Robert F Mullins

Robert F Mullins

UNVERIFIED PROFILE

Are you Robert F Mullins?   Register this Author

Register author
Robert F Mullins

Robert F Mullins

Publications by authors named "Robert F Mullins"

Are you Robert F Mullins?   Register this Author

100Publications

1803Reads

43Profile Views

Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.

Stem Cells Transl Med 2019 Aug 19;8(8):797-809. Epub 2019 Apr 19.

University of Iowa Institute for Vision Research and the Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/sctm.18-0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646699PMC
August 2019

Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.

Acta Biomater 2019 Aug 3;94:204-218. Epub 2019 May 3.

Institute for Vision Research, Department of Ophthalmology and Visual Science, Carver College of Medicine, The University of Iowa, 4111 Medical Education and Research Facility, Iowa City, IA 52242, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2019.04.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659122PMC
August 2019

Development of a Molecularly Stable Gene Therapy Vector for the Treatment of -Associated X-Linked Retinitis Pigmentosa.

Hum Gene Ther 2019 Aug;30(8):967-974

Department of Ophthalmology and Visual Sciences, Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hum.2018.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703244PMC
August 2019

Choriocapillaris Degeneration in Geographic Atrophy.

Am J Pathol 2019 Jul 30;189(7):1473-1480. Epub 2019 Apr 30.

Institute for Vision Research, University of Iowa, Iowa City, Iowa; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616998PMC
July 2019

Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.

Microvasc Res 2019 05 18;123:50-57. Epub 2018 Dec 18.

Institute for Vision Research, The University of Iowa, Iowa City, IA, USA; Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00262862183022
Publisher Site
http://dx.doi.org/10.1016/j.mvr.2018.12.002DOI Listing
May 2019

How much green does it take to be orange? Determining the cost associated with trauma center readiness.

J Trauma Acute Care Surg 2019 May;86(5):765-773

From the Department of Surgery (D.W.A., T.J.J.), The Medical Center, Navicent Health, Macon; Still Burn Center (R.F.M.), Augusta; Emory University at Grady Memorial Hospital (C.J.D., E.V.A), Atlanta; Wellstar Kennestone Hospital (L.E.G.), Kennestone; Augusta University Health (R.S.M.), Augusta; Gwinnett Medical Center (G.S.), Lawrenceville; Georgia Trauma Commission (D.A.); and Doctors Hospital (C.H.F.), Augusta, Georgia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002213DOI Listing
May 2019

Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

Genes (Basel) 2019 04 5;10(4). Epub 2019 Apr 5.

Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52241, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10040278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523438PMC
April 2019

Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration.

Eur J Ophthalmol 2019 Apr 25:1120672119846437. Epub 2019 Apr 25.

1 Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672119846437DOI Listing
April 2019

APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective Trial. Report No. 2.

Retina 2019 Feb;39(2):265-273

Department of Ophthalmology and Visual Sciences, Stephen A Wynn Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IAE.0000000000001952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963961PMC
February 2019

PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.

Cell Rep 2019 Feb;26(7):1951-1964.e8

Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Center for Gene Therapy, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394844PMC
February 2019

Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis.

Ophthalmol Retina 2019 Feb 19;3(2):178-185. Epub 2018 Sep 19.

University of Iowa Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24686530183042
Publisher Site
http://dx.doi.org/10.1016/j.oret.2018.09.006DOI Listing
February 2019

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Transl Vis Sci Technol 2018 Nov 30;7(6):18. Epub 2018 Nov 30.

Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

View Article

Download full-text PDF

Source
http://tvst.arvojournals.org/article.aspx?doi=10.1167/tvst.7
Publisher Site
http://dx.doi.org/10.1167/tvst.7.6.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269133PMC
November 2018

Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications.

Biomacromolecules 2018 09 9;19(9):3682-3692. Epub 2018 Aug 9.

