Medicine, Larissa University Hospital, University of Thessaly, Larissa, Greece (G.N.).

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http://dx.doi.org/10.1161/STROKEAHA.116.016414DOI Listing
April 2017

Which Patients With Atrial Fibrillation and Chronic Kidney Disease Should Receive Anticoagulation-And With Which Anticoagulant?

Can J Cardiol 2017 02 17;33(2):211-213. Epub 2016 Oct 17.

Thrombosis Division, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.10.007DOI Listing
February 2017

Is There a Role for Betrixaban to Prevent Stroke in Medically Ill Patients?

Circulation 2017 02;135(7):656-658

From Department of Radiology, Kings College Hospital, London, United Kingdom (D.J.Q.); and Population Health Research Institute, Hamilton Health Sciences and Department of Medicine, McMaster University, Ontario, Canada (J.W.E., R.G.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026170DOI Listing
February 2017

Stroke prevention in asymptomatic carotid artery disease: revascularization of carotid stenosis is not the solution.

Pol Arch Med Wewn 2015 17;125(5):363-9. Epub 2015 Apr 17.

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January 2017

Global Survey of the Frequency of Atrial Fibrillation-Associated Stroke: Embolic Stroke of Undetermined Source Global Registry.

Stroke 2016 09 9;47(9):2197-202. Epub 2016 Aug 9.

From the Population Health Research Institute, McMaster University, Hamilton Health Sciences, Ontario, Canada (K.S.P., J.B., B.S., M.G., S.J.C., R.G.H.); Department of Cardiovascular Sciences, University of Leuven, Belgium (T.V.); Bayer-Pharma AG, Wuppertal, Germany (H.M.); Instituto Nacional de Neurologia y Neurocirugia, Mexico D.F., Mexico (M.A.B.); University of Galway, Ireland (M.J.O.); Institute for Neurological Research, Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia (FLENI), Buenos Aires, Argentina (M.G.-S.); School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Department of Neurology, Seoul National University Hospital, Korea (B.-W.Y.); Medical City Hospital, Manila, Philippines (A.R.); Department of Neurology, Bichat Hospital, Paris, France (P.L.); Centro Hospitalar e Universitário de Coimbra, Portugal (J.S.-F.); Pirogov Russian National Research Medical University, Moscow, Russia (N.S.); Universitair Ziekenhuis Brussel, Belgium (R.B.); Santa Casa de São Paulo, Medical School, Brazil (R.J.G.); Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia (S.E.K.); Emergency Department Stroke Unit, Hospital Policlinico Umberto I, Department of Neurology and Psychiatry, 'Sapienza' University, Rome, Italy (A.P.); Department of Neurology, University Hospital Heidelberg, Germany (P.V.); Department of Neurology, Tokyo Women's Medical University, Japan (K.K.); Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (Y.W.); Institute of Neuroscience & Psychology, University of Glasgow, Queen Elizabeth University Hospital, United Kingdom (K.M.); and Academic Medical Center, Amsterdam, the Netherlands (J.M.C.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013378DOI Listing
September 2016

Antithrombotic Treatments for Stroke Prevention in Elderly Patients With Nonvalvular Atrial Fibrillation: Drugs and Doses.

Can J Cardiol 2016 09 14;32(9):1108-16. Epub 2016 Jun 14.

McMaster University Hamilton Health Sciences, Population Health Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2016.06.003DOI Listing
September 2016

Stroke: How good is aspirin for patients with acute brain ischaemia?

Nat Rev Neurol 2016 08 8;12(8):434-5. Epub 2016 Jul 8.

Department of Medicine, McMaster University/Population Health Research Institute, Hamilton General Hospital/DBCVSRI C4-105, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada.

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http://dx.doi.org/10.1038/nrneurol.2016.97DOI Listing
August 2016

Effect of apixaban on brain infarction and microbleeds: AVERROES-MRI assessment study.

