Robert G Bristow

Robert G Bristow

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Robert G Bristow

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The tip of the iceberg: predicting PARP inhibitor efficacy in prostate cancer.

Lancet Oncol 2020 Jan 2;21(1):17-19. Epub 2019 Dec 2.

Division of Cancer Sciences, University of Manchester, Manchester, UK; Translational Oncogenomics, Cancer Research UK Manchester Institute and Manchester Cancer Research Centre, Manchester, UK.

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http://dx.doi.org/10.1016/S1470-2045(19)30780-6DOI Listing
January 2020

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Cancer Cell 2019 Dec 14;36(6):674-689.e6. Epub 2019 Nov 14.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.005DOI Listing
December 2019

A Phase 1 Pilot Study of Preoperative Radiation Therapy for Prostate Cancer: Long-Term Toxicity and Oncologic Outcomes.

Int J Radiat Oncol Biol Phys 2019 05 6;104(1):61-66. Epub 2019 Jan 6.

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Techna Institute, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.054DOI Listing
May 2019

The influence of BRCA2 mutation on localized prostate cancer.

Nat Rev Urol 2019 05;16(5):281-290

Monash Partners Comprehensive Cancer Consortium and Cancer Program, Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology and Department of Physiology, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/s41585-019-0164-8DOI Listing
May 2019

and Prognosis in mCRPC Survival: Biology or Coincidence?

Clin Cancer Res 2019 03 4;25(6):1699-1701. Epub 2019 Jan 4.

Translational Oncogenomics Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre, Manchester, United Kingdom.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3401DOI Listing
March 2019

The Proteogenomic Landscape of Curable Prostate Cancer.

Cancer Cell 2019 03;35(3):414-427.e6

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Human Genetics, University of California, 12-109 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, CA 90024, USA; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA 90024, USA; Institute for Precision Health, University of California, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511374PMC
March 2019

Neoadjuvant Chemotherapy Before Bladder-Sparing Chemoradiotherapy in Patients With Nonmetastatic Muscle-Invasive Bladder Cancer.

Clin Genitourin Cancer 2019 Feb 4;17(1):38-45. Epub 2018 Oct 4.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.09.021DOI Listing
February 2019

Genomic Classifier for Guiding Treatment of Intermediate-Risk Prostate Cancers to Dose-Escalated Image Guided Radiation Therapy Without Hormone Therapy.

Int J Radiat Oncol Biol Phys 2019 01 29;103(1):84-91. Epub 2018 Aug 29.

Princess Margaret Cancer Centre, University Health Network, Ontario, Canada; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Oncology Academic Program, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.030DOI Listing
January 2019

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 12;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.016DOI Listing
December 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.

Cell 2018 05 19;173(4):1003-1013.e15. Epub 2018 Apr 19.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.029DOI Listing
May 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

EBioMedicine 2018 May 23;31:182-189. Epub 2018 Apr 23.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014579PMC
May 2018

A Partner in Crime: Tumor-associated Stroma and Metastatic Prostate Cancer.

Eur Urol 2018 04 22;73(4):533-534. Epub 2017 Dec 22.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.11.029DOI Listing
April 2018

NanoStringNormCNV: pre-processing of NanoString CNV data.

Bioinformatics 2018 03;34(6):1034-1036

Informatics and Biocomputing Program, Ontario Institute for Cancer Research.

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http://dx.doi.org/10.1093/bioinformatics/btx707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860631PMC
March 2018

Curative Radiation Therapy at Time of Progression Under Active Surveillance Compared With Up-front Radical Radiation Therapy for Prostate Cancer.

Int J Radiat Oncol Biol Phys 2018 03 1;100(3):702-709. Epub 2017 Nov 1.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016173404
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http://dx.doi.org/10.1016/j.ijrobp.2017.10.041DOI Listing
March 2018

Response.

J Natl Cancer Inst 2017 12;109(12)

Lunenfeld-Tanenbaum Research Institute and Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/jnci/djx122DOI Listing
December 2017

Intraductal Carcinoma of the Prostate: Anonymous to Ominous.

Eur Urol 2017 10 14;72(4):496-498. Epub 2017 Apr 14.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.04.004DOI Listing
October 2017

Comparison of pre-processing methods for Infinium HumanMethylation450 BeadChip array.

Bioinformatics 2017 Oct;33(20):3151-3157

Informatics, Ontario Institute for Cancer Research.