Department of Chemical and Biochemical Engineering , The University of Iowa , 4133 Seamans Center , Iowa City , Iowa 52242 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biomac.8b00784DOI Listing
September 2018

CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

Prog Retin Eye Res 2018 07 22;65:28-49. Epub 2018 Mar 22.

Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.preteyeres.2018.03.003DOI Listing
July 2018

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.

Biol Open 2018 May 8;7(5). Epub 2018 May 8.

Cornea Research Unit, Department of Ophthalmology & Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.032102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992532PMC
May 2018

Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.

Ophthalmic Genet 2018 Jan-Feb;39(1):68-72. Epub 2017 Sep 26.

a The Stephen A. Wynn Institute for Vision Research and the Department of Ophthalmology and Visual Sciences , The University of Iowa , Iowa City , Iowa , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13816810.2017.1369550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751420PMC
March 2018

Rapid Communication: Solution for the MEEK Glue Transfer Problem.

J Burn Care Res 2018 02;39(2):274-277

Burn and Reconstructive Centers of America, Augusta, GA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BCR.0000000000000587DOI Listing
February 2018

CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

Curr Protoc Stem Cell Biol 2018 02 28;44:5B.7.1-5B.7.22. Epub 2018 Feb 28.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpsc.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846340PMC
February 2018

CLINICOPATHOLOGICAL CORRELATION IN A PATIENT WITH PREVIOUSLY TREATED BIRDSHOT CHORIORETINOPATHY.

Retin Cases Brief Rep 2017 Fall;11(4):344-347

Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICB.0000000000000367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269553PMC
January 2018

MMP19 expression in the human optic nerve.

Mol Vis 2016 14;22:1429-1436. Epub 2016 Dec 14.

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA; Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166795PMC
January 2018

Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury.

FASEB J 2017 11 20;31(11):4903-4916. Epub 2017 Jul 20.

Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201700533RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636697PMC
November 2017

Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

Ophthalmology 2017 09 27;124(9):1314-1331. Epub 2017 May 27.

Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, Iowa; Stephen A. Wynn Institute for Vision Research, the University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565704PMC
September 2017

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Mol Ther 2017 09 12;25(9):1999-2013. Epub 2017 Jun 12.

Stephen A. Wynn Institute for Vision Research and Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52241, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589061PMC
September 2017

From compliment to insult: genetics of the complement system in physiology and disease in the human retina.

Hum Mol Genet 2017 08;26(R1):R51-R57

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddx181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886463PMC
August 2017

Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy.

Curr Protoc Stem Cell Biol 2017 Aug 14;42:4A.12.1-4A.12.14. Epub 2017 Aug 14.

Stephen A. Wynn, Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpsc.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609845PMC
August 2017

Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies.

Acta Biomater 2017 07 5;57:293-303. Epub 2017 May 5.

The Stephen A. Wynn Institute for Vision Research, The University of Iowa, Iowa City, IA 52246, USA; Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52246, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2017.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515248PMC
July 2017

Two-photon polymerization for production of human iPSC-derived retinal cell grafts.

Acta Biomater 2017 06 27;55:385-395. Epub 2017 Mar 27.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, 4111 Medical Education and Research Facility, 375 Newton Road, Iowa City, IA 52242, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2017.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495181PMC
June 2017

Bestrophinopathy: An RPE-photoreceptor interface disease.

Prog Retin Eye Res 2017 05 19;58:70-88. Epub 2017 Jan 19.

Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.preteyeres.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441932PMC
May 2017

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.

Stem Cell Res 2017 05 18;21:58-70. Epub 2017 Mar 18.

Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Science, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2017.03.005DOI Listing
May 2017

Drusen on Demand? Authors Describe a Novel Culture System for Generating subRPE Deposits.

Authors:
Robert F Mullins

Invest Ophthalmol Vis Sci 2017 02;58(2):720

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.17-21419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295767PMC
February 2017

Transgenic TBK1 mice have features of normal tension glaucoma.

Hum Mol Genet 2017 01;26(1):124-132

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddw372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075615PMC
January 2017

Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.