Am Heart J 2016 Aug 17;178:145-50. Epub 2016 Apr 17.

Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.ahj.2016.03.019DOI Listing
August 2016

Rapid reversal of haematoma expansion associated with vitamin K antagonists.

Lancet Neurol 2016 05 11;15(6):535-7. Epub 2016 Apr 11.

Population Health Research Institute, Hamilton Health Sciences and McMaster University, Ontario, Canada.

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http://dx.doi.org/10.1016/S1474-4422(16)30008-4DOI Listing
May 2016

Use of Warfarin at Discharge Among Acute Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation in China.

Stroke 2016 Feb 22;47(2):464-70. Epub 2015 Dec 22.

From the Department of Neurology (X.Y., Z.L., Chunjuan Wang, Y.P., H.L., Yilong Wang, Yongjun Wang, X.Z., L.L.), Tiantan Clinical Trial and Research Center for Stroke (Z.L., C.W., Y.P., H.L., Yilong Wang, Yongjun Wang), Division of Vascular Neurology (X.Z., Yongjun Wang), Neuro-intensive Care Unit (L.L.), and Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology (Chunxue Wang), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Cerebrovascular Disease, China National Clinical Research Center for Neurological Diseases, Beijing, China (Z.L., X.Z., L.L., Chunxue Wang, H.L., Y.W., Y.W.); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Chunjuan Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Y.P.); Illinois Neurological Institute Stroke Network, Sisters of the Third Order of St Francis Healthcare System, University of Illinois College of Medicine, Peoria (D.W.); and Department of Medicine, Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada (R.G.H.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011833DOI Listing
February 2016

Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial.

Hypertension 2016 Jan 9;67(1):63-9. Epub 2015 Nov 9.

From the School of Biological and Population Health Sciences, Oregon State University, Corvallis (M.C.O.); Department of Biostatistics, University of Alabama at Birmingham (L.A.M.); Division of Nephrology, Department of Internal Medicine, Bone and Mineral Metabolism, University of Kentucky, Lexington (B.P.S.); Department of Health Restoration and Care Systems Management, School of Nursing, University of Texas Health Science Center, San Antonio (C.L.W.); Department of Medicine, University of California, San Francisco (C.A.P.); Center for Brain Health, Department of Medicine, University of British Columbia, Vancouver, Canada (T.S.F., O.R.B.); Population Health Research Institute, Hamilton, CA (R.G.H.); and Renal Associates PA, San Antonio, TX (P.E.P.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679688PMC
January 2016

Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial.

Age Ageing 2016 Jan 19;45(1):77-83. Epub 2015 Nov 19.

Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1093/ageing/afv156DOI Listing
January 2016

Global survey of the diagnostic evaluation and management of cryptogenic ischemic stroke.

Int J Stroke 2015 Oct 18;10(7):1031-6. Epub 2015 May 18.

Population Health Research Institute, Department of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/ijs.12509DOI Listing
October 2015

Rapid Assessment and Treatment of Transient Ischemic Attacks and Minor Stroke in Canadian Emergency Departments: Time for a Paradigm Shift.

Stroke 2015 Oct 27;46(10):2987-90. Epub 2015 Aug 27.

