Publications by authors named "Robert Fazio"

4 Publications

  • Page 1 of 1

Development of tritiated nitroxide for nuclear battery.

Appl Radiat Isot 2017 Jul 7;125:66-73. Epub 2017 Apr 7.

Vitrax, Placentia, CA 92870, USA.

Beta radioisotope energy sources, such as tritium (H), have shown significant potential in satisfying the needs of a sensor-driven world. The limitations of current beta sources include: (i) low beta-flux power, (ii) intrinsic isotope leakage and (iii) beta self-absorption. The figure of merit is the beta-flux power (dP/dS in μW/cm), where an optimal portion of incident beta particles penetrates the semiconductor depletion region. Thus, the goal of this research was to identify a compound to contain a beta emitter that can permit beta-flux power of at least 0.73 μW/cm from one side, where it can be used for both planar and textured semiconductor structures. Nitroxides were chosen because of previous demonstrated deuteration, ease of synthesis, diversity of structure, and pliability. As a proof-of-principle, nitroxide [1] was prepared and tritiated with a specific activity of 103Ci/g. The corresponding tritiated nitroxide in toluene was found to have no measurable H outgassing after 27 days, thus it was considered stable. After 256 days in solution, analysis of the compound showed only 2% tritium loss, whereas in solid form, there was approximately 50% of tritium loss after 21 days. To compare with the performance of a typical metal tritide carrier, the standard MCNPX Monte Carlo code was used to calculate the beta-flux power of tritiated nitroxide and titanium tritide (0.2 μW/cm and 0.70 μW/cm), respectively. The difference between numerical and empirical results of titanium tritide was 4%, showing the model validity. For the tritiated nitroxide to be comparable to titanium tritide in a planar configuration (2-D), the gravimetric density (H weighted percentage) would need to be at least 9%.
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http://dx.doi.org/10.1016/j.apradiso.2017.04.013DOI Listing
July 2017

Tritium-labeled (E,E)-2,5-bis(4'-hydroxy-3'-carboxystyryl)benzene as a probe for β-amyloid fibrils.

Bioorg Med Chem Lett 2014 Dec 6;24(23):5534-6. Epub 2014 Oct 6.

Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, United States; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536-0230, United States. Electronic address:

Accumulation of Aβ in the brains of Alzheimer disease (AD) patients reflects an imbalance between Aβ production and clearance from their brains. Alternative cleavage of amyloid precursor protein (APP) by processing proteases generates soluble APP fragments including the neurotoxic amyloid Aβ40 and Aβ42 peptides that assemble into fibrils and form plaques. Plaque-buildup occurs over an extended time-frame, and the early detection and modulation of plaque formation are areas of active research. Radiolabeled probes for the detection of amyloid plaques and fibrils in living subjects are important for noninvasive evaluation of AD diagnosis, progression, and differentiation of AD from other neurodegenerative diseases and age-related cognitive decline. Tritium-labeled (E,E)-1-[(3)H]-2,5-bis(4'-hydroxy-3'-carbomethoxystyryl)benzene possesses an improved level of chemical stability relative to a previously reported radioiodinated analog for radiometric quantification of Aβ plaque and tau pathology in brain tissue and in vitro studies with synthetic Aβ and tau fibrils.
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http://dx.doi.org/10.1016/j.bmcl.2014.09.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254541PMC
December 2014

Growth consulting: practical methods of facilitating growth through loss and adversity.

Authors:
Robert J Fazio

J Clin Psychol 2009 May;65(5):532-43

Hold The Door For Others, 613 South 26th St., Philadelphia, PA 19146, USA.

The way that people lead themselves and others through crisis, loss, and adversity impacts their future and the future of those around them. Traditionally, mental health professionals have emphasized the negative consequences of crisis and loss. I present a story of how the simple act of holding the door for others on September 11th created a foundation for positive interventions. I offer the OTHERS(S) model and the process of growth consulting as practical means of creating growth as a result of loss or adversity. A case illustration and examples of clinical methods to facilitate Growth Through Loss and Adversity (GTLA) are provided.
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http://dx.doi.org/10.1002/jclp.20590DOI Listing
May 2009

A solvent-free method for isotopically or radioactively labeling cyclodextrins and cyclodextrin-containing polymers.

Bioconjug Chem 2006 Nov-Dec;17(6):1624-6

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena California 91125, USA.

A method for installing a distinguishable label onto cyclodextrins or cyclodextrin-containing polymers is reported. Cyclodextrins (CD) and cyclodextrin-containing polymers are exposed to labeled (2H or 14C) ethylene oxide (EO) vapor and the alcohol groups on the CD ring open the EO to give ether-linked labeled methylenes and a terminal alcohol. This method provides for the incorporation of an easily tracked and quantified label without the use of solvents or purification steps. The method can be generalized for use with materials that contain nucleophiles other than alcohols, e.g., amines.
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http://dx.doi.org/10.1021/bc060211eDOI Listing
January 2007