J Biomed Mater Res B Appl Biomater 2016 11 28;104(8):1602-1609. Epub 2015 Aug 28.

Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.b.33506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769984PMC
November 2016

West Nile Virus Infection in Human and Mouse Cornea Tissue.

Am J Trop Med Hyg 2016 Nov 26;95(5):1185-1191. Epub 2016 Sep 26.

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.16-0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094237PMC
November 2016

Monomeric C-reactive protein and inflammation in age-related macular degeneration.

J Pathol 2016 10 19;240(2):173-83. Epub 2016 Sep 19.

The Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527328PMC
October 2016

Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3-Associated Retinal Degeneration.

Hum Gene Ther 2016 10 11;27(10):835-846. Epub 2016 Jul 11.

Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, Carver College of Medicine, University of Iowa , Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035933PMC
http://dx.doi.org/10.1089/hum.2016.049DOI Listing
October 2016

Immunosuppressive Treatment for Retinal Degeneration in Juvenile Neuronal Ceroid Lipofuscinosis (Juvenile Batten Disease).

Ophthalmic Genet 2015 19;36(4):359-64. Epub 2014 Feb 19.

b Department of Pediatrics , University of Iowa , Iowa City , IA , USA .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/13816810.2014.886271DOI Listing
July 2016

cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.

Sci Rep 2016 07 29;6:30742. Epub 2016 Jul 29.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep30742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965859PMC
July 2016

Selective accumulation of the complement membrane attack complex in aging choriocapillaris.

Exp Eye Res 2016 05 11;146:393-7. Epub 2015 Sep 11.

The Stephen A. Wynn Institute for Vision Research and the Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788569PMC
May 2016

Association of reduced Connexin 43 expression with retinal vascular lesions in human diabetic retinopathy.

Exp Eye Res 2016 05 29;146:103-6. Epub 2015 Dec 29.

Departments of Medicine and Ophthalmology, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2015.12.011DOI Listing
May 2016

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus.

Proc Natl Acad Sci U S A 2016 May 25;113(19):E2655-64. Epub 2016 Apr 25.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology, University of Iowa, Iowa City, IA 52242; Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, IA 52242; Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242; Iowa City VA Health Care System, Iowa City, IA 52246; Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1522014113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868487PMC
May 2016

A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids.

Curr Protoc Stem Cell Biol 2016 05 12;37:1C.19.1-1C.19.11. Epub 2016 May 12.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpsc.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900235PMC
May 2016

Five-Lumen Antibiotic-Impregnated Femoral Central Venous Catheters in Severely Burned Patients: An Investigation of Device Utility and Catheter-Related Bloodstream Infection Rates.

J Burn Care Res 2015 Jul-Aug;36(4):493-9

From the *Joseph M. Still Burn Center, Doctors Hospital, Augusta, Georgia; †Joseph M. Still Research Foundation, Inc., Augusta, Georgia; ‡Joseph M. Still Burn Centers, Inc., Augusta, Georgia; and §MED Institute, Inc., West Lafayette, Indiana.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BCR.0000000000000186DOI Listing
April 2016

Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration.

J Pathol 2016 Feb 24;238(3):446-56. Epub 2015 Dec 24.

Stephen A Wynn Institute for Vision Research and Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900182PMC
February 2016

Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.

Stem Cells Transl Med 2016 Feb 18;5(2):132-40. Epub 2015 Dec 18.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5966/sctm.2015-0206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729558PMC
February 2016

Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial.

Transl Res 2015 Dec 29;166(6):740-749.e1. Epub 2015 Aug 29.

Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Howard Hughes Medical Institute, Department of Ophthalmology and Visual Science, University of Iowa, Iowa City, Iowa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702513PMC
December 2015

Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.

Invest Ophthalmol Vis Sci 2015 Dec;56(13):8258-67

Stephen A. Wynn Institute for Vision Research Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.15-17073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110238PMC
December 2015

Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study.