From the Departments of Clinical Neurosciences (N.K., M.D.H., A.M.D., S.B.C., M.G.), Emergency Medicine (E.L.), and Radiology (M.G.), Cumming School of Medicine, University of Calgary, Foothills Medical Centre, Calgary, AB; Department of Medicine, Dalhousie University (New Brunswick), Horizon Health Network, Saint John Regional Hospital, Saint John, NB (D.P.V.B.); Department of Neurology, Sherbrooke University, Charles-LeMoyne Hospital, Greenfield Park, QC (J.-M.B.); Department of Medicine (Neurology) (K.B., D.J.G.), University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON; Division of Neurology, Department of Medicine (B.B., K.B., T.J., K.K., A.S.), University of Alberta, University of Alberta Hospital, Edmonton, AB; Neurologue Spécialisée en Maladies Vasculaires Cérébrales, Centre Hospitalier Affilié Universitaire de Québec, Hôpital de l'Enfant-Jésus, Québec, QC (M.-C.C.); Division of Neurology, TIA and Minor Stroke (TAMS) Unit, Toronto Western Hospital, Toronto, ON (L.K.C.); Department of Neurology, Neurosurgery and Medicine, McGill University, McGill University Health Center Stroke Prevention Clinic, Montréal, QC (R.C.); Departments of Medicine, Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada (D.D.); Neurologue Spécialisée en Maladies Vasculaires Cérébrales, Hôpital du Sacré-Coeur de Montréal, Montréal, QC (V.D.); Division of Neurology, University of British Columbia, Vancouver General Hospital, Vancouver, BC (T.S.F.); Section of Neurology, Department of Internal Medicine, University of Manitoba, Winnipeg, MN (E.G., A.T.); Department of Neuroscience, Faculty of Medicine, Université de Montréal, Neurovascular Programme, CHUM, Montréal, QC (L.G., S.L., C.O., A.Y.P.); Division of Neurology, Department of Medicine, Faculty of Medicine (G.J.G., S.J.P.), Dalhousie University, Nova Scotia Health Authority, Halifax, NS; Department of Emergency Medicine, University of British Columbia, Kelowna General Hospit

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http://dx.doi.org/10.1161/STROKEAHA.115.010454DOI Listing
October 2015

What's new in stroke? Phase III randomized clinical trials of 2012-2014.

Int J Stroke 2015 Aug 14;10(6):790-5. Epub 2015 Jul 14.

Stroke Program, Department of Medicine (Neurology), Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1111/ijs.12570DOI Listing
August 2015

Effect of addition of clopidogrel to aspirin on stroke incidence: Meta-analysis of randomized trials.

Int J Stroke 2015 Jul 22;10(5):686-91. Epub 2013 May 22.

Department of Medicine (Neurology), Brain Research Center, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/ijs.12050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971006PMC
July 2015

Should Blood Pressure Targets After Lacunar Stroke Vary by Body Size? The SPS3 Trial.

Am J Hypertens 2015 Jun 1;28(6):756-64. Epub 2014 Dec 1.

Hotchkiss Brain Center, Department of Neurosciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1093/ajh/hpu228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447819PMC
June 2015

Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials.

Int J Stroke 2015 Jun 3;10(4):501-5. Epub 2014 Dec 3.

Population Health Research Institute, Hamilton Health Sciences, Department of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/ijs.12419DOI Listing
June 2015

Left Ventricular Geometry on Transthoracic Echocardiogram and Prognosis after Lacunar Stroke: The SPS3 Trial.

J Stroke Cerebrovasc Dis 2015 Jun 1;24(6):1423-9. Epub 2015 Apr 1.

Division of Neurology, Center for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457650PMC
June 2015

Vertebrobasilar ectasia in patients with lacunar stroke: the secondary prevention of small subcortical strokes trial.

J Stroke Cerebrovasc Dis 2015 May 25;24(5):1052-8. Epub 2015 Mar 25.

Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada; Division of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408219PMC
May 2015

Relationship between degree of left ventricular dysfunction, symptom status, and risk of embolic events in patients with atrial fibrillation and heart failure.

Stroke 2015 Mar 27;46(3):667-72. Epub 2015 Jan 27.

From the Division of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada (R.K.S.); Division of Cardiac Electrophysiology, J.W. Goethe University, Frankfurt, Germany (S.H.H.); Division of Cardiology, Brigham and Women's Hospital, Harvard University, Boston, MA (M.A.P.); Division of Neurology (R.G.H.), Division of Cardiology (S.Y., S.J.C., J.S.H.), Population Health Research Institute (F.Y.), McMaster University, Hamilton, ON, Canada; The Canadian VIGOUR Center, Edmonton, Alberta, Canada (F.A.M.); and Division of General Internal Medicine, University of Alberta, Edmonton, Canada (F.A.M.).