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http://dx.doi.org/10.1093/bioinformatics/btx372DOI Listing
October 2017

Human tissue Kallikreins: Blood levels and response to radiotherapy in intermediate risk prostate cancer.

Radiother Oncol 2017 09 17;124(3):427-432. Epub 2017 Apr 17.

Ontario Cancer Institute, Radiation Medicine Program, Princess Margaret Cancer Centre (University Health Network), Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.03.023DOI Listing
September 2017

TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

Nat Genet 2017 Sep 7;49(9):1336-1345. Epub 2017 Aug 7.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3930DOI Listing
September 2017

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

Radiother Oncol 2017 09 4;124(3):344-356. Epub 2017 Aug 4.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.07.007DOI Listing
September 2017

Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors.

Eur Urol 2017 07 1;72(1):22-31. Epub 2016 Nov 1.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.10.013DOI Listing
July 2017

Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.

PLoS One 2016 29;11(12):e0167272. Epub 2016 Dec 29.

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199060PMC
July 2017

Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.

J Clin Oncol 2017 Jul 14;35(20):2299-2305. Epub 2017 Apr 14.

Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J. Bostrom, Kathy Li, Arnoud J. Templeton, Srikala S. Sridhar, Peter Chung, Robert G. Bristow, Michael Milosevic, Padraig Warde, Neil E. Fleshner, Michael A.S. Jewett, Shaheena Bashir, and Alexandre R. Zlotta, Princess Margaret Cancer Center, University Health Network, University of Toronto; Cynthia Kuk and Alexandre R. Zlotta, Mount Sinai Hospital, University of Toronto; Theodorus H. Van Der Kwast, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2016.69.2327DOI Listing
July 2017

Improved outcomes with dose escalation in localized prostate cancer treated with precision image-guided radiotherapy.

Radiother Oncol 2017 06 20;123(3):459-465. Epub 2017 Apr 20.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.04.003DOI Listing
June 2017

The Evolving Narrative of DNA Repair Gene Defects: Distinguishing Indolent from Lethal Prostate Cancer.

Eur Urol 2017 05 26;71(5):748-749. Epub 2017 Jan 26.

Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.eururo.2017.01.025DOI Listing
May 2017

Targeting DNA repair for precision radiotherapy: Balancing the therapeutic ratio.

Curr Probl Cancer 2017 Jul - Aug;41(4):265-272. Epub 2017 Apr 25.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.currproblcancer.2017.04.002DOI Listing
April 2017

Significant Radiation Enhancement Effects by Gold Nanoparticles in Combination with Cisplatin in Triple Negative Breast Cancer Cells and Tumor Xenografts.

Radiat Res 2017 02 13;187(2):147-160. Epub 2017 Jan 13.

Departments of a   Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

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http://dx.doi.org/10.1667/RR14578.1DOI Listing
February 2017

Nanoparticle-Enabled Selective Destruction of Prostate Tumor Using MRI-Guided Focal Photothermal Therapy.

Prostate 2016 09 16;76(13):1169-81. Epub 2016 May 16.

Princess Margaret Cancer Center, UHN, Toronto, Canada.

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http://dx.doi.org/10.1002/pros.23203DOI Listing
September 2016

BAMQL: a query language for extracting reads from BAM files.

BMC Bioinformatics 2016 Aug 11;17:305. Epub 2016 Aug 11.

Ontario Institute for Cancer Research, Suite 510, 661 University Avenue, M5G 0A3, Toronto, Canada.

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http://dx.doi.org/10.1186/s12859-016-1162-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982315PMC
August 2016

Testosterone in Androgen Receptor Signaling and DNA Repair: Enemy or Frenemy?

Clin Cancer Res 2016 07 10;22(13):3124-6. Epub 2016 May 10.

Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0381DOI Listing
July 2016

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes.

Pract Radiat Oncol 2015 Sep-Oct;5(5):e473-e482. Epub 2015 Apr 18.

Departments of Radiation Oncology, Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2015.02.015DOI Listing
June 2016

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors.

Neoplasia 2016 06;18(6):347-55

Department of Medical Biophysics, University health Network, University of Toronto, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909700PMC
June 2016

Clonality of localized and metastatic prostate cancer.

Curr Opin Urol 2016 May;26(3):219-24

aDepartment of Medical Biophysics, University of Toronto bInformatics and Biocomputing Program, Ontario Institute for Cancer Research cDepartment of Pharmacology and Toxicology, University of Toronto dPrincess Margaret Cancer Centre, University Health Network eDepartment of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MOU.0000000000000279DOI Listing
May 2016

Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer.