Sci Rep 2015 Jul 3;5:11791. Epub 2015 Jul 3.

Stephen A Wynn Institute for Vision Research, Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep11791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490339PMC
July 2015

REFRACTILE DRUSEN: Clinical Imaging and Candidate Histology.

Retina 2015 May;35(5):859-65

*Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York; †Department of Ophthalmology, University of Alabama, Birmingham, Alabama; and ‡Department of Ophthalmology and Visual Sciences, Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IAE.0000000000000503DOI Listing
May 2015

Effect of internal limiting membrane abrasion on retinal tissues in macular holes.

Invest Ophthalmol Vis Sci 2015 May;56(5):2783-9

Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States 2Omics Laboratory, Iowa City, Iowa, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.14-16355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416746PMC
May 2015

Regional assessment of energy-producing metabolic activity in the endothelium of donor corneas.

Invest Ophthalmol Vis Sci 2015 May;56(5):2803-10

University of Iowa Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Iowa City, Iowa, United States 2Iowa Lions Eye Bank, Coralville, Iowa, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.15-16442DOI Listing
May 2015

Validity of Automated Choroidal Segmentation in SS-OCT and SD-OCT.

Invest Ophthalmol Vis Sci 2015 May;56(5):3202-11

Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States 4Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States 6Stephen Wynn Institute for Vi.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.14-15669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451615PMC
May 2015

Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

Prog Retin Eye Res 2015 Mar 5;45:1-29. Epub 2014 Dec 5.

The Stephen A. Wynn Institute for Vision Research, The University of Iowa, United States; Department of Ophthalmology and Visual Sciences, The University of Iowa, United States.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13509462140007
Publisher Site
http://dx.doi.org/10.1016/j.preteyeres.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339497PMC
March 2015

Comparison of retinal and choriocapillaris thicknesses following sitting to supine transition in healthy individuals and patients with age-related macular degeneration.

JAMA Ophthalmol 2015 Mar;133(3):297-303

Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City2The Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2014.5168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777152PMC
March 2015

Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration.

Retina 2015 Jan;35(1):48-57

*Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa; Departments of †Ophthalmology and Visual Sciences, and ‡Biostatistics, University of Iowa, Iowa City, Iowa; and §The Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IAE.0000000000000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513174PMC
January 2015

Vitritis in pediatric genetic retinal disorders.

Ophthalmology 2015 Jan 10;122(1):192-9. Epub 2014 Sep 10.

Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, Iowa; University of Iowa, Stephen A. Wynn Institute for Vision Research, Iowa City, Iowa. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2014.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277925PMC
January 2015

Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases.

Prog Retin Eye Res 2015 Jan 4;44:15-35. Epub 2014 Nov 4.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.preteyeres.2014.10.002DOI Listing
January 2015

Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq.

Exp Eye Res 2014 Dec 5;129:93-106. Epub 2014 Nov 5.

Stephen A. Wynn Institute for Vision Research, The University of Iowa, Iowa City, IA, USA; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Biomedical Engineering, College of Engineering, The University of Iowa, Iowa City, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2014.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259842PMC
December 2014

Stem cells as tools for studying the genetics of inherited retinal degenerations.

Cold Spring Harb Perspect Med 2014 Dec 11;5(5):a017160. Epub 2014 Dec 11.

Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a017160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448588PMC
December 2014

The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning.

Am J Pathol 2014 Nov 7;184(11):3142-53. Epub 2014 Sep 7.

Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa; Stephen A. Wynn Institute for Vision Research, The University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2014.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215023PMC
November 2014

Gene therapy using stem cells.

Cold Spring Harb Perspect Med 2014 Nov 13;5(4). Epub 2014 Nov 13.

The Stephen A. Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a017434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382729PMC
November 2014

A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.

PLoS Genet 2014 Oct 23;10(10):e1004689. Epub 2014 Oct 23.

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Department of Otolaryngology - Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207615PMC
October 2014

Loss of CD34 expression in aging human choriocapillaris endothelial cells.