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http://dx.doi.org/10.1161/STROKEAHA.114.007140DOI Listing
March 2015

Risk of ischaemic stroke according to pattern of atrial fibrillation: analysis of 6563 aspirin-treated patients in ACTIVE-A and AVERROES.

Eur Heart J 2015 Feb 3;36(5):281-7a. Epub 2014 Sep 3.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, 237 Barton St. E., Hamilton, ON, Canada L8L 2X2.

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http://dx.doi.org/10.1093/eurheartj/ehu307DOI Listing
February 2015

Intensity and quality of warfarin anticoagulation in Chinese patients: setting the record straight.

Stroke 2015 Jan 18;46(1):5-6. Epub 2014 Nov 18.

From the Population Health Research Institute, Department of Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/STROKEAHA.114.007486DOI Listing
January 2015

Clinical-MRI correlations in a multiethnic cohort with recent lacunar stroke: the SPS3 trial.

Int J Stroke 2014 Dec 27;9(8):1057-64. Epub 2014 May 27.

Department of Medicine, Division of Neurology, Brain Research Center, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1111/ijs.12282DOI Listing
December 2014

Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.

Lancet Neurol 2014 Dec 23;13(12):1177-85. Epub 2014 Oct 23.

Division of Neurology, Department of Medicine, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70224-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284947PMC
December 2014

Vorapaxar, combination antiplatelet therapy, and stroke.

J Am Coll Cardiol 2014 Dec 1;64(22):2327-9. Epub 2014 Dec 1.

Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2014.09.038DOI Listing
December 2014

Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial.

Stroke 2014 Oct 26;45(10):2989-94. Epub 2014 Aug 26.

From the Divisions of Neurology (M.S., R.G.H.) and Cardiology (S.J.C.), Department of Medicine, McMaster University/Population Health Research Institute, Hamilton, Ontario, Canada; Biostatistics Consultant, Minot, ND (L.A.P.); Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); Department of Neurology, University of Minnesota, Minneapolis (D.C.A.); Department of Neurology, University of Texas Health Science Center, San Antonio (S.P.); and Department of Biostatistics, University of Iowa, Iowa City (C.S.C.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175186PMC
October 2014

Clinical correlates of infarct shape and volume in lacunar strokes: the Secondary Prevention of Small Subcortical Strokes trial.

Stroke 2014 Oct 4;45(10):2952-8. Epub 2014 Sep 4.

From the Division of Neurology, Department of Medicine, Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada (N.A., M.N., T.S.F., F.C., O.R.B.); Biostatistics Consultant, Minot, ND (L.A.P.); Department of Radiology, University of Texas Health Sciences Centre, San Antonio (C.B.); Department of Biostatistics, University of Alabama at Birmingham (L.A.M.); Department of Neurology, Hennepin County Medical Center and the University of Minnesota, Minneapolis (D.C.A.); Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontatio, Canada (R.G.H.); SPS3 Coordinating Center (N.A., L.A.P., M.N., T.S.F., C.B., F.C., R.G.H., O.R.B.); and SPS3 Statistical Center (L.A.M.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198938PMC
October 2014

Embolic strokes of undetermined source: support for a new clinical construct--authors' reply.

Lancet Neurol 2014 Oct;13(10):967

McMaster University and Population Health Research Institute, Hamilton, ON, L8L 2X2, Canada.

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http://dx.doi.org/10.1016/S1474-4422(14)70197-8DOI Listing
October 2014

Lacunar strokes in patients with diabetes mellitus: risk factors, infarct location, and prognosis: the secondary prevention of small subcortical strokes study.

Stroke 2014 Sep 17;45(9):2689-94. Epub 2014 Jul 17.

