Robert Epple

Robert Epple

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Robert Epple

Robert Epple

Publications by authors named "Robert Epple"

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21Publications

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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.

ACS Med Chem Lett 2019 Jun 23;10(6):887-892. Epub 2019 May 23.

Global Discovery Chemistry, and Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580379PMC
June 2019

A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition.

Curr Biol 2017 Feb 9;27(4):549-555. Epub 2017 Feb 9.

Ernst Strüngmann Institute, Deutschordenstraße 46, 60579 Frankfurt/Main, Germany; Faculty of Biology, University of Freiburg, Albertstraße 23, 79104 Freiburg, Germany; BrainLinks-BrainTools, University of Freiburg, Georges-Köhler-Allee 079, 79110 Freiburg, Germany; Bernstein Center Freiburg, University of Freiburg, Hansastr. 9a, 79104 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.12.052DOI Listing
February 2017

Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies.

Front Hum Neurosci 2016 26;10:183. Epub 2016 Apr 26.

Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden Dresden, Germany.

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http://dx.doi.org/10.3389/fnhum.2016.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844623PMC
May 2016

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.

Bioorg Med Chem Lett 2014 Dec 13;24(23):5478-83. Epub 2014 Oct 13.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.10.010DOI Listing
December 2014

Discovery of structurally novel, potent and orally efficacious GPR119 agonists.

Bioorg Med Chem Lett 2014 May 27;24(10):2383-7. Epub 2014 Mar 27.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.03.023DOI Listing
May 2014

Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S.

Bioorg Med Chem Lett 2007 May 27;17(10):2899-903. Epub 2007 Feb 27.

Genomics Institute of the Novartis Research Foundation (GNF), 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.02.049DOI Listing
May 2007

Bicyclic carbamates as inhibitors of papain-like cathepsin proteases.

Bioorg Med Chem Lett 2007 Mar 9;17(5):1254-9. Epub 2006 Dec 9.

Department of Drug Discovery, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.12.014DOI Listing
March 2007

3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.

Bioorg Med Chem Lett 2006 Nov 22;16(21):5488-92. Epub 2006 Aug 22.

Department of Medicinal Chemistry, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.08.052DOI Listing
November 2006

3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.

Bioorg Med Chem Lett 2006 Aug 5;16(16):4376-80. Epub 2006 Jun 5.

Department of Medicinal Chemistry, The Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.05.055DOI Listing
August 2006

1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.

Bioorg Med Chem Lett 2006 Jun 20;16(11):2969-73. Epub 2006 Mar 20.

Department of Medicinal Chemistry, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.02.079DOI Listing
June 2006

Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.

Bioorg Med Chem Lett 2005 Nov 23;15(22):4979-84. Epub 2005 Sep 23.

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.017DOI Listing
November 2005

Solid-phase synthesis of nucleoside analogues.

J Comb Chem 2003 May-Jun;5(3):292-310

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1021/cc020087fDOI Listing
February 2004

A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins.

Angew Chem Int Ed Engl 2002 Feb;41(3):472-5

Department of Chemistry and The Skaggs Institute for Chemical Biology, BCC-315 The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/1521-3773(20020201)41:3<472::aid-anie472>3.0.co;2-7DOI Listing
February 2002

Flavin- and Deazaflavin-Containing Model Compounds Mimic the Energy Transfer Step in Type-II DNA-Photolyases.

Angew Chem Int Ed Engl 1998 Apr;37(7):938-941

Laboratorium für Organische Chemie, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich (Switzerland), Fax: (+41) 1-632-1109.

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http://dx.doi.org/10.1002/(SICI)1521-3773(19980420)37:7<938::AID-ANIE938>3.0.CO;2-PDOI Listing
April 1998