Publications by authors named "Robert G Bristow"

100Publications

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.

Mol Cell 2020 11;80(4):562-577

Pathology and Laboratory Medicine and Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.

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November 2020

It's All the RAVE: Time to Give up on the "Chronic Radiation Proctitis" Misnomer.

Gastroenterology 2020 Oct 20. Epub 2020 Oct 20.

School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.

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October 2020

Determining the Impact of Spatial Heterogeneity on Genomic Prognostic Biomarkers for Localized Prostate Cancer.

Eur Urol Oncol 2020 Jun 27. Epub 2020 Jun 27.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada. Electronic address:

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June 2020

Divergent mutational processes distinguish hypoxic and normoxic tumours.

Nat Commun 2020 02 5;11(1):737. Epub 2020 Feb 5.

Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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February 2020

The tip of the iceberg: predicting PARP inhibitor efficacy in prostate cancer.

Lancet Oncol 2020 01 2;21(1):17-19. Epub 2019 Dec 2.

Division of Cancer Sciences, University of Manchester, Manchester, UK; Translational Oncogenomics, Cancer Research UK Manchester Institute and Manchester Cancer Research Centre, Manchester, UK.

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January 2020

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Cancer Cell 2019 12 14;36(6):674-689.e6. Epub 2019 Nov 14.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address:

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December 2019

The Proteogenomic Landscape of Curable Prostate Cancer.

Cancer Cell 2019 03;35(3):414-427.e6

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Human Genetics, University of California, 12-109 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Department of Urology, University of California, Los Angeles, CA 90024, USA; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA 90024, USA; Institute for Precision Health, University of California, Los Angeles, CA 90024, USA. Electronic address:

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March 2019

The influence of BRCA2 mutation on localized prostate cancer.

Nat Rev Urol 2019 05;16(5):281-290

Monash Partners Comprehensive Cancer Consortium and Cancer Program, Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology and Department of Physiology, Monash University, Melbourne, Victoria, Australia.

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May 2019

A Phase 1 Pilot Study of Preoperative Radiation Therapy for Prostate Cancer: Long-Term Toxicity and Oncologic Outcomes.

Int J Radiat Oncol Biol Phys 2019 05 6;104(1):61-66. Epub 2019 Jan 6.

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Techna Institute, University Health Network, Toronto, Canada. Electronic address:

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May 2019

and Prognosis in mCRPC Survival: Biology or Coincidence?

Clin Cancer Res 2019 03 4;25(6):1699-1701. Epub 2019 Jan 4.

Translational Oncogenomics Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre, Manchester, United Kingdom.

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March 2019

Genomic Classifier for Guiding Treatment of Intermediate-Risk Prostate Cancers to Dose-Escalated Image Guided Radiation Therapy Without Hormone Therapy.

Int J Radiat Oncol Biol Phys 2019 01 29;103(1):84-91. Epub 2018 Aug 29.

Princess Margaret Cancer Centre, University Health Network, Ontario, Canada; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Oncology Academic Program, Duke-NUS Medical School, Singapore.

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January 2019

Response.

J Natl Cancer Inst 2017 12;109(12)

Lunenfeld-Tanenbaum Research Institute and Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, ON, Canada.

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December 2017

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

EBioMedicine 2018 May 23;31:182-189. Epub 2018 Apr 23.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

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May 2018

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.

Cell 2018 05 19;173(4):1003-1013.e15. Epub 2018 Apr 19.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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May 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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May 2018

A Partner in Crime: Tumor-associated Stroma and Metastatic Prostate Cancer.

Eur Urol 2018 04 22;73(4):533-534. Epub 2017 Dec 22.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

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April 2018

Curative Radiation Therapy at Time of Progression Under Active Surveillance Compared With Up-front Radical Radiation Therapy for Prostate Cancer.

Int J Radiat Oncol Biol Phys 2018 03 1;100(3):702-709. Epub 2017 Nov 1.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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March 2018

NanoStringNormCNV: pre-processing of NanoString CNV data.

Bioinformatics 2018 03;34(6):1034-1036

Informatics and Biocomputing Program, Ontario Institute for Cancer Research.

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March 2018

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

Radiother Oncol 2017 09 4;124(3):344-356. Epub 2017 Aug 4.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. Electronic address:

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September 2017

Targeting DNA repair for precision radiotherapy: Balancing the therapeutic ratio.