Radiat Res 2016 05 2;185(5):549-62. Epub 2016 May 2.

a   Departments of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

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http://dx.doi.org/10.1667/RR14315.1DOI Listing
May 2016

In Vitro and In Vivo Studies of a New Class of Anticancer Molecules for Targeted Radiotherapy of Cancer.

Mol Cancer Ther 2016 04 26;15(4):640-50. Epub 2016 Feb 26.

Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada. Departments of Biology and Chemistry, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0862DOI Listing
April 2016

Liver Failure After Abdominal Irradiation: Identifying the Right Suspects.

J Clin Oncol 2016 Mar 28;34(9):e80-3. Epub 2014 Jul 28.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2013.50.9547DOI Listing
March 2016

Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer.

Front Oncol 2016 16;6:24. Epub 2016 Feb 16.

Radiation Medicine Program, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2016.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754414PMC
February 2016

Hypoxia and Predicting Radiation Response.

Semin Radiat Oncol 2015 Oct 15;25(4):260-72. Epub 2015 May 15.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2015.05.004DOI Listing
October 2015

Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.

Radiother Oncol 2015 Sep 2;116(3):388-91. Epub 2015 Apr 2.

Ontario Cancer Institute, Princess Margaret Cancer Centre (University Health Network), Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.03.027DOI Listing
September 2015

Not all gleason pattern 4 prostate cancers are created equal: A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series.

Prostate 2015 Sep 11;75(12):1277-84. Epub 2015 May 11.

Department of Laboratory Medicine and Pathology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.23009DOI Listing
September 2015

In vivo studies of the PARP inhibitor, AZD-2281, in combination with fractionated radiotherapy: An exploration of the therapeutic ratio.

Radiother Oncol 2015 Sep 12;116(3):486-94. Epub 2015 Aug 12.

Princess Margaret Cancer Centre (Radiation Medicine Program, University Health Network), Toronto, Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.08.003DOI Listing
September 2015

Spatial genomic heterogeneity within localized, multifocal prostate cancer.

Nat Genet 2015 Jul 25;47(7):736-45. Epub 2015 May 25.

1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3315DOI Listing
July 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Synergistic action of image-guided radiotherapy and androgen deprivation therapy.

Nat Rev Urol 2015 Apr 24;12(4):193-204. Epub 2015 Mar 24.

Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1038/nrurol.2015.50DOI Listing
April 2015

Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer.

Urol Oncol 2015 Feb 24;33(2):85-94. Epub 2014 Apr 24.

Department of Pathology and Laboratory Medicine, Toronto General Hospital (University Health Network), Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2013.10.020DOI Listing
February 2015

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression.

Oncotarget 2015 Feb;6(4):1900-19

McMaster Institute of Urology, Division of Urology, Department of Surgery, McMaster University, ON, Canada.

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http://www.oncotarget.com/fulltext/2953
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385825PMC
http://dx.doi.org/10.18632/oncotarget.2953DOI Listing
February 2015

Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells.

Radiat Res 2014 Nov 31;182(5):475-88. Epub 2014 Oct 31.

a  Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://www.bioone.org/doi/10.1667/RR13642.1
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http://dx.doi.org/10.1667/RR13642.1DOI Listing
November 2014

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer.

Oncotarget 2014 Nov;5(22):11081-90

Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology, Pharmacology & Toxicology and Biostatistics, Computer Science, University of Toronto, Toronto, ON, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://www.oncotarget.com/fulltext/2404
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294365PMC
http://dx.doi.org/10.18632/oncotarget.2404DOI Listing
November 2014

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Int J Cancer 2014 Oct 25;135(7):1692-9. Epub 2014 Apr 25.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.28403DOI Listing
October 2014

Resistance to bleomycin in cancer cell lines is characterized by prolonged doubling time, reduced DNA damage and evasion of G2/M arrest and apoptosis.

PLoS One 2013 4;8(12):e82363. Epub 2013 Dec 4.

Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada ; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857806PMC
October 2014

Use of Sequenom sample ID Plus® SNP genotyping in identification of FFPE tumor samples.

PLoS One 2014 13;9(2):e88163. Epub 2014 Feb 13.

Department of Genome Technologies, Ontario Institute for Cancer Research, Toronto, Canada ; Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923782PMC
October 2014

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

PLoS One 2014 28;9(2):e89997. Epub 2014 Feb 28.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada ; Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands ; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938561PMC
October 2014

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.

Mol Cancer Res 2014 Oct 16;12(10):1407-15. Epub 2014 Jul 16.