From the Departments of Neurology (S.P.), Radiology (C.B.), and Medicine (P.P.), University of Texas Health Science Center, San Antonio, TX; University of Alabama at Birmingham (L.A.M.); Department of Medicine (Neurology), University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); and Department of Medicine (Neurology), McMaster University/Population Health Research Institute Hamilton, Ontario, Canada (R.G.H.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146755PMC
September 2014

Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation: a secondary analysis of the AVERROES study.

Stroke 2014 Jul 10;45(7):2127-30. Epub 2014 Jun 10.

From the University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada (J.E., S.Y., O.S., R.G.H., S.C.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005746DOI Listing
July 2014

Vitamin K antagonists and risk of subdural hematoma: meta-analysis of randomized clinical trials.

Stroke 2014 Jun 13;45(6):1672-8. Epub 2014 May 13.

From the Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (B.J.C., R.G.H.); and Biostatistics Consultant, Minot, ND (L.A.P.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005430DOI Listing
June 2014

Stroke prevention in atrial fibrillation: Commentary regarding the AAN's evidence-based guideline update.

Neurol Clin Pract 2014 Apr;4(2):96-98

McMaster University/Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada.

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http://dx.doi.org/10.1212/CPJ.0000000000000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001177PMC
April 2014

ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?

Neurology 2014 Feb 2;82(5):382-9. Epub 2014 Jan 2.

From the Department of Neurology, Neurosurgery and Medicine (R.C.), McGill University, Montreal, Canada; Department of Biostatistics (Y.Z., L.A.M.), University of Alabama at Birmingham; Department of Medicine (Neurology) (R.G.H.), McMaster University, Hamilton, Canada; Hennepin County Medical Center (Neurology) (D.C.A.), University of Minnesota Medical School, Minneapolis; Department of Clinical Pharmacy (R.L.T.), University of Texas, Austin; and Department of Medicine (O.R.B.), Brain Research Center, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917683PMC
February 2014

Direct-acting oral anticoagulants: the brain gets a break.

JAMA Neurol 2013 Dec;70(12):1483-4

Department of Medicine, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaneurol.2013.4347DOI Listing
December 2013

Anticoagulation in Patients Aged ≥75 years with Atrial Fibrillation: Role of Novel Oral Anticoagulants.

Cardiol Ther 2013 Dec 6;2(2):135-49. Epub 2013 Aug 6.

Department of Medicine (Stroke Program), Population Health Research Institute, McMaster University and Hamilton Health Sciences, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada,

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http://dx.doi.org/10.1007/s40119-013-0019-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107426PMC
December 2013

Balancing the benefits and risks of 2 doses of dabigatran compared with warfarin in atrial fibrillation.

J Am Coll Cardiol 2013 Sep 13;62(10):900-8. Epub 2013 Jun 13.

Population Health Research Institute, McMaster University, 237 Barton St. East, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2013.05.042DOI Listing
September 2013

Assessment of anticoagulation intensity and management of bleeding with old and new oral anticoagulants.

Can J Cardiol 2013 Jul;29(7 Suppl):S34-44

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2013.04.013DOI Listing
July 2013

Stroke prevention in atrial fibrillation patients with chronic kidney disease.

Can J Cardiol 2013 Jul;29(7 Suppl):S71-8

Department of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2013.04.005DOI Listing
July 2013

Anticoagulant therapy in acute brain ischaemia.

Lancet Neurol 2013 Jun 2;12(6):526-7. Epub 2013 May 2.

Department of Medicine (Thrombosis), McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/S1474-4422(13)70083-8DOI Listing
June 2013

Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials.

J Stroke Cerebrovasc Dis 2013 May 16;22(4):444-8. Epub 2013 Feb 16.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.01.007DOI Listing
May 2013

Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes.

Stroke 2013 Jan 20;44(1):99-104. Epub 2012 Nov 20.

MSc, FAHA, FRCPC, Stroke Outcomes Research Center, Department of Medicine, St. Michael's Hospital, University of Toronto, 55 Queen St E, Toronto, Ontario, M5C 1R6, Canada.