Curr Probl Cancer 2017 Jul - Aug;41(4):265-272. Epub 2017 Apr 25.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Electronic address:

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April 2017

Comparison of pre-processing methods for Infinium HumanMethylation450 BeadChip array.

Bioinformatics 2017 Oct;33(20):3151-3157

Informatics, Ontario Institute for Cancer Research.

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October 2017

Improved outcomes with dose escalation in localized prostate cancer treated with precision image-guided radiotherapy.

Radiother Oncol 2017 06 20;123(3):459-465. Epub 2017 Apr 20.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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June 2017

Human tissue Kallikreins: Blood levels and response to radiotherapy in intermediate risk prostate cancer.

Radiother Oncol 2017 09 17;124(3):427-432. Epub 2017 Apr 17.

Ontario Cancer Institute, Radiation Medicine Program, Princess Margaret Cancer Centre (University Health Network), Toronto, Canada. Electronic address:

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September 2017

Intraductal Carcinoma of the Prostate: Anonymous to Ominous.

Eur Urol 2017 10 14;72(4):496-498. Epub 2017 Apr 14.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada. Electronic address:

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October 2017

Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.

J Clin Oncol 2017 Jul 14;35(20):2299-2305. Epub 2017 Apr 14.

Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J. Bostrom, Kathy Li, Arnoud J. Templeton, Srikala S. Sridhar, Peter Chung, Robert G. Bristow, Michael Milosevic, Padraig Warde, Neil E. Fleshner, Michael A.S. Jewett, Shaheena Bashir, and Alexandre R. Zlotta, Princess Margaret Cancer Center, University Health Network, University of Toronto; Cynthia Kuk and Alexandre R. Zlotta, Mount Sinai Hospital, University of Toronto; Theodorus H. Van Der Kwast, University Health Network, University of Toronto, Toronto, ON, Canada.

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July 2017

The Evolving Narrative of DNA Repair Gene Defects: Distinguishing Indolent from Lethal Prostate Cancer.

Eur Urol 2017 05 26;71(5):748-749. Epub 2017 Jan 26.

Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

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May 2017

Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.

PLoS One 2016 29;11(12):e0167272. Epub 2016 Dec 29.

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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July 2017

Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors.

Eur Urol 2017 07 1;72(1):22-31. Epub 2016 Nov 1.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address:

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July 2017

BAMQL: a query language for extracting reads from BAM files.

BMC Bioinformatics 2016 Aug 11;17:305. Epub 2016 Aug 11.

Ontario Institute for Cancer Research, Suite 510, 661 University Avenue, M5G 0A3, Toronto, Canada.

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August 2016

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors.

Neoplasia 2016 06;18(6):347-55

Department of Medical Biophysics, University health Network, University of Toronto, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:

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June 2016

Testosterone in Androgen Receptor Signaling and DNA Repair: Enemy or Frenemy?

Clin Cancer Res 2016 07 10;22(13):3124-6. Epub 2016 May 10.

Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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July 2016

Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer.

Radiat Res 2016 05 2;185(5):549-62. Epub 2016 May 2.

a   Departments of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

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May 2016

In Vitro and In Vivo Studies of a New Class of Anticancer Molecules for Targeted Radiotherapy of Cancer.

Mol Cancer Ther 2016 04 26;15(4):640-50. Epub 2016 Feb 26.

Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada. Departments of Biology and Chemistry, University of Waterloo, Waterloo, Ontario, Canada.

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April 2016

Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer.

Front Oncol 2016 16;6:24. Epub 2016 Feb 16.

Radiation Medicine Program, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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February 2016

Clonality of localized and metastatic prostate cancer.

Curr Opin Urol 2016 May;26(3):219-24

aDepartment of Medical Biophysics, University of Toronto bInformatics and Biocomputing Program, Ontario Institute for Cancer Research cDepartment of Pharmacology and Toxicology, University of Toronto dPrincess Margaret Cancer Centre, University Health Network eDepartment of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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May 2016

Hypoxia and Predicting Radiation Response.

Semin Radiat Oncol 2015 Oct 15;25(4):260-72. Epub 2015 May 15.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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October 2015

In vivo studies of the PARP inhibitor, AZD-2281, in combination with fractionated radiotherapy: An exploration of the therapeutic ratio.

Radiother Oncol 2015 Sep 12;116(3):486-94. Epub 2015 Aug 12.