PLoS One 2014 21;9(1):e86538. Epub 2014 Jan 21.

Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America ; Stephen A. Wynn Institute for Vision Research, The University of Iowa, Iowa City, Iowa, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897719PMC
September 2014

Stem cells for investigation and treatment of inherited retinal disease.

Hum Mol Genet 2014 Sep 18;23(R1):R9-R16. Epub 2014 Mar 18.

Stephen A. Wynn Institute for Vision Research and Howard Hughes Medical Institute, Department of Ophthalmology and Visual Science, Carver College of Medicine, University of Iowa, Iowa city, IA, USA

View Article

Download full-text PDF

Source
https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
Publisher Site
http://dx.doi.org/10.1093/hmg/ddu124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170716PMC
September 2014

Outer segment length in different best disease genotypes.

JAMA Ophthalmol 2014 Sep;132(9):1152-3

Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City.

View Article

Download full-text PDF

Source
http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaophthalmol.2014.2980DOI Listing
September 2014

Is age-related macular degeneration a microvascular disease?

Adv Exp Med Biol 2014 ;801:283-9

Department of Ophthalmology and Visual Sciences, The University of Lowa, 52242, Lowa City, IA, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4614-3209-8_36DOI Listing
July 2014

Mechanical properties of murine and porcine ocular tissues in compression.

Exp Eye Res 2014 Apr 5;121:194-9. Epub 2014 Mar 5.

Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA; The Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2014.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997121PMC
April 2014

Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells.

Mol Vis 2013 16;19:2274-97. Epub 2013 Nov 16.

Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA ; Stephen A. Wynn Institute for Vision Research, The University of Iowa, Iowa City, IA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834599PMC
March 2014

Structural and biochemical analyses of choroidal thickness in human donor eyes.

Invest Ophthalmol Vis Sci 2014 Mar 6;55(3):1352-60. Epub 2014 Mar 6.

Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.13-13754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945900PMC
March 2014

Photoreceptor cells with profound structural deficits can support useful vision in mice.

Invest Ophthalmol Vis Sci 2014 Mar 25;55(3):1859-66. Epub 2014 Mar 25.

Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.13-13661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968928PMC
March 2014

Fcγ receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration.

Invest Ophthalmol Vis Sci 2014 Jan 13;55(1):247-58. Epub 2014 Jan 13.

Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.13-11821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891269PMC
January 2014

Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.

J Stem Cell Res Ther 2014 Jan;3(5):161

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA ; Stephen A. Wynn Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4172/2157-7633.1000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038935PMC
January 2014

Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1.

Invest Ophthalmol Vis Sci 2013 Sep 11;54(9):6118-32. Epub 2013 Sep 11.

Department of Ophthalmology, University of Iowa, Iowa City, Iowa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.13-11673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771708PMC
September 2013

Selection of Phototransduction Genes in Homo sapiens.

Invest Ophthalmol Vis Sci 2013 Aug 13;54(8):5489-96. Epub 2013 Aug 13.

Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.12-11454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743458PMC
August 2013

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.

Elife 2013 Aug 27;2:e00824. Epub 2013 Aug 27.

Department of Ophthalmology and Visual Sciences , University of Iowa Carver College of Medicine , Iowa City , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.00824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755341PMC
August 2013

Prioritization of retinal disease genes: an integrative approach.

Hum Mutat 2013 Jun 12;34(6):853-9. Epub 2013 Apr 12.

Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509594PMC
June 2013

Human photoreceptor outer segments shorten during light adaptation.

Invest Ophthalmol Vis Sci 2013 May 1;54(5):3721-8. Epub 2013 May 1.

Institute for Vision Research, University of Iowa, Iowa City, IA 52242, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.13-11812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668803PMC
May 2013

Automated segmentation of the choroid from clinical SD-OCT.

Invest Ophthalmol Vis Sci 2012 Nov 1;53(12):7510-9. Epub 2012 Nov 1.

Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.12-10311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490539PMC
November 2012