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http://dx.doi.org/10.1161/STROKEAHA.112.676551DOI Listing
January 2013

Sex, stroke, and atrial fibrillation.

Arch Neurol 2012 Dec;69(12):1641-3

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http://dx.doi.org/10.1001/archneurol.2012.2691DOI Listing
December 2012

Anticoagulants in patients with atrial fibrillation and end-stage renal disease.

Postgrad Med 2012 Nov;124(6):17-25

Department of Medicine (Nephrology), McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.3810/pgm.2012.11.2609DOI Listing
November 2012

Anticoagulants in atrial fibrillation patients with chronic kidney disease.

Nat Rev Nephrol 2012 Oct 24;8(10):569-78. Epub 2012 Jul 24.

Division of Neurology, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada.

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http://mcmasterstrokeprogram.ca/workfiles/Anticoag%20of%20AF
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http://www.nature.com/doifinder/10.1038/nrneph.2012.160
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http://dx.doi.org/10.1038/nrneph.2012.160DOI Listing
October 2012

Cognitive impairment in lacunar strokes: the SPS3 trial.

Ann Neurol 2012 Sep;72(3):351-62

Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/ana.23733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198173PMC
September 2012

Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials.

Stroke 2012 Aug;43(8):2157-62

Department of Neurology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.

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http://dx.doi.org/10.1161/STROKEAHA.112.656173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970708PMC
August 2012

Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial.

Stroke 2012 Jun 5;43(6):1511-7. Epub 2012 Apr 5.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.112.650614
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http://dx.doi.org/10.1161/STROKEAHA.112.650614DOI Listing
June 2012

Reducing the risk of recurrent stroke in patients with AF.

Lancet Neurol 2012 Jun 8;11(6):479-81. Epub 2012 May 8.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/S1474-4422(12)70096-0DOI Listing
June 2012

Antithrombotic therapy for stroke prevention in atrial fibrillation and mechanical heart valves.

Am J Hematol 2012 May 3;87 Suppl 1:S100-7. Epub 2012 Mar 3.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1002/ajh.23136DOI Listing
May 2012

Warfarin in atrial fibrillation patients with moderate chronic kidney disease.

Clin J Am Soc Nephrol 2011 Nov 8;6(11):2599-604. Epub 2011 Sep 8.

Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.

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http://dx.doi.org/10.2215/CJN.02400311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359566PMC
November 2011

The unmet need of patients with atrial fibrillation: AVERROES and the novel oral anticoagulants.

Authors:
Robert G Hart

Int J Stroke 2011 Jun;6(3):207-8

Department of Neurology, University of Texas Health Science Center, 8300 Floyd Curl Drive MC#7883, San Antonio, TX 78229 3900, USA.

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http://dx.doi.org/10.1111/j.1747-4949.2011.00617.xDOI Listing
June 2011

What's new in stroke? The top 10 studies of 2009-2011: part I.

Pol Arch Med Wewn 2011 Jun;121(6):193-9

Vascular Neurology, Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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June 2011

What's new in stroke? The top 10 studies of 2009-2011: part II.

Pol Arch Med Wewn 2011 Jun;121(6):200-7

Vascular Neurology, Department of Neurology, University of Texas Health Science Center, San Antonio, United States.

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June 2011

Thrombolysis for acute stroke in hemodialysis: international survey of expert opinion.

Clin J Am Soc Nephrol 2011 May 10;6(5):1089-93. Epub 2011 Mar 10.

Department of Neurology, University of Texas Health Science Center, 8300 Floyd Curl Drive MC# 7883, San Antonio, TX 78229-3900, USA.

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http://dx.doi.org/10.2215/CJN.10481110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087775PMC
May 2011

Irbesartan in patients with atrial fibrillation.

N Engl J Med 2011 Mar;364(10):928-38

Population Health Research Institute, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1056/NEJMoa1008816DOI Listing
March 2011