Princess Margaret Cancer Centre (Radiation Medicine Program, University Health Network), Toronto, Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada. Electronic address:

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September 2015

Phase 2 trial of guideline-based postoperative image guided intensity modulated radiation therapy for prostate cancer: Toxicity, biochemical, and patient-reported health-related quality-of-life outcomes.

Pract Radiat Oncol 2015 Sep-Oct;5(5):e473-e482. Epub 2015 Apr 18.

Departments of Radiation Oncology, Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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June 2016

Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.

Radiother Oncol 2015 Sep 2;116(3):388-91. Epub 2015 Apr 2.

Ontario Cancer Institute, Princess Margaret Cancer Centre (University Health Network), Canada; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada. Electronic address:

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September 2015

Synergistic action of image-guided radiotherapy and androgen deprivation therapy.

Nat Rev Urol 2015 Apr 24;12(4):193-204. Epub 2015 Mar 24.

Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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April 2015

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression.

Oncotarget 2015 Feb;6(4):1900-19

McMaster Institute of Urology, Division of Urology, Department of Surgery, McMaster University, ON, Canada.

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February 2015

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer.

Oncotarget 2014 Nov;5(22):11081-90

Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology, Pharmacology & Toxicology and Biostatistics, Computer Science, University of Toronto, Toronto, ON, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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November 2014

SeqControl: process control for DNA sequencing.

Nat Methods 2014 Oct 31;11(10):1071-5. Epub 2014 Aug 31.

1] Informatics &Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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October 2014

Liver Failure After Abdominal Irradiation: Identifying the Right Suspects.

J Clin Oncol 2016 Mar 28;34(9):e80-3. Epub 2014 Jul 28.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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March 2016

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.

Mol Cancer Res 2014 Oct 16;12(10):1407-15. Epub 2014 Jul 16.

Princess Margaret Cancer Centre (University Health Network), Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

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October 2014

Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer.

Urol Oncol 2015 Feb 24;33(2):85-94. Epub 2014 Apr 24.

Department of Pathology and Laboratory Medicine, Toronto General Hospital (University Health Network), Toronto, Ontario, Canada. Electronic address:

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February 2015

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

PLoS One 2014 28;9(2):e89997. Epub 2014 Feb 28.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada ; Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands ; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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October 2014

Use of Sequenom sample ID Plus® SNP genotyping in identification of FFPE tumor samples.

PLoS One 2014 13;9(2):e88163. Epub 2014 Feb 13.

Department of Genome Technologies, Ontario Institute for Cancer Research, Toronto, Canada ; Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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October 2014

Resistance to bleomycin in cancer cell lines is characterized by prolonged doubling time, reduced DNA damage and evasion of G2/M arrest and apoptosis.

PLoS One 2013 4;8(12):e82363. Epub 2013 Dec 4.

Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada ; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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October 2014

Prognostic utility of cell cycle progession score in men with prostate cancer after primary external beam radiation therapy. In regard to Freedland et al.

Int J Radiat Oncol Biol Phys 2014 Jan;88(1):237-40

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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January 2014

DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

Mol Cell 2014 Jan 5;53(1):7-18. Epub 2013 Dec 5.

Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address:

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January 2014

Intratumoral hypoxia as the genesis of genetic instability and clinical prognosis in prostate cancer.

Adv Exp Med Biol 2014 ;772:189-204

Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, ON, Canada,

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July 2014

Tumor hypoxia as a driving force in genetic instability.

Genome Integr 2013 Oct 24;4(1). Epub 2013 Oct 24.

Ontario Cancer Institute, Radiation Medicine Program, Princess Margaret Cancer Centre (University Health Network), Toronto, ON, Canada.

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October 2013

miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.

Cancer Res 2013 Dec 21;73(23):6972-86. Epub 2013 Oct 21.

Authors' Affiliations: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre; Departments of Medicine, Medical Biophysics, and Radiation Oncology, University of Toronto; and Ontario Cancer Institute, University Health Network, Toronto, Canada.

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December 2013

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Clin Cancer Res 2013 Dec 18;19(24):6741-50. Epub 2013 Oct 18.

Authors' Affiliations: Princess Margaret Cancer Centre and Radiation Medicine Program, University Health Network; Institute of Medical Science, Department of Radiation Oncology, Faculty of Medicine, Department of Medical Biophysics, University of Toronto; Selective Therapies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada; and Department of Radiation Oncology (Maastro Lab), GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

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December 2013