Princess Margaret Cancer Centre (University Health Network), Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0246DOI Listing
October 2014

SeqControl: process control for DNA sequencing.

Nat Methods 2014 Oct 31;11(10):1071-5. Epub 2014 Aug 31.

1] Informatics &Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nmeth.3094DOI Listing
October 2014

Synergistic nanoparticulate drug combination overcomes multidrug resistance, increases efficacy, and reduces cardiotoxicity in a nonimmunocompromised breast tumor model.

Mol Pharm 2014 Aug 3;11(8):2659-74. Epub 2014 Jun 3.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1021/mp500093cDOI Listing
August 2014

Intratumoral hypoxia as the genesis of genetic instability and clinical prognosis in prostate cancer.

Adv Exp Med Biol 2014 ;772:189-204

Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, ON, Canada,

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http://dx.doi.org/10.1007/978-1-4614-5915-6_9DOI Listing
July 2014

DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

Mol Cell 2014 Jan 5;53(1):7-18. Epub 2013 Dec 5.

Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909494PMC
January 2014

Prognostic utility of cell cycle progession score in men with prostate cancer after primary external beam radiation therapy. In regard to Freedland et al.

Int J Radiat Oncol Biol Phys 2014 Jan;88(1):237-40

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2013.10.009DOI Listing
January 2014

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Clin Cancer Res 2013 Dec 18;19(24):6741-50. Epub 2013 Oct 18.

Authors' Affiliations: Princess Margaret Cancer Centre and Radiation Medicine Program, University Health Network; Institute of Medical Science, Department of Radiation Oncology, Faculty of Medicine, Department of Medical Biophysics, University of Toronto; Selective Therapies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada; and Department of Radiation Oncology (Maastro Lab), GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1787DOI Listing
December 2013

miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.

Cancer Res 2013 Dec 21;73(23):6972-86. Epub 2013 Oct 21.

Authors' Affiliations: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre; Departments of Medicine, Medical Biophysics, and Radiation Oncology, University of Toronto; and Ontario Cancer Institute, University Health Network, Toronto, Canada.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1657DOI Listing
December 2013

Tumor hypoxia as a driving force in genetic instability.

Genome Integr 2013 Oct 24;4(1). Epub 2013 Oct 24.

Ontario Cancer Institute, Radiation Medicine Program, Princess Margaret Cancer Centre (University Health Network), Toronto, ON, Canada.

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http://dx.doi.org/10.1186/2041-9414-4-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016142PMC
October 2013

TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair.

Clin Cancer Res 2013 Sep 5;19(18):5202-9. Epub 2013 Aug 5.

Authors' Affiliations: Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology and Biostatistics, University of Toronto; Radiation Medicine Program, Princess Margaret Hospital, University Health Network; Informatics and Bio-Computing Platform, Ontario Institute for Cancer Research, Toronto, Ontario; Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre; Laboratory for Advanced Genome Analysis - Vancouver Prostate Centre, Vancouver, British Columbia; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Rockville, Maryland; Division of Urology, University of Montreal Health Center, Montreal, Quebec; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario; and Department of Pathology and Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1049DOI Listing
September 2013

Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin.

Int J Radiat Biol 2013 Aug 23;89(8):618-27. Epub 2013 Apr 23.

Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3109/09553002.2013.782450DOI Listing
August 2013

4FISH-IF, a four-color dual-gene FISH combined with p63 immunofluorescence to evaluate NKX3.1 and MYC status in prostate cancer.

J Histochem Cytochem 2013 Jul 2;61(7):500-9. Epub 2013 May 2.

Department of Laboratory Medicine and Pathology/Applied Molecular Oncology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1369/0022155413490946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707357PMC
July 2013

Inherently multimodal nanoparticle-driven tracking and real-time delineation of orthotopic prostate tumors and micrometastases.

ACS Nano 2013 May 5;7(5):4221-32. Epub 2013 Apr 5.

Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN, 610 University Avenue, Toronto, ON Canada M5G 2M9.

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http://dx.doi.org/10.1021/nn400669rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667620PMC
May 2013

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Cancer Res 2013 Mar 9;73(5):1611-20. Epub 2013 Jan 9.

Sections of Experimental Oncology and Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590104PMC
March 2013

In reply to Nieder.

Int J Radiat Oncol Biol Phys 2013 Mar;85(3):581

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http://dx.doi.org/10.1016/j.ijrobp.2012.08.012DOI Listing
March 2013